Alicia Alonso

Department of Medicine, Weill Cornell Medical College

Affiliated withWeill Cornell Medical College

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 115	2015

Other Publications

Article	Year
Membrane restructuring via ceramide results in enhanced solute efflux. The Journal of biological chemistry\| PubMed ID: 11796726	2002
Sphingomyelinase cleavage of sphingomyelin in pure and mixed lipid membranes. Influence of the physical state of the sphingolipid. Chemistry and physics of lipids\| PubMed ID: 11841822	2002
Sphingomyelinases: enzymology and membrane activity. FEBS letters\| PubMed ID: 12401200	2002
Surfactant effects of chlorpromazine and imipramine on lipid bilayers containing sphingomyelin and cholesterol. Journal of colloid and interface science\| PubMed ID: 12573633	2002
Sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes. The Journal of biological chemistry\| PubMed ID: 12855704	2003
Genomic microarray analysis reveals distinct locations for the CENP-A binding domains in three human chromosome 13q32 neocentromeres. Human molecular genetics\| PubMed ID: 12928482	2003
Interaction of phospholipases C and sphingomyelinase with liposomes. Methods in enzymology\| PubMed ID: 14610804	2003
Membrane fusion induced by the catalytic activity of a phospholipase C/sphingomyelinase from Listeria monocytogenes. Biochemistry\| PubMed ID: 15035639	2004
Human cytomegalovirus: detection of congenital and perinatal infection in Argentina. BMC pediatrics\| PubMed ID: 15214967	2004
Asymmetric addition of ceramides but not dihydroceramides promotes transbilayer (flip-flop) lipid motion in membranes. Biophysical journal\| PubMed ID: 15465865	2005
Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases. FEBS letters\| PubMed ID: 15620691	2005
Biophysics (and sociology) of ceramides. Biochemical Society symposium\| PubMed ID: 15649141	2005
Different effects of long- and short-chain ceramides on the gel-fluid and lamellar-hexagonal transitions of phospholipids: a calorimetric, NMR, and x-ray diffraction study. Biophysical journal\| PubMed ID: 15695626	2005
Domain formation in sphingomyelin/cholesterol mixed membranes studied by spin-label electron spin resonance spectroscopy. Biochemistry\| PubMed ID: 15779918	2005
Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides. Biochimica et biophysica acta\| PubMed ID: 15904658	2005
Modulation of PI-specific phospholipase C by membrane curvature and molecular order. Biochemistry\| PubMed ID: 16114896	2005
Detergent-resistant, ceramide-enriched domains in sphingomyelin/ceramide bilayers. Biophysical journal\| PubMed ID: 16284266	2006
Alkanes are not innocuous vehicles for hydrophobic reagents in membrane studies. Chemistry and physics of lipids\| PubMed ID: 16413518	2006
Sphingosine increases the permeability of model and cell membranes. Biophysical journal\| PubMed ID: 16533839	2006
Detergent solubilization of phosphatidylcholine bilayers in the fluid state: influence of the acyl chain structure. Biochimica et biophysica acta\| PubMed ID: 16579963	2006
Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs. Genome biology\| PubMed ID: 17040560	2006
Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids. Biochimica et biophysica acta\| PubMed ID: 17070498	2006
Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine). Biochimica et biophysica acta\| PubMed ID: 17543274	2007
Leakage-free membrane fusion induced by the hydrolytic activity of PlcHR(2), a novel phospholipase C/sphingomyelinase from Pseudomonas aeruginosa. Biochimica et biophysica acta\| PubMed ID: 17560896	2007
Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. Genome biology\| PubMed ID: 17651496	2007
Triton X-100 partitioning into sphingomyelin bilayers at subsolubilizing detergent concentrations: effect of lipid phase and a comparison with dipalmitoylphosphatidylcholine. Biophysical journal\| PubMed ID: 17675347	2007
Giant unilamellar vesicles electroformed from native membranes and organic lipid mixtures under physiological conditions. Biophysical journal\| PubMed ID: 17704162	2007
Lower muscle strength gains in older men with type 2 diabetes after resistance training. Journal of diabetes and its complications\| PubMed ID: 18280441	2008
Membrane organization and ionization behavior of the minor but crucial lipid ceramide-1-phosphate. Biophysical journal\| PubMed ID: 18296489	2008
Cholesterol displacement by ceramide in sphingomyelin-containing liquid-ordered domains, and generation of gel regions in giant lipidic vesicles. FEBS letters\| PubMed ID: 18755187	2008
Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis. Biochemistry\| PubMed ID: 18826261	2008
Effects of ceramide and other simple sphingolipids on membrane lateral structure. Biochimica et biophysica acta\| PubMed ID: 18848519	2009
Phase diagrams of lipid mixtures relevant to the study of membrane rafts. Biochimica et biophysica acta\| PubMed ID: 18952002	2008
Calcium inhibits diacylglycerol uptake by serum albumin. Biochimica et biophysica acta\| PubMed ID: 19101500	2009
Ceramide-induced transbilayer (flip-flop) lipid movement in membranes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19160667	2009
Phospholipase C and sphingomyelinase activities of the Clostridium perfringens alpha-toxin. Chemistry and physics of lipids\| PubMed ID: 19428363	2009
Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug. Journal of chemical biology\| PubMed ID: 19568801	2008
Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments. Biophysical journal\| PubMed ID: 19720028	2009
End-products diacylglycerol and ceramide modulate membrane fusion induced by a phospholipase C/sphingomyelinase from Pseudomonas aeruginosa. Biochimica et biophysica acta\| PubMed ID: 19891956	2010
Coexistence of immiscible mixtures of palmitoylsphingomyelin and palmitoylceramide in monolayers and bilayers. Biophysical journal\| PubMed ID: 19917225	2009
Electroformation of giant unilamellar vesicles from native membranes and organic lipid mixtures for the study of lipid domains under physiological ionic-strength conditions. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20013393	2010
Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes. FEBS letters\| PubMed ID: 20043909	2010
Detergent effects on membranes at subsolubilizing concentrations: transmembrane lipid motion, bilayer permeabilization, and vesicle lysis/reassembly are independent phenomena. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20170131	2010
A paucity of heterochromatin at functional human neocentromeres. Epigenetics & chromatin\| PubMed ID: 20210998	2010
Quantitation of cholesterol incorporation into extruded lipid bilayers. Biochimica et biophysica acta\| PubMed ID: 20537979	2010
Dihydrosphingomyelin impairs HIV-1 infection by rigidifying liquid-ordered membrane domains. Chemistry & biology\| PubMed ID: 20659689	2010
Cholesterol displaces palmitoylceramide from its tight packing with palmitoylsphingomyelin in the absence of a liquid-disordered phase. Biophysical journal\| PubMed ID: 20712995	2010
Effects of bilayer composition and physical properties on the phospholipase C and sphingomyelinase activities of Clostridium perfringens α-toxin. Biochimica et biophysica acta\| PubMed ID: 20727345	2011
Multiple phospholipid substrates of phospholipase C/sphingomyelinase HR2 from Pseudomonas aeruginosa. Chemistry and physics of lipids\| PubMed ID: 21073866	2011
Imaging the early stages of phospholipase C/sphingomyelinase activity on vesicles containing coexisting ordered-disordered and gel-fluid domains. Journal of lipid research\| PubMed ID: 21252263	2011
Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis. Translational oncogenomics\| PubMed ID: 21566746	2008
Unexpected wide substrate specificity of C. perfringens α-toxin phospholipase C. Biochimica et biophysica acta\| PubMed ID: 21704605	2011
Formation of novel CENP-A domains on tandem repetitive DNA and across chromosome breakpoints on human chromosome 8q21 neocentromeres. Chromosoma\| PubMed ID: 21826412	2011
Phospholipases C and sphingomyelinases: Lipids as substrates and modulators of enzyme activity. Progress in lipid research\| PubMed ID: 22504350	2012
Lipid bilayers in the gel phase become saturated by triton X-100 at lower surfactant concentrations than those in the fluid phase. Biophysical journal\| PubMed ID: 22713566	2012
Accumulated bending energy elicits neutral sphingomyelinase activity in human red blood cells. Biophysical journal\| PubMed ID: 22824271	2012
Recruitment of a phospholipase C/sphingomyelinase into non-lamellar lipid droplets during hydrolysis of lipid bilayers. Chemistry and physics of lipids\| PubMed ID: 23253877	2013
Detergent solubilization of lipid bilayers: a balance of driving forces. Trends in biochemical sciences\| PubMed ID: 23290685	2013
The onset of Triton X-100 solubilization of sphingomyelin/ceramide bilayers: effects of temperature and composition. Chemistry and physics of lipids\| PubMed ID: 23453949	2013
In situ synthesis of fluorescent membrane lipids (ceramides) using click chemistry. Journal of chemical biology\| PubMed ID: 23596500	2012
The octamer is the major form of CENP-A nucleosomes at human centromeres. Nature structural & molecular biology\| PubMed ID: 23644596	2013
A topical microemulsion for the prevention of allergic rhinitis symptoms: results of a randomized, controlled, double-blind, parallel group, multicentre, multinational clinical trial (Nares ... Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology\| PubMed ID: 23981504	2013
Membrane binding and insertion of the predicted transmembrane domain of human scramblase 1. Biochimica et biophysica acta\| PubMed ID: 24099740	2014
Lipid bilayers containing sphingomyelins and ceramides of varying N-acyl lengths: a glimpse into sphingolipid complexity. Biochimica et biophysica acta\| PubMed ID: 24144542	2014
Lamellar gel (lβ) phases of ternary lipid composition containing ceramide and cholesterol. Biophysical journal\| PubMed ID: 24507602	2014
Histones and DNA compete for binding polyphosphoinositides in bilayers. Biophysical journal\| PubMed ID: 24606933	2014
Membrane binding of human phospholipid scramblase 1 cytoplasmic domain. Biochimica et biophysica acta\| PubMed ID: 24680654	2014
Sphingosine induces the aggregation of imine-containing peroxidized vesicles. Biochimica et biophysica acta\| PubMed ID: 24802275	2014
Membrane permeabilization induced by sphingosine: effect of negatively charged lipids. Biophysical journal\| PubMed ID: 24940775	2014
A cholesterol recognition motif in human phospholipid scramblase 1. Biophysical journal\| PubMed ID: 25229146	2014
Biophysical properties of sphingosine, ceramides and other simple sphingolipids. Biochemical Society transactions\| PubMed ID: 25233422	2014
High-melting lipid mixtures and the origin of detergent-resistant membranes studied with temperature-solubilization diagrams. Biophysical journal\| PubMed ID: 25517149	2014
Biophysical properties of novel 1-deoxy-(dihydro)ceramides occurring in mammalian cells. Biophysical journal\| PubMed ID: 25517151	2014
Fluorescent Polyene Ceramide Analogues as Membrane Probes. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 25658138	2015
Histones cause aggregation and fusion of lipid vesicles containing phosphatidylinositol-4-phosphate. Biophysical journal\| PubMed ID: 25692591	2015
Atomic force microscopy characterization of palmitoylceramide and cholesterol effects on phospholipid bilayers: a topographic and nanomechanical study. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 25693914	2015