Daniel T. Laskowitz

Multidisciplinary Neuroprotection Laboratories, Duke University

Research Area

Biography

Daniel T. Laskowitz has not added Biography.
If you are Daniel T. Laskowitz and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 33	2014

Other Publications

Article	Year
Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Annals of neurology\| PubMed ID: 11782990	2002
The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery. Anesthesia and analgesia\| PubMed ID: 11812686	2002
Apolipoprotein E isoform mediated regulation of nitric oxide release. Free radical biology & medicine\| PubMed ID: 12031891	2002
Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis? Anesthesia and analgesia\| PubMed ID: 12031994	2002
Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis. Neurological research\| PubMed ID: 12117325	2002
Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. Stroke; a journal of cerebral circulation\| PubMed ID: 12215605	2002
Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurgery\| PubMed ID: 12383357	2002
Apolipoprotein E protects against NMDA excitotoxicity. Neurobiology of disease\| PubMed ID: 12460559	2002
Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke; a journal of cerebral circulation\| PubMed ID: 12468796	2002
Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 12539012	2003
Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery. Stroke; a journal of cerebral circulation\| PubMed ID: 12574568	2003
Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation. Journal of radiation research\| PubMed ID: 12793762	2002
Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Journal of neurosurgery\| PubMed ID: 12816268	2003
Early biomarkers of stroke. Clinical chemistry\| PubMed ID: 14500614	2003
APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. The Journal of biological chemistry\| PubMed ID: 14507923	2003
Novel diagnostic test for acute stroke. Stroke; a journal of cerebral circulation\| PubMed ID: 14671250	2004
Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage. Neurosurgery\| PubMed ID: 15157293	2004
Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol lowering. Clinical neurosurgery\| PubMed ID: 15571161	2004
A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. Experimental neurology\| PubMed ID: 15698624	2005
Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury. Neuroscience letters\| PubMed ID: 15896489	2005
Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. Stroke; a journal of cerebral circulation\| PubMed ID: 16051891	2005
Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass. Journal of cardiothoracic and vascular anesthesia\| PubMed ID: 16130053	2005
APOE polymorphism is associated with risk of severe sepsis in surgical patients. Critical care medicine\| PubMed ID: 16276176	2005
Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. European journal of pharmacology\| PubMed ID: 16455070	2006
A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. Neurocritical care\| PubMed ID: 16498192	2006
Changing outcome from aneurysmal subarachnoid hemorrhage: another step closer. Anesthesiology\| PubMed ID: 16571953	2006
Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-res... Clinical neurosurgery\| PubMed ID: 16626096	2005
Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery. Psychosomatic medicine\| PubMed ID: 16738066	2006
Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 16740622	2006
Central nervous system injury associated with cardiac surgery. Lancet\| PubMed ID: 16920475	2006
Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage. Neurocritical care\| PubMed ID: 16960300	2006
Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage. Neurosurgical focus\| PubMed ID: 17029343	2006
Can D-dimer levels identify patients at risk for early neurological deterioration in acute ischemic stroke? Nature clinical practice. Neurology\| PubMed ID: 17057742	2006
Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience. Journal of neurosurgery\| PubMed ID: 17121126	2006
Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Critical care medicine\| PubMed ID: 17133176	2007
Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway. Neurological research\| PubMed ID: 17509222	2007
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Experimental neurology\| PubMed ID: 17521631	2007
COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. Journal of neurotrauma\| PubMed ID: 17610350	2007
Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions. Pharmacogenomics\| PubMed ID: 17716229	2007
Preclinical models of intracerebral hemorrhage: a translational perspective. Neurocritical care\| PubMed ID: 18058257	2008
Statins in acute brain injury: getting the cart before the horse. Neurocritical care\| PubMed ID: 18094941	2008
Challenges in enrollment of minority, pediatric, and geriatric patients in emergency and acute care clinical research. Annals of emergency medicine\| PubMed ID: 18191297	2008
Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction. Ultrasound in medicine & biology\| PubMed ID: 18395321	2008
Management of post-subarachnoid hemorrhage vasospasm. Current atherosclerosis reports\| PubMed ID: 18606107	2008
Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives. Experimental neurology\| PubMed ID: 18625221	2008
The use of S100B as a biomarker in subarachnoid hemorrhage: clarity in its promise and limits. Critical care medicine\| PubMed ID: 18664797	2008
The ultrasound brain helmet: feasibility study of multiple simultaneous 3D scans of cerebral vasculature. Ultrasound in medicine & biology\| PubMed ID: 18947918	2009
Clinical usefulness of a biomarker-based diagnostic test for acute stroke: the Biomarker Rapid Assessment in Ischemic Injury (BRAIN) study. Stroke; a journal of cerebral circulation\| PubMed ID: 18948614	2009
Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. Stroke; a journal of cerebral circulation\| PubMed ID: 19109539	2009
Use of emergency department transcranial Doppler assessment of reperfusion after intravenous tPA for ischemic stroke. The Journal of emergency medicine\| PubMed ID: 19111426	2012
Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery. Stroke; a journal of cerebral circulation\| PubMed ID: 19164788	2009
Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 19251191	2009
S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals\| PubMed ID: 19505208	2009
Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. Journal of neurotrauma\| PubMed ID: 19803787	2010
Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage. Journal of neurosurgical anesthesiology\| PubMed ID: 19955895	2009
Statins in traumatic brain injury. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 20129498	2010
Clinical application of blood biomarkers in cerebrovascular disease. Expert review of neurotherapeutics\| PubMed ID: 20136376	2010
Engaging students in dedicated research and scholarship during medical school: the long-term experiences at Duke and Stanford. Academic medicine : journal of the Association of American Medical Colleges\| PubMed ID: 20182114	2010
Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. Anesthesiology\| PubMed ID: 20216394	2010
Defining optimal cerebral perfusion pressures in acute brain injury: a step toward individualization of care? Critical care medicine\| PubMed ID: 20404636	2010
Discriminative capacity of biomarkers for acute stroke in the emergency department. The Journal of emergency medicine\| PubMed ID: 20417054	2011
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology\| PubMed ID: 20548049	2010
Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. Journal of neurotrauma\| PubMed ID: 20812776	2010
Biomarkers in stroke: when will they impact care? Journal of the American College of Cardiology\| PubMed ID: 20846605	2010
Progressive multifocal leukoencephalopathy with occult Waldenström macroglobulinemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 20855833	2010
Neuroprotection in subarachnoid hemorrhage. Stroke; a journal of cerebral circulation\| PubMed ID: 20876512	2010
A reversible aptamer improves outcome and safety in murine models of stroke and hemorrhage. Oligonucleotides\| PubMed ID: 21142878	2011
The ultrasound brain helmet: new transducers and volume registration for in vivo simultaneous multi-transducer 3-D transcranial imaging. IEEE transactions on ultrasonics, ferroelectrics, and frequency control\| PubMed ID: 21693401	2011
The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage. Neurocritical care\| PubMed ID: 21989844	2012
Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: A translational approach. Journal of neurotrauma\| PubMed ID: 22233347	2012
Evolving role of biomarkers in acute cerebrovascular disease. Annals of neurology\| PubMed ID: 22451199	2012
Depression and antidepressant use after stroke and transient ischemic attack. Stroke; a journal of cerebral circulation\| PubMed ID: 22461330	2012
TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice. Anesthesiology\| PubMed ID: 22487803	2012
Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 22704946	2012
Biomarkers in traumatic brain injury. Current neurology and neuroscience reports\| PubMed ID: 22811071	2012
Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. The Journal of biological chemistry\| PubMed ID: 23118226	2012
Letter by El Husseini et al regarding article, "What causes disability after transient ischemic attack and minor stroke?". Stroke; a journal of cerebral circulation\| PubMed ID: 23160877	2012
ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Experimental neurology\| PubMed ID: 23219883	2013
Lacosamide improves outcome in a murine model of traumatic brain injury. Neurocritical care\| PubMed ID: 23269559	2013
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Critical care (London, England)\| PubMed ID: 23388612	2013
Simultaneous bilateral real-time 3-d transcranial ultrasound imaging at 1 MHz through poor acoustic windows. Ultrasound in medicine & biology\| PubMed ID: 23415287	2013
Teaching neuroimages: vein of Galen aneurysm mimicking pineal mass in a young adult. Neurology\| PubMed ID: 23713094	2013
Interaction between sex and apolipoprotein e genetic background in a murine model of intracerebral hemorrhage. Translational stroke research\| PubMed ID: 23935764	2012
Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage. Journal of neuroinflammation\| PubMed ID: 23962089	2013
Predictors of late neurological deterioration after spontaneous intracerebral hemorrhage. Neurocritical care\| PubMed ID: 23979796	2013
Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery. Stroke; a journal of cerebral circulation\| PubMed ID: 24105697	2013
A Blood-based Biomarker Panel to Detect Acute Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\| PubMed ID: 24119630	2014
Predictors of extraventricular drain-associated bacterial ventriculitis. Journal of critical care\| PubMed ID: 24125770	2014
3-D transcranial ultrasound imaging with bilateral phase aberration correction of multiple isoplanatic patches: a pilot human study with microbubble contrast enhancement. Ultrasound in medicine & biology\| PubMed ID: 24239360	2014
Genetic influences and neuropathological sequelae of repetitive brain injury. Annals of neurology\| PubMed ID: 24243027	2014
Gender and age interact to affect early outcome after intracerebral hemorrhage. PloS one\| PubMed ID: 24312335	2013
pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH. Neurocritical care\| PubMed ID: 24420693	2014
The role of neuroendocrine pathways in prognosis after stroke. Expert review of neurotherapeutics\| PubMed ID: 24428141	2014
Response to letter regarding article, "Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery". Stroke; a journal of cerebral circulation\| PubMed ID: 24448987	2014
Statins and Delirium During Critical Illness: A Multicenter, Prospective Cohort Study. Critical care medicine\| PubMed ID: 24810528	2014