Mark W. Dewhirst

Department of Radiation Oncology, Duke University Medical Center

Affiliated withDuke University Medical Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2014

Other Publications

Article	Year
Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. BMC cancer\| PubMed ID: 15949035	2005
Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. Cancer research\| PubMed ID: 15958560	2005
Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. Cancer research\| PubMed ID: 15994919	2005
Method for improved accuracy in endogenous urea recovery marker calibrations for microdialysis in tumors. Journal of pharmacological and toxicological methods\| PubMed ID: 15996879	2005
Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient. Cancer chemotherapy and pharmacology\| PubMed ID: 16001167	2006
Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16033838	2005
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer cell\| PubMed ID: 16098463	2005
A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. International journal of radiation oncology, biology, physics\| PubMed ID: 16168847	2005
In regard to Vasanathan et al. (Int J Radiat Oncol Biol Phys 2005;61:145-153). International journal of radiation oncology, biology, physics\| PubMed ID: 16168856	2005
Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. Journal of biomedical optics\| PubMed ID: 16178638	2005
In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212). International journal of radiation oncology, biology, physics\| PubMed ID: 16199328	2005
A comparison of antiangiogenic therapies for the prevention of liver metastases. The Journal of surgical research\| PubMed ID: 16242720	2006
Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 16278169	2005
Thermal medicine, heat shock proteins and cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 16338847	2005
Re-setting the biologic rationale for thermal therapy. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 16338861	2005
Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. Cancer chemotherapy and pharmacology\| PubMed ID: 16341532	2006
Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16397054	2006
New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 16402149	2006
Erythropoietin biology in cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16428469	2006
A unique role of the DNA fragmentation factor in maintaining genomic stability. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16432220	2006
Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16467094	2006
Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer research\| PubMed ID: 16489024	2006
Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity. Molecular cancer therapeutics\| PubMed ID: 16505109	2006
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. Journal of the National Cancer Institute\| PubMed ID: 16507830	2006
The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma. Radiation research\| PubMed ID: 16518899	2006
Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging. Advances in experimental medicine and biology\| PubMed ID: 16594171	2005
Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assay. Angiogenesis\| PubMed ID: 16622786	2006
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16705036	2006
Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 16741309	2006
Hyperthermia mediated liposomal drug delivery. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 16754340	2006
Prospective thermal dosimetry: the key to hyperthermia's future. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 16754346	2006
Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 16754596	2006
Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 16754599	2006
Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16818699	2006
Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury. International journal of radiation oncology, biology, physics\| PubMed ID: 16904841	2006
Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs. Journal of the National Cancer Institute\| PubMed ID: 16912264	2006
Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16963563	2006
Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17020978	2006
Chemodosimetry of in vivo tumor liposomal drug concentration using MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 17029236	2006
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature\| PubMed ID: 17051156	2006
Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 17079216	2006
A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17121901	2006
Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation. Cancer research\| PubMed ID: 17178846	2006
Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects. Journal of the National Cancer Institute\| PubMed ID: 17202113	2007
Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. International journal of radiation oncology, biology, physics\| PubMed ID: 17236973	2007
Effects of fluctuating oxygenation on tirapazamine efficacy: Theoretical predictions. International journal of radiation oncology, biology, physics\| PubMed ID: 17236974	2007
A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. Molecular cancer therapeutics\| PubMed ID: 17237297	2007
Multiple etiologies of tumor hypoxia require multifaceted solutions. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17255256	2007
Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer research\| PubMed ID: 17283112	2007
An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy. Annals of biomedical engineering\| PubMed ID: 17417737	2007
Regulation of HIF-1alpha stability through S-nitrosylation. Molecular cell\| PubMed ID: 17434127	2007
Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. Cancer research\| PubMed ID: 17440098	2007
Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. Cancer metastasis reviews\| PubMed ID: 17440683	2007
Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors. Cancer research\| PubMed ID: 17483356	2007
Targeting the molecular effects of a hypoxic tumor microenvironment. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 17485359	2007
Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. Cancer research\| PubMed ID: 17510399	2007
In memoriam: Edward L Gillette (1932-2006). Radiation research\| PubMed ID: 17523854	2007
Requirements for T lymphocyte migration in explanted lymph nodes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17548612	2007
Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 17560674	2007
The potential role of intrinsic hypoxia markers as prognostic variables in cancer. Antioxidants & redox signaling\| PubMed ID: 17571959	2007
Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. PloS one\| PubMed ID: 17579721	2007
Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. Blood\| PubMed ID: 17609430	2007
Predicting lung radiotherapy-induced pneumonitis using a model combining parametric Lyman probit with nonparametric decision trees. International journal of radiation oncology, biology, physics\| PubMed ID: 17637394	2007
RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17912235	2008
Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer. The Journal of surgical research\| PubMed ID: 17950331	2008
Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. Free radical research\| PubMed ID: 17957541	2007
Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model. Anticancer research\| PubMed ID: 17970050	2007
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18182667	2008
PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator. AJR. American journal of roentgenology\| PubMed ID: 18212229	2008
Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 18214771	2008
Analytic solution to steady-state radial diffusion of a substrate with first-order reaction kinetics in the tissue of a Krogh's cylinder. Radiation research\| PubMed ID: 18302491	2008
Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors. Journal of biomedical optics\| PubMed ID: 18315384	2008
Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors. Cancer chemotherapy and pharmacology\| PubMed ID: 18365198	2009
One-stop-shop tumor imaging: buy hypoxia, get lactate free. The Journal of clinical investigation\| PubMed ID: 18431517	2008
Bromelain treatment decreases neutrophil migration to sites of inflammation. Clinical immunology (Orlando, Fla.)\| PubMed ID: 18482869	2008
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nature reviews. Cancer\| PubMed ID: 18500244	2008
Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy. Cancer investigation\| PubMed ID: 18584345	2008
Low-intensity alternating electric fields: a potentially safe and effective treatment of cancer? Onkologie\| PubMed ID: 18596380	2008
Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 18608573	2008
Radiofrequency ablation: the effect of distance and baseline temperature on thermal dose required for coagulation. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 18608586	2008
The pervasive presence of fluctuating oxygenation in tumors. Cancer research\| PubMed ID: 18632635	2008
Hyperthermia and nanotechnology - a note from the Editor-in-chief. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 18923988	2008
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. Cancer research\| PubMed ID: 18974123	2008
In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy. AJR. American journal of roentgenology\| PubMed ID: 19020250	2008
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. The Journal of clinical investigation\| PubMed ID: 19033663	2008
Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B. Organic letters\| PubMed ID: 19111058	2009
Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. Optics letters\| PubMed ID: 19183634	2009
Hyperthermia classic commentary: 'Arrhenius relationships from the molecule and cell to the clinic' by William Dewey, Int. J. Hyperthermia, 10:457-483, 1994. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 19219696	2009
Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer. Medical oncology (Northwood, London, England)\| PubMed ID: 19235531	2010
The performance of a reduced-order adaptive controller when used in multi-antenna hyperthermia treatments with nonlinear temperature-dependent perfusion. Physics in medicine and biology\| PubMed ID: 19265209	2009
Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. Free radical biology & medicine\| PubMed ID: 19361553	2009
Quantitative diffuse reflectance and fluorescence spectroscopy: tool to monitor tumor physiology in vivo. Journal of biomedical optics\| PubMed ID: 19405740	2009
Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. Bioorganic & medicinal chemistry letters\| PubMed ID: 19423348	2009
Structural adaptation and heterogeneity of normal and tumor microvascular networks. PLoS computational biology\| PubMed ID: 19478883	2009
Novel imaging provides new insights into mechanisms of oxygen transport in tumors. Current molecular medicine\| PubMed ID: 19519401	2009
Increased skin carcinogenesis in caspase-activated DNase knockout mice. Carcinogenesis\| PubMed ID: 19541853	2009
Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer. Biomarker insights\| PubMed ID: 19578493	2008
Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. Free radical biology & medicine\| PubMed ID: 19591920	2009
Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19622579	2009
DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 19657852	2009
Characterization of a 137Cs irradiator from a new perspective with modern dosimetric tools. Health physics\| PubMed ID: 19667802	2009
A dual-emissive-materials design concept enables tumour hypoxia imaging. Nature materials\| PubMed ID: 19668206	2009
Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors. Neoplasia (New York, N.Y.)\| PubMed ID: 19724683	2009
Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts. Journal of biomedical optics\| PubMed ID: 19895152	2009
Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 19896999	2010
Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiation research\| PubMed ID: 19929412	2009
Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19959769	2010
Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. Medical physics\| PubMed ID: 19994492	2009
Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation. Future oncology (London, England)\| PubMed ID: 20021214	2010
Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 20170362	2010
Longitudinal optical imaging of tumor metabolism and hemodynamics. Journal of biomedical optics\| PubMed ID: 20210438	2010
Application of mixed spin iMQCs for temperature and chemical-selective imaging. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 20303808	2010
A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 20377362	2010
Mathematical formulation and analysis of the nonlinear system reconstruction of the online image-guided adaptive control of hyperthermia. Medical physics\| PubMed ID: 20384234	2010
Effective learning strategies for real-time image-guided adaptive control of multiple-source hyperthermia applicators. Medical physics\| PubMed ID: 20384266	2010
Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities. Amino acids\| PubMed ID: 20473774	2012
Effect of pazopanib on tumor microenvironment and liposome delivery. Molecular cancer therapeutics\| PubMed ID: 20515941	2010
Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 20597627	2010
The shunt problem: control of functional shunting in normal and tumour vasculature. Nature reviews. Cancer\| PubMed ID: 20631803	2010
A feasibility study using radiochromic films for fast neutron 2D passive dosimetry. Physics in medicine and biology\| PubMed ID: 20693612	2010
Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation. ACS nano\| PubMed ID: 20704337	2010
Low-carbohydrate diets and prostate cancer: how low is "low enough"? Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 20716631	2010
Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity. Contrast media & molecular imaging\| PubMed ID: 20812289	2010
Individual responses to chemotherapy-induced oxidative stress. Breast cancer research and treatment\| PubMed ID: 20830514	2011
Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: a review of the randomised data. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 20849256	2010
Hyperthermia for locally advanced breast cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 20849257	2010
Magnetic resonance imaging: a potential tool in assessing the addition of hyperthermia to neoadjuvant therapy in patients with locally advanced breast cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 20849258	2010
Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. Free radical research\| PubMed ID: 20942564	2011
NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21059928	2010
Durable palliation of breast cancer chest wall recurrence with radiation therapy, hyperthermia, and chemotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 21074876	2010
Optical imaging of tumor hypoxia dynamics. Journal of biomedical optics\| PubMed ID: 21198195	2010
Molecular imaging of hypoxia. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 21233176	2011
Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors. Anti-cancer agents in medicinal chemistry\| PubMed ID: 21291403	2011
Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21292819	2011
Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 21314334	2011
ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells. Breast cancer research and treatment\| PubMed ID: 21559822	2012
Thresholds for thermal damage to normal tissues: an update. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 21591897	2011
Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics. Free radical biology & medicine\| PubMed ID: 21616142	2011
Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes. Breast cancer research : BCR\| PubMed ID: 21672245	2011
In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21763734	2011
Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate. Free radical research\| PubMed ID: 21859376	2011
In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters. Nature protocols\| PubMed ID: 21886101	2011
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. The Journal of clinical investigation\| PubMed ID: 21926464	2011
Structural adaptation of normal and tumour vascular networks. Basic & clinical pharmacology & toxicology\| PubMed ID: 21995550	2012
Introduction to the special issue on molecular imaging in radiation biology. Radiation research\| PubMed ID: 22332930	2012
Application of optical imaging and spectroscopy to radiation biology. Radiation research\| PubMed ID: 22360397	2012
Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma. Medical physics\| PubMed ID: 22380348	2012
Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. BJU international\| PubMed ID: 22394625	2012
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. PloS one\| PubMed ID: 22428047	2012
Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22496203	2012
Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 22604887	2012
Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain, behavior, and immunity\| PubMed ID: 22610066	2013
A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion. Cancer\| PubMed ID: 22674423	2012
Miniature microwave applicator for murine bladder hyperthermia studies. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 22690856	2012
High-resolution in vivo imaging of fluorescent proteins using window chamber models. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22700402	2012
A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5). Nuclear medicine and biology\| PubMed ID: 22727821	2012
Thermal dose fractionation affects tumour physiological response. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 22804741	2012
Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors. Cancer research\| PubMed ID: 22952218	2012
Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways. The Prostate\| PubMed ID: 23192356	2013
Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe. Journal of biophotonics\| PubMed ID: 23242854	2014
Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response. PloS one\| PubMed ID: 23326340	2013
The impact of temperature and urinary constituents on urine viscosity and its relevance to bladder hyperthermia treatment. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 23489163	2013
Radiation induces aerobic glycolysis through reactive oxygen species. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 23541363	2013
CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels? European radiology\| PubMed ID: 23553588	2013
Angiogenesis: an adaptive dynamic biological patterning problem. PLoS computational biology\| PubMed ID: 23555218	2013
Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose. Cancer investigation\| PubMed ID: 23621632	2013
Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes. Surgical oncology clinics of North America\| PubMed ID: 23622079	2013
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Science signaling\| PubMed ID: 23652204	2013
18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23740105	2013
Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm. Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 23781901	2013
Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the T... The open nanomedicine journal\| PubMed ID: 23807899	2011
Preclinical Dosimetry of Magnetic Fluid Hyperthermia for Bladder Cancer. Proceedings of SPIE\| PubMed ID: 23837123	2013
Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 23842792	2013
A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 23879689	2013
Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 23924317	2013
A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 23957326	2013
Tumor cells upregulate normoxic HIF-1α in response to doxorubicin. Cancer research\| PubMed ID: 23959856	2013
Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma. Annals of surgical oncology\| PubMed ID: 23982250	2014
Introduction: tumor as an organ. Seminars in radiation oncology\| PubMed ID: 24012336	2013
Understanding the tumor microenvironment and radioresistance by combining functional imaging with global gene expression. Seminars in radiation oncology\| PubMed ID: 24012344	2013
Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 24050253	2013
Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. PloS one\| PubMed ID: 24069390	2013
PET with 62Cu-ATSM and 62Cu-PTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions. AJR. American journal of roentgenology\| PubMed ID: 24147499	2013
Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer. PloS one\| PubMed ID: 24204635	2013
Imaging tumor hypoxia to advance radiation oncology. Antioxidants & redox signaling\| PubMed ID: 24329000	2014
Control time reduction using virtual source projection for treating a leg sarcoma with nonlinear perfusion. Proceedings of SPIE\| PubMed ID: 24392195	2009
Rationalization of thermal injury quantification methods: application to skin burns. Burns : journal of the International Society for Burn Injuries\| PubMed ID: 24418648	2014
Temperature matters! And why it should matter to tumor immunologists. Cancer immunology research\| PubMed ID: 24490177	2013
A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 24490762	2014
Toward an organ based dose prescription method for the improved accuracy of murine dose in orthovoltage x-ray irradiators. Medical physics\| PubMed ID: 24593746	2014
Therapeutic properties of aerobic training after a cancer diagnosis: more than a one-trick pony? Journal of the National Cancer Institute\| PubMed ID: 24627274	2014
Targeting N-cadherin Increases Vascular Permeability and Differentially Activates AKT in Melanoma. Annals of surgery\| PubMed ID: 24646553	2014
Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 24669804	2014
The additive damage model: a mathematical model for cellular responses to drug combinations. Journal of theoretical biology\| PubMed ID: 24799130	2014
Linking the history of radiation biology to the hallmarks of cancer. Radiation research\| PubMed ID: 24811865	2014
Comparison of the Hypoxia PET Tracer 18F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 24854792	2014
Verification of a novel method for tube voltage constancy measurement of orthovoltage x-ray irradiators. Medical physics\| PubMed ID: 25086562	2014
Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurren... International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 25144817	2014
Systemic anti-tumour effects of local thermally sensitive liposome therapy. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group\| PubMed ID: 25164143	2014
Radioprotection of the brain white matter by Mn(III) N-butoxyethylpyridylporphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+ Molecular cancer therapeutics\| PubMed ID: 25319393	2014