Inti Zlobec

Institute of Pathology, University of Bern

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 66	2014

Other Publications

Article	Year
A predictive model of rectal tumor response to preoperative radiotherapy using classification and regression tree methods. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16061859	2005
VEGF as a predictive marker of rectal tumor response to preoperative radiotherapy. Cancer\| PubMed ID: 16222693	2005
The predictive value of apoptosis protease-activating factor 1 in rectal tumors treated with preoperative, high-dose-rate brachytherapy. Cancer\| PubMed ID: 16315248	2006
Scoring of p53, VEGF, Bcl-2 and APAF-1 immunohistochemistry and interobserver reliability in colorectal cancer. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 16741523	2006
Overexpression of the receptor for hyaluronic acid mediated motility is an independent adverse prognostic factor in colorectal cancer. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 16763611	2006
Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in ... Human pathology\| PubMed ID: 16867865	2006
Prognostic value of cell cycle and apoptosis regulatory proteins in mismatch repair-proficient colorectal cancer: a tissue microarray-based approach. American journal of clinical pathology\| PubMed ID: 17145638	2007
Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer. Journal of clinical pathology\| PubMed ID: 17182662	2007
Intratumoral budding as a potential parameter of tumor progression in mismatch repair-proficient and mismatch repair-deficient colorectal cancer patients. Human pathology\| PubMed ID: 21664647	2011
Napoleon Bonaparte's gastric cancer: a clinicopathologic approach to staging, pathogenesis, and etiology. Nature clinical practice. Gastroenterology & hepatology\| PubMed ID: 17203089	2007
Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: a potential role for dysregulation of the transformin... European journal of cancer (Oxford, England : 1990)\| PubMed ID: 17223543	2007
Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 17277767	2007
Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 17350821	2007
Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer. American journal of clinical pathology\| PubMed ID: 17439843	2007
HER2 gene status in primary breast cancers and matched distant metastases. Breast cancer research : BCR\| PubMed ID: 17511881	2007
Value of staining intensity in the interpretation of immunohistochemistry for tumor markers in colorectal cancer. Virchows Archiv : an international journal of pathology\| PubMed ID: 17674041	2007
Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer. Cancer\| PubMed ID: 18076013	2008
Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18172264	2008
KIT, PDGFRalpha and EGFR analysis in nephroblastoma. Virchows Archiv : an international journal of pathology\| PubMed ID: 18478259	2008
Local recurrence in mismatch repair-proficient colon cancer predicted by an infiltrative tumor border and lack of CD8+ tumor-infiltrating lymphocytes. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18559598	2008
RHAMM, p21 combined phenotype identifies microsatellite instability-high colorectal cancers with a highly adverse prognosis. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18559599	2008
Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 18587323	2008
Is immunohistochemical epidermal growth factor receptor expression overestimated as a prognostic factor in head-neck squamous cell carcinoma? A retrospective analysis based on a tissue micro... Human pathology\| PubMed ID: 18620726	2008
Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and ex... American journal of clinical pathology\| PubMed ID: 18854271	2008
Immunophenotyping and oncogene amplifications in tumors of the papilla of Vater. Virchows Archiv : an international journal of pathology\| PubMed ID: 18936968	2008
Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 19043399	2009
Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 19117060	2009
The prognostic value of cytology and fluorescence in situ hybridization in the follow-up of nonmuscle-invasive bladder cancer after intravesical Bacillus Calmette-Guérin therapy. International journal of cancer. Journal international du cancer\| PubMed ID: 19230026	2009
HOX D13 expression across 79 tumor tissue types. International journal of cancer. Journal international du cancer\| PubMed ID: 19488988	2009
Tumor border configuration added to TNM staging better stratifies stage II colorectal cancer patients into prognostic subgroups. Cancer\| PubMed ID: 19517467	2009
Combined histomorphologic and immunohistochemical phenotype to predict the presence of vascular invasion in colon cancer. Diseases of the colon and rectum\| PubMed ID: 19581855	2009
Assessment of mean EGFR gene copy number is a highly reproducible method for evaluating FISH in histological and cytological cancer specimens. Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 19616866	2010
Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality? International journal of cancer. Journal international du cancer\| PubMed ID: 19697324	2010
Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer. Human pathology\| PubMed ID: 19740518	2010
High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. International journal of cancer. Journal international du cancer\| PubMed ID: 19856313	2010
Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis. International journal of cancer. Journal international du cancer\| PubMed ID: 19908233	2010
Systematic assessment of the prognostic impact of membranous CD44v6 protein expression in colorectal cancer. Histopathology\| PubMed ID: 19912362	2009
Prognostic immunophenotypic biomarker studies in diffuse large B cell lymphoma with special emphasis on rational determination of cut-off scores. Leukemia & lymphoma\| PubMed ID: 19925052	2010
Invasive front of colorectal cancer: dynamic interface of pro-/anti-tumor factors. World journal of gastroenterology : WJG\| PubMed ID: 20014453	2009
BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin's lymphoma from primary mediastinal large B-cell lymphoma. Histopathology\| PubMed ID: 20102401	2010
ABCG5-positivity in tumor buds is an indicator of poor prognosis in node-negative colorectal cancer patients. World journal of gastroenterology : WJG\| PubMed ID: 20135722	2010
Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. Chest\| PubMed ID: 20139227	2010
Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer. International journal of cancer. Journal international du cancer\| PubMed ID: 20162668	2010
Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 20185297	2010
Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer. BMC cancer\| PubMed ID: 20222950	2010
Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN). Pathology\| PubMed ID: 20350215	2010
The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 20542683	2010
Role of tumor size in the pre-operative management of rectal cancer patients. BMC gastroenterology\| PubMed ID: 20550703	2010
Expression of p16 in lymph node metastases of adjuvantly treated stage III colorectal cancer patients identifies poor prognostic subgroups: a retrospective analysis of biomarkers in matched ... Cancer\| PubMed ID: 20572035	2010
Tumor infiltration by FcγRIII (CD16)+ myeloid cells is associated with improved survival in patients with colorectal carcinoma. International journal of cancer. Journal international du cancer\| PubMed ID: 20715106	2011
Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer. Histopathology\| PubMed ID: 20716165	2010
Co-overexpression of p21 and Ki-67 in head and neck squamous cell carcinoma relative to a significantly poor prognosis. Head & neck\| PubMed ID: 20848449	2011
Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients. World journal of gastroenterology : WJG\| PubMed ID: 20939111	2010
TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer. PloS one\| PubMed ID: 21179245	2010
Can molecular markers stratify the diagnostic value of high-grade prostatic intraepithelial neoplasia? Human pathology\| PubMed ID: 21237492	2011
Deletion of the inhibitor of growth 4 (ING4) tumor suppressor gene is prevalent in human epidermal growth factor 2 (HER2)-positive breast cancer. Human pathology\| PubMed ID: 21315418	2011
Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget. Oncotarget\| PubMed ID: 21317460	2010
High-level cytoplasmic cyclin D1 expression in lymph node metastases from prostate cancer independently predicts early biochemical failure and death in surgically treated patients. Histopathology\| PubMed ID: 21438905	2011
Assessing downgrading of locally advanced rectal cancer after chemo-radiotherapy. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 21439814	2011
High CD10 expression in lymph node metastases from surgically treated prostate cancer independently predicts early death. Virchows Archiv : an international journal of pathology\| PubMed ID: 21538124	2011
Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features. The Journal of pathology\| PubMed ID: 21660972	2011
Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer. Human pathology\| PubMed ID: 21664646	2011
Prognostic significance of CD8+ T lymphocytes in breast cancer depends upon both oestrogen receptor status and histological grade. Histopathology\| PubMed ID: 21707712	2011
VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 21743435	2011
Immunophenotyping analysis in invasive micropapillary carcinoma of the breast: role of CD24 and CD44 isoforms expression. Breast (Edinburgh, Scotland)\| PubMed ID: 22014860	2012
Characterization of the immunological microenvironment of tumour buds and its impact on prognosis in mismatch repair-proficient and -deficient colorectal cancers. Histopathology\| PubMed ID: 22034888	2011
Effect of EpCAM, CD44, CD133 and CD166 expression on patient survival in tumours of the ampulla of Vater. Journal of clinical pathology\| PubMed ID: 22130902	2012
Standardization of whole slide image morphologic assessment with definition of a new application: Digital slide dynamic morphometry. Journal of pathology informatics\| PubMed ID: 22200031	2011
HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma. Histopathology\| PubMed ID: 22276603	2012
Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+ tumor infiltrating lymphocytes in ductal and lobular breast cancers. BMC cancer\| PubMed ID: 22471961	2012
Intra-tumoral budding in preoperative biopsy specimens predicts lymph node and distant metastasis in patients with colorectal cancer. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 22481282	2012
The clinical impact of p16 status in fine-needle aspirates of cervical lymph node metastasis of head and neck squamous cell carcinomas. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery\| PubMed ID: 22588195	2013
Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer. Frontiers in oncology\| PubMed ID: 22655257	2012
Diagnostic reproducibility of tumour budding in colorectal cancer: a multicentre, multinational study using virtual microscopy. Histopathology\| PubMed ID: 22765314	2012
The impact of CpG island methylator phenotype and microsatellite instability on tumour budding in colorectal cancer. Histopathology\| PubMed ID: 22803799	2012
Prognostic impact of β-2-microglobulin expression in colorectal cancers stratified by mismatch repair status. Journal of clinical pathology\| PubMed ID: 22859396	2012
Role of KCNMA1 in Breast Cancer. PloS one\| PubMed ID: 22899999	2012
Role of intra- and peritumoral budding in the interdisciplinary management of rectal cancer patients. International journal of surgical oncology\| PubMed ID: 22900161	2012
Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing. Journal of translational medicine\| PubMed ID: 22925370	2012
Proposal for a 10-high-power-fields scoring method for the assessment of tumor budding in colorectal cancer. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 23018875	2013
Cancer classification using the Immunoscore: a worldwide task force. Journal of translational medicine\| PubMed ID: 23034130	2012
Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 23089465	2013
Tumor budding score based on 10 high-power fields is a promising basis for a standardized prognostic scoring system in stage II colorectal cancer. Human pathology\| PubMed ID: 23159156	2013
Prediction of outcome in patients with low-grade squamous intraepithelial lesions by fluorescence in situ hybridization analysis of human papillomavirus, TERC, and MYC. Cancer cytopathology\| PubMed ID: 23408758	2013
Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. European journal of cancer (Oxford, England : 1990)\| PubMed ID: 23478000	2013
Novel biomarkers for the prediction of metastasis in colorectal cancer. Expert opinion on medical diagnostics\| PubMed ID: 23530884	2013
Estrogen receptor β expression and androgen receptor phosphorylation correlate with a poor clinical outcome in hormone-naive prostate cancer and are elevated in castration-resistant disease. Endocrine-related cancer\| PubMed ID: 23580588	2013
Next-generation tissue microarray (ngTMA) increases the quality of biomarker studies: an example using CD3, CD8, and CD45RO in the tumor microenvironment of six different solid tumor types. Journal of translational medicine\| PubMed ID: 23627766	2013
High myeloperoxidase positive cell infiltration in colorectal cancer is an independent favorable prognostic factor. PloS one\| PubMed ID: 23734221	2013
The growing galectin network in colon cancer and clinical relevance of cytoplasmic galectin-3 reactivity. Anticancer research\| PubMed ID: 23898060	2013
ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy. Nature communications\| PubMed ID: 23945651	2013
The apoptotic and proliferation rate of tumour budding cells in colorectal cancer outlines a heterogeneous population of cells with various impacts on clinical outcome. Histopathology\| PubMed ID: 24111856	2014
Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. The Journal of pathology\| PubMed ID: 24122236	2014
Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer. Frontiers in oncology\| PubMed ID: 24130965	2013
Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency. International journal of cancer. Journal international du cancer\| PubMed ID: 24166180	2014
A multifactorial histopathologic score for the prediction of prognosis of resected esophageal adenocarcinomas after neoadjuvant chemotherapy. Annals of surgical oncology\| PubMed ID: 24281419	2014
Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity\| PubMed ID: 24290911	2013
Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC). Journal of translational medicine\| PubMed ID: 24330423	2013
HLA class II antigen expression in colorectal carcinoma tumors as a favorable prognostic marker. Neoplasia (New York, N.Y.)\| PubMed ID: 24563618	2014
Proper paraffin slide storage is crucial for translational research projects involving immunohistochemistry stains. Clinical and translational medicine\| PubMed ID: 24636624	2014
CD8/CD45RO T-cell infiltration in endoscopic biopsies of colorectal cancer predicts nodal metastasis and survival. Journal of translational medicine\| PubMed ID: 24679169	2014
Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patien... Oncotarget\| PubMed ID: 25015728	2014
Assessment of Tumor Regression of Esophageal Adenocarcinomas After Neoadjuvant Chemotherapy: Comparison of 2 Commonly Used Scoring Approaches. The American journal of surgical pathology\| PubMed ID: 25140894	2014
Tumor budding in upper gastrointestinal carcinomas. Frontiers in oncology\| PubMed ID: 25177546	2014