David S. Park

Department of Cellular and Molecular Medicine, University of Ottawa

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2015

Other Publications

Article	Year
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. The Journal of biological chemistry\| PubMed ID: 11739396	2002
Caveolin-1 expression enhances endothelial capillary tubule formation. The Journal of biological chemistry\| PubMed ID: 11748236	2002
Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 11823715	2002
Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype. The American journal of pathology\| PubMed ID: 12057923	2002
Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis. Biochemistry\| PubMed ID: 12069580	2002
Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. The Journal of biological chemistry\| PubMed ID: 12091388	2002
Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a... The Journal of biological chemistry\| PubMed ID: 12091389	2002
Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. The EMBO journal\| PubMed ID: 12093735	2002
Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade. The Journal of biological chemistry\| PubMed ID: 12138167	2002
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. The Journal of cell biology\| PubMed ID: 12147675	2002
Cyclin-dependent kinases as potential targets to improve stroke outcome. Pharmacology & therapeutics\| PubMed ID: 12191606	2002
Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis. The Journal of biological chemistry\| PubMed ID: 12351630	2002
Constitutive nuclear factor-kappa B activity is required for central neuron survival. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12351721	2002
Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial c... The American journal of pathology\| PubMed ID: 12368209	2002
Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. American journal of physiology. Cell physiology\| PubMed ID: 12388077	2003
Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Molecular biology of the cell\| PubMed ID: 12388746	2002
Glomerular endothelial fenestrae in vivo are not formed from caveolae. Journal of the American Society of Nephrology : JASN\| PubMed ID: 12397033	2002
Cyclin-dependent kinases and stroke. Expert opinion on therapeutic targets\| PubMed ID: 12540283	2001
Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12598612	2003
Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Molecular biology of the cell\| PubMed ID: 12631721	2003
Caveolin, caveolae, and endothelial cell function. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 12689915	2003
Calpains mediate p53 activation and neuronal death evoked by DNA damage. The Journal of biological chemistry\| PubMed ID: 12721303	2003
Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12764095	2003
Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage. The Journal of biological chemistry\| PubMed ID: 12857758	2003
Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins. The American journal of pathology\| PubMed ID: 14507673	2003
Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 14563650	2004
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14595022	2003
Caveolin-1 null (-/-) mice show dramatic reductions in life span. Biochemistry\| PubMed ID: 14690422	2003
Emerging pathogenic role for cyclin dependent kinases in neurodegeneration. Cell cycle (Georgetown, Tex.)\| PubMed ID: 14726693	2004
Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14985447	2004
Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15044535	2004
The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1. The Journal of biological chemistry\| PubMed ID: 15105421	2004
CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease. Trends in molecular medicine\| PubMed ID: 15350897	2004
p107 regulates neural precursor cells in the mammalian brain. The Journal of cell biology\| PubMed ID: 15353549	2004
p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15525786	2004
c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. The Journal of biological chemistry\| PubMed ID: 15528206	2005
Comparison of rectilinear biphasic waveform energy versus truncated exponential biphasic waveform energy for transthoracic cardioversion of atrial fibrillation. The American journal of cardiology\| PubMed ID: 15566922	2004
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron\| PubMed ID: 15603737	2004
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15703386	2005
MR imaging of caveolin gene-specific alterations in right ventricular wall thickness. Magnetic resonance imaging\| PubMed ID: 15733789	2005
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15784737	2005
Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16166266	2005
Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16192386	2005
Apical role for BRG1 in cytokine-induced promoter assembly. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16195385	2005
MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons. Brain research\| PubMed ID: 16325158	2005
Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase. Journal of neurochemistry\| PubMed ID: 16336220	2006
Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16407541	2006
NFkappaB in neurons? The uncertainty principle in neurobiology. Journal of neurochemistry\| PubMed ID: 16573643	2006
Caveolin-1 and regulation of cellular cholesterol homeostasis. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16603689	2006
Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. The EMBO journal\| PubMed ID: 16917506	2006
The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16928871	2006
Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17012241	2006
Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17376993	2007
Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Molecular and cellular biology\| PubMed ID: 17452454	2007
Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death. The Journal of biological chemistry\| PubMed ID: 17537722	2007
Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17537963	2007
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate. The Journal of cell biology\| PubMed ID: 17591923	2007
The nuclear localization of SET mediated by impalpha3/impbeta attenuates its cytosolic toxicity in neurons. Journal of neurochemistry\| PubMed ID: 17608644	2007
Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease. Neuron\| PubMed ID: 17610816	2007
Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice. The Journal of biological chemistry\| PubMed ID: 17984095	2008
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18003894	2007
Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia. Journal of neurochemistry\| PubMed ID: 18205749	2008
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18218782	2008
CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18495890	2008
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18550749	2008
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19144925	2009
E2F4 is required for early eye patterning. Developmental neuroscience\| PubMed ID: 19325228	2009
Parkinson's disease: to live or die by autophagy. Science signaling\| PubMed ID: 19351953	2009
The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells. Molecular and cellular biology\| PubMed ID: 19564414	2009
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Human molecular genetics\| PubMed ID: 19692353	2009
Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19812325	2009
Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage. Journal of neurochemistry\| PubMed ID: 19895669	2010
Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19926863	2009
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133695	2010
Sertad1 plays an essential role in developmental and pathological neuron death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20237268	2010
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death. Nature cell biology\| PubMed ID: 20473298	2010
Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. Human molecular genetics\| PubMed ID: 20624856	2010
Cdk5: Links to DNA damage. Cell cycle (Georgetown, Tex.)\| PubMed ID: 20724832	2010
The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity. The Journal of biological chemistry\| PubMed ID: 21041314	2011
Rb/E2F regulates expression of neogenin during neuronal migration. Molecular and cellular biology\| PubMed ID: 21059867	2011
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. The EMBO journal\| PubMed ID: 21139567	2011
Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21159964	2010
The cardiac conduction system. Circulation\| PubMed ID: 21357845	2011
Structural and functional analyses of a glycoside hydrolase family 5 enzyme with an unexpected β-fucosidase activity. Biochemistry\| PubMed ID: 21410228	2011
Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncology reports\| PubMed ID: 21479363	2011
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 21552986	2011
Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss. The Journal of biological chemistry\| PubMed ID: 21693708	2011
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system. Human molecular genetics\| PubMed ID: 22076440	2012
Animal models of Parkinson's disease. Parkinson's disease\| PubMed ID: 22220287	2011
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. EMBO reports\| PubMed ID: 22354088	2012
Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease ge... The Journal of biological chemistry\| PubMed ID: 22511790	2012
Forever young: induced pluripotent stem cells as models of inherited arrhythmias. Circulation\| PubMed ID: 22647977	2012
The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22699903	2012
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Human molecular genetics\| PubMed ID: 22872702	2012
Programmed cell death in Parkinson's disease. Cold Spring Harbor perspectives in medicine\| PubMed ID: 22908196	2012
Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23019375	2012
The retinoblastoma protein is essential for survival of postmitotic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23077065	2012
LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction. Human molecular genetics\| PubMed ID: 23187960	2013
Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23271053	2013
Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells. Cell stem cell\| PubMed ID: 23499385	2013
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23536090	2013
Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyr... The Journal of biological chemistry\| PubMed ID: 23536182	2013
LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23574720	2013
The funny and not-so-funny effects of dronedarone. Heart rhythm : the official journal of the Heart Rhythm Society\| PubMed ID: 23973951	2013
Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system. Biology open\| PubMed ID: 24143284	2013
Nav-igating through a complex landscape: SCN10A and cardiac conduction. The Journal of clinical investigation\| PubMed ID: 24642462	2014
Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival. Nature communications\| PubMed ID: 24686499	2014
Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice. PloS one\| PubMed ID: 24733019	2014
Regulation of ischemic neuronal death by E2F4-p130 protein complexes. The Journal of biological chemistry\| PubMed ID: 24828495	2014
Triple alternans during a tachycardia--what is the mechanism? Heart rhythm : the official journal of the Heart Rhythm Society\| PubMed ID: 24846375	2014
Regulation of the VHL/HIF-1 pathway by DJ-1. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24899725	2014
Preexcitation on surface ECG: Where is the accessory pathway? Heart rhythm : the official journal of the Heart Rhythm Society\| PubMed ID: 24997403	2014
DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. PloS one\| PubMed ID: 25210784	2014
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand. The EMBO journal\| PubMed ID: 25298396	2014
Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias. The Journal of clinical investigation\| PubMed ID: 25500882	2014