Gabriela Chiosis

Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center

Affiliated withMemorial Sloan Kettering Cancer Center

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 12	2014
Publication title	2025

Other Publications

Article	Year
Synthesis of a red-shifted fluorescence polarization probe for Hsp90. Bioorganic & medicinal chemistry letters\| PubMed ID: 16797988	2006
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. The Journal of biological chemistry\| PubMed ID: 12176997	2002
Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. Bioorganic & medicinal chemistry\| PubMed ID: 12213470	2002
BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood\| PubMed ID: 12351420	2002
17AAG: low target binding affinity and potent cell activity--finding an explanation. Molecular cancer therapeutics\| PubMed ID: 12589029	2003
Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol. Angewandte Chemie (International ed. in English)\| PubMed ID: 12645064	2003
Vancomycin resistance: occurrence, mechanisms and strategies to combat it. Expert opinion on therapeutic targets\| PubMed ID: 12783569	2003
Microtiter cell-based assay for detection of agents that alter cellular levels of Her2 and EGFR. Chemistry & biology\| PubMed ID: 12890536	2003
Development of purine-scaffold small molecule inhibitors of Hsp90. Current cancer drug targets\| PubMed ID: 14529388	2003
Synthesis of novel fluorescent probes for the molecular chaperone Hsp90. Bioorganic & medicinal chemistry letters\| PubMed ID: 14592488	2003
General method for the synthesis of 8-arylsulfanyl adenine derivatives. The Journal of organic chemistry\| PubMed ID: 15104473	2004
Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. Chemistry & biology\| PubMed ID: 15217612	2004
Development of a fluorescence polarization assay for the molecular chaperone Hsp90. Journal of biomolecular screening\| PubMed ID: 15296636	2004
Hsp90: the vulnerable chaperone. Drug discovery today\| PubMed ID: 15475321	2004
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90. Journal of medicinal chemistry\| PubMed ID: 15828828	2005
Small molecule microarrays: from proteins to mammalian cells - are we there yet? Trends in biotechnology\| PubMed ID: 15922078	2005
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. Journal of medicinal chemistry\| PubMed ID: 16392823	2006
Targeting chaperones in transformed systems--a focus on Hsp90 and cancer. Expert opinion on therapeutic targets\| PubMed ID: 16441227	2006
New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies. Journal of medicinal chemistry\| PubMed ID: 16451061	2006
Synthesis of Hsp90 dimerization modulators. Bioorganic & medicinal chemistry letters\| PubMed ID: 16621545	2006
Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. Protein science : a publication of the Protein Society\| PubMed ID: 16731965	2006
Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents. Current opinion in investigational drugs (London, England : 2000)\| PubMed ID: 16784024	2006
Discovery and development of purine-scaffold Hsp90 inhibitors. Current topics in medicinal chemistry\| PubMed ID: 16842155	2006
Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators. Current topics in medicinal chemistry\| PubMed ID: 16842158	2006
Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors. Journal of medicinal chemistry\| PubMed ID: 16884307	2006
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer cell\| PubMed ID: 17010675	2006
Purine-scaffold Hsp90 inhibitors. IDrugs : the investigational drugs journal\| PubMed ID: 17096299	2006
Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive. ACS chemical biology\| PubMed ID: 17163756	2006
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17517623	2007
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nature chemical biology\| PubMed ID: 17603540	2007
High-throughput screening fluorescence polarization assay for tumor-specific Hsp90. Journal of biomolecular screening\| PubMed ID: 17942784	2007
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins. Current medicinal chemistry\| PubMed ID: 18045130	2007
Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. Cancer research\| PubMed ID: 18172314	2008
Development and application of Hsp90 inhibitors. Drug discovery today\| PubMed ID: 18190862	2008
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18367605	2008
Design of a fluorescence polarization assay platform for the study of human Hsp70. Bioorganic & medicinal chemistry letters\| PubMed ID: 18515098	2008
The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding. FEBS letters\| PubMed ID: 18539149	2008
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling. Bioorganic & medicinal chemistry\| PubMed ID: 18571929	2008
Targeting Hsp90: small-molecule inhibitors and their clinical development. Current opinion in pharmacology\| PubMed ID: 18644253	2008
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines. Cancer research\| PubMed ID: 18794111	2008
Discovery and development of heat shock protein 90 inhibitors. Bioorganic & medicinal chemistry\| PubMed ID: 19017562	2009
Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines. Bioorganic & medicinal chemistry letters\| PubMed ID: 19058963	2009
Heat shock protein 90: translation from cancer to Alzheimer's disease treatment? BMC neuroscience\| PubMed ID: 19090995	2008
Assay for isolation of inhibitors of her2-kinase expression. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19347621	2009
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416831	2009
Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma. Hepatology (Baltimore, Md.)\| PubMed ID: 19441108	2009
Purine-scaffold Hsp90 inhibitors. Current topics in medicinal chemistry\| PubMed ID: 19860732	2009
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. Nature medicine\| PubMed ID: 19966776	2009
Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab. PloS one\| PubMed ID: 20111600	2010
Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90. The Journal of organic chemistry\| PubMed ID: 20392070	2010
Heat shock protein 90 in neurodegenerative diseases. Molecular neurodegeneration\| PubMed ID: 20525284	2010
Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90. PLoS neglected tropical diseases\| PubMed ID: 20559560	2010
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. The Journal of clinical investigation\| PubMed ID: 20852385	2010
The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1. Journal of hematology & oncology\| PubMed ID: 20977755	2010
BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. The Journal of clinical investigation\| PubMed ID: 21041953	2010
Design of a flexible cell-based assay for the evaluation of heat shock protein 70 expression modulators. Assay and drug development technologies\| PubMed ID: 21133677	2011
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21372220	2011
Design, synthesis, and evaluation of small molecule Hsp90 probes. Bioorganic & medicinal chemistry\| PubMed ID: 21459002	2011
Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy. Bioorganic & medicinal chemistry letters\| PubMed ID: 21802945	2011
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature chemical biology\| PubMed ID: 21946277	2011
HSP90 inhibitors as therapy for multiple myeloma. Clinical lymphoma, myeloma & leukemia\| PubMed ID: 22035754	2011
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers. Biochimica et biophysica acta\| PubMed ID: 22062686	2012
Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment. Expert opinion on drug discovery\| PubMed ID: 22400044	2011
Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33. The Journal of experimental medicine\| PubMed ID: 22451720	2012
Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability. Biochemical and biophysical research communications\| PubMed ID: 22554506	2012
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature\| PubMed ID: 22820254	2012
Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22895790	2012
The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE. Journal of neuroimmunology\| PubMed ID: 23123171	2013
A global view of Hsp90 functions. Nature structural & molecular biology\| PubMed ID: 23288357	2013
Discovery and development of purine-scaffold Hsp90 inhibitors. Expert opinion on drug discovery\| PubMed ID: 23480142	2008
Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23578997	2013
Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes. Beilstein journal of organic chemistry\| PubMed ID: 23616796	2013
α7 helix region of αI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: a potential therapeutic target for cancer metastasis. The Journal of biological chemistry\| PubMed ID: 23671277	2013
Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors. Oncotarget\| PubMed ID: 23867252	2013
Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies. Blood\| PubMed ID: 23943653	2013
Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series. Journal of medicinal chemistry\| PubMed ID: 23965125	2013
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nature chemical biology\| PubMed ID: 23995768	2013
Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 24077352	2013
A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90). PloS one\| PubMed ID: 24098696	2013
Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chemistry & biology\| PubMed ID: 24239008	2013
Regulatory chaperone complexes in neurodegenerative diseases: a perspective on therapeutic intervention. Current Alzheimer research\| PubMed ID: 24251390	2014
Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma. Molecular oncology\| PubMed ID: 24388362	2014
Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms. Blood\| PubMed ID: 24470592	2014
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. Journal of medicinal chemistry\| PubMed ID: 24548207	2014
Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric si... Journal of medicinal chemistry\| PubMed ID: 24548239	2014
Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nature communications\| PubMed ID: 24594970	2014
Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions. Expert opinion on investigational drugs\| PubMed ID: 24669860	2014
Protein chaperones: a composition of matter review (2008 - 2013). Expert opinion on therapeutic patents\| PubMed ID: 24742089	2014
Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer. ACS chemical biology\| PubMed ID: 24934503	2014
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention. Journal of Alzheimer's disease & Parkinsonism\| PubMed ID: 25258700	2013
Selective targeting of the stress chaperome as a therapeutic strategy. Trends in pharmacological sciences\| PubMed ID: 25262919	2014
Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. Journal of hepatology\| PubMed ID: 25463537	2015
Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25516983	2014
Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions. Journal of molecular biology\| PubMed ID: 25913688	2015
Radioiodinated PARP1 tracers for glioblastoma imaging. EJNMMI research\| PubMed ID: 26337803	2015
Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias. Blood\| PubMed ID: 26443624	2015
Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 26493053	2016
Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma. The Journal of clinical investigation\| PubMed ID: 26529251	2015
Multifunctional MRI/PET Nanobeacons Derived from the in Situ Self-Assembly of Translational Polymers and Clinical Cargo through Coalescent Intermolecular Forces. Nano letters\| PubMed ID: 26540670	2015
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas. Blood\| PubMed ID: 26603836	2015
A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species. Cell reports\| PubMed ID: 26628369	2015
Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71. Journal of labelled compounds & radiopharmaceuticals\| PubMed ID: 26806023	2016
Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease. Cell chemical biology\| PubMed ID: 26933742	2016
Editorial (Thematic Issue: Heat Shock Proteins in Disease - From Molecular Mechanisms to Therapeutics). Current topics in medicinal chemistry\| PubMed ID: 27549859	2016
RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures. Nano letters\| PubMed ID: 27669096	2016
The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature\| PubMed ID: 27706135	2016
The epichaperome: the power of many as the power of one. Oncoscience\| PubMed ID: 28050576	2016
Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma. Molecular cancer therapeutics\| PubMed ID: 28619753	2017
Proteomic interrogation of HSP90 and insights for medical research. Expert review of proteomics\| PubMed ID: 28990809	2017
Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. The Journal of experimental medicine\| PubMed ID: 29141866	2018
Adapting to stress - chaperome networks in cancer. Nature reviews. Cancer\| PubMed ID: 29795326	2018
Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate. Tetrahedron letters\| PubMed ID: 30026636	2017
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nature communications\| PubMed ID: 30341316	2018
Chaperome heterogeneity and its implications for cancer study and treatment. The Journal of biological chemistry\| PubMed ID: 30409908	2019
A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond. Cold Spring Harbor perspectives in biology\| PubMed ID: 30936118	2020
Author Correction: Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching. Nature communications\| PubMed ID: 31000704	2019
Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. Proteins\| PubMed ID: 31141217	2019
Reply to 'H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines'. Nature genetics\| PubMed ID: 31548719	2019
Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers. Nature communications\| PubMed ID: 31554806	2019
Paradigms for Precision Medicine in Epichaperome Cancer Therapy. Cancer cell\| PubMed ID: 31668946	2019
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nature communications\| PubMed ID: 31949159	2020
Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs. ACS chemical biology\| PubMed ID: 32191434	2020
Chaperome Networks - Redundancy and Implications for Cancer Treatment. Advances in experimental medicine and biology\| PubMed ID: 32297213	2020
First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 32366671	2020
Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies. Methods in enzymology\| PubMed ID: 32475406	2020
Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone. Cell reports\| PubMed ID: 32610141	2020
Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer. Nature biomedical engineering\| PubMed ID: 32661307	2020
Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33199632	2020
Measuring Tumor Epichaperome Expression Using [I] PU-H71 Positron Emission Tomography as a Biomarker of Response for PU-H71 Plus Nab-Paclitaxel in HER2-Negative Metastatic Breast Cancer. JCO precision oncology\| PubMed ID: 33283132	2020
Disease-specific interactome alterations via epichaperomics: the case for Alzheimer's disease. The FEBS journal\| PubMed ID: 34028172	2022
Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia. NPJ precision oncology\| PubMed ID: 34040147	2021
Myeloid Endoplasmic Reticulum Resident Chaperone GP96 Facilitates Inflammation and Steatosis in Alcohol-Associated Liver Disease. Hepatology communications\| PubMed ID: 34278167	2021
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nature communications\| PubMed ID: 34344873	2021
The penalty of stress - Epichaperomes negatively reshaping the brain in neurodegenerative disorders. Journal of neurochemistry\| PubMed ID: 34657288	2021
Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer. Communications biology\| PubMed ID: 34824367	2021
Synthesis of I-labeled epichaperome probes and assessment in visualizing pathologic protein-protein interaction networks in tumor bearing mice. STAR protocols\| PubMed ID: 35496791	2022
Targeting stressor-induced dysfunctions in protein-protein interaction networks via epichaperomes. Trends in pharmacological sciences\| PubMed ID: 36414432	2023
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications\| PubMed ID: 37085479	2023
How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view. Structure (London, England : 1993)\| PubMed ID: 37343552	2023
Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation. Nature communications\| PubMed ID: 37353488	2023
Structural and functional complexity of HSP90 in cellular homeostasis and disease. Nature reviews. Molecular cell biology\| PubMed ID: 37524848	2023
Use of Native-PAGE for the Identification of Epichaperomes in Cell Lines. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 37540435	2023
Selective inhibition of hsp90 paralogs: Uncovering the role of helix 1 in Grp94-selective ligand binding. bioRxiv : the preprint server for biology\| PubMed ID: 37577523	2024
Experimental traumatic brain injury increases epichaperome formation. Neurobiology of disease\| PubMed ID: 37863370	2023
Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action. Biomedicines\| PubMed ID: 37892973	2023
Stress biology: Complexity and multifariousness in health and disease. Cell stress & chaperones\| PubMed ID: 38311120	2024
N-Glycosylation as a Modulator of Protein Conformation and Assembly in Disease. Biomolecules\| PubMed ID: 38540703	2024
Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. Nature medicine\| PubMed ID: 38570701	2024
Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation. Research square\| PubMed ID: 38645031	2024
Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders. Biomedicines\| PubMed ID: 38927459	2024
Introducing dysfunctional Protein-Protein Interactome (dfPPI) - A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease. Current opinion in structural biology\| PubMed ID: 39003916	2024
N-Glycosylation-Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 39042517	2024
Cracking the chaperone code through the computational microscope. Cell stress & chaperones\| PubMed ID: 39142378	2024
Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation. Nature communications\| PubMed ID: 39414766	2024
Selective Inhibition of hsp90 Paralogs: Uncovering the Role of Helix 1 in Grp94-Selective Ligand Binding. Proteins\| PubMed ID: 39473058	2025
Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals. Acta neuropathologica communications\| PubMed ID: 39605035	2024
Editorial overview: Protein networks in health and disease. Current opinion in structural biology\| PubMed ID: 39642844	2025
Epichaperome-targeted myocardial imaging by I-PU-H71 PET. Clinical and translational imaging\| PubMed ID: 39935517	2024
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum. Research square\| PubMed ID: 39989971	2025
Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's dis... Frontiers in molecular neuroscience\| PubMed ID: 40078964	2025
Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases. RSC chemical biology\| PubMed ID: 40144950	2025
Frontal cortex pyramidal neuron expression profiles differentiate the prodromal stage from progressive degeneration across the Alzheimer's disease spectrum. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 40709510	2025
Benefits of Maternal Choline Supplementation on Aged Basal Forebrain Cholinergic Neurons (BFCNs) in a Mouse Model of Down Syndrome and Alzheimer's Disease. Biomolecules\| PubMed ID: 40867575	2025
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease. Trends in biochemical sciences\| PubMed ID: 40877054	2025