Ravi Mahadeva

Department of Respiratory Medicine, University of Cambridge - Addenbrooke's Hospital

Affiliated withUniversity of Cambridge - Addenbrooke's Hospital

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 38	2015

Other Publications

Article	Year
6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis. The Journal of biological chemistry\| PubMed ID: 11773044	2002
Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro. The Journal of biological chemistry\| PubMed ID: 11880376	2002
Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema. American journal of respiratory cell and molecular biology\| PubMed ID: 12034572	2002
Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy. The Journal of clinical investigation\| PubMed ID: 12464660	2002
Alpha(1)-antitrypsin deficiency, liver disease and emphysema. The international journal of biochemistry & cell biology\| PubMed ID: 12672469	2003
Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease. The Journal of biological chemistry\| PubMed ID: 12807889	2003
Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema. American journal of respiratory cell and molecular biology\| PubMed ID: 15016619	2004
Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. The American journal of pathology\| PubMed ID: 15681822	2005
Identification of a 4-mer peptide inhibitor that effectively blocks the polymerization of pathogenic Z alpha1-antitrypsin. American journal of respiratory cell and molecular biology\| PubMed ID: 16778151	2006
Sirolimus-induced pulmonary hypersensitivity associated with a CD4 T-cell infiltrate. Chest\| PubMed ID: 16778294	2006
Animal models of pulmonary emphysema. Current drug targets. Inflammation and allergy\| PubMed ID: 17305522	2005
Pulmonary fibrosis secondary to siderosis causing symptomatic respiratory disease: a case report. Journal of medical case reports\| PubMed ID: 18681950	2008
Acupuncture induced pneumothorax - a case report. Acupuncture in medicine : journal of the British Medical Acupuncture Society\| PubMed ID: 18818566	2008
Small-molecule peptides inhibit Z alpha1-antitrypsin polymerization. Journal of cellular and molecular medicine\| PubMed ID: 19120695	2009
Oxidized {alpha}1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 19525388	2009
Cholesterol rich lipid raft microdomains are gateway for acute phase protein, SERPINA1. The international journal of biochemistry & cell biology\| PubMed ID: 20561599	2010
Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema. American journal of respiratory cell and molecular biology\| PubMed ID: 20971880	2011
Tonsillar cyst: an unusual cause of ventilatory failure. JRSM short reports\| PubMed ID: 21103137	2010
Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 21494752	2011
Targeting serpins in high-throughput and structure-based drug design. Methods in enzymology\| PubMed ID: 22078534	2011
The serpinopathies studying serpin polymerization in vivo. Methods in enzymology\| PubMed ID: 22078544	2011
Preventing and reversing the cellular consequences of Z alpha-1 antitrypsin accumulation by targeting s4A. Journal of hepatology\| PubMed ID: 22425623	2012
Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23975926	2013
Z α1-antitrypsin confers a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine\| PubMed ID: 24592811	2014
Acute-phase protein α1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24760148	2014
Pneumothorax after endobronchial valve treatment: no drain, no gain? Respiration; international review of thoracic diseases\| PubMed ID: 24903903	2014