Colin W. Pouton

Drug Discovery Biology, Monash University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2014

Other Publications

Article	Year
Pharmaceutical applications of embryonic stem cells. Advanced drug delivery reviews\| PubMed ID: 16290153	2005
Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 16815001	2006
Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon. Life sciences\| PubMed ID: 17258778	2007
Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs. Pharmaceutical research\| PubMed ID: 17372700	2007
Heterogeneous population of dopaminergic neurons derived from mouse embryonic stem cells: preliminary phenotyping based on receptor expression and function. The European journal of neuroscience\| PubMed ID: 17419751	2007
A microtubule-facilitated nuclear import pathway for cancer regulatory proteins. Traffic (Copenhagen, Denmark)\| PubMed ID: 17511743	2007
Dynein light chain association sequences can facilitate nuclear protein import. Molecular biology of the cell\| PubMed ID: 17567954	2007
Embryonic stem cells as a source of models for drug discovery. Nature reviews. Drug discovery\| PubMed ID: 17667955	2007
Targeted delivery to the nucleus. Advanced drug delivery reviews\| PubMed ID: 17681634	2007
Dual acting antioxidant A1 adenosine receptor agonists. Bioorganic & medicinal chemistry letters\| PubMed ID: 17689079	2007
Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs. Journal of pharmaceutical sciences\| PubMed ID: 18064698	2008
Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Advanced drug delivery reviews\| PubMed ID: 18068260	2008
Enhancing intestinal drug solubilisation using lipid-based delivery systems. Advanced drug delivery reviews\| PubMed ID: 18155801	2008
Preparation and in vitro evaluation of novel lipopeptide transfection agents for efficient gene delivery. Bioconjugate chemistry\| PubMed ID: 18333604	2008
Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution. Journal of pharmaceutical sciences\| PubMed ID: 19130605	2009
Structure and dynamics of glyceride lipid formulations, with propylene glycol and water. Molecular pharmaceutics\| PubMed ID: 19260675	2009
Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides. Expert reviews in molecular medicine\| PubMed ID: 19302730	2009
A stably engineered, suicidal strain of listeria monocytogenes delivers protein and/or DNA to fully differentiated intestinal epithelial monolayers. Molecular pharmaceutics\| PubMed ID: 19317435	2009
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine. Journal of cardiovascular pharmacology\| PubMed ID: 19333129	2009
Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus. Journal of cellular biochemistry\| PubMed ID: 19507231	2009
Troubleshooting immunohistochemical labelling of proliferating cell nuclear antigen (PCNA) in cryocut tissue sections of mouse prostate. Journal of pharmacological and toxicological methods\| PubMed ID: 19945538	2010
Investigations into the binding affinities of different human 5-HT4 receptor splice variants. Pharmacology\| PubMed ID: 20299822	2010
Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists. Bioorganic & medicinal chemistry\| PubMed ID: 20385496	2010
A novel highly selective adenosine A1 receptor agonist VCP28 reduces ischemia injury in a cardiac cell line and ischemia-reperfusion injury in isolated rat hearts at concentrations that do n... Journal of cardiovascular pharmacology\| PubMed ID: 20571427	2010
Adenovirus: a blueprint for non-viral gene delivery. Current opinion in biotechnology\| PubMed ID: 20638266	2010
Interaction of viruses with host cell molecular motors. Current opinion in biotechnology\| PubMed ID: 20638267	2010
Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart. Journal of cardiovascular pharmacology\| PubMed ID: 20930592	2010
Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility. Journal of drug targeting\| PubMed ID: 20973755	2010
Mechanism of microtubule-facilitated "fast track" nuclear import. The Journal of biological chemistry\| PubMed ID: 21339293	2011
A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives. Stem cells (Dayton, Ohio)\| PubMed ID: 21425409	2011
Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 21472823	2011
Extended periods of neural induction and propagation of embryonic stem cell-derived neural progenitors with EGF and FGF2 enhances Lmx1a expression and neurogenic potential. Neurochemistry international\| PubMed ID: 21624410	2011
Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds. Journal of nucleic acids\| PubMed ID: 21772990	2011
Using molecular dynamics to study liquid phase behavior: simulations of the ternary sodium laurate/sodium oleate/water system. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 21838286	2011
NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nature methods\| PubMed ID: 22020065	2011
Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation. Molecular pharmaceutics\| PubMed ID: 22141328	2012
In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation. PloS one\| PubMed ID: 22384125	2012
Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists. Journal of medicinal chemistry\| PubMed ID: 22432713	2012
Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 22495882	2012
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of represen... Journal of pharmaceutical sciences\| PubMed ID: 22644939	2012
Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems. Molecular pharmaceutics\| PubMed ID: 22656917	2012
Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N(6)-substituents as adenosine A(1) receptor agonists. ChemMedChem\| PubMed ID: 22684887	2012
Colloidal characteristics and formulation of pure protein particulate vaccines. The Journal of pharmacy and pharmacology\| PubMed ID: 22943169	2012
Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, ... Molecular pharmaceutics\| PubMed ID: 23030411	2012
Synthesis and biological evaluation of N-substituted noscapine analogues. ChemMedChem\| PubMed ID: 23055449	2012
In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization... International journal of pharmaceutics\| PubMed ID: 23178598	2013
Strategies to address low drug solubility in discovery and development. Pharmacological reviews\| PubMed ID: 23383426	2013
Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis. Molecular pharmaceutics\| PubMed ID: 23631696	2013
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of ty... Pharmaceutical research\| PubMed ID: 23661145	2013
In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the inte... European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 23684915	2013
Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway. Pharmaceutical research\| PubMed ID: 23824582	2013
Glyceride lipid formulations: molecular dynamics modeling of phase behavior during dispersion and molecular interactions between drugs and excipients. Pharmaceutical research\| PubMed ID: 24092054	2013
DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification. PloS one\| PubMed ID: 24194952	2013
The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents. ChemMedChem\| PubMed ID: 24339417	2014
Choice of nonionic surfactant used to formulate type IIIA self-emulsifying drug delivery systems and the physicochemical properties of the drug have a pronounced influence on the degree of d... Journal of pharmaceutical sciences\| PubMed ID: 24470073	2014
Non-linear increases in danazol exposure with dose in older vs. younger beagle dogs: the potential role of differences in bile salt concentration, thermodynamic activity, and formulation dig... Pharmaceutical research\| PubMed ID: 24477676	2014
Human leukocyte antigen haplotype phasing by allele-specific enrichment with peptide nucleic acid probes. Molecular genetics & genomic medicine\| PubMed ID: 24936514	2014
SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development. Stem cell research\| PubMed ID: 24968096	2014
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system. Journal of pharmaceutical sciences\| PubMed ID: 24985238	2014
Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components. Molecular pharmaceutics\| PubMed ID: 24987935	2014
'Stealth' lipid-based formulations: Poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25058571	2014