Rekha G. Panchal

Division of Molecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases

Affiliated withUS Army Medical Research Institute of Infectious Diseases

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2014

Other Publications

Article	Year
Release of mitochondrial Ca2+ via the permeability transition activates endoplasmic reticulum Ca2+ uptake. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12039849	2002
Pore formation is not associated with macroscopic redistribution of P2X7 receptors. American journal of physiology. Cell physiology\| PubMed ID: 12055075	2002
Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12206993	2002
The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells. Cancer gene therapy\| PubMed ID: 12489024	2003
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region. The Journal of biological chemistry\| PubMed ID: 12496266	2003
Molecular mechanisms of filovirus cellular trafficking. Microbes and infection / Institut Pasteur\| PubMed ID: 12787740	2003
Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity. Biochemical and biophysical research communications\| PubMed ID: 14511652	2003
In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14673115	2003
Identification of small molecule inhibitors of anthrax lethal factor. Nature structural & molecular biology\| PubMed ID: 14718925	2004
Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding. Bioorganic & medicinal chemistry\| PubMed ID: 15598556	2005
Purified Bacillus anthracis lethal toxin complex formed in vitro and during infection exhibits functional and biological activity. The Journal of biological chemistry\| PubMed ID: 15644338	2005
Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15843553	2005
Analysis of Ebola virus and VLP release using an immunocapture assay. Journal of virological methods\| PubMed ID: 15893559	2005
An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition. Journal of structural biology\| PubMed ID: 15908231	2005
Functional reconstitution of protein ion channels into planar polymerizable phospholipid membranes. Nano letters\| PubMed ID: 15943465	2005
Anthrax biosensor, protective antigen ion channel asymmetric blockade. The Journal of biological chemistry\| PubMed ID: 16087661	2005
Antisense treatments for biothreat agents. Current opinion in molecular therapeutics\| PubMed ID: 16610760	2006
Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization. Vaccine\| PubMed ID: 16790303	2006
Anthrax lethal toxin impairs innate immune functions of alveolar macrophages and facilitates Bacillus anthracis survival. Infection and immunity\| PubMed ID: 16926394	2006
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons. The Journal of biological chemistry\| PubMed ID: 17092934	2007
Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery. Journal of biomolecular screening\| PubMed ID: 17332092	2007
Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis. Chemistry & biology\| PubMed ID: 17379140	2007
A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease. Journal of medicinal chemistry\| PubMed ID: 17417831	2007
Filovirus-like particles produced in insect cells: immunogenicity and protection in rodents. The Journal of infectious diseases\| PubMed ID: 17940979	2007
Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols). Biophysical journal\| PubMed ID: 18645196	2008
Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages. Infection and immunity\| PubMed ID: 19168747	2009
Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis. The Journal of biological chemistry\| PubMed ID: 19269962	2009
Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains. Antimicrobial agents and chemotherapy\| PubMed ID: 19635954	2009
Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection. Cell host & microbe\| PubMed ID: 19683682	2009
Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. Bioorganic & medicinal chemistry\| PubMed ID: 20188576	2010
Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. Antimicrobial agents and chemotherapy\| PubMed ID: 20625154	2010
Development of high-content imaging assays for lethal viral pathogens. Journal of biomolecular screening\| PubMed ID: 20639507	2010
The rapidly advancing field of biodefense benefits many other, critical public health concerns. Discovery medicine\| PubMed ID: 20704875	2005
A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus. Journal of medicinal chemistry\| PubMed ID: 21265542	2011
Identification of a small-molecule entry inhibitor for filoviruses. Journal of virology\| PubMed ID: 21270170	2011
Identification of an antioxidant small-molecule with broad-spectrum antiviral activity. Antiviral research\| PubMed ID: 22027648	2012
High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22891353	2012
Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis. Nucleic acid therapeutics\| PubMed ID: 22978365	2012
A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor. Viruses\| PubMed ID: 23012625	2012
Shedding light on filovirus infection with high-content imaging. Viruses\| PubMed ID: 23012631	2012
Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis. The Journal of antibiotics\| PubMed ID: 23149517	2013
High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection. Viruses\| PubMed ID: 23202445	2012
Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections. Viruses\| PubMed ID: 23202506	2012
Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for yersinia pestis infection. PloS one\| PubMed ID: 23383093	2013
A systematic screen of FDA-approved drugs for inhibitors of biological threat agents. PloS one\| PubMed ID: 23577127	2013
Characterization of the Burkholderia thailandensis SOS response by using whole-transcriptome shotgun sequencing. Applied and environmental microbiology\| PubMed ID: 23872555	2013
Anthrax toxin-induced rupture of artificial lipid bilayer membranes. The Journal of chemical physics\| PubMed ID: 23947891	2013
Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090. Bioorganic & medicinal chemistry\| PubMed ID: 24239389	2013
Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns. PloS one\| PubMed ID: 24516547	2014
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature\| PubMed ID: 24590073	2014
Induced IL-10 splice altering approach to antiviral drug discovery. Nucleic acid therapeutics\| PubMed ID: 24655055	2014
A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages. BMC microbiology\| PubMed ID: 24750902	2014
Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds. Bioorganic & medicinal chemistry letters\| PubMed ID: 24969013	2014
Applications of In Vivo Imaging in the Evaluation of the Pathophysiology of Viral and Bacterial Infections and in Development of Countermeasures to BSL3/4 Pathogens. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 25008802	2014
Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names. Viruses\| PubMed ID: 25256396	2014