Matthias Ernst

The Walter and Eliza Hall Institute for Medical Research

Affiliated withThe Walter and Eliza Hall Institute for Medical Research University of Melbourne Olivia Newton-John Cancer Research Institute

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2015

Other Publications

Article	Year
LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival. Nature medicine\| PubMed ID: 12042813	2002
Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression. The Journal of biological chemistry\| PubMed ID: 12114523	2002
Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response. The Journal of experimental medicine\| PubMed ID: 12208875	2002
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nature medicine\| PubMed ID: 12219085	2002
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutation research\| PubMed ID: 12351151	2002
Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling. Experimental hematology\| PubMed ID: 12423677	2002
AACR special meeting in cancer research: colon cancer--genetics to prevention. Cancer research\| PubMed ID: 12438280	2002
Determination of internuclear distances in uniformly labeled molecules by rotational-resonance solid-state NMR. Journal of the American Chemical Society\| PubMed ID: 12603160	2003
The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover. Arthritis and rheumatism\| PubMed ID: 12746890	2003
Heteronuclear spin decoupling in solid-state NMR under magic-angle sample spinning. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 12762980	2003
Low-power XiX decoupling in MAS NMR experiments. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 12914849	2003
The role of gp130/IL-6 cytokines in the development of pulmonary fibrosis: critical determinants of disease susceptibility and progression? Pharmacology & therapeutics\| PubMed ID: 12951164	2003
NMR spectra of a microcrystalline protein at 30 kHz MAS. Journal of the American Chemical Society\| PubMed ID: 14677971	2003
Acquiring signalling specificity from the cytokine receptor gp130. Trends in genetics : TIG\| PubMed ID: 14698616	2004
Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology\| PubMed ID: 14699500	2004
Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression. Molecular and cellular biology\| PubMed ID: 14749363	2004
Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways. The Journal of clinical investigation\| PubMed ID: 14755335	2004
Low-power high-resolution solid-state NMR of peptides and proteins. Journal of the American Chemical Society\| PubMed ID: 15080665	2004
Rotational-resonance distance measurements in multi-spin systems. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 15140443	2004
Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK. The Journal of biological chemistry\| PubMed ID: 15292206	2004
Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo. The Prostate\| PubMed ID: 15389784	2005
The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis. Blood\| PubMed ID: 15650055	2005
High-resolution solid-state NMR spectroscopy of the prion protein HET-s in its amyloid conformation. Angewandte Chemie (International ed. in English)\| PubMed ID: 15770629	2005
Interleukin-11 receptor signaling is required for normal bone remodeling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 15940362	2005
Correlation of structural elements and infectivity of the HET-s prion. Nature\| PubMed ID: 15944710	2005
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15976028	2005
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nature medicine\| PubMed ID: 16041381	2005
Decoupling and recoupling using continuous-wave irradiation in magic-angle-spinning solid-state NMR: a unified description using bimodal Floquet theory. The Journal of chemical physics\| PubMed ID: 16122295	2005
Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130. Gastroenterology\| PubMed ID: 16143138	2005
Amplitude-modulated decoupling in rotating solids: a bimodal Floquet approach. Solid state nuclear magnetic resonance\| PubMed ID: 16216477	2006
13C, 15N resonance assignment of parts of the HET-s prion protein in its amyloid form. Journal of biomolecular NMR\| PubMed ID: 16518695	2006
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature medicine\| PubMed ID: 16604088	2006
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. Molecular biology of the cell\| PubMed ID: 16624864	2006
DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma. Carcinogenesis\| PubMed ID: 16829686	2007
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nature immunology\| PubMed ID: 16906166	2006
Observation of highly flexible residues in amyloid fibrils of the HET-s prion. Journal of the American Chemical Society\| PubMed ID: 17017802	2006
STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis. Gastroenterology\| PubMed ID: 17030178	2006
Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood\| PubMed ID: 17082315	2007
General nature of the STAT3-activated anti-inflammatory response. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17114459	2006
STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology\| PubMed ID: 17241879	2007
Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation. Hepatology (Baltimore, Md.)\| PubMed ID: 17256754	2007
c-Myb is required for progenitor cell homeostasis in colonic crypts. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360438	2007
TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice. Gastroenterology\| PubMed ID: 17408644	2007
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27. Blood\| PubMed ID: 17609432	2007
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nature immunology\| PubMed ID: 17994025	2007
Operator-based triple-mode Floquet theory in solid-state NMR. The Journal of chemical physics\| PubMed ID: 18052439	2007
IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice. Blood\| PubMed ID: 18156493	2008
Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration. The Journal of biological chemistry\| PubMed ID: 18216023	2008
Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha. Growth factors (Chur, Switzerland)\| PubMed ID: 18236210	2007
Insights into homonuclear decoupling from efficient numerical simulation: techniques and examples. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 18321741	2008
Identification of putative targets of DNA (cytosine-5) methylation-mediated transcriptional silencing using a novel conditionally active form of DNA methyltransferase 3a. Growth factors (Chur, Switzerland)\| PubMed ID: 18365873	2007
STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. The Journal of clinical investigation\| PubMed ID: 18431520	2008
IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18641358	2008
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19109195	2009
The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development. Gastroenterology\| PubMed ID: 19121317	2009
Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity. Diabetes\| PubMed ID: 19136654	2009
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer cell\| PubMed ID: 19185844	2009
Dipolar truncation in magic-angle spinning NMR recoupling experiments. The Journal of chemical physics\| PubMed ID: 19317544	2009
Understanding two-pulse phase-modulated decoupling in solid-state NMR. The Journal of chemical physics\| PubMed ID: 19317548	2009
Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling. Gastroenterology\| PubMed ID: 19454286	2009
Development and assessment of a short-range meta-GGA functional. The Journal of chemical physics\| PubMed ID: 19548716	2009
Optimal preparation methods for automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling of low molecular weight proteins and peptides. Rapid communications in mass spectrometry : RCM\| PubMed ID: 19630030	2009
A33 antigen-deficient mice have defective colonic mucosal repair. Inflammatory bowel diseases\| PubMed ID: 19856415	2010
Complex hydrides with (BH(4))(-) and (NH(2))(-) anions as new lithium fast-ion conductors. Journal of the American Chemical Society\| PubMed ID: 19856969	2009
Direct detection of (3h)J(NC') hydrogen-bond scalar couplings in proteins by solid-state NMR spectroscopy. Angewandte Chemie (International ed. in English)\| PubMed ID: 19894242	2009
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS genetics\| PubMed ID: 20084116	2010
Involvement of gp130-associated cytokine signaling in Müller cell activation following optic nerve lesion. Glia\| PubMed ID: 20091786	2010
Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling? Cell division\| PubMed ID: 20478049	2010
Operator-based Floquet theory in solid-state NMR. Solid state nuclear magnetic resonance\| PubMed ID: 20573488	2010
Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial... Circulation\| PubMed ID: 20585009	2010
More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer. Journal of leukocyte biology\| PubMed ID: 20610798	2010
Characteristics of zero-quantum correlation spectroscopy in MAS NMR experiments. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 20920869	2010
Quantitative analysis of protein backbone dynamics in microcrystalline ubiquitin by solid-state NMR spectroscopy. Journal of the American Chemical Society\| PubMed ID: 20977205	2010
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21148800	2011
Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. American journal of respiratory cell and molecular biology\| PubMed ID: 21297079	2011
Smad3 dosage determines androgen responsiveness and sets the pace of postnatal testis development. Endocrinology\| PubMed ID: 21385936	2011
A proton-detected 4D solid-state NMR experiment for protein structure determination. Chemphyschem : a European journal of chemical physics and physical chemistry\| PubMed ID: 21442705	2011
Accurate measurement of one-bond H-X heteronuclear dipolar couplings in MAS solid-state NMR. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 21482161	2011
Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21515788	2011
Rotational motion in LiBH4/LiI solid solutions. The journal of physical chemistry. A\| PubMed ID: 21545168	2011
PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. Cancer research\| PubMed ID: 21558389	2011
The amyloid-Congo red interface at atomic resolution. Angewandte Chemie (International ed. in English)\| PubMed ID: 21591034	2011
IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21606248	2011
LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling. Immunology and cell biology\| PubMed ID: 21670738	2012
Solid-state NMR measurements of asymmetric dipolar couplings provide insight into protein side-chain motion. Angewandte Chemie (International ed. in English)\| PubMed ID: 21915969	2011
Cancer research: past, present and future. Nature reviews. Cancer\| PubMed ID: 21918542	2011
Second-order dipolar order in magic-angle spinning nuclear magnetic resonance. The Journal of chemical physics\| PubMed ID: 22029324	2011
A supplementary coil for ²H decoupling with commercial HCN MAS probes. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 22088662	2012
IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling. Journal of leukocyte biology\| PubMed ID: 22140267	2012
A multi-sample 94 GHz dissolution dynamic-nuclear-polarization system. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 22142831	2012
Colorectal cancer mouse models: integrating inflammation and the stroma. Journal of gastroenterology and hepatology\| PubMed ID: 22188027	2012
Stat3: linking inflammation to (gastrointestinal) tumourigenesis. Clinical and experimental pharmacology & physiology\| PubMed ID: 22211709	2012
Interleukin-11 links oxidative stress and compensatory proliferation. Science signaling\| PubMed ID: 22253262	2012
Comparative 2D DIGE analysis of the depleted serum proteome for biomarker discovery. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22311763	2012
Simultaneous acquisition of PAR and PAIN spectra. Journal of biomolecular NMR\| PubMed ID: 22371268	2012
Properties of the DREAM scheme and its optimization for application to proteins. Journal of biomolecular NMR\| PubMed ID: 22562365	2012
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis. EMBO molecular medicine\| PubMed ID: 22684844	2012
2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer. Journal of proteomics\| PubMed ID: 22789672	2012
Site-resolved measurement of microsecond-to-millisecond conformational-exchange processes in proteins by solid-state NMR spectroscopy. Journal of the American Chemical Society\| PubMed ID: 22908968	2012
Research in magnetic resonance. Chimia\| PubMed ID: 23146256	2012
Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation. Stem cells translational medicine\| PubMed ID: 23197851	2012
mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. The Journal of clinical investigation\| PubMed ID: 23321674	2013
Accelerating hyperpolarized metabolic imaging of the heart by exploiting spatiotemporal correlations. NMR in biomedicine\| PubMed ID: 23616307	2013
PAIN with and without PAR: variants for third-spin assisted heteronuclear polarization transfer. Journal of biomolecular NMR\| PubMed ID: 23807391	2013
Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice. Arthritis and rheumatism\| PubMed ID: 23818297	2013
Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis. PLoS pathogens\| PubMed ID: 23853585	2013
Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically. Cancer cell\| PubMed ID: 23948300	2013
Targeting IL-11 signaling in colon cancer. Oncotarget\| PubMed ID: 24163267	2013
Adiabatic Rotor-Echo-Short-Pulse-Irradiation mediated cross-polarization. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 24220613	2013
Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice. The Biochemical journal\| PubMed ID: 24320611	2014
Improved decoupling during symmetry-based C9-TOBSY sequences. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 24384065	2014
Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice. Molecular cancer therapeutics\| PubMed ID: 24398427	2014
Low-power polarization transfer between deuterons and spin-1/2 nuclei using adiabatic (RESPIRATION)CP in solid-state NMR. Physical chemistry chemical physics : PCCP\| PubMed ID: 24418905	2014
Epithelial gp130/Stat3 functions: an intestinal signaling node in health and disease. Seminars in immunology\| PubMed ID: 24434062	2014
Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer. Biochimica et biophysica acta\| PubMed ID: 24512919	2014
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell\| PubMed ID: 24813849	2014
Hybrid multiband excitation multiecho acquisition for hyperpolarized (13) C spectroscopic imaging. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 24845417	2014
Quantitative intratumoural microdistribution and kinetics of (131)I-huA33 antibody in patients with colorectal carcinoma. EJNMMI research\| PubMed ID: 24995151	2014
Spectral editing through laser-flash excitation in two-dimensional photo-CIDNP MAS NMR experiments. Journal of magnetic resonance (San Diego, Calif. : 1997)\| PubMed ID: 25063951	2014
Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25074610	2014
The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice. Science signaling\| PubMed ID: 25118329	2014
Cross-polarization for dissolution dynamic nuclear polarization. Physical chemistry chemical physics : PCCP\| PubMed ID: 25182534	2014
De novo 3D structure determination from sub-milligram protein samples by solid-state 100 kHz MAS NMR spectroscopy. Angewandte Chemie (International ed. in English)\| PubMed ID: 25225004	2014
Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration. Science signaling\| PubMed ID: 25270258	2014
IL-17 cuts to the chase in colon cancer. Immunity\| PubMed ID: 25526302	2014
Asynchronous symmetry-based sequences for homonuclear dipolar recoupling in solid-state nuclear magnetic resonance. The Journal of chemical physics\| PubMed ID: 25681942	2015