Billy W. Day

Department of Pharmaceutical Sciences, University of Pittsburgh

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 48	2010

Other Publications

Article	Year
Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A. Journal of medicinal chemistry\| PubMed ID: 11960501	2002
Discodermolide/Dictyostatin hybrids: synthesis and biological evaluation. Organic letters\| PubMed ID: 12465908	2002
The antisignaling agent SC-alpha alpha delta 9, 4-(benzyl-(2-[(2,5-diphenyloxazole-4-carbonyl)amino]ethyl)carbamoyl)- 2-decanoylaminobutyric acid, is a structurally unique phospholipid analo... Molecular cancer therapeutics\| PubMed ID: 12481409	2002
Synthesis and high content cell-based profiling of simplified analogues of the microtubule stabilizer (+)-discodermolide. Molecular cancer therapeutics\| PubMed ID: 12516963	2002
Simplified discodermolide analogues: synthesis and biological evaluation of 4-epi-7-dehydroxy-14,16-didemethyl-(+)-discodermolides as microtubule-stabilizing agents. Journal of medicinal chemistry\| PubMed ID: 12825928	2003
Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide. Bioorganic & medicinal chemistry\| PubMed ID: 12837544	2003
Identification of structural components associated with cytostatic activity in MCF-7 but not in MDA-MB-231 cells. Bioorganic & medicinal chemistry\| PubMed ID: 14604689	2003
Altered levels and regulation of stathmin in paclitaxel-resistant ovarian cancer cells. Oncogene\| PubMed ID: 14654788	2003
Chemistry and biology of curacin A. Current pharmaceutical design\| PubMed ID: 15134491	2004
Detection of conjugated C16 PUFAs in rat tissues as possible partial beta-oxidation products of naturally occurring conjugated linoleic acid and its metabolites. Biochimica et biophysica acta\| PubMed ID: 15158763	2004
Inhibition of estrogen receptor alpha-mediated transcription by antiestrogenic 1,1-dichloro-2,2,3-triarylcyclopropanes. Molecular pharmacology\| PubMed ID: 15235102	2004
Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. The Journal of biological chemistry\| PubMed ID: 15448148	2004
New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides. Bioorganic & medicinal chemistry\| PubMed ID: 15582460	2005
CoMFA, HQSAR and molecular docking studies of butitaxel analogues with beta-tubulin. Journal of molecular modeling\| PubMed ID: 15616834	2005
Proteomic characterization of harvested pseudopodia with differential gel electrophoresis and specific antibodies. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 15654357	2005
Microwave-assisted "libraries from libraries" approach toward the synthesis of allyl- and C-cyclopropylalkylamides. Journal of combinatorial chemistry\| PubMed ID: 15762763	2005
HPRT gene alterations in umbilical cord blood T-lymphocytes in newborns of mothers exposed to tobacco smoke during pregnancy. Mutation research\| PubMed ID: 15790499	2005
A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development. Molecular pharmacology\| PubMed ID: 15872116	2005
Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin. Organic letters\| PubMed ID: 15987158	2005
Redox regulation of Cdc25B by cell-active quinolinediones. Molecular pharmacology\| PubMed ID: 16155209	2005
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. Journal of medicinal chemistry\| PubMed ID: 16162011	2005
Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 16195250	2006
Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress. Molecular biology of the cell\| PubMed ID: 16251354	2006
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry\| PubMed ID: 16274252	2005
Systems cell biology knowledge created from high content screening. Assay and drug development technologies\| PubMed ID: 16305307	2005
Brisk production of nitric oxide and associated formation of S-nitrosothiols in early hemorrhage. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 16339342	2006
Fluorous mixture synthesis of (-)-dictyostatin and three stereoisomers. Organic letters\| PubMed ID: 16408900	2006
Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer. Cancer research\| PubMed ID: 16424007	2006
Synthesis and biological evaluation of purealin and analogues as cytoplasmic dynein heavy chain inhibitors. Journal of medicinal chemistry\| PubMed ID: 16539395	2006
Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells. Chemical research in toxicology\| PubMed ID: 16841962	2006
Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Molecular pharmacology\| PubMed ID: 16887932	2006
Albumin marks pseudopodia of astrocytoma cells responding to hepatocyte growth factor or serum. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 16969371	2006
Production and characterization of monoclonal antibodies against ochratoxin B. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 17161512	2007
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nature chemical biology\| PubMed ID: 17206139	2007
Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC. Environmental and molecular mutagenesis\| PubMed ID: 17358027	2007
Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin. Journal of medicinal chemistry\| PubMed ID: 17542572	2007
New opportunities for pregnane X receptor (PXR) targeting in drug development. lessons from Enantio- and species-specific PXR ligands identified from a discovery library of amino acid analog... Mini reviews in medicinal chemistry\| PubMed ID: 17584160	2007
Structure-activity and high-content imaging analyses of novel tubulysins. Chemical biology & drug design\| PubMed ID: 17683369	2007
Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin. Molecular pharmacology\| PubMed ID: 18073274	2008
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. Bioorganic & medicinal chemistry\| PubMed ID: 18164205	2008
Tubulin-perturbing naphthoquinone spiroketals. Chemical biology & drug design\| PubMed ID: 18194192	2008
(Z)-1,1-Dichloro-2-(4-methoxyphenyl)-3-phenylcyclopropane induces concentration-dependent growth inhibition, apoptosis, and coordinates regulation of apoptotic genes in TRAMP cells. Urologic oncology\| PubMed ID: 18367102	2008
Mild, efficient Friedel-Crafts acylations from carboxylic acids using cyanuric chloride and AlCl3. Organic letters\| PubMed ID: 18512929	2008
Guidelines for reporting the use of gel electrophoresis in proteomics. Nature biotechnology\| PubMed ID: 18688234	2008
Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers. Tetrahedron\| PubMed ID: 18728696	2007
Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts. Journal of medicinal chemistry\| PubMed ID: 18839939	2008
APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase. Molecular cell\| PubMed ID: 19061640	2008
Microtubule binding and disruption and induction of premature senescence by disorazole C(1). The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19066338	2009
Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. Bioorganic & medicinal chemistry\| PubMed ID: 19195901	2009
Polyhydroxylalkyleneamines: a class of hydrophilic cationic polymer-based gene transfer agents. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 19332088	2009
Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta. Bioorganic & medicinal chemistry letters\| PubMed ID: 19356928	2009
Design and synthesis of a library of tetracyclic hydroazulenoisoindoles. Journal of combinatorial chemistry\| PubMed ID: 19366169	2009
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nature chemical biology\| PubMed ID: 19578332	2009
Evaluation of biosensor surfaces for the detection of microtubule perturbation. Biosensors & bioelectronics\| PubMed ID: 19595587	2009
Meayamycin inhibits pre-messenger RNA splicing and exhibits picomolar activity against multidrug-resistant cells. Molecular cancer therapeutics\| PubMed ID: 19671752	2009
High-content analysis of cancer-cell-specific apoptosis and inhibition of in vivo angiogenesis by synthetic (-)-pironetin and analogs. Chemical biology & drug design\| PubMed ID: 19691472	2009
Human liver microsomal metabolism of (+)-discodermolide. Journal of natural products\| PubMed ID: 19775091	2009
Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas. International journal of cancer. Journal international du cancer\| PubMed ID: 19795461	2010
Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compounds. ACS chemical biology\| PubMed ID: 19807124	2009
A functionalizable polyester with free hydroxyl groups and tunable physiochemical and biological properties. Biomaterials\| PubMed ID: 20149441	2010
Azide-tetrazole equilibrium of C-6 azidopurine nucleosides and their ligation reactions with alkynes. The Journal of organic chemistry\| PubMed ID: 20297785	2010
Inhibition of histone deacetylase expands the renal progenitor cell population. Journal of the American Society of Nephrology : JASN\| PubMed ID: 20378823	2010
Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin. Journal of the American Chemical Society\| PubMed ID: 20545347	2010
Regulation of the autophagy protein LC3 by phosphorylation. The Journal of cell biology\| PubMed ID: 20713600	2010
Characterization and detection of cellular and proteomic alterations in stable stathmin-overexpressing, taxol-resistant BT549 breast cancer cells using offgel IEF/PAGE difference gel electro... Mutation research\| PubMed ID: 20816848	2011
A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos. Molecular cancer therapeutics\| PubMed ID: 21490306	2011
Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs. Journal of the American Chemical Society\| PubMed ID: 21902245	2011
Characterization of Inhibitors of Glucocorticoid Receptor Nuclear Translocation: A Model of Cytoplasmic Dynein-Mediated Cargo Transport. Assay and drug development technologies\| PubMed ID: 21919741	2011
Efficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, two potent new microtubule-stabilizing agents. Beilstein journal of organic chemistry\| PubMed ID: 22043248	2011
Theory and applications of surface plasmon resonance, resonant mirror, resonant waveguide grating, and dual polarization interferometry biosensors. Sensors (Basel, Switzerland)\| PubMed ID: 22163431	2010
Synthesis and Biological Evaluation of Neopeltolide and Analogs. The Journal of organic chemistry\| PubMed ID: 22329423	2012