Martin J. Lohse

Institute of Pharmacology and Toxicology and Bio-Imaging Center/Rudolf Virchow Center, University of Würzburg, Germany

Affiliated withUniversity of Würzburg, Germany Max Delbrück Center for Molecular Medicine, Berlin

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 14	2014
Publication title Cited by 1	2021

Other Publications

Article	Year
New directions in pharmacology. Lancet (London, England)\| PubMed ID: 10691466	1999
Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. The Journal of biological chemistry\| PubMed ID: 11726668	2002
Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice. Circulation research\| PubMed ID: 11964375	2002
Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo. Nature genetics\| PubMed ID: 12068299	2002
Magnesium and the parathyroid. Current opinion in nephrology and hypertension\| PubMed ID: 12105390	2002
Modulation of a brain voltage-gated K+ channel by syntaxin 1A requires the physical interaction of Gbetagamma with the channel. The Journal of biological chemistry\| PubMed ID: 12114518	2002
Dual regulation of the parathyroid hormone (PTH)/PTH-related peptide receptor signaling by protein kinase C and beta-arrestins. Endocrinology\| PubMed ID: 12239097	2002
Regulation of the inward rectifying properties of G-protein-activated inwardly rectifying K+ (GIRK) channels by Gbeta gamma subunits. The Journal of biological chemistry\| PubMed ID: 12403784	2003
Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation\| PubMed ID: 12417548	2002
Mutation of Asn293 to Asp in transmembrane helix VI abolishes agonist-induced but not constitutive activity of the beta(2)-adrenergic receptor. Molecular pharmacology\| PubMed ID: 12435811	2002
Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing. The Journal of biological chemistry\| PubMed ID: 12466282	2003
The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site. The Journal of biological chemistry\| PubMed ID: 12486133	2003
Peptide G protein agonists from a phage display library. Biochemical pharmacology\| PubMed ID: 12623127	2003
Alterations in the myocardial creatine kinase system precede the development of contractile dysfunction in beta(1)-adrenergic receptor transgenic mice. Journal of molecular and cellular cardiology\| PubMed ID: 12689818	2003
Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 12764077	2003
Measurement of the millisecond activation switch of G protein-coupled receptors in living cells. Nature biotechnology\| PubMed ID: 12808462	2003
Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor. Circulation\| PubMed ID: 12847069	2003
Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12933343	2003
Direct optical recording of intrinsic efficacy at a G protein-coupled receptor. Life sciences\| PubMed ID: 14607268	2003
What is the role of beta-adrenergic signaling in heart failure? Circulation research\| PubMed ID: 14615493	2003
Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation\| PubMed ID: 14623810	2003
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature\| PubMed ID: 14654844	2003
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14673086	2003
Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation\| PubMed ID: 14967726	2004
Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to beta-adrenergic agonists. Cardiovascular research\| PubMed ID: 15023559	2004
Calcium channel function and regulation in beta 1- and beta 2-adrenoceptor transgenic mice. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 15083268	2004
Beta-adrenoceptor polymorphisms and heart failure. Trends in molecular medicine\| PubMed ID: 15106619	2004
Molecular mechanisms of receptor activation: real-time analysis by fluorescence resonance energy transfer. Autonomic & autacoid pharmacology\| PubMed ID: 15134067	2003
Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. The Journal of clinical investigation\| PubMed ID: 15146239	2004
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circulation research\| PubMed ID: 15178638	2004
Novel single chain cAMP sensors for receptor-induced signal propagation. The Journal of biological chemistry\| PubMed ID: 15231839	2004
Kinetics of G-protein-coupled receptor signalling and desensitization. Biochemical Society transactions\| PubMed ID: 15506955	2004
Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis. The Journal of biological chemistry\| PubMed ID: 15557342	2005
Beta-arrestin binding to the beta2-adrenergic receptor requires both receptor phosphorylation and receptor activation. The Journal of biological chemistry\| PubMed ID: 15634674	2005
Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling. The Journal of clinical endocrinology and metabolism\| PubMed ID: 15728216	2005
Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation... The Journal of biological chemistry\| PubMed ID: 15745879	2005
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nature methods\| PubMed ID: 15782185	2005
G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region. The Journal of biological chemistry\| PubMed ID: 15866880	2005
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. The Journal of biological chemistry\| PubMed ID: 15987680	2005
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. Nature medicine\| PubMed ID: 16025126	2005
Peptide inhibitors of G protein-coupled receptor kinases. Biochemical pharmacology\| PubMed ID: 16102734	2005
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16236727	2005
Dynamics of receptor/G protein coupling in living cells. The EMBO journal\| PubMed ID: 16292347	2005
Fluorescent sensors for rapid monitoring of intracellular cGMP. Nature methods\| PubMed ID: 16369548	2006
beta(1)-Adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy. Trends in cardiovascular medicine\| PubMed ID: 16387626	2006
Molecular basis of inverse agonism in a G protein-coupled receptor. Nature chemical biology\| PubMed ID: 16407989	2005
SUMO-1 controls the protein stability and the biological function of phosducin. The Journal of biological chemistry\| PubMed ID: 16421094	2006
Monitoring of cAMP synthesis and degradation in living cells. Physiology (Bethesda, Md.)\| PubMed ID: 16565474	2006
Molecular basis of partial agonism at the neurotransmitter alpha2A-adrenergic receptor and Gi-protein heterotrimer. The Journal of biological chemistry\| PubMed ID: 16787921	2006
Beta 1-adrenergic receptor-directed autoimmunity as a cause of dilated cardiomyopathy in rats. International journal of cardiology\| PubMed ID: 16872696	2006
Gs activation is time-limiting in initiating receptor-mediated signaling. The Journal of biological chemistry\| PubMed ID: 16963443	2006
Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16983074	2006
Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells. Science's STKE : signal transduction knowledge environment\| PubMed ID: 16985238	2006
Stimulating autoantibodies directed against the cardiac beta1-adrenergic receptor predict increased mortality in idiopathic cardiomyopathy. American heart journal\| PubMed ID: 16996841	2006
Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circulation research\| PubMed ID: 17038640	2006
G protein-coupled receptors: too many dimers? Nature methods\| PubMed ID: 17117152	2006
Interstitial remodeling in beta1-adrenergic receptor transgenic mice. Basic research in cardiology\| PubMed ID: 17122889	2007
Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. The Journal of clinical investigation\| PubMed ID: 17200720	2007
Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine. Circulation\| PubMed ID: 17261653	2007
cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes. The Journal of physiology\| PubMed ID: 17289786	2007
A role for caspase-1 in heart failure. Circulation research\| PubMed ID: 17303764	2007
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacological reviews\| PubMed ID: 17329545	2007
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC bioinformatics\| PubMed ID: 17537266	2007
Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. The Journal of biological chemistry\| PubMed ID: 17616524	2007
A novel fluorescence method for the rapid detection of functional beta1-adrenergic receptor autoantibodies in heart failure. Journal of the American College of Cardiology\| PubMed ID: 17662395	2007
Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells. Advances in protein chemistry\| PubMed ID: 17854658	2007
Monitoring receptor signaling by intramolecular FRET. Current opinion in pharmacology\| PubMed ID: 17919975	2007
Activation of AP-1 contributes to the beta-adrenoceptor-mediated myocardial induction of interleukin-6. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 17948064	2007
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nature chemical biology\| PubMed ID: 18193048	2008
Kinetics of G-protein-coupled receptor signals in intact cells. British journal of pharmacology\| PubMed ID: 18193071	2008
An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro. RNA (New York, N.Y.)\| PubMed ID: 18230760	2008
Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends in pharmacological sciences\| PubMed ID: 18262662	2008
Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron\| PubMed ID: 18439407	2008
Real-time monitoring of phosphodiesterase inhibition in intact cells. Cellular signalling\| PubMed ID: 18467075	2008
Integrin alpha E(CD103)beta 7 influences cellular shape and motility in a ligand-dependent fashion. Blood\| PubMed ID: 18492951	2008
Cytoplasmic cAMP concentrations in intact cardiac myocytes. American journal of physiology. Cell physiology\| PubMed ID: 18550706	2008
Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. The Journal of biological chemistry\| PubMed ID: 18703513	2008
Blocking them all: beta-arrestins inhibit cellular signaling. Molecular cell\| PubMed ID: 18775321	2008
Pathological autoantibodies in cardiomyopathy. Autoimmunity\| PubMed ID: 18781471	2008
Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization. The Journal of biological chemistry\| PubMed ID: 18801735	2008
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nature medicine\| PubMed ID: 19060905	2009
Novel techniques for real-time monitoring of cGMP in living cells. Handbook of experimental pharmacology\| PubMed ID: 19089332	2009
Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction. Circulation\| PubMed ID: 19103994	2009
Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition. Circulation\| PubMed ID: 19139388	2009
GPCR and G proteins: drug efficacy and activation in live cells. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 19196832	2009
Building a new conceptual framework for receptor heteromers. Nature chemical biology\| PubMed ID: 19219011	2009
Analysis of receptor oligomerization by FRAP microscopy. Nature methods\| PubMed ID: 19234451	2009
Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PloS one\| PubMed ID: 19352508	2009
Cardiac hypertrophy: targeting Raf/MEK/ERK1/2-signaling. The international journal of biochemistry & cell biology\| PubMed ID: 19666137	2009
A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy. PflÃ¼gers Archiv : European journal of physiology\| PubMed ID: 19680684	2009
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS biology\| PubMed ID: 19688034	2009
beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites. Molecular pharmacology\| PubMed ID: 19741005	2009
Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells. American journal of physiology. Cell physiology\| PubMed ID: 19889965	2010
Dimerization in GPCR mobility and signaling. Current opinion in pharmacology\| PubMed ID: 19910252	2010
Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. The Journal of clinical investigation\| PubMed ID: 19959875	2009
Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells. Journal of cell science\| PubMed ID: 20016070	2010
Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1. The Journal of biological chemistry\| PubMed ID: 20080964	2010
A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation. The Journal of biological chemistry\| PubMed ID: 20083608	2010
Ca2+ cycling and new therapeutic approaches for heart failure. Circulation\| PubMed ID: 20124124	2010
Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science (New York, N.Y.)\| PubMed ID: 20185685	2010
Signaling by internalized G-protein-coupled receptors. Trends in pharmacological sciences\| PubMed ID: 20303186	2010
Imaging of persistent cAMP signaling by internalized G protein-coupled receptors. Journal of molecular endocrinology\| PubMed ID: 20378719	2010
Targeting receptor antibodies in immune cardiomyopathy. Seminars in thrombosis and hemostasis\| PubMed ID: 20414837	2010
Polarization of migrating monocytic cells is independent of PI 3-kinase activity. PloS one\| PubMed ID: 20419163	2010
Site-specific, orthogonal labeling of proteins in intact cells with two small biarsenical fluorophores. Bioconjugate chemistry\| PubMed ID: 20429545	2010
Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study. European journal of heart failure\| PubMed ID: 20494925	2010
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics (Oxford, England)\| PubMed ID: 20501551	2010
Real-time monitoring of somatostatin receptor-cAMP signaling in live pituitary. Endocrinology\| PubMed ID: 20610560	2010
Microscopy: GPCR dimers moving closer. Nature chemical biology\| PubMed ID: 20644543	2010
Formation of a ternary complex among NHERF1, beta-arrestin, and parathyroid hormone receptor. The Journal of biological chemistry\| PubMed ID: 20656684	2010
FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors. Bioorganic & medicinal chemistry\| PubMed ID: 20716489	2011
Sensing G protein-coupled receptor activation. Neuropharmacology\| PubMed ID: 20727363	2011
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor. The Journal of biological chemistry\| PubMed ID: 20837485	2010
Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorphisms. Current biology : CB\| PubMed ID: 20869245	2010
Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nature protocols\| PubMed ID: 20885379	2010
Rotational diffusion of the α(2a) adrenergic receptor revealed by FlAsH labeling in living cells. Biophysical journal\| PubMed ID: 21320460	2011
Distinct pharmacological properties of morphine metabolites at G(i)-protein and Î²-arrestin signaling pathways activated by the human Î¼-opioid receptor. Biochemical pharmacology\| PubMed ID: 21396918	2011
FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells. Nature protocols\| PubMed ID: 21412271	2011
Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Molecular pharmacology\| PubMed ID: 21880827	2011
Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22291442	2012
Nonequilibrium activation of a G-protein-coupled receptor. Molecular pharmacology\| PubMed ID: 22379120	2012
Fluorescence/bioluminescence resonance energy transfer techniques to study G-protein-coupled receptor activation and signaling. Pharmacological reviews\| PubMed ID: 22407612	2012
The guanine nucleotide exchange factor Vav2 is a negative regulator of parathyroid hormone receptor/Gq signaling. Molecular pharmacology\| PubMed ID: 22554804	2012
Comparison of the activation kinetics of the M3 acetylcholine receptor and a constitutively active mutant receptor in living cells. Molecular pharmacology\| PubMed ID: 22564786	2012
Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2. The Journal of biological chemistry\| PubMed ID: 22610096	2012
Detection of anti-β1-AR autoantibodies in heart failure by a cell-based competition ELISA. Circulation research\| PubMed ID: 22811559	2012
β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway. Cardiovascular research\| PubMed ID: 22843704	2012
Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1. Science signaling\| PubMed ID: 22894836	2012
Administration of the cyclic peptide COR-1 in humans (phase I study): ex vivo measurements of anti-β1-adrenergic receptor antibody neutralization and of immune parameters. European journal of heart failure\| PubMed ID: 22968742	2012
Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23267088	2013
Cell biology: Receptor signals come in waves. Nature\| PubMed ID: 23515157	2013
Interference with ERK(Thr188) phosphorylation impairs pathological but not physiological cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23589880	2013
Time-resolved fluorescence ligand binding for G protein-coupled receptors. Nature protocols\| PubMed ID: 23764938	2013
Gene amplification and functional diversification of melanocortin 4 receptor at an extremely polymorphic locus controlling sexual maturation in the platyfish. Genetics\| PubMed ID: 24077304	2013
Arrestin interactions with G protein-coupled receptors. Handbook of experimental pharmacology\| PubMed ID: 24292823	2014
Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium. Cell\| PubMed ID: 24485454	2014
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacological reviews\| PubMed ID: 24515647	2014
Kinetics and mechanism of G protein-coupled receptor activation. Current opinion in cell biology\| PubMed ID: 24530699	2014
Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. The New England journal of medicine\| PubMed ID: 24571724	2014
Role of membrane microdomains in compartmentation of cAMP signaling. PloS one\| PubMed ID: 24752595	2014
β-Myosin Heavy Chain Variant Val606Met Causes Very Mild Hypertrophic Cardiomyopathy in Mice, but Exacerbates HCM Phenotypes in Mice Carrying Other HCM Mutations. Circulation research\| PubMed ID: 24829265	2014
Spatial and Temporal Aspects of Signaling by G-Protein-Coupled Receptors. Molecular pharmacology\| PubMed ID: 26184590	2015
The ins and outs of adrenergic signaling. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 26199112	2015
A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics. Communications biology\| PubMed ID: 30271985	2018
Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 31023886	2019