Patrick H. Maxwell

Department of Biological Sciences, Rensselaer Polytechnic Institute

Affiliated withRensselaer Polytechnic Institute

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2014

Other Publications

Article	Year
Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 11839666	2002
Oxygen sensors and angiogenesis. Seminars in cell & developmental biology\| PubMed ID: 11969369	2002
Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer research\| PubMed ID: 12019178	2002
The use of dioxygen by HIF prolyl hydroxylase (PHD1). Bioorganic & medicinal chemistry letters\| PubMed ID: 12039559	2002
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature\| PubMed ID: 12050673	2002
Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12089367	2002
Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex. Advances in enzyme regulation\| PubMed ID: 12123724	2002
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer cell\| PubMed ID: 12124175	2002
Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12149454	2002
Oxygen homeostasis and cancer: insights from a rare disease. Clinical medicine (London, England)\| PubMed ID: 12195866	2002
Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia. Kidney international\| PubMed ID: 12234311	2002
Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy. Blood\| PubMed ID: 12239150	2002
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nature genetics\| PubMed ID: 12415268	2002
Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12490539	2003
Evidence for hypoxia-induced neuronal-to-chromaffin metaplasia in neuroblastoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12665472	2003
Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. The Journal of clinical investigation\| PubMed ID: 12750401	2003
HIF and oxygen sensing; as important to life as the air we breathe? Annals of medicine\| PubMed ID: 12822740	2003
HIF-1's relationship to oxygen: simple yet sophisticated. Cell cycle (Georgetown, Tex.)\| PubMed ID: 14712080	2004
Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15213261	2004
Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15247145	2004
Ty1 mobilizes subtelomeric Y' elements in telomerase-negative Saccharomyces cerevisiae survivors. Molecular and cellular biology\| PubMed ID: 15509791	2004
The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha. Advances in enzyme regulation\| PubMed ID: 15581484	2004
Distinct novel mutations affecting the same base in the NIPA1 gene cause autosomal dominant hereditary spastic paraplegia in two Chinese families. Human mutation\| PubMed ID: 15643603	2005
Is it rejection? Be on the lookout for 'decoys'. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 15919691	2005
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Molecular and cellular biology\| PubMed ID: 15964822	2005
Manipulation of oxygen tensions for in vitro cell culture using a hypoxic workstation. Expert review of proteomics\| PubMed ID: 16000078	2005
A common pathway for genetic events leading to pheochromocytoma. Cancer cell\| PubMed ID: 16098460	2005
Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer cell\| PubMed ID: 16098466	2005
The HIF pathway in cancer. Seminars in cell & developmental biology\| PubMed ID: 16144689	2005
Hypoxia-inducible factor as a physiological regulator. Experimental physiology\| PubMed ID: 16157658	2005
HIF, a missing link between metabolism and cancer. Nature medicine\| PubMed ID: 16211034	2005
Genetic studies of IgA nephropathy. Nephron. Experimental nephrology\| PubMed ID: 16282702	2006
Effects of VHL deficiency on endolymphatic duct and sac. Cancer research\| PubMed ID: 16322231	2005
Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer research\| PubMed ID: 16357161	2005
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16407130	2006
Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 16431886	2006
Correction of severe anaemia using immuno-regulated gene therapy is achieved by restoring the early erythroblast compartment. British journal of haematology\| PubMed ID: 16445835	2006
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer research\| PubMed ID: 16585181	2006
Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. The Journal of experimental medicine\| PubMed ID: 16754715	2006
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. Journal of molecular and cellular cardiology\| PubMed ID: 16765982	2006
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS medicine\| PubMed ID: 16768548	2006
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16775032	2006
Low oxygen stimulates the intellect. Symposium on hypoxia and development, physiology and disease. EMBO reports\| PubMed ID: 16799463	2006
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. Arthritis research & therapy\| PubMed ID: 16859540	2006
Identification of multiple transcription initiation, polyadenylation, and splice sites in the Drosophila melanogaster TART family of telomeric retrotransposons. Nucleic acids research\| PubMed ID: 17020919	2006
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. The EMBO journal\| PubMed ID: 17093497	2006
Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. Blood\| PubMed ID: 17299096	2007
Genetic insights into the hypoxia-inducible factor (HIF) pathway. Advances in enzyme regulation\| PubMed ID: 17335877	2007
Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis? Cell cycle (Georgetown, Tex.)\| PubMed ID: 17374993	2007
Host factors that control long terminal repeat retrotransposons in Saccharomyces cerevisiae: implications for regulation of mammalian retroviruses. Eukaryotic cell\| PubMed ID: 17496126	2007
Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia. International journal of cancer. Journal international du cancer\| PubMed ID: 17640059	2007
Inadvertent postdialysis anticoagulation due to heparin line locks. Hemodialysis international. International Symposium on Home Hemodialysis\| PubMed ID: 17922740	2007
Expression of hypoxia-inducible factors in normal human lung development. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society\| PubMed ID: 17990921	2008
Retrosequence formation restructures the yeast genome. Genes & development\| PubMed ID: 18079177	2007
Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 18178798	2008
Role of Gas6 in erythropoiesis and anemia in mice. The Journal of clinical investigation\| PubMed ID: 18188450	2008
The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. Molecular and cellular biology\| PubMed ID: 18285459	2008
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Molecular and cellular biology\| PubMed ID: 18332118	2008
Developmental and tissue-specific accumulation pattern for the Drosophila melanogaster TART ORF1 protein. Gene\| PubMed ID: 18406546	2008
Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation. Blood\| PubMed ID: 18650473	2008
Incorporation of Y'-Ty1 cDNA destabilizes telomeres in Saccharomyces cerevisiae telomerase-negative mutants. Genetics\| PubMed ID: 18660531	2008
Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease. Neoplasia (New York, N.Y.)\| PubMed ID: 18813354	2008
The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 18813897	2008
Variations within oxygen-regulated gene expression in humans. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19008490	2009
Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. The Journal of clinical investigation\| PubMed ID: 19065050	2009
Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin. Molecular biology of the cell\| PubMed ID: 19073886	2009
Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19144758	2009
Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells. Advances in enzyme regulation\| PubMed ID: 19162062	2009
Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. Kidney international\| PubMed ID: 19212416	2009
Oxygen availability sHIFts the cell cycle. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19377302	2009
Rrm3 protects the Saccharomyces cerevisiae genome from instability at nascent sites of retrotransposition. Genetics\| PubMed ID: 19414561	2009
Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 19629420	2009
Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection. Antioxidants & redox signaling\| PubMed ID: 19737089	2010
Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nature genetics\| PubMed ID: 19820698	2009
Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin. Haematologica\| PubMed ID: 19833632	2010
The role of HIF in immunity. The international journal of biochemistry & cell biology\| PubMed ID: 19840863	2010
Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. PloS one\| PubMed ID: 19924283	2009
Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 20031928	2010
Genetic loci influencing kidney function and chronic kidney disease. Nature genetics\| PubMed ID: 20383145	2010
HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. PloS one\| PubMed ID: 20559438	2010
HLA has strongest association with IgA nephropathy in genome-wide analysis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 20595679	2010
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology\| PubMed ID: 20600011	2010
Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. Lancet\| PubMed ID: 20800271	2010
Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype. PloS one\| PubMed ID: 20862257	2010
VHL inactivation induces HEF1 and Aurora kinase A. Journal of the American Society of Nephrology : JASN\| PubMed ID: 20864688	2010
Hypoxia and upregulation of hypoxia-inducible factor 1{alpha} stimulate venous thrombus recanalization. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20930171	2010
Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis. Cancer research\| PubMed ID: 20978192	2010
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. The Journal of clinical investigation\| PubMed ID: 21317538	2011
Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21389259	2011
Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension. Blood\| PubMed ID: 21454469	2011
Copy number profiling in von Hippel-Lindau disease renal cell carcinoma. Genes, chromosomes & cancer\| PubMed ID: 21456047	2011
Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 21499240	2011
Familial C3 glomerulopathy associated with CFHR5 mutations: clinical characteristics of 91 patients in 16 pedigrees. Clinical journal of the American Society of Nephrology : CJASN\| PubMed ID: 21566112	2011
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells. Molecular cancer\| PubMed ID: 21791076	2011
Seeing the smoking gun: a sensitive and specific method to visualize loss of the tumour suppressor, fumarate hydratase, in human tissues. The Journal of pathology\| PubMed ID: 21792933	2011
Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 21876537	2011
Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21921145	2011
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer cell\| PubMed ID: 22014577	2011
Retrotransposition is associated with genome instability during chronological aging. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22021441	2011
Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression. The Journal of clinical investigation\| PubMed ID: 22214851	2012
Tumor strengths and frailties: Aspiring to prevent colon cancer. Nature medicine\| PubMed ID: 22227665	2012
The ERA-EDTA Working Group on inherited kidney disorders. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 22287704	2012
Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy. The American journal of pathology\| PubMed ID: 22342523	2012
Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development (Cambridge, England)\| PubMed ID: 22627278	2012
Increasing evidence that genetic variation in complement factor H related 5 (CFHR5) causes disease: a commentary on 'Atypical haemolytic uremic syndrome and genetic aberrations in the comple... Journal of human genetics\| PubMed ID: 22739721	2012
What happens to clinical training fellows? A retrospective study of the 20 years outcome of a Medical Research Council UK cohort. BMJ open\| PubMed ID: 22936819	2012
C3 glomerulonephritis and CFHR5 nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 23125424	2013
Incidence of end-stage renal disease in the Turkish-Cypriot population of Northern Cyprus: a population based study. PloS one\| PubMed ID: 23349874	2013
Epistatic role of the MYH9/APOL1 region on familial hematuria genes. PloS one\| PubMed ID: 23516419	2013
Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination. Circulation research\| PubMed ID: 23564640	2013
The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition. The Journal of cell biology\| PubMed ID: 23712262	2013
Renal cell carcinoma: translational aspects of metabolism and therapeutic consequences. Kidney international\| PubMed ID: 23823604	2013
The hypoxia-inducible factor renders cancer cells more sensitive to vitamin C-induced toxicity. The Journal of biological chemistry\| PubMed ID: 24371136	2014
HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. Cardiovascular research\| PubMed ID: 25063991	2014
Extension of Saccharomyces paradoxus Chronological Lifespan by Retrotransposons in Certain Media Conditions Is Associated with Changes in Reactive Oxygen Species. Genetics\| PubMed ID: 25106655	2014