Brian K. Kaspar

Center for Gene Therapy, Ohio State University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 78	2014

Other Publications

Article	Year
Targeted retrograde gene delivery for neuronal protection. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 11786045	2002
Adeno-associated virus effectively mediates conditional gene modification in the brain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11842206	2002
The adult substantia nigra contains progenitor cells with neurogenic potential. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12151543	2002
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nature neuroscience\| PubMed ID: 12469128	2003
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12832526	2003
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science (New York, N.Y.)\| PubMed ID: 12907804	2003
IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. The Journal of cell biology\| PubMed ID: 14709544	2004
Myocardial gene transfer and long-term expression following intracoronary delivery of adeno-associated virus. The journal of gene medicine\| PubMed ID: 15515115	2005
Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Annals of neurology\| PubMed ID: 15852369	2005
Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Annals of neurology\| PubMed ID: 15852403	2005
In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 16357334	2006
Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nature biotechnology\| PubMed ID: 16429148	2006
Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17164329	2006
Construction of diverse adeno-associated viral libraries for directed evolution of enhanced gene delivery vehicles. Nature protocols\| PubMed ID: 17406299	2006
Gene therapy for duchenne muscular dystrophy: expectations and challenges. Archives of neurology\| PubMed ID: 17846262	2007
Gene-targeted therapies for the central nervous system. Archives of neurology\| PubMed ID: 18268183	2008
Physical activity and neuroprotection in amyotrophic lateral sclerosis. Neuromolecular medicine\| PubMed ID: 18286388	2008
Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18334646	2008
Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18388910	2008
Mesenchymal stem cells as trojan horses for GDNF delivery in ALS. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19023270	2008
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes. Nature biotechnology\| PubMed ID: 19098898	2009
Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease. Muscle & nerve\| PubMed ID: 19208403	2009
Directed evolution of adeno-associated virus to an infectious respiratory virus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19237554	2009
Gene therapy and informed consent decision making: nursing research directions. Biological research for nursing\| PubMed ID: 19398415	2009
Two factor reprogramming of human neural stem cells into pluripotency. PloS one\| PubMed ID: 19763260	2009
AAV as a gene transfer vector for the treatment of neurological disorders: novel treatment thoughts for ALS. Current gene therapy\| PubMed ID: 19860657	2009
Over the barrier and through the blood: to CNS delivery we go. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19949299	2009
Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN. Nature biotechnology\| PubMed ID: 20190738	2010
Follistatin gene delivery enhances muscle growth and strength in nonhuman primates. Science translational medicine\| PubMed ID: 20368179	2009
Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20498043	2010
Could gene therapy be the future for muscular dystrophy? Therapy\| PubMed ID: 20543898	2010
TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice. Experimental neurology\| PubMed ID: 20553714	2010
Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery. Human molecular genetics\| PubMed ID: 20639395	2010
Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult rats. The European journal of neuroscience\| PubMed ID: 20849530	2010
AAV4-mediated expression of IGF-1 and VEGF within cellular components of the ventricular system improves survival outcome in familial ALS mice. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20859261	2010
Secretin deficiency causes impairment in survival of neural progenitor cells in mice. Human molecular genetics\| PubMed ID: 21159798	2011
A role for glia in the progression of Rett's syndrome. Nature\| PubMed ID: 21716289	2011
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21772256	2011
Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21811247	2011
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons. Nature biotechnology\| PubMed ID: 21832997	2011
Disease progression in a mouse model of amyotrophic lateral sclerosis: the influence of chronic stress and corticosterone. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21876068	2011
mdx(⁵cv) mice manifest more severe muscle dysfunction and diaphragm force deficits than do mdx Mice. The American journal of pathology\| PubMed ID: 21893021	2011
Transforming growth factor α transforms astrocytes to a growth-supportive phenotype after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22016551	2011
Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates. Human gene therapy\| PubMed ID: 22201473	2012
Knee extensor strength exhibits potential to predict function in sporadic inclusion-body myositis. Muscle & nerve\| PubMed ID: 22246869	2012
Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling. Aging cell\| PubMed ID: 22404871	2012
Gene therapy for muscular dystrophy: lessons learned and path forward. Neuroscience letters\| PubMed ID: 22609847	2012
Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. Human gene therapy\| PubMed ID: 22838844	2012
Gene delivery improvement for treating the lysosomal storage disorder metachromatic leukodystrophy. Human gene therapy\| PubMed ID: 22900577	2012
Transplantation of gene-corrected motor neurons as a therapeutic strategy for spinal muscular atrophy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23449105	2013
Neural stem cells as a therapeutic approach for amyotrophic lateral sclerosis. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23449106	2013
Micro-dystrophin and follistatin co-delivery restores muscle function in aged DMD model. Human molecular genetics\| PubMed ID: 23863459	2013
Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23966684	2013
Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24008656	2013
Active and passive immunization strategies based on the SDPM1 peptide demonstrate pre-clinical efficacy in the APPswePSEN1dE9 mouse model for Alzheimer's disease. Neurobiology of disease\| PubMed ID: 24021662	2014
AAV1.NT-3 gene therapy for charcot-marie-tooth neuropathy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24162799	2014
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24379375	2014
Electrophysiological Biomarkers in Spinal Muscular Atrophy: Preclinical Proof of Concept. Annals of clinical and translational neurology\| PubMed ID: 24511555	2014
Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis. Neuron\| PubMed ID: 24607225	2014
Making sense of pain: are pluripotent stem cell-derived sensory neurons a new tool for studying pain mechanisms? Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25082088	2014
A Phase I/IIa Follistatin Gene Therapy Trial for Becker Muscular Dystrophy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25322757	2014
Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA - a dose response study in mice and nonhuman primates. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25358252	2014