Cynthia C Bartholomae

Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)

Affiliated withNational Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 14	2014

Other Publications

Article	Year
Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19110638	2009
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. The Journal of clinical investigation\| PubMed ID: 19307726	2009
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science (New York, N.Y.)\| PubMed ID: 19892975	2009
Comprehensive genomic access to vector integration in clinical gene therapy. Nature medicine\| PubMed ID: 19966782	2009
Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing. Nature protocols\| PubMed ID: 20671722	2010
Lentiviral vector integration profiles differ in rodent postmitotic tissues. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21364536	2011
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. Hepatology (Baltimore, Md.)\| PubMed ID: 21520180	2011
Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21540837	2011
An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nature biotechnology\| PubMed ID: 21822255	2011
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21862999	2011
Retroviral gene therapy for X-linked chronic granulomatous disease: results from phase I/II trial. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21878903	2011
Analyzing the number of common integration sites of viral vectors--new methods and computer programs. PloS one\| PubMed ID: 22022353	2011
Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy. Methods in enzymology\| PubMed ID: 22365775	2012
Insertion site pattern: global approach by linear amplification-mediated PCR and mass sequencing. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22367877	2012
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22371846	2013
Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites. Human gene therapy methods\| PubMed ID: 22559057	2012
Dissecting the genomic complexity underlying medulloblastoma. Nature\| PubMed ID: 22832583	2012
Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector. Experimental hematology\| PubMed ID: 22989760	2013
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer. Nature methods\| PubMed ID: 23314173	2013
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer cell\| PubMed ID: 23410972	2013
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature genetics\| PubMed ID: 23817572	2013
Integration-deficient lentiviral vectors expressing codon-optimized R338L human FIX restore normal hemostasis in Hemophilia B mice. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23941813	2014
Transgenic Expression of Human Glial Cell Line-Derived Neurotrophic Factor from Integration-Deficient Lentiviral Vectors is Neuroprotective in a Rodent Model of Parkinson's Disease. Human gene therapy\| PubMed ID: 24635742	2014
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer cell\| PubMed ID: 24651015	2014
Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature\| PubMed ID: 24847876	2014