Kostas Pantopoulos

Lady Davis Institute for Medical Research, Jewish General Hospital

Affiliated withJewish General Hospital McGill University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 37	2014

Other Publications

Article	Year
Activation of iron regulatory protein-1 by oxidative stress. Methods in enzymology\| PubMed ID: 11885287	2002
Redox control of iron regulatory proteins. Redox report : communications in free radical research\| PubMed ID: 11981450	2002
Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant. Molecular and cellular biology\| PubMed ID: 12052872	2002
The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells. FEBS letters\| PubMed ID: 12372619	2002
The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin. The Biochemical journal\| PubMed ID: 12464008	2003
Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1. The Journal of biological chemistry\| PubMed ID: 12888561	2003
A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation. Molecular and cellular biology\| PubMed ID: 12972614	2003
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Molecular and cellular biology\| PubMed ID: 14729944	2004
ANP-induced decrease of iron regulatory protein activity is independent of HO-1 induction. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 15087280	2004
Iron metabolism and the IRE/IRP regulatory system: an update. Annals of the New York Academy of Sciences\| PubMed ID: 15105251	2004
Oxidation-induced ferritin turnover in microglial cells: role of proteasome. Free radical biology & medicine\| PubMed ID: 15607911	2005
IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities. The Biochemical journal\| PubMed ID: 15636585	2005
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. The Journal of biological chemistry\| PubMed ID: 15637067	2005
Nitric oxide inhibits the degradation of IRP2. Molecular and cellular biology\| PubMed ID: 15684386	2005
The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL. Biochimica et biophysica acta\| PubMed ID: 15777842	2005
Inhibition of transferrin receptor 1 transcription by a cell density response element. The Biochemical journal\| PubMed ID: 16092918	2005
Hepcidin generated by hepatoma cells inhibits iron export from co-cultured THP1 monocytes. Journal of hepatology\| PubMed ID: 16460831	2006
Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absence of S nitrosylation at C178. Molecular and cellular biology\| PubMed ID: 16479012	2006
Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. The Journal of biological chemistry\| PubMed ID: 16737972	2006
In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin. Blood\| PubMed ID: 16757684	2006
Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts. Carcinogenesis\| PubMed ID: 17127713	2007
Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway. Molecular and cellular biology\| PubMed ID: 17242182	2007
Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells. Journal of hepatology\| PubMed ID: 17399844	2007
Sustained hydrogen peroxide induces iron uptake by transferrin receptor-1 independent of the iron regulatory protein/iron-responsive element network. The Journal of biological chemistry\| PubMed ID: 17517884	2007
Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein. The Biochemical journal\| PubMed ID: 17760563	2007
Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity. BMC molecular biology\| PubMed ID: 18226225	2008
Insights on regulation and function of the iron regulatory protein 1 (IRP1). Hemoglobin\| PubMed ID: 18274988	2008
Oxidative stress and iron homeostasis: mechanistic and health aspects. Critical reviews in clinical laboratory sciences\| PubMed ID: 18293179	2008
Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris. Biochimie\| PubMed ID: 18295606	2008
A role for lysosomes in the turnover of human iron regulatory protein 2. The international journal of biochemistry & cell biology\| PubMed ID: 18582596	2008
Function of the hemochromatosis protein HFE: Lessons from animal models. World journal of gastroenterology : WJG\| PubMed ID: 19058322	2008
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Molecular cell\| PubMed ID: 19111663	2008
HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues. Journal of neurochemistry\| PubMed ID: 19250338	2009
Iron absorption and distribution in TNF(DeltaARE/+) mice, a model of chronic inflammation. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)\| PubMed ID: 20122582	2010
Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert. PloS one\| PubMed ID: 20405006	2010
Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells. Journal of hepatology\| PubMed ID: 20813419	2010
eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}. Cancer research\| PubMed ID: 20924113	2010
Redox control of iron regulatory protein 2 stability. FEBS letters\| PubMed ID: 21281640	2011
Regulation of cellular iron metabolism. The Biochemical journal\| PubMed ID: 21348856	2011
Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin. Hepatology (Baltimore, Md.)\| PubMed ID: 21748766	2011
Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice. Metallomics : integrated biometal science\| PubMed ID: 21901209	2011
Accelerated CCl4-induced liver fibrosis in Hjv-/- mice, associated with an oxidative burst and precocious profibrogenic gene expression. PloS one\| PubMed ID: 21966437	2011
Regulation of iron transport and the role of transferrin. Biochimica et biophysica acta\| PubMed ID: 22085723	2012
Synthesis of biocompatible poly(ɛ-caprolactone)- block-poly(propylene adipate) copolymers appropriate for drug nanoencapsulation in the form of core-shell nanoparticles. International journal of nanomedicine\| PubMed ID: 22162656	2011
Alternative ferritin mRNA translation via internal initiation. RNA (New York, N.Y.)\| PubMed ID: 22271759	2012
Mechanisms of mammalian iron homeostasis. Biochemistry\| PubMed ID: 22703180	2012
Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 22847740	2013
Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment. Journal of neurochemistry\| PubMed ID: 22881289	2012
Oxygen-dependent secretion of a bioactive hepcidin-GFP chimera. Biochemical and biophysical research communications\| PubMed ID: 23665013	2013
IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation. Blood\| PubMed ID: 23777768	2013
Hepatitis C virus infection causes iron deficiency in Huh7.5.1 cells. PloS one\| PubMed ID: 24349485	2013
Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels. PloS one\| PubMed ID: 24409331	2014
The IRP/IRE system in vivo: insights from mouse models. Frontiers in pharmacology\| PubMed ID: 25120486	2014
Chronic hepatitis C and liver fibrosis. World journal of gastroenterology : WJG\| PubMed ID: 25170193	2014
NTBI unveiled by chelatable fluorescent beads. The Biochemical journal\| PubMed ID: 25301074	2014