Sunder Sims-Lucas

Rangos Research Center, Children's Hospital of Pittsburgh of UPMC

Affiliated withChildren's Hospital of Pittsburgh of UPMC University of Pittsburgh School of Medicine University of Pittsburgh

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Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 2	2015
Publication title	2026

Other Publications

Article	Year
Augmented and accelerated nephrogenesis in TGF-beta2 heterozygous mutant mice. Pediatric research\| PubMed ID: 18317401	2008
Role of fibroblast growth factor receptor 2 in kidney mesenchyme. Pediatric research\| PubMed ID: 18670373	2008
Endogenous fibroblastic progenitor cells in the adult mouse lung are highly enriched in the sca-1 positive cell fraction. Stem cells (Dayton, Ohio)\| PubMed ID: 19074419	2009
Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia. American journal of physiology. Renal physiology\| PubMed ID: 19741018	2009
Three-dimensional imaging reveals ureteric and mesenchymal defects in Fgfr2-mutant kidneys. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19833900	2009
Redirection of renal mesenchyme to stromal and chondrocytic fates in the presence of TGF-beta2. Differentiation; research in biological diversity\| PubMed ID: 20163909	2010
High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma. The Journal of urology\| PubMed ID: 20303521	2010
Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 21128305	2011
Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent. American journal of physiology. Renal physiology\| PubMed ID: 21325495	2011
Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium. Development (Cambridge, England)\| PubMed ID: 21350013	2011
Betaglycan is required for the establishment of nephron endowment in the mouse. PloS one\| PubMed ID: 21533152	2011
The pro-apoptotic protein Bim is a microRNA target in kidney progenitors. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21546576	2011
Whole-mount imaging demonstrates hypervascularity of the pancreatic ducts and other pancreatic structures. Anatomical record (Hoboken, N.J. : 2007)\| PubMed ID: 22282427	2012
Ureteric morphogenesis requires Fgfr1 and Fgfr2/Frs2α signaling in the metanephric mesenchyme. Journal of the American Society of Nephrology : JASN\| PubMed ID: 22282599	2012
Mitochondrial structure, function and dynamics are temporally controlled by c-Myc. PloS one\| PubMed ID: 22629444	2012
Analysis of 3D branching pattern: hematoxylin and eosin method. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22639252	2012
Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract. Kidney international\| PubMed ID: 23302724	2013
Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux. PloS one\| PubMed ID: 23409123	2013
Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme. PloS one\| PubMed ID: 23823180	2013
Histologic evidence of intrapulmonary anastomoses by three-dimensional reconstruction in severe bronchopulmonary dysplasia. Annals of the American Thoracic Society\| PubMed ID: 23987309	2013
Three-dimensional reconstruction identifies misaligned pulmonary veins as intrapulmonary shunt vessels in alveolar capillary dysplasia. The Journal of pediatrics\| PubMed ID: 24079727	2014
Dicer function is required in the metanephric mesenchyme for early kidney development. American journal of physiology. Renal physiology\| PubMed ID: 24500693	2014
Ablation of the renal stroma defines its critical role in nephron progenitor and vasculature patterning. PloS one\| PubMed ID: 24505489	2014
Unwrapping the origins and roles of the renal endothelium. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 24633402	2014
Renal blood flow and oxygenation drive nephron progenitor differentiation. American journal of physiology. Renal physiology\| PubMed ID: 24920757	2014
Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins. Thorax\| PubMed ID: 25052575	2015
Functional Genetic Targeting of Embryonic Kidney Progenitor Cells Ex Vivo. Journal of the American Society of Nephrology : JASN\| PubMed ID: 25201883	2014
Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. The Journal of pediatrics\| PubMed ID: 25306189	2015
Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors. Developmental biology\| PubMed ID: 25641696	2015
Fibroblast growth factor receptor signaling in kidney and lower urinary tract development. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 26293980	2016
Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiological reports\| PubMed ID: 26438731	2015
The multifaceted role of the renal microvasculature during acute kidney injury. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 26493067	2016
Prorenin receptor is critical for nephron progenitors. Developmental biology\| PubMed ID: 26658320	2016
Role of hypoxia during nephrogenesis. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 26872484	2016
Intrapulmonary Bronchopulmonary Anastomoses and Plexiform Lesions in Idiopathic Pulmonary Arterial Hypertension. American journal of respiratory and critical care medicine\| PubMed ID: 26930433	2016
A FANCD2/FANCI-Associated Nuclease 1-Knockout Model Develops Karyomegalic Interstitial Nephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 27026368	2016
CD146(+) cells are essential for kidney vasculature development. Kidney international\| PubMed ID: 27165833	2016
Dictyostelium discoideum RabS and Rab2 colocalize with the Golgi and contractile vacuole system and regulate osmoregulation. Journal of biosciences\| PubMed ID: 27240981	2016
Ablation of the epithelial-specific splicing factor Esrp1 results in ureteric branching defects and reduced nephron number. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 27404344	2016
Testicular Hypoplasia Is Driven by Defective Vascular Formation. Urology\| PubMed ID: 27765594	2017
N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics. Cell death discovery\| PubMed ID: 28028439	2016
Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. The Journal of biological chemistry\| PubMed ID: 28458255	2017
Endothelial marker-expressing stromal cells are critical for kidney formation. American journal of physiology. Renal physiology\| PubMed ID: 28539333	2017
A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome. Cell reports\| PubMed ID: 30540952	2018
Metabolic requirements of the nephron. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 30554363	2020
Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation. Journal of the American Society of Nephrology : JASN\| PubMed ID: 31142573	2019
Kidney-in-a-lymph node: A novel organogenesis assay to model human renal development and test nephron progenitor cell fates. Journal of tissue engineering and regenerative medicine\| PubMed ID: 31267702	2019
In utero exposure to maternal diabetes impairs nephron progenitor differentiation. American journal of physiology. Renal physiology\| PubMed ID: 31509011	2019
Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI. Journal of the American Society of Nephrology : JASN\| PubMed ID: 31575700	2019
Increased rates of vesicoureteral reflux in mice from deletion of Dicer in the peri-Wolffian duct stroma. Pediatric research\| PubMed ID: 32015493	2020
Prenatal hypoxia increases susceptibility to kidney injury. PloS one\| PubMed ID: 32084244	2020
Deletion of hypoxia-responsive microRNA-210 results in a sex-specific decrease in nephron number. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32141129	2020
Von Hippel-Lindau: implications in development and disease-response. Annals of translational medicine\| PubMed ID: 32175434	2020
Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice. Scientific reports\| PubMed ID: 33110171	2020
A novel ultrasound-guided mouse model of sudden cardiac arrest. PloS one\| PubMed ID: 33275630	2020
Sirtuins play critical and diverse roles in acute kidney injury. Pediatric nephrology (Berlin, Germany)\| PubMed ID: 33411071	2021
Endothelial-Derived Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 33514560	2021
Development of a mechanically matched silk scaffolded 3D clear cell renal cell carcinoma model. Materials science & engineering. C, Materials for biological applications\| PubMed ID: 34082952	2021
Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4 T Cells in Type 1 Diabetes. Frontiers in immunology\| PubMed ID: 34163475	2021
The Extracellular Matrix Environment of Clear Cell Renal Cell Carcinoma Determines Cancer Associated Fibroblast Growth. Cancers\| PubMed ID: 34884982	2021
Role of ERK signaling in bladder urothelium in response to cyclophosphamide injury. Physiological reports\| PubMed ID: 35854647	2022
Targets for Renal Carcinoma Growth Control Identified by Screening FOXD1 Cell Proliferation Pathways. Cancers\| PubMed ID: 36010951	2022
Stress-Induced Changes in Trophic Factor Expression in the Rodent Urinary Bladder: Possible Links With Angiogenesis. International neurourology journal\| PubMed ID: 36599338	2022
Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization and de novo cell types. bioRxiv : the preprint server for biology\| PubMed ID: 37333155	2023
Metformin preconditioning protects against myocardial stunning and preserves protein translation in a mouse model of cardiac arrest. Journal of molecular and cellular cardiology plus\| PubMed ID: 37425219	2023
Substantial downregulation of mitochondrial and peroxisomal proteins during acute kidney injury revealed by data-independent acquisition proteomics. Proteomics\| PubMed ID: 37775337	2024
Delayed graft function post renal transplantation: a review on animal models and therapeutics. American journal of physiology. Renal physiology\| PubMed ID: 37855040	2023
Dicarboxylic Acid Dietary Supplementation Protects against AKI. Journal of the American Society of Nephrology : JASN\| PubMed ID: 38044490	2024
In utero exposure to maternal diabetes exacerbates dietary sodium intake-induced endothelial dysfunction by activating cyclooxygenase 2-derived prostanoids. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 38446637	2024
Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity. The Journal of clinical investigation\| PubMed ID: 38687608	2024
Succinylation of Park7 activates a protective metabolic response to acute kidney injury. American journal of physiology. Renal physiology\| PubMed ID: 38695076	2024
A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells. Kidney international\| PubMed ID: 38901605	2024
Cystic fibrosis-related metabolic defects: crosstalk between ion channels and organs. The Journal of clinical investigation\| PubMed ID: 38949023	2024
Sirtuin-5 Is Recruited to Hepatic Peroxisomes in Mice Fed Dodecanedioic Acid but Has Little Impact on the Peroxisomal Succinylome. Biomolecules\| PubMed ID: 39766215	2024
Loss of long-chain acyl-CoA dehydrogenase protects against acute kidney injury. JCI insight\| PubMed ID: 39932791	2025
Mitochondrial organization in the developing proximal tubule is controlled by LRRK2. Nature communications\| PubMed ID: 41168178	2025