Dirk Foell

Department of Pediatric Rheumatology and Immunology, University Children's Hospital Münster

Affiliated withUniversity Children's Hospital Münster University Children's Hospital

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 19	2014
Publication title Cited by 1	2019

Other Publications

Article	Year
Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802069	2008
Early detection of severe cholestatic hepatopathy in COACH syndrome. American journal of medical genetics\| PubMed ID: 12210305	2002
S100A12 (EN-RAGE) in monitoring Kawasaki disease. Lancet\| PubMed ID: 12699958	2003
Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis. Arthritis and rheumatism\| PubMed ID: 13130482	2003
Absence of S100A12 in mouse: implications for RAGE-S100A12 interaction. Trends in immunology\| PubMed ID: 14644132	2003
Methotrexate treatment in juvenile idiopathic arthritis: when is the right time to stop? Annals of the rheumatic diseases\| PubMed ID: 14722212	2004
Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations. Arthritis and rheumatism\| PubMed ID: 15077313	2004
Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammation. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 15149869	2004
Wegener granulomatosis in childhood and adolescence. European journal of pediatrics\| PubMed ID: 15168108	2004
MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Blood\| PubMed ID: 15331440	2004
Neutrophil-derived S100A12 is profoundly upregulated in the early stage of acute Kawasaki disease. The American journal of cardiology\| PubMed ID: 15374807	2004
Early recruitment of phagocytes contributes to the vascular inflammation of giant cell arteritis. The Journal of pathology\| PubMed ID: 15476267	2004
Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis and rheumatism\| PubMed ID: 15593206	2004
Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood\| PubMed ID: 15598812	2005
Differential expression and response to anti-TNFalpha treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis. The Journal of pathology\| PubMed ID: 15809977	2005
Early activation of cutaneous vessels and epithelial cells is characteristic of acute systemic onset juvenile idiopathic arthritis. Experimental dermatology\| PubMed ID: 15810883	2005
Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis. Arthritis research & therapy\| PubMed ID: 15899044	2005
S100 proteins in monitoring inflammation: the importance of a gold standard and a validated methodology. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16148085	2005
Systemic juvenile rheumatoid arthritis: cognitive function and social adjustment. Annals of neurology\| PubMed ID: 16178013	2005
Carboxylated glycans mediate colitis through activation of NF-kappa B. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16210648	2005
S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. Journal of leukocyte biology\| PubMed ID: 16943388	2007
Expression of myeloid-related protein-8 and -14 in patients with acute Kawasaki disease. Journal of the American College of Cardiology\| PubMed ID: 16979015	2006
Effects of intra-articular corticosteroids and anti-TNF therapy on neutrophil activation in rheumatoid arthritis. Annals of the rheumatic diseases\| PubMed ID: 17223658	2007
Neutrophil-derived S100A12 in acute lung injury and respiratory distress syndrome. Critical care medicine\| PubMed ID: 17414728	2007
Mechanisms of disease: a 'DAMP' view of inflammatory arthritis. Nature clinical practice. Rheumatology\| PubMed ID: 17599072	2007
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nature medicine\| PubMed ID: 17767165	2007
Acute Kawasaki disease is associated with reverse regulation of soluble receptor for advance glycation end products and its proinflammatory ligand S100A12. Arthritis and rheumatism\| PubMed ID: 18050248	2007
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis\| PubMed ID: 18689872	2008
Phagocyte-specific S100 proteins are released from affected mucosa and promote immune responses during inflammatory bowel disease. The Journal of pathology\| PubMed ID: 18729068	2008
S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin. Arthritis and rheumatism\| PubMed ID: 19035478	2008
Monitoring disease activity by stool analyses: from occult blood to molecular markers of intestinal inflammation and damage. Gut\| PubMed ID: 19136508	2009
Elevated human beta-defensin-2 levels indicate an activation of the innate immune system in patients with irritable bowel syndrome. The American journal of gastroenterology\| PubMed ID: 19174795	2009
The myeloid-related proteins 8 and 14 complex, a novel ligand of toll-like receptor 4, and interleukin-1beta form a positive feedback mechanism in systemic-onset juvenile idiopathic arthriti... Arthritis and rheumatism\| PubMed ID: 19248102	2009
Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function. BMC biochemistry\| PubMed ID: 19386136	2009
Infliximab reduces the cytokine-mediated inflammation but does not suppress cellular infiltration of the vessel wall in refractory Kawasaki disease. Pediatric research\| PubMed ID: 19430379	2009
The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. Journal of leukocyte biology\| PubMed ID: 19451397	2009
Diagnostic value of [(18)F]-FDG PET/CT in children with fever of unknown origin or unexplained signs of inflammation. European journal of nuclear medicine and molecular imaging\| PubMed ID: 19526234	2010
Neutrophil-derived S100A12 as novel biomarker of inflammation in familial Mediterranean fever. Annals of the rheumatic diseases\| PubMed ID: 19762364	2010
Expression and role of myeloid-related protein-14 in clinical and experimental sepsis. American journal of respiratory and critical care medicine\| PubMed ID: 19762566	2009
Achalasia mistaken as eating disorders: report of two children and review of the literature. European journal of gastroenterology & hepatology\| PubMed ID: 19809334	2010
Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission: a randomized clinical trial. JAMA : the journal of the American Medical Association\| PubMed ID: 20371785	2010
Keratinocytes determine Th1 immunity during early experimental leishmaniasis. PLoS pathogens\| PubMed ID: 20442861	2010
The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nature medicine\| PubMed ID: 20473308	2010
Carboxylated N-glycans on RAGE promote S100A12 binding and signaling. Journal of cellular biochemistry\| PubMed ID: 20512925	2010
Body mass index and creatinine clearance are associated with steady-state serum concentrations of the cell damage marker S100B in renal transplant recipients. Medical science monitor : international medical journal of experimental and clinical research\| PubMed ID: 20581773	2010
Life-threatening hypersplenism due to idiopathic portal hypertension in early childhood: case report and review of the literature. BMC gastroenterology\| PubMed ID: 20961440	2010
Noninvasive assessment of pediatric inflammatory bowel disease with ¹⁸F-fluorodeoxyglucose-positron emission tomography and computed tomography. European journal of gastroenterology & hepatology\| PubMed ID: 21042220	2011
B cell depletion for autoimmune diseases in paediatric patients. Clinical rheumatology\| PubMed ID: 21120559	2011
Translational research network and patient registry for auto-inflammatory diseases. Rheumatology (Oxford, England)\| PubMed ID: 21148158	2011
The functional -374T/A polymorphism of the receptor for advanced glycation end products may modulate Crohn's disease. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21311028	2011
Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome. Arthritis and rheumatism\| PubMed ID: 21360513	2011
Granulocyte macrophage-colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn disease. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 21502824	2011
Therapeutic approaches in the treatment of juvenile dermatomyositis in patients with recent-onset disease and in those experiencing disease flare: an international multicenter PRINTO study. Arthritis and rheumatism\| PubMed ID: 21647864	2011
MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes. Annals of the rheumatic diseases\| PubMed ID: 21908452	2011
The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis. Annals of the rheumatic diseases\| PubMed ID: 22267331	2012
CREMα overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity. Journal of molecular cell biology\| PubMed ID: 22355096	2012
Multiple juvenile idiopathic arthritis subtypes demonstrate proinflammatory IgG glycosylation. Arthritis and rheumatism\| PubMed ID: 22549726	2012
Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative stud... Annals of the rheumatic diseases\| PubMed ID: 22689317	2012
Fecal phagocyte-specific S100A12 for diagnosing necrotizing enterocolitis. The Journal of pediatrics\| PubMed ID: 22796048	2012
Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome. Journal of leukocyte biology\| PubMed ID: 22892107	2012
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis. The EMBO journal\| PubMed ID: 23188082	2013
Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers. Clinical immunology (Orlando, Fla.)\| PubMed ID: 23269200	2013
Improving relapse prediction in inflammatory bowel disease by neutrophil-derived S100A12. Inflammatory bowel diseases\| PubMed ID: 23377171	2013
Fecal S100A12: identifying intestinal distress in very-low-birth-weight infants. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 23549327	2013
Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4. American journal of respiratory and critical care medicine\| PubMed ID: 23611140	2013
Peripheral monocyte functions and activation in patients with quiescent Crohn's disease. PloS one\| PubMed ID: 23658649	2013
Treatment of Muckle-Wells syndrome: analysis of two IL-1-blocking regimens. Arthritis research & therapy\| PubMed ID: 23718630	2013
Long-term safety and efficacy of rilonacept in patients with systemic juvenile idiopathic arthritis. Arthritis and rheumatism\| PubMed ID: 23754188	2013
Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. Arthritis and rheumatism\| PubMed ID: 23983059	2013
Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease. The American journal of gastroenterology\| PubMed ID: 24145675	2013
MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis. Annals of the rheumatic diseases\| PubMed ID: 24297376	2013
Validation of relapse risk biomarkers for routine use in patients with juvenile idiopathic arthritis. Arthritis care & research\| PubMed ID: 24339418	2014
Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24470119	2014
Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome. World journal of gastroenterology : WJG\| PubMed ID: 24574706	2014
Significance of hydrogen breath tests in children with suspected carbohydrate malabsorption. BMC pediatrics\| PubMed ID: 24575947	2014
A12: The Role of Serum S100A12 Protein Levels in Disease Flare After Withdrawal of Anti-tumor Necrosis Factor Therapy in Polyarticular Forms of Juvenile Idiopathic Arthritis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24677901	2014
A20: Understanding the Use and Biology of TNF Therapy in JIA-Clinical Outcomes. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24677947	2014
A68: The Role of Serum S100A12 Protein Levels in Maintaining Inactive Disease on Anti-tumor Necrosis Factor Therapy in Polyarticular Forms of Juvenile Idiopathic Arthritis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24677999	2014
Clinical features of childhood granulomatosis with polyangiitis (wegener's granulomatosis). Pediatric rheumatology online journal\| PubMed ID: 24891844	2014
Activated STING in a vascular and pulmonary syndrome. The New England journal of medicine\| PubMed ID: 25029335	2014
Monocyte-induced development of Th17 cells and the release of S100 proteins are involved in the pathogenesis of graft-versus-host disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25187661	2014
Management of juvenile idiopathic arthritis: hitting the target. Nature reviews. Rheumatology\| PubMed ID: 25561365	2015
Reprogramming of monocytes by GM-CSF contributes to regulatory immune functions during intestinal inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25653427	2015
Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases. The Journal of allergy and clinical immunology\| PubMed ID: 26025129	2015
Redox distress and genetic defects conspire in systemic autoinflammatory diseases. Nature reviews. Rheumatology\| PubMed ID: 26241183	2015
MRP8/14 serum levels as a predictor of response to starting and stopping anti-TNF treatment in juvenile idiopathic arthritis. Arthritis research & therapy\| PubMed ID: 26249667	2015
Detection of Early Murine Colorectal Cancer by MMP-2/-9-Guided Fluorescence Endoscopy. Inflammatory bowel diseases\| PubMed ID: 26457379	2016
Increased serum concentrations of neutrophil-derived protein S100A12 in heterozygous carriers of MEFV mutations. Clinical and experimental rheumatology\| PubMed ID: 26486615	2015
Sleep Fragmentation and Biomarkers in Juvenile Idiopathic Arthritis. Biological research for nursing\| PubMed ID: 26512051	2016
HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26598658	2015
No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis. Pediatric rheumatology online journal\| PubMed ID: 26667304	2015
[Translational research in pediatric rheumatology. Current research approaches to the innate immune system]. Zeitschrift fur Rheumatologie\| PubMed ID: 26800663	2016
Correlation of Secretory Activity of Neutrophils With Genotype in Patients With Familial Mediterranean Fever. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 27333294	2016
Review of biomarkers in systemic juvenile idiopathic arthritis: helpful tools or just playing tricks? Arthritis research & therapy\| PubMed ID: 27411444	2016
Alarmins firing arthritis: Helpful diagnostic tools and promising therapeutic targets. Joint, bone, spine : revue du rhumatisme\| PubMed ID: 27659403	2017
Partial correction of neutrophil dysfunction by oral galactose therapy in glycogen storage disease type Ib. International immunopharmacology\| PubMed ID: 28126686	2017
Granulocyte Macrophage Colony-Stimulating Factor-Activated CD39+/CD73+ Murine Monocytes Modulate Intestinal Inflammation via Induction of Regulatory T Cells. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 28210690	2015
Proinflammatory Cytokine Environments Can Drive Interleukin-17 Overexpression by γ/δ T Cells in Systemic Juvenile Idiopathic Arthritis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 28296284	2017
Early Outcomes in Children With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 28371513	2017
Munchausen by proxy syndrome mimicking systemic autoinflammatory disease: case report and review of the literature. Pediatric rheumatology online journal\| PubMed ID: 28381287	2017
Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood\| PubMed ID: 29326099	2018
S100A12 Is Associated with Response to Therapy in Juvenile Idiopathic Arthritis. The Journal of rheumatology\| PubMed ID: 29335345	2018
Identification of an Amino Acid Motif in HLA-DRβ1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 29513936	2018
IL-6 blockade in systemic juvenile idiopathic arthritis - achievement of inactive disease and remission (data from the German AID-registry). Pediatric rheumatology online journal\| PubMed ID: 29622022	2018
The German version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR). Rheumatology international\| PubMed ID: 29637325	2018
Treating juvenile idiopathic arthritis to target: recommendations of an international task force. Annals of the rheumatic diseases\| PubMed ID: 29643108	2018
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies. The Journal of clinical investigation\| PubMed ID: 29649002	2018
Proteomics in Chronic Arthritis-Will We Finally Have Useful Biomarkers? Current rheumatology reports\| PubMed ID: 30008153	2018
Calcium and zinc tune autoinflammatory Toll-like receptor 4 signaling by S100A12. The Journal of allergy and clinical immunology\| PubMed ID: 30010542	2018
The role of S100 proteins in the pathogenesis and monitoring of autoinflammatory diseases. Molecular and cellular pediatrics\| PubMed ID: 30255357	2018
Monocyte-Derived Interleukin-1β As the Driver of S100A12-Induced Sterile Inflammatory Activation of Human Coronary Artery Endothelial Cells: Implications for the Pathogenesis of Kawasaki Dis... Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 30447136	2019
Evaluation of the S100 protein A12 as a biomarker of neonatal sepsis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\| PubMed ID: 30563403	2018
Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study. The Lancet. Child & adolescent health\| PubMed ID: 30819662	2019
Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis. Annals of the rheumatic diseases\| PubMed ID: 31005900	2019
Classification criteria for autoinflammatory recurrent fevers. Annals of the rheumatic diseases\| PubMed ID: 31018962	2019
The German National Registry of Primary Immunodeficiencies (2012-2017). Frontiers in immunology\| PubMed ID: 31379802	2019