Cynthia E. Dunbar

Hematology Branch, NHLBI/NIH

Affiliated withNHLBI/NIH

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2014

Other Publications

Article	Year
Retroviral transduction and engraftment ability of primate hematopoietic progenitor and stem cells transduced under serum-free versus serum-containing conditions. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 11863422	2002
Genetic marking as an approach to studying in vivo hematopoiesis: progress in the non-human primate model. Oncogene\| PubMed ID: 12032769	2002
Plasticity and hematopoiesis: Circe's transforming potion? Current opinion in hematology\| PubMed ID: 12042699	2002
Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene. Blood\| PubMed ID: 12130532	2002
Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation. Experimental hematology\| PubMed ID: 12160846	2002
Polyclonal long-term repopulating stem cell clones in a primate model. Blood\| PubMed ID: 12351380	2002
High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia. Blood\| PubMed ID: 12393623	2003
Retroviral transduction efficiency of G-CSF+SCF-mobilized peripheral blood CD34+ cells is superior to G-CSF or G-CSF+Flt3-L-mobilized cells in nonhuman primates. Blood\| PubMed ID: 12424191	2003
Update on hematopoietic stem cell gene transfer using non-human primate models. Current opinion in molecular therapeutics\| PubMed ID: 12435050	2002
Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial. Blood\| PubMed ID: 12456496	2003
Prolonged multilineage clonal hematopoiesis in a rhesus recipient of CD34 positive cells marked with a RD114 pseudotyped oncoretroviral vector. Blood cells, molecules & diseases\| PubMed ID: 12667996	2003
Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood\| PubMed ID: 12676779	2003
Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing. Annals of the New York Academy of Sciences\| PubMed ID: 12799289	2003
Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells. Circulation\| PubMed ID: 12912822	2003
Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydro... Blood\| PubMed ID: 12920024	2004
Direct comparison of RD114-pseudotyped versus amphotropic-pseudotyped retroviral vectors for transduction of rhesus macaque long-term repopulating cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 14529834	2003
Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates. Blood\| PubMed ID: 14962906	2004
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system. Blood\| PubMed ID: 14976042	2004
Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15006605	2004
In vivo gene marking of rhesus macaque long-term repopulating hematopoietic cells using a VSV-G pseudotyped versus amphotropic oncoretroviral vector. The journal of gene medicine\| PubMed ID: 15079811	2004
The presence of the carboxy-terminal fragment of fibronectin allows maintenance of non-human primate long-term hematopoietic repopulating cells during extended ex vivo culture and transducti... Experimental hematology\| PubMed ID: 15102477	2004
The impact of low-dose busulfan on clonal dynamics in nonhuman primates. Blood\| PubMed ID: 15126320	2004
MRI detection of single particles for cellular imaging. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15256592	2004
Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells. Blood\| PubMed ID: 15383461	2005
Gene therapy for hematologic disease: Don't throw the baby out with the bathwater! Seminars in hematology\| PubMed ID: 15508110	2004
Genetic manipulation of hematopoietic stem cells. Seminars in hematology\| PubMed ID: 15508111	2004
Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS biology\| PubMed ID: 15550989	2004
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood\| PubMed ID: 15572591	2005
Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells. Blood\| PubMed ID: 15933056	2005
Stem cell gene transfer: insights into integration and hematopoiesis from primate genetic marking studies. Annals of the New York Academy of Sciences\| PubMed ID: 15958711	2005
Large granular lymphocytic proliferation-associated cyclic thrombocytopenia. American journal of hematology\| PubMed ID: 16044437	2005
A new direction for gene therapy: intrathymic T cell-specific lentiviral gene transfer. The Journal of clinical investigation\| PubMed ID: 16075048	2005
Hematopoietic stem cell gene therapy: dead or alive? Trends in biotechnology\| PubMed ID: 16216357	2005
Resetting the immune system in immune thrombocytopenic purpura: immunoablative strategies. Clinical advances in hematology & oncology : H&O\| PubMed ID: 16235418	2003
Outcomes and risks of granulocyte colony-stimulating factor in patients with coronary artery disease. Journal of the American College of Cardiology\| PubMed ID: 16256862	2005
Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood\| PubMed ID: 16439674	2006
Mobilization as a preparative regimen for hematopoietic stem cell transplantation. Blood\| PubMed ID: 16439683	2006
AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates. Blood\| PubMed ID: 16439684	2006
Anti-interleukin-2 receptor antibody (daclizumab) treatment of corticosteroid-refractory autoimmune thrombocytopenic purpura. Haematologica\| PubMed ID: 16461323	2006
Combination therapy with rFVIIa and platelets for hemorrhage in patients with severe thrombocytopenia and alloimmunization. American journal of hematology\| PubMed ID: 16493611	2006
In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell transplantation in rhesus... Stem cells (Dayton, Ohio)\| PubMed ID: 16497945	2006
Genotoxicity of retroviral integration in hematopoietic cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16624621	2006
Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex vivo hematopoietic stem cell gene therapy. Blood\| PubMed ID: 16868255	2006
Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates. Human gene therapy\| PubMed ID: 17328682	2007
Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene. Blood\| PubMed ID: 17353346	2007
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood\| PubMed ID: 17374737	2007
Hematopoietic stem-cell behavior in nonhuman primates. Blood\| PubMed ID: 17526860	2007
Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI. Contrast media & molecular imaging\| PubMed ID: 17541955	2007
No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells. Stem cells (Dayton, Ohio)\| PubMed ID: 17615269	2007
Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors. Human gene therapy\| PubMed ID: 17655493	2007
Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing. Blood\| PubMed ID: 17709602	2007
The yin and yang of stem cell gene therapy: insights into hematopoiesis, leukemogenesis, and gene therapy safety. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program\| PubMed ID: 18024665	2007
The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18227842	2008
HOXB4 and retroviral vectors: adding fuel to the fire. The Journal of clinical investigation\| PubMed ID: 18357348	2008
Large animal models for stem and progenitor cell analysis. Current protocols in immunology / edited by John E. Coligan ... [et al.]\| PubMed ID: 18432946	2005
Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population. Blood\| PubMed ID: 18523146	2008
Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18578011	2008
Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer. Human gene therapy\| PubMed ID: 18764738	2008
More frequent Blood transfusions. Blood\| PubMed ID: 19122117	2009
'Ghostbusting' at blood. Blood\| PubMed ID: 19147793	2009
Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche. Nature cell biology\| PubMed ID: 19198600	2009
Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells. Blood\| PubMed ID: 19339698	2009
Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates. The American journal of pathology\| PubMed ID: 19349370	2009
Introducing "e-Blood". Blood\| PubMed ID: 19423743	2009
In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. The Journal of clinical investigation\| PubMed ID: 19509470	2009
Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate. Human gene therapy\| PubMed ID: 20102258	2010
Keeping up with Blood: introducing our CME program. Blood\| PubMed ID: 20110432	2010
Gene therapy activates EVI1, destabilizes chromosomes. Nature medicine\| PubMed ID: 20134468	2010
No evidence for clonal selection due to lentiviral integration sites in human induced pluripotent stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 20166152	2010
Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20571542	2010
Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers. Blood\| PubMed ID: 21163926	2011
Contributions of gene marking to cell and gene therapies. Human gene therapy\| PubMed ID: 21261461	2011
Patients, hematologists, and time. Blood\| PubMed ID: 21393501	2011
CD9 up-regulation on CD34+ cells with ingenol 3,20-dibenzoate does not improve homing in NSG mice. Blood\| PubMed ID: 21617010	2011
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21862999	2011
Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia. Blood\| PubMed ID: 21878674	2011
Transient silencing of PTEN in human CD34(+) cells enhances their proliferative potential and ability to engraft immunodeficient mice. Experimental hematology\| PubMed ID: 22019626	2012
Hematopoietic stem cell engineering at a crossroads. Blood\| PubMed ID: 22096239	2012
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity. Frontiers of medicine\| PubMed ID: 22198747	2011
Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain. Blood\| PubMed ID: 22228628	2012
Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22565846	2012
Eltrombopag and improved hematopoiesis in refractory aplastic anemia. The New England journal of medicine\| PubMed ID: 22762314	2012
Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 22910293	2012
High efficiency restriction enzyme-free linear amplification-mediated polymerase chain reaction approach for tracking lentiviral integration sites does not abrogate retrieval bias. Human gene therapy\| PubMed ID: 22992116	2013
Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy. Blood\| PubMed ID: 22995900	2012
Measurement of the absolute immature platelet number reflects marrow production and is not impacted by platelet transfusion. Transfusion\| PubMed ID: 23043309	2013
BCL2A1a over-expression in murine hematopoietic stem and progenitor cells decreases apoptosis and results in hematopoietic transformation. PloS one\| PubMed ID: 23118966	2012
An educational infusion: more synergy between Blood and the American Society of Hematology. Blood\| PubMed ID: 23197578	2012
Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23207694	2013
Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs. The Journal of clinical investigation\| PubMed ID: 23585473	2013
Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes. International journal of hematology\| PubMed ID: 23690288	2013
No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23863881	2014
Hematopoietic stem cell gene therapy:assessing the relevance of preclinical models. Seminars in hematology\| PubMed ID: 24014892	2013
Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number. Molecular therapy. Nucleic acids\| PubMed ID: 24045711	2013
Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood\| PubMed ID: 24345753	2014
Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib. Blood\| PubMed ID: 24687085	2014
Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study. Cell stem cell\| PubMed ID: 24702996	2014
Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells. Cell stem cell\| PubMed ID: 24702997	2014
IFN-γ regulates survival and function of tumor-induced CD11b(+) Gr-1(high) myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1. European journal of immunology\| PubMed ID: 24810636	2014
Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model. Cell reports\| PubMed ID: 24835994	2014