Jeffrey D. Rothstein

Department of Neurology, Johns Hopkins University

Affiliated withJohns Hopkins University Johns Hopkins School of Medicine Johns Hopkins University School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 1	2007
Publication title Cited by 18	2012
Publication title
Publication title Cited by 2	2021

Other Publications

Article	Year
The development of excitatory synapses in cultured spinal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9295380	1997
Glutamate transporter protein subtypes are expressed differentially during rat CNS development. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9334410	1997
Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat b... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11245672	2001
Mechanisms for reversible regulation between G13 and Rho exchange factors. The Journal of biological chemistry\| PubMed ID: 11698392	2002
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11818550	2002
Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. Brain research. Developmental brain research\| PubMed ID: 11882343	2002
A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12151515	2002
Paving new pathways. Nature medicine\| PubMed ID: 12205454	2002
Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Annals of neurology\| PubMed ID: 12325074	2002
Therapeutic developments in the treatment of amyotrophic lateral sclerosis. Expert opinion on investigational drugs\| PubMed ID: 12387699	2002
Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Annals of neurology\| PubMed ID: 12447931	2002
Aggregate formation in Cu,Zn superoxide dismutase-related proteins. The Journal of biological chemistry\| PubMed ID: 12551935	2003
Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice. Neuroscience letters\| PubMed ID: 12566164	2003
Of mice and men: reconciling preclinical ALS mouse studies and human clinical trials. Annals of neurology\| PubMed ID: 12666108	2003
NAALADase inhibition protects motor neurons against chronic glutamate toxicity. European journal of pharmacology\| PubMed ID: 12826236	2003
Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12832537	2003
Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy. The American journal of pathology\| PubMed ID: 12875997	2003
Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology\| PubMed ID: 12890621	2003
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science (New York, N.Y.)\| PubMed ID: 12907804	2003
Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. Journal of neurochemistry\| PubMed ID: 12911626	2003
Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14715943	2004
Glutamate transporter expression and function in human glial progenitors. Glia\| PubMed ID: 14730707	2004
Reality and immortality--neural stem cells for therapies. Nature biotechnology\| PubMed ID: 14990948	2004
Altered expression of the glutamate transporter EAAT2b in neurological disease. Annals of neurology\| PubMed ID: 15048885	2004
Glutamate receptor antagonists protect from virus-induced neural degeneration. Annals of neurology\| PubMed ID: 15048893	2004
Glutamate transporters: animal models to neurologic disease. Neurobiology of disease\| PubMed ID: 15056453	2004
Retinal colocalization and in vitro interaction of the glutamate transporter EAAT3 and the serum- and glucocorticoid-inducible kinase SGK1 [correction]. Investigative ophthalmology & visual science\| PubMed ID: 15111600	2004
Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15118094	2004
Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15140926	2004
Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. The Journal of biological chemistry\| PubMed ID: 15143072	2004
Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15329404	2004
Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Molecular and cellular neurosciences\| PubMed ID: 15519246	2004
Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature\| PubMed ID: 15635412	2005
Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro. Glia\| PubMed ID: 15657939	2005
Expression of glutamate transporter subtypes during normal human corticogenesis and type II lissencephaly. Brain research. Developmental brain research\| PubMed ID: 15804404	2005
Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15994438	2005
Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS. Neurobiology of disease\| PubMed ID: 16084734	2006
Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection. Neurobiology of disease\| PubMed ID: 16274998	2006
Aquaporin 4 is increased in association with human immunodeficiency virus dementia: implications for disease pathogenesis. Journal of neurovirology\| PubMed ID: 16338747	2005
Spectrin mutations cause spinocerebellar ataxia type 5. Nature genetics\| PubMed ID: 16429157	2006
Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity. The Journal of biological chemistry\| PubMed ID: 16478718	2006
Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. Journal of neurochemistry\| PubMed ID: 16573655	2006
Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice. Experimental neurology\| PubMed ID: 16753145	2006
Trial of celecoxib in amyotrophic lateral sclerosis. Annals of neurology\| PubMed ID: 16802291	2006
Recovery from paralysis in adult rats using embryonic stem cells. Annals of neurology\| PubMed ID: 16802299	2006
The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16855093	2006
Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosome-mediated transgenesis. Experimental neurology\| PubMed ID: 17022974	2007
Glucocorticoid regulation of GLT-1 glutamate transporter isoform expression in the rat hippocampus. Neuroendocrinology\| PubMed ID: 17028421	2006
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17093100	2006
Mechanisms of Disease: astrocytes in neurodegenerative disease. Nature clinical practice. Neurology\| PubMed ID: 17117171	2006
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. BMC neurology\| PubMed ID: 17166276	2006
Targeting an old mechanism in a new disease-protection of glutamatergic dysfunction in depression. Biological psychiatry\| PubMed ID: 17223439	2007
Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS. Neurobiology of disease\| PubMed ID: 17276077	2007
TDP-43 in amyotrophic lateral sclerosis: pathophysiology or patho-babel? Annals of neurology\| PubMed ID: 17469124	2007
Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17581948	2007
Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS. Brain research\| PubMed ID: 17963733	2007
Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. The Journal of biological chemistry\| PubMed ID: 18096700	2008
The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein. The Journal of biological chemistry\| PubMed ID: 18167356	2008
Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18305234	2008
Models of amyotrophic lateral sclerosis. Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]\| PubMed ID: 18428572	2002
Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PloS one\| PubMed ID: 18682740	2008
Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nature neuroscience\| PubMed ID: 18931666	2008
Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Annals of neurology\| PubMed ID: 19191304	2009
Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron\| PubMed ID: 19323997	2009
Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis. Brain research\| PubMed ID: 19368827	2009
Regulation of the Na(+)-coupled glutamate transporter EAAT3 by PIKfyve. Neurochemistry international\| PubMed ID: 19418632	2009
Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1. Glia\| PubMed ID: 19672971	2010
A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases\| PubMed ID: 19961264	2010
GLT-1 Promoter Activity in Astrocytes and Neurons of Mouse Hippocampus and Somatic Sensory Cortex. Frontiers in neuroanatomy\| PubMed ID: 20161698	2010
Quantitative analysis of EAAT4 promoter activity in neurons and astrocytes of mouse somatic sensory cortex. Neuroscience letters\| PubMed ID: 20211693	2010
Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20371805	2010
Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20505095	2010
Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology\| PubMed ID: 21034752	2011
Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia\| PubMed ID: 21046559	2011
NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron\| PubMed ID: 21092857	2010
New treatments in amyotrophic lateral sclerosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 21116264	2011
Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury. Journal of neuroscience research\| PubMed ID: 21488085	2011
John W. "Jack" Griffin, MD. Annals of neurology\| PubMed ID: 21681788	2011
Nuclear factor-ÎºB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21697367	2011
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron\| PubMed ID: 21944779	2011
Human nasal olfactory epithelium as a dynamic marker for CNS therapy development. Experimental neurology\| PubMed ID: 21945230	2011
Plasticity of astroglial networks in olfactory glomeruli. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21997206	2011
Neuronal activity regulates glutamate transporter dynamics in developing astrocytes. Glia\| PubMed ID: 22052455	2012
Î²-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22090485	2011
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22431618	2012
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nature neuroscience\| PubMed ID: 23542689	2013
Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma. Journal of neurosurgery\| PubMed ID: 23909244	2013
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24248382	2013
Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models. Journal of neurosurgery\| PubMed ID: 24484234	2014
Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial. PloS one\| PubMed ID: 24841795	2014
Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies. Trends in neurosciences\| PubMed ID: 24927875	2014
Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study. Acta neuropathologica communications\| PubMed ID: 25510661	2014
C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC. Neuron\| PubMed ID: 27151634	2016
Astroglia in Thick Tissue with Super Resolution and Cellular Reconstruction. PloS one\| PubMed ID: 27494718	2016
Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27834214	2016
Astroglial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model. Journal of neurogenetics\| PubMed ID: 28019127	2017
Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron\| PubMed ID: 28384479	2017
3D Printer Generated Tissue iMolds for Cleared Tissue Using Single- and Multi-Photon Microscopy for Deep Tissue Evaluation. Biological procedures online\| PubMed ID: 28690429	2017
Edaravone: A new drug approved for ALS. Cell\| PubMed ID: 29100067	2017
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron\| PubMed ID: 29566793	2018
Stress Granule Assembly Disrupts Nucleocytoplasmic Transport. Cell\| PubMed ID: 29628143	2018
Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis. Brain : a journal of neurology\| PubMed ID: 30007309	2018
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron\| PubMed ID: 30189209	2018
Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nature neuroscience\| PubMed ID: 30936556	2019
The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model. Fluids and barriers of the CNS\| PubMed ID: 31303172	2019
Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging. Glia\| PubMed ID: 31453649	2020
CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron\| PubMed ID: 31587919	2019
Astrocyte Diversity: Current Insights and Future Directions. Neurochemical research\| PubMed ID: 32006215	2020
arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import. eLife\| PubMed ID: 32119645	2020
Amyotrophic lateral sclerosis care and research in the United States during the COVID-19 pandemic: Challenges and opportunities. Muscle & nerve\| PubMed ID: 32445195	2020
GC Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron\| PubMed ID: 32673563	2020
Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice. Neuron\| PubMed ID: 33022228	2020
MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration. Cell reports\| PubMed ID: 33440165	2021
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature\| PubMed ID: 33589820	2021
Reactive astrocyte nomenclature, definitions, and future directions. Nature neuroscience\| PubMed ID: 33589835	2021
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD. Acta neuropathologica communications\| PubMed ID: 33741069	2021
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction. Cell reports\| PubMed ID: 33789100	2021
A Helicase Unwinds Hexanucleotide Repeat RNA G-Quadruplexes and Facilitates Repeat-Associated Non-AUG Translation. Journal of the American Chemical Society\| PubMed ID: 33855846	2021
The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei. Acta neuropathologica communications\| PubMed ID: 34281622	2021
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS. Science translational medicine\| PubMed ID: 34321318	2021
RNA Is a Double-Edged Sword in ALS Pathogenesis. Frontiers in cellular neuroscience\| PubMed ID: 34349625	2021
Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD. Nature communications\| PubMed ID: 34389711	2021