Karen Mossman

Department of Pathology and Molecular Medicine, McMaster University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2014

Other Publications

Article	Year
Herpes simplex virus ICP0 and ICP34.5 counteract distinct interferon-induced barriers to virus replication. Journal of virology\| PubMed ID: 11799195	2002
Activation and inhibition of virus and interferon: the herpesvirus story. Viral immunology\| PubMed ID: 11952145	2002
The herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genes. Journal of virology\| PubMed ID: 14747533	2004
Innate cellular response to virus particle entry requires IRF3 but not virus replication. Journal of virology\| PubMed ID: 14747536	2004
Analysis of anti-interferon properties of the herpes simplex virus type I ICP0 protein. Methods in molecular medicine\| PubMed ID: 16000863	2005
Herpesviruses and the innate immune response. Viral immunology\| PubMed ID: 16035939	2005
The role of ICP0-Null HSV-1 and interferon signaling defects in the effective treatment of breast adenocarcinoma. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16140040	2005
Functional inaccessibility of quiescent herpes simplex virus genomes. Virology journal\| PubMed ID: 16300675	2005
ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cells. Journal of virology\| PubMed ID: 16352546	2006
Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virions. Journal of virology\| PubMed ID: 16352547	2006
Induction of innate immunity against herpes simplex virus type 2 infection via local delivery of Toll-like receptor ligands correlates with beta interferon production. Journal of virology\| PubMed ID: 17005672	2006
The IFN-independent response to virus particle entry provides a first line of antiviral defense that is independent of TLRs and retinoic acid-inducible gene I. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17114474	2006
Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17456598	2007
Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17911587	2007
Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke. Journal of leukocyte biology\| PubMed ID: 18055568	2008
Cigarette smoke suppresses type I interferon-mediated antiviral immunity in lung fibroblast and epithelial cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 18338949	2008
Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase. Human gene therapy\| PubMed ID: 18764764	2008
Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-beta production. Molecular immunology\| PubMed ID: 18930547	2009
Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18981086	2008
Characterization of the interferon regulatory factor 3-mediated antiviral response in a cell line deficient for IFN production. Molecular immunology\| PubMed ID: 19038458	2009
FimH adhesin of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signalling. PLoS pathogens\| PubMed ID: 19057665	2008
Differential modification of interferon regulatory factor 3 following virus particle entry. Journal of virology\| PubMed ID: 19211751	2009
Cell fusion-induced activation of interferon-stimulated genes is not required for restriction of a herpes simplex virus VP16/ICP0 mutant in heterokarya formed between permissive and restrict... Journal of virology\| PubMed ID: 19535444	2009
Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs. Molecular immunology\| PubMed ID: 19592095	2009
Mechanisms employed by herpes simplex virus 1 to inhibit the interferon response. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 19694546	2009
Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19864603	2009
An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses. PLoS pathogens\| PubMed ID: 20360967	2010
Cellular localization of the herpes simplex virus ICP0 protein dictates its ability to block IRF3-mediated innate immune responses. PloS one\| PubMed ID: 20454685	2010
Recognition of virus infection and innate host responses to viral gene therapy vectors. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20551916	2010
Replication of subgenomic hepatitis C virus replicons in mouse fibroblasts is facilitated by deletion of interferon regulatory factor 3 and expression of liver-specific microRNA 122. Journal of virology\| PubMed ID: 20592082	2010
Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection. PloS one\| PubMed ID: 20967263	2010
Adaptive antiviral immunity is a determinant of the therapeutic success of oncolytic virotherapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21119618	2011
IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells. Cancer research\| PubMed ID: 21307131	2011
A critical role for IL-15 in TLR-mediated innate antiviral immunity against genital HSV-2 infection. Immunology and cell biology\| PubMed ID: 21339766	2011
Retroviral expression of MIR2 decreases both surface MHC class I and the alloimmune CTL response. Journal of tissue engineering and regenerative medicine\| PubMed ID: 21695793	2011
Membrane perturbation elicits an IRF3-dependent, interferon-independent antiviral response. Journal of virology\| PubMed ID: 21813605	2011
Varicella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3. Journal of virology\| PubMed ID: 21835786	2011
Innate and adaptive immune responses to herpes simplex virus. Viruses\| PubMed ID: 21994578	2009
Methods related to molecular virology. Methods (San Diego, Calif.)\| PubMed ID: 22050902	2011
Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5. Journal of virology\| PubMed ID: 22301138	2012
The nitric oxide pathway provides innate antiviral protection in conjunction with the type I interferon pathway in fibroblasts. PloS one\| PubMed ID: 22363706	2012
Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology. Autoimmunity reviews\| PubMed ID: 22440397	2012
Comparative functional evaluation of immunocompetent mouse breast cancer models established from PyMT-tumors using small animal PET with [(18)F]FDG and [(18)F]FLT. American journal of nuclear medicine and molecular imaging\| PubMed ID: 23133804	2012
Recent advances in understanding viral evasion of type I interferon. Immunology\| PubMed ID: 23173987	2013
MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23197261	2013
The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway. PloS one\| PubMed ID: 23382920	2013
Proinflammatory cytokines and chemokines - but not interferon-β - produced in response to HSV-2 in primary human genital epithelial cells are associated with viral replication and the presen... American journal of reproductive immunology (New York, N.Y. : 1989)\| PubMed ID: 23621693	2013
Novel paradigms of innate immune sensing of viral infections. Cytokine\| PubMed ID: 23800788	2013
HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24043886	2013
Oncolytic virotherapy and immunogenic cancer cell death: sharpening the sword for improved cancer treatment strategies. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24048442	2014
Immunogenic HSV-mediated oncolysis shapes the antitumor immune response and contributes to therapeutic efficacy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 24343053	2014
Rewiring cancer cell death to enhance oncolytic viro-immunotherapy. Oncoimmunology\| PubMed ID: 24498567	2013
Permissiveness of human cancer cells to oncolytic bovine herpesvirus 1 is mediated in part by KRAS activity. Journal of virology\| PubMed ID: 24696490	2014
Combining oncolytic HSV-1 with immunogenic cell death-inducing drug mitoxantrone breaks cancer immune tolerance and improves therapeutic efficacy. Cancer immunology research\| PubMed ID: 24777969	2013
Novel roles of cytoplasmic ICP0: proteasome-independent functions of the RING finger are required to block interferon-stimulated gene production but not to promote viral replication. Journal of virology\| PubMed ID: 24807717	2014
Extracellular dsRNA: its function and mechanism of cellular uptake. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 24905198	2014
Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25049377	2014
Danger, diversity and priming in innate antiviral immunity. Cytokine & growth factor reviews\| PubMed ID: 25081316	2014