Dan E. Berkowitz

Department of Biomedical Engineering, Johns Hopkins University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 10	2014

Other Publications

Article	Year
Impaired pulmonary artery contractile responses in a rat model of microgravity: role of nitric oxide. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 11744640	2002
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature\| PubMed ID: 11907582	2002
Estrogen has opposing effects on vascular reactivity in obese, insulin-resistant male Zucker rats. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 11960955	2002
Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. Circulation research\| PubMed ID: 12764022	2003
Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation\| PubMed ID: 12885755	2003
Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation\| PubMed ID: 14517171	2003
Enhanced vasodilatory responses to milrinone in catecholamine-precontracted small pulmonary arteries. Anesthesia and analgesia\| PubMed ID: 15155314	2004
Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. Hypertension\| PubMed ID: 15466664	2004
Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone. Circulation research\| PubMed ID: 15472121	2004
Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15486091	2004
Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy. The Journal of physiology\| PubMed ID: 15760936	2005
Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 15778286	2005
P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction. Journal of molecular and cellular cardiology\| PubMed ID: 16242150	2005
Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circulation research\| PubMed ID: 16339484	2006
Knockdown of arginase I restores NO signaling in the vasculature of old rats. Hypertension\| PubMed ID: 16380531	2006
Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537391	2006
Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537512	2006
Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling. Circulation research\| PubMed ID: 17008605	2006
Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17082368	2007
Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17106067	2006
Myocyte nitroso-redox imbalance in sepsis: NO simple answer. Circulation research\| PubMed ID: 17204656	2007
Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta. Radiation and environmental biophysics\| PubMed ID: 17256177	2007
Microgravity and cardiac atrophy: no sex discrimination. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 17363626	2007
Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction. Circulation research\| PubMed ID: 17704205	2007
Pulse pressure is an age-independent predictor of stroke development after cardiac surgery. Hypertension\| PubMed ID: 17785628	2007
Mitochondrial arginase II constrains endothelial NOS-3 activity. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17827260	2007
Endothelial arginase II: a novel target for the treatment of atherosclerosis. Circulation research\| PubMed ID: 18309100	2008
Selective fluorescent labeling of S-nitrosothiols (S-FLOS): a novel method for studying S-nitrosation. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 18706513	2008
Arginase and vascular aging. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 18719233	2008
Perioperative blood pressure management: does central vascular stiffness matter? Anesthesia and analgesia\| PubMed ID: 18806011	2008
Increased oxidant activity mediates vascular dysfunction in vibration injury. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 18955588	2009
Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction. The Journal of urology\| PubMed ID: 19095260	2009
Simulated microgravity-induced aortic remodeling. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19299573	2009
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19661445	2009
Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 20167676	2010
Single exposure to radiation produces early anti-angiogenic effects in mouse aorta. Radiation and environmental biophysics\| PubMed ID: 20401726	2010
Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness. Circulation research\| PubMed ID: 20489165	2010
Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway. European journal of applied physiology\| PubMed ID: 20512503	2010
Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries. Circulation research\| PubMed ID: 20522806	2010
Î²2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation. Anesthesia and analgesia\| PubMed ID: 20705779	2010
OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling. Atherosclerosis\| PubMed ID: 21130456	2011
Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 21278136	2011
Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity. Cardiovascular research\| PubMed ID: 21421555	2011
Review article: implications of vascular aging. Anesthesia and analgesia\| PubMed ID: 21474663	2011
Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans. The Journal of physiology\| PubMed ID: 21486801	2011
S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase. Molecular and cellular biochemistry\| PubMed ID: 21533769	2011
HZE ⁵⁶Fe-ion irradiation induces endothelial dysfunction in rat aorta: role of xanthine oxidase. Radiation research\| PubMed ID: 21787183	2011
Vascular stiffness and increased pulse pressure in the aging cardiovascular system. Cardiology research and practice\| PubMed ID: 21845218	2011
Endothelial arginase II and atherosclerosis. Korean journal of anesthesiology\| PubMed ID: 21860744	2011
Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans. Hypertension\| PubMed ID: 21931069	2011
Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circulation research\| PubMed ID: 21980127	2011
Nitric oxide regulates tissue transglutaminase localization and function in the vasculature. Amino acids\| PubMed ID: 21984378	2013
Nitric oxide regulates non-classical secretion of tissue transglutaminase. Communicative & integrative biology\| PubMed ID: 22046470	2011
Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve. European journal of applied physiology\| PubMed ID: 22160208	2012
Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation. The Journal of surgical research\| PubMed ID: 22464394	2012
Chronic oral administration of the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) improves erectile function in aged rats. Journal of andrology\| PubMed ID: 22492840	2012
Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 22500004	2012
Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness. Experimental gerontology\| PubMed ID: 22569357	2012
Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation. The Journal of surgical research\| PubMed ID: 22771242	2012
Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice. Experimental & molecular medicine\| PubMed ID: 22854495	2012
Vasopressin-mediated enhancement of adrenergic vasoconstriction involves both the tyrosine kinase and the protein kinase C pathways. Anesthesia and analgesia\| PubMed ID: 22886838	2012
Interleukin 10 knockout frail mice develop cardiac and vascular dysfunction with increased age. Experimental gerontology\| PubMed ID: 23159957	2013
A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform. The Journal of surgical research\| PubMed ID: 23218735	2013
Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration. Anesthesia and analgesia\| PubMed ID: 23449853	2013
Sildenafil citrate protects skeletal muscle of ischemia-reperfusion injury: immunohistochemical study in rat model. Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia\| PubMed ID: 23568236	2013
Nitroprusside inhibits calcium-induced impairment of red blood cell deformability. Transfusion\| PubMed ID: 23781865	2014
Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. PloS one\| PubMed ID: 23844149	2013
Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 23873798	2013
Arginase II: atherogenesis beyond enzyme activity. Journal of the American Heart Association\| PubMed ID: 23938287	2013
Development of novel arginase inhibitors for therapy of endothelial dysfunction. Frontiers in immunology\| PubMed ID: 24062745	2013
Contribution of arginase activation to vascular dysfunction in cigarette smoking. Atherosclerosis\| PubMed ID: 24125417	2013
New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease. Blood cells, molecules & diseases\| PubMed ID: 24246527	2014
Effect of isoflurane on myocardial energetic and oxidative stress in cardiac muscle from Zucker diabetic fatty rat. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 24431470	2014
Exercise, vascular stiffness, and tissue transglutaminase. Journal of the American Heart Association\| PubMed ID: 24721796	2014
Impaired red blood cell deformability after transfusion of stored allogeneic blood but not autologous salvaged blood in cardiac surgery patients. Anesthesia and analgesia\| PubMed ID: 24806142	2014
OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase. Circulation research\| PubMed ID: 24903103	2014
Melanopsin mediates light-dependent relaxation in blood vessels. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25404319	2014