Douglas R. Seals

Department of Integrative Physiology, University of Colorado, Boulder

Affiliated withUniversity of Colorado, Boulder

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 25	2014

Other Publications

Article	Year
Decline in insulin action with age in endurance-trained humans. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 12391128	2002
The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 11832414	2002
Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 11896010	2002
Is autonomic support of arterial blood pressure related to habitual exercise status in healthy men? The Journal of physiology\| PubMed ID: 11956356	2002
Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress. Biogerontology\| PubMed ID: 12014841	2002
Changes in maximal aerobic capacity with age in endurance-trained women: 7-yr follow-up. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 12015340	2002
Arterial intima-media thickness: site-specific associations with HRT and habitual exercise. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12234791	2002
Declines in physiological functional capacity with age: a longitudinal study in peak swimming performance. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 12391125	2003
Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. The Journal of physiology\| PubMed ID: 24665093	2014
Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 12533496	2003
Use of acetylene breathing to determine cardiac output in young and older adults. Medicine and science in sports and exercise\| PubMed ID: 12544636	2003
Basal leg blood flow in healthy women is related to age and hormone replacement therapy status. The Journal of physiology\| PubMed ID: 12562958	2003
Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovascular research\| PubMed ID: 12618248	2003
Baroreflex buffering is reduced with age in healthy men. Circulation\| PubMed ID: 12665501	2003
Habitual exercise and the age-associated decline in large artery compliance. Exercise and sport sciences reviews\| PubMed ID: 12715969	2003
Baroreflex buffering in sedentary and endurance exercise-trained healthy men. Hypertension\| PubMed ID: 12732585	2003
Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 14555676	2003
Adiposity contributes to differences in left ventricular structure and diastolic function with age in healthy men. The Journal of clinical endocrinology and metabolism\| PubMed ID: 14557469	2003
Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic activity with primary aging in adult humans. The Journal of clinical endocrinology and metabolism\| PubMed ID: 14557479	2003
Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness. European heart journal\| PubMed ID: 14659773	2003
Chronic sympathetic activation: consequence and cause of age-associated obesity? Diabetes\| PubMed ID: 14747276	2004
Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. The Journal of physiology\| PubMed ID: 14754992	2004
Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 14962830	2004
Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15020306	2004
Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension. Hypertension\| PubMed ID: 15173128	2004
Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15178547	2004
High energy flux mediates the tonically augmented beta-adrenergic support of resting metabolic rate in habitually exercising older adults. The Journal of clinical endocrinology and metabolism\| PubMed ID: 15240648	2004
Role of sympathetic neural activation in age- and habitual exercise-related differences in the thermic effect of food. The Journal of clinical endocrinology and metabolism\| PubMed ID: 15472218	2004
Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15475526	2004
Ascorbic acid does not affect the age-associated reduction in maximal cardiac output and oxygen consumption in healthy adults. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 15501926	2005
Stiffening our resolve against adult weight gain. Hypertension\| PubMed ID: 15623541	2005
Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men. Circulation\| PubMed ID: 15687139	2005
Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men. Circulation\| PubMed ID: 15837943	2005
Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women. Hypertension\| PubMed ID: 15867135	2005
Aortic input impedance increases with age in healthy men and women. Hypertension\| PubMed ID: 15867143	2005
Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. The Journal of physiology\| PubMed ID: 16141271	2005
Thermogenic responsiveness to nonspecific beta-adrenergic stimulation is not related to genetic variation in codon 16 of the beta2-adrenergic receptor. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16278251	2006
Thermogenic responsiveness to beta-adrenergic stimulation is augmented in exercising versus sedentary adults: role of oxidative stress. The Journal of physiology\| PubMed ID: 16308351	2006
Cardiac vagal modulation of heart rate during prolonged submaximal exercise in animals with healed myocardial infarctions: effects of training. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16339826	2006
Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing. The Journal of physiology\| PubMed ID: 16439428	2006
Modulatory influences on ageing of the vasculature in healthy humans. Experimental gerontology\| PubMed ID: 16537099	2006
Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 16946027	2007
Oxidative stress explains differences in large elastic artery compliance between sedentary and habitually exercising postmenopausal women. Menopause (New York, N.Y.)\| PubMed ID: 16977254	2006
Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology\| PubMed ID: 17001222	2006
Oxidative stress contributes to chronic leg vasoconstriction in estrogen-deficient postmenopausal women. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17110511	2007
A transdisciplinary model integrating genetic, physiological, and psychological correlates of voluntary exercise. Health psychology : official journal of the Division of Health Psychology, American Psychological Association\| PubMed ID: 17209695	2007
Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress. Circulation\| PubMed ID: 17242275	2007
Commentary on Viewpoint "Human experimentation: no accurate, quantitative data?". Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17341743	2007
Thermic effect of food and beta-adrenergic thermogenic responsiveness in habitually exercising and sedentary healthy adult humans. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17463294	2007
Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circulation research\| PubMed ID: 17478731	2007
Increased thermogenic responsiveness to intravenous beta-adrenergic stimulation in habitually exercising humans is not related to skeletal muscle beta2-adrenergic receptor density. Experimental physiology\| PubMed ID: 17573413	2007
Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms. The Journal of physiology\| PubMed ID: 17717011	2008
High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17965239	2007
Decreased maximal heart rate with aging is related to reduced {beta}-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 18483165	2008
Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension\| PubMed ID: 18504322	2008
Habitual exercise and arterial aging. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 18583377	2008
Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 18669935	2008
Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging cell\| PubMed ID: 18782346	2008
Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise. American journal of hypertension\| PubMed ID: 19114985	2009
2013 APS Edward F. Adolph Distinguished Lecture The Remarkable Anti-Aging Effects of Aerobic Exercise on Systemic Arteries. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 24855137	2014
B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 19211548	2009
Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation\| PubMed ID: 19237660	2009
Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulati... The Journal of physiology\| PubMed ID: 19417091	2009
Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19465546	2009
Vascular endothelial estrogen receptor alpha is modulated by estrogen status and related to endothelial function and endothelial nitric oxide synthase in healthy women. The Journal of clinical endocrinology and metabolism\| PubMed ID: 19509105	2009
Protein expression in vascular endothelial cells obtained from human peripheral arteries and veins. Journal of vascular research\| PubMed ID: 19672102	2010
Habitual exercise and vascular ageing. The Journal of physiology\| PubMed ID: 19723776	2009
Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure. Therapeutic advances in cardiovascular disease\| PubMed ID: 19723834	2009
Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults. Hypertension\| PubMed ID: 20048194	2010
Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. Mechanisms of ageing and development\| PubMed ID: 20064545	2010
Role of NFkappaB in age-related vascular endothelial dysfunction in humans. Aging\| PubMed ID: 20157550	2009
Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clinical science (London, England : 1979)\| PubMed ID: 20642454	2011
Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise. The Journal of physiology\| PubMed ID: 20807791	2010
Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK. Mechanisms of ageing and development\| PubMed ID: 20934448	2010
25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension\| PubMed ID: 21115878	2011
The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association. Circulation\| PubMed ID: 21233236	2011
Aging and vascular endothelial function in humans. Clinical science (London, England : 1979)\| PubMed ID: 21244363	2011
Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging. Aging cell\| PubMed ID: 21276184	2011
Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 21303813	2011
Exercise protects against myocardial ischemia-reperfusion injury via stimulation of β(3)-adrenergic receptors and increased nitric oxide signaling: role of nitrite and nitrosothiols. Circulation research\| PubMed ID: 21527738	2011
Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise. Physiological genomics\| PubMed ID: 21610086	2011
Aerobic exercise reverses arterial inflammation with aging in mice. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21622824	2011
SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans. The Journal of physiology\| PubMed ID: 21746786	2011
Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 21903879	2011
Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress. Aging cell\| PubMed ID: 21943306	2011
Replicative aging induces endothelial to mesenchymal transition in human aortic endothelial cells: potential role of inflammation. Journal of vascular research\| PubMed ID: 21985896	2012
MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation. Experimental gerontology\| PubMed ID: 22037549	2012
Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice. Aging cell\| PubMed ID: 22168264	2012
Vascular Endothelial Function Is Not Related to Serum Uric Acid in Healthy Adults. American journal of hypertension\| PubMed ID: 22237152	2012
Vascular health in the ageing athlete. Experimental physiology\| PubMed ID: 22266948	2012
Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism. Mechanisms of ageing and development\| PubMed ID: 22484146	2012
Translational evidence that impaired autophagy contributes to arterial ageing. The Journal of physiology\| PubMed ID: 22570377	2012
Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products. Experimental gerontology\| PubMed ID: 22588062	2012
Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study. American journal of hypertension\| PubMed ID: 22673017	2012
Hysterectomy is associated with large artery stiffening in estrogen-deficient postmenopausal women. Menopause (New York, N.Y.)\| PubMed ID: 22692329	2012
Vascular smooth muscle responsiveness to nitric oxide is reduced in healthy adults with increased adiposity. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22821988	2012
Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging. Clinical science (London, England : 1979)\| PubMed ID: 23025811	2013
Fenofibrate improves vascular endothelial function by reducing oxidative stress while increasing endothelial nitric oxide synthase in healthy normolipidemic older adults. Hypertension\| PubMed ID: 23108655	2012
Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure. Journal of the American College of Cardiology\| PubMed ID: 23141486	2013
Curcumin ameliorates arterial dysfunction and oxidative stress with aging. Experimental gerontology\| PubMed ID: 23142245	2013
The dependence of FMD% on baseline diameter: a problem solved by allometric scaling - no problem in this case. Clinical science (London, England : 1979)\| PubMed ID: 23368887	2013
The autophagy enhancer spermidine reverses arterial aging. Mechanisms of ageing and development\| PubMed ID: 23612189	2013
Aortic Pulse Wave Velocity and Reflecting Distance Estimation from Peripheral Waveforms in Humans: Detection of Age- and Exercise Training-Related Differences. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 23624628	2013
Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging cell\| PubMed ID: 23714110	2013
Translational physiology: from molecules to public health. The Journal of physiology\| PubMed ID: 23732641	2013
Response to effect of fenofibrate on vascular endothelial function: statistical appraisal and its validity. Hypertension\| PubMed ID: 23819148	2013
Activation of the unfolded protein response in vascular endothelial cells of nondiabetic obese adults. The Journal of clinical endocrinology and metabolism\| PubMed ID: 23913943	2013
Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 23929930	2013
Aging compounds western diet-associated large artery endothelial dysfunction in mice: prevention by voluntary aerobic exercise. Experimental gerontology\| PubMed ID: 23954368	2013
Essential role of estrogen for improvements in vascular endothelial function with endurance exercise in postmenopausal women. The Journal of clinical endocrinology and metabolism\| PubMed ID: 24092827	2013
Battery of behavioral tests in mice that models age-associated changes in human motor function. Age (Dordrecht, Netherlands)\| PubMed ID: 24122289	2014
Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 24311750	2014
Superoxide signaling in perivascular adipose tissue promotes age-related artery stiffness. Aging cell\| PubMed ID: 24341314	2014
Inorganic nitrite supplementation for healthy arterial aging. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 24408999	2014