Peter Kleinebudde

Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University

Affiliated withHeinrich-Heine University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 25	2014

Other Publications

Article	Year
Pectinic acid, a novel excipient for production of pellets by extrusion/spheronisation: preliminary studies. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 12084508	2002
Quantum chemical descriptors in the formulation of pectin pellets produced by extrusion/spheronisation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 12128168	2002
Development of fast-disintegrating pellets in a rotary processor. Drug development and industrial pharmacy\| PubMed ID: 12476866	2002
Coating uniformity: influence of atomizing air pressure. Pharmaceutical development and technology\| PubMed ID: 12665196	2003
Coating uniformity and coating efficiency in a Bohle Lab-Coater using oval tablets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 12837475	2003
How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Comparison of four magnesium carbonates. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 12885393	2003
Pediatric drug formulations of sodium benzoate: I. Coated granules with a hydrophilic binder. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 12957639	2003
Pediatric drug formulations of sodium benzoate: II. Coated granules with a lipophilic binder. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 12957640	2003
Disintegrating pellets from a water-insoluble pectin derivative produced by extrusion/spheronisation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 14602179	2003
How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 15196589	2004
Properties of microcrystalline cellulose and powder cellulose after extrusion/spheronization as studied by fourier transform Raman spectroscopy and environmental scanning electron microscopy... AAPS pharmSci\| PubMed ID: 15198519	2003
Roll compaction/dry granulation: pharmaceutical applications. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 15296958	2004
Preliminary assessment of carrageenan as excipient for extrusion/spheronisation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 15567309	2005
Studies of the retrogradation process for various starch gels using Raman spectroscopy. Carbohydrate research\| PubMed ID: 16168973	2005
Coprocessing of powdered cellulose and magnesium carbonate: direct tableting versus tableting after roll compaction/dry granulation. Pharmaceutical development and technology\| PubMed ID: 16176015	2005
Use of kappa-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. II. Influence of drug and filler type. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 16325384	2006
Use of kappa-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. I. Influence of type and fraction of filler. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 16326085	2006
Mathematical modeling of an aqueous film coating process in a Bohle Lab-Coater, part 1: development of the model. AAPS PharmSciTech\| PubMed ID: 16796359	2006
Mathematical modeling of an aqueous film coating process in a Bohle Lab-Coater: part 2: application of the model. AAPS PharmSciTech\| PubMed ID: 16796360	2006
Influence of scale-up on the abrasion of tablets in a pan coater. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 16875807	2006
Comparison study of laboratory and production spray guns in film coating: effect of pattern air and nozzle diameter. Pharmaceutical development and technology\| PubMed ID: 17101513	2006
Use of chitosan-alginate as alternative pelletization aid to microcrystalline cellulose in extrusion/spheronization. Journal of pharmaceutical sciences\| PubMed ID: 17286294	2007
Roll compaction/dry granulation: effect of raw material particle size on granule and tablet properties. International journal of pharmaceutics\| PubMed ID: 17324537	2007
Comparison of a laboratory and a production coating spray gun with respect to scale-up. AAPS PharmSciTech\| PubMed ID: 17408226	2007
Effect of drying on extruded pellets based on kappa-carrageenan. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 17448646	2007
Abrasion of tablets during scale-up: the influence of different crushing forces in laboratory and production perforated pan coaters. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 17475452	2007
Solid lipid extrusion of sustained release dosage forms. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 17481868	2007
Influence of chitosan type on the properties of extruded pellets with low amount of microcrystalline cellulose. AAPS PharmSciTech\| PubMed ID: 17915814	2007
Comparison of different dry binders for roll compaction/dry granulation. Pharmaceutical development and technology\| PubMed ID: 17963152	2007
Properties of pellets manufactured by wet extrusion/spheronization process using kappa-carrageenan: effect of process parameters. AAPS PharmSciTech\| PubMed ID: 18181555	2007
Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 18291547	2008
The behavior of different carrageenans in pelletization by extrusion/spheronization. Pharmaceutical development and technology\| PubMed ID: 18300097	2008
Impact of screw elements on continuous granulation with a twin-screw extruder. Journal of pharmaceutical sciences\| PubMed ID: 18300301	2008
Studies on the reduction of tensile strength of tablets after roll compaction/dry granulation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18511247	2008
Understanding the solid-state behaviour of triglyceride solid lipid extrudates and its influence on dissolution. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18588976	2009
The 6th world meeting on pharmaceutics, biopharmaceutics and pharmaceutical technology (PBP meeting) April 7-10, 2008, Barcelona, Spain. AAPS PharmSciTech\| PubMed ID: 18618267	2008
Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18647650	2009
Controlled release solid dosage forms using combinations of (meth)acrylate copolymers. Pharmaceutical development and technology\| PubMed ID: 18720248	2008
Controlled release of active as a consequence of the die diameter in solid lipid extrusion. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 18725256	2008
Solid lipid extrudates as sustained-release matrices: the effect of surface structure on drug release properties. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 18765281	2008
Evaluation of the composition of the binder bridges in matrix granules prepared with a small-scale high-shear granulator. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 18774256	2008
Theme issue "Solid state and solid dosage forms". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18817869	2009
Mechanism of drug release from polymethacrylate-based extrudates and milled strands prepared by hot-melt extrusion. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18951978	2009
Spheronization of small extrudates containing kappa-carrageenan. Journal of pharmaceutical sciences\| PubMed ID: 19130471	2009
Chemical imaging of oral solid dosage forms and changes upon dissolution using coherent anti-Stokes Raman scattering microscopy. Analytical chemistry\| PubMed ID: 19209888	2009
Improved bioavailability of darunavir by use of kappa-carrageenan versus microcrystalline cellulose as pelletisation aid. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 19303929	2009
Tailor-made dissolution profiles by extruded matrices based on lipid polyethylene glycol mixtures. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 19358867	2009
Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging. Journal of pharmaceutical sciences\| PubMed ID: 19367620	2009
Influence of structural variations on drug release from lipid/polyethylene glycol matrices. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 19406229	2009
Investigating dissolution performance critical areas on coated tablets: a case study using terahertz pulsed imaging. Journal of pharmaceutical sciences\| PubMed ID: 19569058	2010
Investigating the relationship between drug distribution in solid lipid matrices and dissolution behaviour using Raman spectroscopy and mapping. Journal of pharmaceutical sciences\| PubMed ID: 19691104	2010
Effect of lubricant on spreading of coating liquid on surface of tablets containing pancreatin. Pharmaceutical development and technology\| PubMed ID: 19772392	2010
Feasibility of Raman spectroscopy as PAT tool in active coating. Drug development and industrial pharmacy\| PubMed ID: 19778159	2010
Influence of the composition of glycerides on the solid-state behaviour and the dissolution profiles of solid lipid extrudates. International journal of pharmaceutics\| PubMed ID: 19782882	2009
Performance qualification of an electronic tongue based on ICH guideline Q2. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 19853397	2010
Investigating the principles of recrystallization from glyceride melts. AAPS PharmSciTech\| PubMed ID: 19862628	2009
Continuous granulation with a twin-screw extruder: impact of material throughput. Pharmaceutical development and technology\| PubMed ID: 19921959	2010
Role of surface free energy and spreading coefficient in the formulation of active agent-layered pellets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 19931611	2010
Compression behaviour of kappa-carrageenan pellets. International journal of pharmaceutics\| PubMed ID: 20100553	2010
Two-step solid lipid extrusion as a process to modify dissolution behavior. AAPS PharmSciTech\| PubMed ID: 20309654	2010
Improvement of dissolution behavior for poorly water-soluble drug by application of cyclodextrin in extrusion process: comparison between melt extrusion and wet extrusion. AAPS PharmSciTech\| PubMed ID: 20496019	2010
Validation of Raman spectroscopic procedures in agreement with ICH guideline Q2 with considering the transfer to real time monitoring of an active coating process. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 20638213	2010
Analysis of pellet properties with use of artificial neural networks. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 20659554	2010
Roll compaction/dry granulation: comparison between roll mill and oscillating granulator in dry granulation. Pharmaceutical development and technology\| PubMed ID: 20731538	2012
Pharmaceutical review articles: from good to great. Pharmaceutical development and technology\| PubMed ID: 20735298	2010
Evaluation of predictive models for stable solid solution formation. Journal of pharmaceutical sciences\| PubMed ID: 20803574	2011
Rational development of taste masked oral liquids guided by an electronic tongue. International journal of pharmaceutics\| PubMed ID: 20816732	2010
Increased compactibility of acetames after roll compaction. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 20932904	2011
Solid lipid extrusion with small die diameters--electrostatic charging, taste masking and continuous production. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 20940049	2011
Taste sensing systems (electronic tongues) for pharmaceutical applications. International journal of pharmaceutics\| PubMed ID: 21094230	2011
Suitability of κ-carrageenan pellets for the formulation of multiparticulate tablets with modified release. International journal of pharmaceutics\| PubMed ID: 21335073	2011
A comparative study on two electronic tongues for pharmaceutical formulation development. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 21353433	2011
Suitability of a flat die press for the manufacture of pharmaceutical pellets by extrusion/spheronization. Drug development and industrial pharmacy\| PubMed ID: 21446830	2011
Dissolution from solid lipid extrudates containing release modifiers. International journal of pharmaceutics\| PubMed ID: 21515350	2011
Analysis of matrix dosage forms during dissolution testing using raman microscopy. Journal of pharmaceutical sciences\| PubMed ID: 21560128	2011
Development of a taste-masked generic ibuprofen suspension: Top-down approach guided by electronic tongue measurements. Journal of pharmaceutical sciences\| PubMed ID: 21607955	2011
Development of mini-tablets with 1mm and 2mm diameter. International journal of pharmaceutics\| PubMed ID: 21726616	2011
Melt extruded helical waxy matrices as a new sustained drug delivery system. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 21827851	2011
Drug release from extruded solid lipid matrices: theoretical predictions and independent experiments. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 22008146	2012
Prediction of dissolution time and coating thickness of sustained release formulations using Raman spectroscopy and terahertz pulsed imaging. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 22245221	2012
Application of mixtures of polymeric carriers for dissolution enhancement of fenofibrate using hot-melt extrusion. International journal of pharmaceutics\| PubMed ID: 22440149	2012
Pellet layering: scale-up considerations using different kinds of processing equipment. Drug development and industrial pharmacy\| PubMed ID: 22452570	2012
Application of artificial neural networks (ANNs) and genetic programming (GP) for prediction of drug release from solid lipid matrices. International journal of pharmaceutics\| PubMed ID: 22728260	2012
Application of mixtures of polymeric carriers for dissolution enhancement of oxeglitazar using hot-melt extrusion. International journal of pharmaceutics\| PubMed ID: 23073606	2012
Validation of Terahertz coating thickness measurements using X-ray microtomography. Molecular pharmaceutics\| PubMed ID: 23116336	2012
Monitoring of an active coating process for two-layer tablets-model development strategies. Journal of pharmaceutical sciences\| PubMed ID: 23188659	2013
Experimental analysis of tablet properties for discrete element modeling of an active coating process. AAPS PharmSciTech\| PubMed ID: 23354469	2013
PAT-tools for process control in pharmaceutical film coating applications. International journal of pharmaceutics\| PubMed ID: 23380626	2013
Preparing of pellets by extrusion/spheronization using different types of equipment and process conditions. Drug development and industrial pharmacy\| PubMed ID: 23596971	2014
Development of a Raman method to follow the evolution of coating thickness of pellets. Drug development and industrial pharmacy\| PubMed ID: 23662715	2013
Critical factors in the measurement of tablet film coatings using terahertz pulsed imaging. Journal of pharmaceutical sciences\| PubMed ID: 23681565	2013
Oromucosal film preparations: classification and characterization methods. Expert opinion on drug delivery\| PubMed ID: 23768198	2013
Assessment of test methods evaluating mucoadhesive polymers and dosage forms: an overview. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 23851076	2013
Influence of MCC II fraction and storage conditions on pellet properties. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 23872176	2013
Evaluation of critical process parameters for intra-tablet coating uniformity using terahertz pulsed imaging. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 23872179	2013
Influence of process parameters and equipment on dry foam formulation properties using indomethacin as model drug. International journal of pharmaceutics\| PubMed ID: 23891743	2013
In situ dissolution analysis using coherent anti-Stokes Raman scattering (CARS) and hyperspectral CARS microscopy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 23994672	2013
Optimization of the inter-tablet coating uniformity for an active coating process at lab and pilot scale. International journal of pharmaceutics\| PubMed ID: 24055439	2013
Compaction behavior of isomalt after roll compaction. Pharmaceutics\| PubMed ID: 24300366	2012
From Mini to Micro Scale-Feasibility of Raman Spectroscopy as a Process Analytical Tool (PAT). Pharmaceutics\| PubMed ID: 24309305	2011
Tablet disintegration studied by high-resolution real-time magnetic resonance imaging. Journal of pharmaceutical sciences\| PubMed ID: 24475490	2014
Performance of tablet disintegrants: impact of storage conditions and relative tablet density. Pharmaceutical development and technology\| PubMed ID: 24848093	2014
Impact of fillers on dissolution kinetic of fenofibrate dry foams. Pharmaceutical development and technology\| PubMed ID: 24901031	2014
Systematic classification of tablet disintegrants by water uptake and force development kinetics. The Journal of pharmacy and pharmacology\| PubMed ID: 24943882	2014
Influence of storage condition on properties of MCC II-based pellets with theophylline-monohydrate. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 24950003	2014