Lakshmi Santhanam

Department of Biomedical Engineering, Johns Hopkins University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 10	2014
Publication title	2026

Other Publications

Article	Year
Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium : journal of endothelial cell research\| PubMed ID: 12380644	2002
Structural diversity of peroxidase-catalyzed oxidation products of o-methoxyphenols. Organic letters\| PubMed ID: 15176797	2004
Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress. Molecular biology of the cell\| PubMed ID: 16251354	2006
Sos-mediated activation of rac1 by p66shc. The Journal of cell biology\| PubMed ID: 16520382	2006
Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537391	2006
Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta. Radiation and environmental biophysics\| PubMed ID: 17256177	2007
Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction. Circulation research\| PubMed ID: 17704205	2007
Endothelial arginase II: a novel target for the treatment of atherosclerosis. Circulation research\| PubMed ID: 18309100	2008
Selective fluorescent labeling of S-nitrosothiols (S-FLOS): a novel method for studying S-nitrosation. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 18706513	2008
Arginase and vascular aging. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 18719233	2008
Cyclohexanone contamination from extracorporeal circuits impairs cardiovascular function. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 19411286	2009
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 19661445	2009
Dietary inhibition of xanthine oxidase attenuates radiation-induced endothelial dysfunction in rat aorta. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 20167676	2010
Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness. Circulation research\| PubMed ID: 20489165	2010
Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans. The Journal of physiology\| PubMed ID: 21486801	2011
S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase. Molecular and cellular biochemistry\| PubMed ID: 21533769	2011
Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans. Hypertension\| PubMed ID: 21931069	2011
Nitric oxide regulates tissue transglutaminase localization and function in the vasculature. Amino acids\| PubMed ID: 21984378	2013
Nitric oxide regulates non-classical secretion of tissue transglutaminase. Communicative & integrative biology\| PubMed ID: 22046470	2011
Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve. European journal of applied physiology\| PubMed ID: 22160208	2012
Hydrogen sulfide decreases reactive oxygen in a model of lung transplantation. The Journal of surgical research\| PubMed ID: 22464394	2012
Endothelial nitric oxide synthase mediates cutaneous vasodilation during local heating and is attenuated in middle-aged human skin. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 22500004	2012
Inhaled hydrogen sulfide improves graft function in an experimental model of lung transplantation. The Journal of surgical research\| PubMed ID: 22771242	2012
A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform. The Journal of surgical research\| PubMed ID: 23218735	2013
Rho-Kinase activity and cutaneous vasoconstriction is upregulated in essential hypertensive humans. Microvascular research\| PubMed ID: 23481864	2013
Nitroprusside inhibits calcium-induced impairment of red blood cell deformability. Transfusion\| PubMed ID: 23781865	2014
Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 23873798	2013
Arterial stiffening precedes systolic hypertension in diet-induced obesity. Hypertension\| PubMed ID: 24060894	2013
Contribution of arginase activation to vascular dysfunction in cigarette smoking. Atherosclerosis\| PubMed ID: 24125417	2013
Exercise, vascular stiffness, and tissue transglutaminase. Journal of the American Heart Association\| PubMed ID: 24721796	2014
Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell metabolism\| PubMed ID: 24882067	2014
Melanopsin mediates light-dependent relaxation in blood vessels. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25404319	2014