Hak-Kim Chan

Faculty of Pharmacy, University of Sydney

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2014

Other Publications

Article	Year
Solubility prediction of anthracene in mixed solvents using a minimum number of experimental data. Chemical & pharmaceutical bulletin\| PubMed ID: 11824580	2002
A solid-state NMR study of protein mobility in lyophilized protein-sugar powders. Journal of pharmaceutical sciences\| PubMed ID: 11948532	2002
Solubility prediction in supercritical CO(2) using minimum number of experiments. Journal of pharmaceutical sciences\| PubMed ID: 11977104	2002
A cosolvency model to predict solubility of drugs at several temperatures from a limited number of solubility measurements. Chemical & pharmaceutical bulletin\| PubMed ID: 12036011	2002
Effect of powder polydispersity on aerosol generation. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques\| PubMed ID: 12207868	2002
Mathematical representation of apparent dissociation constants in aqueous-organic solvent mixtures. International journal of pharmaceutics\| PubMed ID: 12270616	2002
Changes in lung deposition of aerosols due to hygroscopic growth: a fast SPECT study. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine\| PubMed ID: 12396419	2002
The role of particle properties in pharmaceutical powder inhalation formulations. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine\| PubMed ID: 12396421	2002
Mannitol as a challenge test to identify exercise-induced bronchoconstriction in elite athletes. American journal of respiratory and critical care medicine\| PubMed ID: 12456381	2003
Comparison of different algorithms to calculate electrophoretic mobility of analytes as a function of binary solvent composition. Electrophoresis\| PubMed ID: 12761789	2003
Novel alternative methods for the delivery of drugs for the treatment of asthma. Advanced drug delivery reviews\| PubMed ID: 12842601	2003
Inhalation challenge with bovine dander allergens: who needs it? Chest\| PubMed ID: 12853550	2003
Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. Chest\| PubMed ID: 14555564	2003
Responsiveness to three bronchial provocation tests in patients with asthma. Chest\| PubMed ID: 14665497	2003
Feasibility of preparing nanodrugs by high-gravity reactive precipitation. International journal of pharmaceutics\| PubMed ID: 14698598	2004
A simple relationship between dielectric constant of mixed solvents with solvent composition and temperature. International journal of pharmaceutics\| PubMed ID: 14706247	2004
Generation of fine powders of recombinant human deoxyribonuclease using the aerosol solvent extraction system. Pharmaceutical research\| PubMed ID: 14725370	2003
Physical stability of salmon calcitonin spray-dried powders for inhalation. Journal of pharmaceutical sciences\| PubMed ID: 14762916	2004
Coughing during mannitol challenge is associated with asthma. Chest\| PubMed ID: 15189912	2004
Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length. Journal of pharmaceutical sciences\| PubMed ID: 15389665	2004
Effect of mouthpiece washing on aerosol performance of CFC-free Ventolin. The Journal of asthma : official journal of the Association for the Care of Asthma\| PubMed ID: 15584631	2004
Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept. Pulmonary pharmacology & therapeutics\| PubMed ID: 15649849	2005
Modeling the entrainer effects on solubility of solutes in supercritical carbon dioxide. Chemical & pharmaceutical bulletin\| PubMed ID: 15744100	2005
How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharmaceutical research\| PubMed ID: 15771241	2005
A unified cosolvency model for calculating solute solubility in mixed solvents. Chemical & pharmaceutical bulletin\| PubMed ID: 15930773	2005
The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical research\| PubMed ID: 15948036	2005
Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical research\| PubMed ID: 16132356	2005
Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. Respirology (Carlton, Vic.)\| PubMed ID: 16135166	2005
Effect of amino acids on the dispersion of disodium cromoglycate powders. Journal of pharmaceutical sciences\| PubMed ID: 16136546	2005
Electrostatic charge characteristics of aerosols produced from metered dose inhalers. Journal of pharmaceutical sciences\| PubMed ID: 16258995	2005
The 15th International Society of Aerosols in Medicine Congress. Perth, Australia, 14-18 March 2005. Expert opinion on drug delivery\| PubMed ID: 16370947	2006
SPECT Imaging for Radioaerosol Deposition and Clearance Studies. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine\| PubMed ID: 16551210	2006
Dry powder aerosol delivery systems: current and future research directions. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine\| PubMed ID: 16551211	2006
Solubility prediction of paracetamol in binary and ternary solvent mixtures using Jouyban-Acree model. Chemical & pharmaceutical bulletin\| PubMed ID: 16595939	2006
Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size. Journal of pharmaceutical sciences\| PubMed ID: 16625656	2006
Production of salbutamol sulfate for inhalation by high-gravity controlled antisolvent precipitation. International journal of pharmaceutics\| PubMed ID: 17052870	2007
The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug development and industrial pharmacy\| PubMed ID: 17192255	2007
Lung deposition of mannitol powder aerosol in healthy subjects. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine\| PubMed ID: 17196080	2006
Influence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systems. Pharmaceutical research\| PubMed ID: 17377746	2007
Focused-ion-beam milling: a novel approach to probing the interior of particles used for inhalation aerosols. Pharmaceutical research\| PubMed ID: 17404810	2007
Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhaler. Pharmaceutical research\| PubMed ID: 17404813	2007
The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. Journal of pharmaceutical sciences\| PubMed ID: 17455362	2007
Effect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosols. Pharmaceutical research\| PubMed ID: 17619997	2008
Preparation of inhalable salbutamol sulphate using reactive high gravity controlled precipitation. Journal of pharmaceutical sciences\| PubMed ID: 17722000	2008
The influence of drug morphology on aerosolisation efficiency of dry powder inhaler formulations. Journal of pharmaceutical sciences\| PubMed ID: 17894369	2008
Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers. International journal of pharmaceutics\| PubMed ID: 17904774	2008
Cospray dried antibiotics for dry powder lung delivery. Journal of pharmaceutical sciences\| PubMed ID: 17990305	2008
In vitro and in vivo aspects of cascade impactor tests and inhaler performance: a review. AAPS PharmSciTech\| PubMed ID: 18181531	2007
Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles. Drug development and industrial pharmacy\| PubMed ID: 18214756	2008
Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: influence of polymer concentration on physical and in vitro characteristic... European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18226880	2008
What is a suitable dissolution method for drug nanoparticles? Pharmaceutical research\| PubMed ID: 18320295	2008
Physicochemical characterization and stability of rifampicin liposome dry powder formulations for inhalation. Journal of pharmaceutical sciences\| PubMed ID: 18484099	2009
In vitro/in vivo comparisons in pulmonary drug delivery. Journal of aerosol medicine and pulmonary drug delivery\| PubMed ID: 18518834	2008
Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: evaluation of in vitro release profiling methodologies for controlled rele... European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 18534832	2008
Dissolution kinetic behavior of drug nanoparticles and their conformity to the diffusion model. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 18558778	2008
Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 18586091	2008
What is the role of particle morphology in pharmaceutical powder aerosols? Expert opinion on drug delivery\| PubMed ID: 18712999	2008
Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 18759384	2008
Lactose composite carriers for respiratory delivery. Pharmaceutical research\| PubMed ID: 19015956	2009
Introduction of the electrical next generation impactor (eNGI) and investigation of its capabilities for the study of pressurized metered dose inhalers. Pharmaceutical research\| PubMed ID: 19015961	2009
Preparation and evaluation of controlled release microparticles for respiratory protein therapy. Journal of pharmaceutical sciences\| PubMed ID: 19130607	2009
Recent advances in controlled release pulmonary therapy. Current drug delivery\| PubMed ID: 19534707	2009
Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 19559086	2009
Development of an in vivo ovine dry powder inhalation model for the evaluation of conventional and controlled release microparticles. The AAPS journal\| PubMed ID: 19568940	2009
Controlled release antibiotics for dry powder lung delivery. Drug development and industrial pharmacy\| PubMed ID: 19656005	2010
The influence of flow rate on the aerosol deposition profile and electrostatic charge of single and combination metered dose inhalers. Pharmaceutical research\| PubMed ID: 19806433	2009
Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 19932579	2010
Does electrostatic charge affect powder aerosolisation? Journal of pharmaceutical sciences\| PubMed ID: 19941330	2010
Electrostatics of pharmaceutical inhalation aerosols. The Journal of pharmacy and pharmacology\| PubMed ID: 19958580	2009
A novel method for the production of crystalline micronised particles. International journal of pharmaceutics\| PubMed ID: 20043982	2010
Can low-dose combination products for inhalation be formulated in single crystalline particles? European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 20172026	2010
The contribution of different formulation components on the aerosol charge in carrier-based dry powder inhaler systems. Pharmaceutical research\| PubMed ID: 20354768	2010
Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 20371286	2010
Particle aerosolisation and break-up in dry powder inhalers 1: evaluation and modelling of venturi effects for agglomerated systems. Pharmaceutical research\| PubMed ID: 20372989	2010
Electrostatic charge characteristics of jet nebulized aerosols. Journal of aerosol medicine and pulmonary drug delivery\| PubMed ID: 20500092	2010
Impact angles as an alternative way to improve aerosolisation of powders for inhalation? European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 20615465	2010
Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy. International journal of pharmaceutics\| PubMed ID: 20951781	2011
Method to introduce mannitol powder to intubated patients to improve sputum clearance. Journal of aerosol medicine and pulmonary drug delivery\| PubMed ID: 20961167	2011
Formation, characterization, and fate of inhaled drug nanoparticles. Advanced drug delivery reviews\| PubMed ID: 21118707	2011
Pulmonary formulations: what remains to be done? Journal of aerosol medicine and pulmonary drug delivery\| PubMed ID: 21133800	2010
Formation of protein nano-matrix particles with controlled surface architecture for respiratory drug delivery. Pharmaceutical research\| PubMed ID: 21136142	2011
Mannitol delivery by vibrating mesh nebulisation for enhancing mucociliary clearance. Journal of pharmaceutical sciences\| PubMed ID: 21283985	2011
Pulmonary delivery of therapeutic siRNA. Advanced drug delivery reviews\| PubMed ID: 21356260	2012
Particle aerosolisation and break-up in dry powder inhalers: evaluation and modelling of impaction effects for agglomerated systems. Journal of pharmaceutical sciences\| PubMed ID: 21360707	2011
Production methods for nanodrug particles using the bottom-up approach. Advanced drug delivery reviews\| PubMed ID: 21457742	2011
Nanodrug particles and nanoformulations for drug delivery. Advanced drug delivery reviews\| PubMed ID: 21601602	2011
Particle aerosolisation and break-up in dry powder inhalers: evaluation and modelling of the influence of grid structures for agglomerated systems. Journal of pharmaceutical sciences\| PubMed ID: 21695695	2011
Isoniazid proliposome powders for inhalation-preparation, characterization and cell culture studies. International journal of molecular sciences\| PubMed ID: 21845086	2011
Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former. International journal of pharmaceutics\| PubMed ID: 21864662	2011
The use of computational approaches in inhaler development. Advanced drug delivery reviews\| PubMed ID: 22063020	2012
Constant size, variable density aerosol particles by ultrasonic spray freeze drying. International journal of pharmaceutics\| PubMed ID: 22322208	2012
Does the United States Pharmacopeia throat introduce de-agglomeration of carrier-free powder from inhalers? Pharmaceutical research\| PubMed ID: 22327971	2012
Delivery of high solubility polyols by vibrating mesh nebulizer to enhance mucociliary clearance. Journal of aerosol medicine and pulmonary drug delivery\| PubMed ID: 22393906	2012
Personalizing aerosol medicine: development of delivery systems tailored to the individual. Therapeutic delivery\| PubMed ID: 22833956	2010
A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 22982733	2012
Synergistic combination dry powders for inhaled antimicrobial therapy: Formulation, characterization and in vitro evaluation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 23010564	2012
Standardization of techniques for using single-photon emission computed tomography (SPECT) for aerosol deposition assessment of orally inhaled products. Journal of aerosol medicine and pulmonary drug delivery\| PubMed ID: 23215845	2012
Validation of radiolabeling of drug formulations for aerosol deposition assessment of orally inhaled products. Journal of aerosol medicine and pulmonary drug delivery\| PubMed ID: 23215848	2012
Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research. Psychoneuroendocrinology\| PubMed ID: 23265311	2013
Effect of device design on the aerosolization of a carrier-based dry powder inhaler--a case study on Aerolizer(®) Foradile (®). The AAPS journal\| PubMed ID: 23371759	2013
Unitary hormonal models, peripheral markers, and evaluation of response to drug: a response to Weisman and Feldman. Psychoneuroendocrinology\| PubMed ID: 23582730	2013
Nanotechnology versus other techniques in improving drug dissolution. Current pharmaceutical design\| PubMed ID: 23651399	2014
Novel alternatives to reduce powder retention in the dry powder inhaler during aerosolization. International journal of pharmaceutics\| PubMed ID: 23680726	2013
Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 23702276	2014
TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine\| PubMed ID: 23880366	2013
Aerosol delivery of nanoparticles in uniform mannitol carriers formulated by ultrasonic spray freeze drying. Pharmaceutical research\| PubMed ID: 23893019	2013
Colistin powders with high aerosolisation efficiency for respiratory infection: preparation and in vitro evaluation. Journal of pharmaceutical sciences\| PubMed ID: 23904207	2013
Pulmonary drug delivery. Therapeutic delivery\| PubMed ID: 23919463	2013
Electrostatics in pharmaceutical aerosols for inhalation. Therapeutic delivery\| PubMed ID: 23919475	2013
Liposomal formulations for inhalation. Therapeutic delivery\| PubMed ID: 23919478	2013
Overcoming dose limitations using the orbital(®) multi-breath dry powder inhaler. Journal of aerosol medicine and pulmonary drug delivery\| PubMed ID: 24004178	2014
The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers. Drug development and industrial pharmacy\| PubMed ID: 24087854	2013
Synergistic antibiotic combination powders of colistin and rifampicin provide high aerosolization efficiency and moisture protection. The AAPS journal\| PubMed ID: 24129586	2014
Inhaled antibiotics to treat lung infection. Pharmaceutical patent analyst\| PubMed ID: 24237172	2013
A rifapentine-containing inhaled triple antibiotic formulation for rapid treatment of tubercular infection. Pharmaceutical research\| PubMed ID: 24242939	2014
Delivery of inhalation drugs to children for asthma and other respiratory diseases. Advanced drug delivery reviews\| PubMed ID: 24270011	2014
The influence of actuator materials and nozzle designs on electrostatic charge of pressurised metered dose inhaler (pMDI) formulations. Pharmaceutical research\| PubMed ID: 24297072	2014
Effect of crystallinity on electrostatic charging in dry powder inhaler formulations. Pharmaceutical research\| PubMed ID: 24464269	2014
Steroid-decorated antibiotic microparticles for inhaled anti-infective therapy. Journal of pharmaceutical sciences\| PubMed ID: 24510431	2014
A novel inhalable form of rifapentine. Journal of pharmaceutical sciences\| PubMed ID: 24585270	2014
Nanodrugs: pharmacokinetics and safety. International journal of nanomedicine\| PubMed ID: 24591825	2014
Modifying the release properties of liposomes toward personalized medicine. Journal of pharmaceutical sciences\| PubMed ID: 24715635	2014
Advances in Device and Formulation Technologies for Pulmonary Drug Delivery. AAPS PharmSciTech\| PubMed ID: 24728868	2014
Emerging inhalation aerosol devices and strategies: Where are we headed? Advanced drug delivery reviews\| PubMed ID: 24732364	2014
Isothermal Microcalorimetry of Pressurized Systems I: A Rapid Method to Evaluate Pressurized Metered Dose Inhaler Formulations. Pharmaceutical research\| PubMed ID: 24760449	2014
Multi-breath dry powder inhaler for delivery of cohesive powders in the treatment of bronchiectasis. Drug development and industrial pharmacy\| PubMed ID: 24811055	2014
Pulmonary drug delivery by powder aerosols. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24818765	2014
Attachment of micro- and nano-particles on tipless cantilevers for colloidal probe microscopy. Journal of colloid and interface science\| PubMed ID: 24863782	2014
NanoXCT: A Novel Technique to Probe the Internal Architecture of Pharmaceutical Particles. Pharmaceutical research\| PubMed ID: 24867423	2014
Aerosol Performance and Long-Term Stability of Surfactant-Associated Liposomal Ciprofloxacin Formulations with Modified Encapsulation and Release Properties. AAPS PharmSciTech\| PubMed ID: 24889736	2014