a-low-cost-method-for-analyzing-seizure-like-activity-movement

A Low-cost Method for Analyzing Seizure-like Activity and Movement in <em>Drosophila</em>

Video tracking systems have been used widely to analyze Drosophila melanogaster movement and detect various abnormalities in locomotive behavior. While ...

Franciscan University of Steubenville

Immunotherapy and allergic fungal sinusitis.

LMO2 and gene therapy for severe combined immunodeficiency.

The nature of inpatient pediatrics is changing. Over the past decade, several factors have converged to influence the kinds of children currently being hospitalized. There has been a shift in the relative proportion of otherwise healthy children with acute illnesses being hospitalized to children with increasing medical complexity. This article focuses on hospitalist care of medically complex children and provides an overview on (1) the challenges in defining this population, (2) the unique issues surrounding their inpatient care (using a family-centered care approach that includes coordinated care, minimizing secondary complications, nutritional needs, functional limitations, transdisciplinary collaboration, and primary care issues), (3) technology devices commonly found, and (4) a proposal for a research agenda regarding medically complex children.

Hospitalist care of the medically complex child.

The goals were (1) to identify evidence-based clinical process measures that are appropriate, feasible, and reliable for assessing the quality of inpatient asthma care for children and (2) to evaluate provider compliance with these measures.

Quality of care for children hospitalized with asthma.

Families of children with complex chronic medical illnesses (CCMI) benefit from coordinated, family-centered healthcare.

Children with chronic complex medical illnesses: Is inpatient care family-centered?

Delays in discharges affect both efficiency and timeliness of care; 2 measures of quality of inpatient care.

Delays in discharge in a tertiary care pediatric hospital.

To evaluate admission medication reconciliation in children with medically complex conditions (MCC) by determining the availability and accuracy of five information sources and characterising admitting order errors.

Hospital admission medication reconciliation in medically complex children: an observational study.

Hospitalized children are perceived to be increasingly medically complex, but no such trend has been documented. The objective of this study was to determine whether the proportion of pediatric inpatient use that is attributable to patients with a diagnosis of one or more complex chronic condition (CCC) has increased over time and to assess the degree to which CCC hospitalizations are associated with attributes that are consistent with heightened medical complexity.

Children with complex chronic conditions in inpatient hospital settings in the United States.

Survival of children and young people with cerebral palsy.

To describe patient demographics, interventions, and outcomes in hospitalized children with macrophage activation syndrome (MAS) complicating systemic lupus erythematosus (SLE) or juvenile idiopathic arthritis (JIA).

Macrophage activation syndrome in children with systemic lupus erythematosus and children with juvenile idiopathic arthritis.

The Joint Commission introduced 3 Children's Asthma Care (CAC 1-3) measures to improve the quality of pediatric inpatient asthma care. Validity of the commission's measures has not yet been demonstrated. The objectives of this quality improvement study were to examine changes in provider compliance with CAC 1-3 and associated asthma hospitalization outcomes after full implementation of an asthma care process model (CPM).

The Joint Commission Children's Asthma Care quality measures and asthma readmissions.

There is increasing evidence that alterations in metabolism can affect seizure susceptibility in a wide range of organisms. In order to investigate the link between metabolism and seizures, we took advantage of a group of Drosophila mutants, the Bang-sensitive (BS) paralytics, which are 3-10 times more susceptible to seizure-like activity (SLA) than wild type flies following a variety of stimuli including mechanical shock. To alter metabolism, we introduced the atsugari (atu) mutation into three of the BS mutants, easily shocked (eas), bang senseless (bss), and technical knockout (tko). The atu mutants, which exhibit reduced expression of the Drosophila ortholog of dystroglycan gene, have previously been shown to have a higher metabolic rate than wild type flies. Following mechanical shock, all three BS;atu double mutants displayed a reduction in SLA and the eas;atu and tko;atu double mutants recovered from the shock quicker than the respective single mutant BS flies. In addition, the eas;atu and tko;atu flies displayed higher levels of metabolism as compared to the single mutant BS flies. To further study the correlation between metabolism and seizure susceptibility, the three BS strains were fed a sulfonylurea drug (tolbutamide) known to both increase heamolymph glucose concentrations and stimulate lipid metabolism in flies. Following mechanical shock, the eas and tko mutants fed tolbutamide displayed less SLA and recovered quicker than unfed flies. While the bss mutants fed tolbutamide did not display a reduction in SLA, they did recover quicker than unfed controls. These data indicate that the upregulation of metabolism can have a protective effect against seizure susceptibility, a result that suggests new avenues for possible drug development.

Genetic and pharmacological manipulations that alter metabolism suppress seizure-like activity in Drosophila.

This paper describes the development and evaluation of an innovative application designed to engage children and their parents in weekly asthma self-monitoring and self-management to prompt an early response to deteriorations in chronic asthma control, and to provide their physicians with longitudinal data to assess the effectiveness of asthma therapy and prompt adjustments. The evaluation included 2 iterative usability testing cycles with 6 children with asthma and 2 parents of children with asthma to assess user performance and satisfaction with the application. Several usability problems were identified and changes were made to ensure acceptability of the application and relevance of the content. This novel application is unique compared to existing asthma tools and may shift asthma care from the current reactive, acute care model to a preventive, proactive patient-centered approach where treatment decisions are tailored to patients' individual patterns of chronic asthma control to prevent acute exacerbations.

Development of a novel tool for engaging children and parents in asthma self-management.

To establish longitudinal validation of a new tool, the Asthma Symptom Tracker (AST). AST combines weekly use of the Asthma Control Test with a color-coded graph for visual trending.

Article	Year
Immunotherapy and allergic fungal sinusitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 12027079	2002
LMO2 and gene therapy for severe combined immunodeficiency. The New England journal of medicine\| PubMed ID: 15195349	2004
Hospitalist care of the medically complex child. Pediatric clinics of North America\| PubMed ID: 16009262	2005
Quality of care for children hospitalized with asthma. Pediatrics\| PubMed ID: 18977987	2008
Children with chronic complex medical illnesses: Is inpatient care family-centered? Journal of pediatric rehabilitation medicine\| PubMed ID: 19779597	2008
Delays in discharge in a tertiary care pediatric hospital. Journal of hospital medicine : an official publication of the Society of Hospital Medicine\| PubMed ID: 19824097	2009
Hospital admission medication reconciliation in medically complex children: an observational study. Archives of disease in childhood\| PubMed ID: 19948664	2010
Children with complex chronic conditions in inpatient hospital settings in the United States. Pediatrics\| PubMed ID: 20855394	2010
Survival of children and young people with cerebral palsy. Developmental medicine and child neurology\| PubMed ID: 21745201	2011
Macrophage activation syndrome in children with systemic lupus erythematosus and children with juvenile idiopathic arthritis. Arthritis and rheumatism\| PubMed ID: 22886474	2012
The Joint Commission Children's Asthma Care quality measures and asthma readmissions. Pediatrics\| PubMed ID: 22908110	2012
Genetic and pharmacological manipulations that alter metabolism suppress seizure-like activity in Drosophila. Brain research\| PubMed ID: 23247062	2013
Development of a novel tool for engaging children and parents in asthma self-management. AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium\| PubMed ID: 23304339	2012
Longitudinal validation of a tool for asthma self-monitoring. Pediatrics\| PubMed ID: 24218469	2013

Bryan Stone

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