George R. Douglas

Environmental Health Science and Research Bureau, Environmental Health Centre

Affiliated withEnvironmental Health Centre

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 28	2014

Other Publications

Article	Year
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutagenesis in cultured Big Blue rat mammary epithelial and fibroblast cells. Environmental and molecular mutagenesis\| PubMed ID: 11921195	2002
Mutagenicity of the oral carcinogen 4-nitroquinoline-1-oxide in cultured BigBlue rat tongue epithelial cells and fibroblasts. Mutation research\| PubMed ID: 12517416	2003
Treatment and sampling protocols for transgenic mutation assays. Environmental and molecular mutagenesis\| PubMed ID: 12552586	2003
In vivo transgenic mutation assays. Mutation research\| PubMed ID: 14550498	2003
Development and characterization of a stable epithelial cell line from Muta Mouse lung. Environmental and molecular mutagenesis\| PubMed ID: 14556224	2003
Comprehensive comparison of six microarray technologies. Nucleic acids research\| PubMed ID: 15333675	2004
Molecular insight into the effects of hypothyroidism on the developing cerebellum. Biochemical and biophysical research communications\| PubMed ID: 15823568	2005
Automation of cDNA microarray hybridization and washing yields improved data quality. Journal of biochemical and biophysical methods\| PubMed ID: 16005076	2005
A lacZ transgenic mouse assay for the detection of mutations in follicular granulosa cells. Mutation research\| PubMed ID: 16039675	2005
Detailed review of transgenic rodent mutation assays. Mutation research\| PubMed ID: 16081315	2005
Assessment of 3-nitrobenzanthrone reductase activity in mammalian tissues by normal-phase HPLC with fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 16095987	2005
Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use. Environmental health perspectives\| PubMed ID: 16507466	2006
Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid. Mutation research\| PubMed ID: 16516931	2006
Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability... Mutation research\| PubMed ID: 16542687	2006
Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray. BMC genomics\| PubMed ID: 17052352	2006
Hepatic gene expression changes in hypothyroid juvenile mice: characterization of a novel negative thyroid-responsive element. Endocrinology\| PubMed ID: 17463053	2007
Mainstream tobacco smoke causes paternal germ-line DNA mutation. Cancer research\| PubMed ID: 17545587	2007
Increased mutant frequency by carbon black, but not quartz, in the lacZ and cII transgenes of muta mouse lung epithelial cells. Environmental and molecular mutagenesis\| PubMed ID: 17584883	2007
Analysis of gene expression in two human-derived cell lines exposed in vitro to a 1.9 GHz pulse-modulated radiofrequency field. Proteomics\| PubMed ID: 17902192	2007
Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18195365	2008
Mutagenic and carcinogenic hazards of settled house dust. I: Polycyclic aromatic hydrocarbon content and excess lifetime cancer risk from preschool exposure. Environmental science & technology\| PubMed ID: 18441830	2008
Mutagenic and carcinogenic hazards of settled house dust. II: Salmonella mutagenicity. Environmental science & technology\| PubMed ID: 18441831	2008
Tissue-specific metabolic activation and mutagenicity of 3-nitrobenzanthrone in MutaMouse. Environmental and molecular mutagenesis\| PubMed ID: 18613036	2008
Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse. Mutagenesis\| PubMed ID: 18635558	2008
Toxicogenomic analysis of mainstream tobacco smoke-exposed mice reveals repression of plasminogen activator inhibitor-1 gene in heart. Inhalation toxicology\| PubMed ID: 18925475	2009
Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme. Mutagenesis\| PubMed ID: 19535363	2009
The genotoxicity of mainstream and sidestream marijuana and tobacco smoke condensates. Chemical research in toxicology\| PubMed ID: 19947653	2009
Induction of lacZ mutations in MutaMouse primary hepatocytes. Environmental and molecular mutagenesis\| PubMed ID: 19953605	2010
Characterisation of Muta™Mouse λgt10-lacZ transgene: evidence for in vivo rearrangements. Mutagenesis\| PubMed ID: 20724577	2010
New and emerging technologies for genetic toxicity testing. Environmental and molecular mutagenesis\| PubMed ID: 20740635	2011
Mutation spectrum in FE1-MUTA(TM) Mouse lung epithelial cells exposed to nanoparticulate carbon black. Environmental and molecular mutagenesis\| PubMed ID: 20963790	2011
Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 21335049	2011
Suitable top concentration for tests with mammalian cells: mouse lymphoma assay workgroup. Mutation research\| PubMed ID: 21514400	2011
Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta™ Mouse. Environmental and molecular mutagenesis\| PubMed ID: 21976233	2011
Harnessing genomics to identify environmental determinants of heritable disease. Mutation research\| PubMed ID: 22935230	2012
The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development. Environmental and molecular mutagenesis\| PubMed ID: 23355186	2013
No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea. Mutation research\| PubMed ID: 23499255	2013