Xander H.T Wehrens

Department of Molecular Physiology and Biophysics, Baylor College of Medicine (BCM)

Affiliated withBaylor College of Medicine (BCM)

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 48	2010
Publication title Cited by 19	2010

Other Publications

Article	Year
Especially polymorphonuclear leukocytes, but also monomorphonuclear leukocytes, roll spontaneously in venules of intact rat skin: involvement of E-selectin. The Journal of investigative dermatology\| PubMed ID: 11841551	2002
Angiogenesis-independent cardioprotection in FGF-1 transgenic mice. Cardiovascular research\| PubMed ID: 12176126	2002
Novel insights in the congenital long QT syndrome. Annals of internal medicine\| PubMed ID: 12484714	2002
K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annual review of pharmacology and toxicology\| PubMed ID: 12540747	2003
A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating. Human mutation\| PubMed ID: 12673799	2003
Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation\| PubMed ID: 12695286	2003
Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation\| PubMed ID: 12743001	2003
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell\| PubMed ID: 12837242	2003
Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends in biochemical sciences\| PubMed ID: 14659699	2003
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circulation research\| PubMed ID: 15016728	2004
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (New York, N.Y.)\| PubMed ID: 15073377	2004
Fetal cardiovascular response to large placental chorioangiomas. Journal of perinatal medicine\| PubMed ID: 15085884	2004
Molecular determinants of altered contractility in heart failure. Annals of medicine\| PubMed ID: 15176427	2004
Cardiac rupture complicating myocardial infarction. International journal of cardiology\| PubMed ID: 15193834	2004
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation\| PubMed ID: 15197150	2004
Cardiac ryanodine receptor function and regulation in heart disease. Annals of the New York Academy of Sciences\| PubMed ID: 15201156	2004
Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nature reviews. Drug discovery\| PubMed ID: 15232578	2004
Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochemical and biophysical research communications\| PubMed ID: 15336974	2004
Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations. Mayo Clinic proceedings. Mayo Clinic\| PubMed ID: 15544013	2004
Intracellular calcium release and cardiac disease. Annual review of physiology\| PubMed ID: 15709953	2005
Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation\| PubMed ID: 15851612	2005
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15972811	2005
Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation\| PubMed ID: 15983258	2005
Ryanodine receptor-targeted anti-arrhythmic therapy. Annals of the New York Academy of Sciences\| PubMed ID: 16093511	2005
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell\| PubMed ID: 16213210	2005
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16407108	2006
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16481613	2006
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16672364	2006
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16873551	2006
Subcellular targeting of phosphatases: a novel function of ankyrins. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17449551	2007
Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias. European heart journal\| PubMed ID: 17459904	2007
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. Journal of molecular and cellular cardiology\| PubMed ID: 17509612	2007
The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms? Heart rhythm : the official journal of the Heart Rhythm Society\| PubMed ID: 17556207	2007
Ryanodine receptors as pharmacological targets for heart disease. Acta pharmacologica Sinica\| PubMed ID: 17588328	2007
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17630346	2007
Mutation-specific effects of lidocaine in Brugada syndrome. International journal of cardiology\| PubMed ID: 17761312	2007
Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda, Md.)\| PubMed ID: 17928548	2007
Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart rhythm : the official journal of the Heart Rhythm Society\| PubMed ID: 18598963	2008
Alternative splicing: a key mechanism for ankyrin-B functional diversity? Journal of molecular and cellular cardiology\| PubMed ID: 18838078	2008
Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19131475	2009
Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19276108	2009
Molecular evolution of the junctophilin gene family. Physiological genomics\| PubMed ID: 19318539	2009
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. The Journal of clinical investigation\| PubMed ID: 19603549	2009
Animal models of arrhythmogenic cardiomyopathy. Disease models & mechanisms\| PubMed ID: 19892887	2009
PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. The Journal of clinical investigation\| PubMed ID: 19907076	2009
Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 20009080	2009
Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Human molecular genetics\| PubMed ID: 20051426	2010
Stress synchronizes calcium release and promotes SR calcium leak. The Journal of physiology\| PubMed ID: 20123791	2010
Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension\| PubMed ID: 20157052	2010
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20457925	2010
Digoxin treatment in heart failure - unveiling risk by cluster analysis of DIG data. International journal of cardiology\| PubMed ID: 20471706	2011
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20615971	2010
Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends in cardiovascular medicine\| PubMed ID: 20685575	2010
Emerging role of junctophilin-2 as a regulator of calcium handling in the heart. Acta pharmacologica Sinica\| PubMed ID: 20694023	2010
CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart rhythm : the official journal of the Heart Rhythm Society\| PubMed ID: 20887810	2011
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovascular research\| PubMed ID: 20943673	2011
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation\| PubMed ID: 21098440	2010
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circulation. Heart failure\| PubMed ID: 21216834	2011
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation\| PubMed ID: 21339484	2011
Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship. American heart journal\| PubMed ID: 21392613	2011
Targeting ryanodine receptors for anti-arrhythmic therapy. Acta pharmacologica Sinica\| PubMed ID: 21642946	2011
Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation\| PubMed ID: 21859974	2011
Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. International journal of cardiology\| PubMed ID: 22093963	2011
Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform. Heart rhythm : the official journal of the Heart Rhythm Society\| PubMed ID: 22138134	2011
Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice. Circulation research\| PubMed ID: 22158709	2012
Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Science translational medicine\| PubMed ID: 22174313	2011