Hubert Serve

Department of Hematology/Oncology, Goethe University of Frankfurt

Affiliated withGoethe University of Frankfurt German Cancer Consortium German Cancer Research Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2015

Other Publications

Article	Year
Carboplatin/etoposide induces remission of metastasised malignant peripheral nerve tumours (malignant schwannoma) refractory to first-line therapy. Oncology reports\| PubMed ID: 11956640	2002
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the ... Blood\| PubMed ID: 12070009	2002
Analysing c-kit internalization using a functional c-kit-EGFP chimera containing the fluorochrome within the extracellular domain. Oncogene\| PubMed ID: 12085229	2002
The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. Nature medicine\| PubMed ID: 12091906	2002
Quantification of cyclin A1 and glyceraldehyde-3-phosphate dehydrogenase expression in testicular biopsies of infertile patients by fluorescence real-time RT-PCR. International journal of andrology\| PubMed ID: 12121569	2002
Cyclin A1 and gametogenesis in fertile and infertile patients: a potential new molecular diagnostic marker. Human reproduction (Oxford, England)\| PubMed ID: 12202422	2002
A single amino acid exchange inverts susceptibility of related receptor tyrosine kinases for the ATP site inhibitor STI-571. The Journal of biological chemistry\| PubMed ID: 12435730	2003
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood\| PubMed ID: 12468433	2003
Cyclin A1 is highly expressed in aggressive testicular germ cell tumors. Cancer letters\| PubMed ID: 12536081	2003
Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice. International journal of molecular medicine\| PubMed ID: 12579332	2003
Phase I study of liposomal daunorubicin in relapsed and refractory acute myeloid leukemia. Oncology reports\| PubMed ID: 12792745	2003
Synergistic growth inhibitory effects of interferon-alpha and lovastatin on bcr-abl positive leukemic cells. International journal of oncology\| PubMed ID: 12792788	2003
Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12819347	2003
A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia. Blood\| PubMed ID: 12843001	2003
Re: Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development. Journal of the National Cancer Institute\| PubMed ID: 12902450	2003
MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene\| PubMed ID: 12970751	2003
Redirection of oncoproteins to kill cancer cells. Cell cycle (Georgetown, Tex.)\| PubMed ID: 14504468	2003
E- and A-type cyclins as markers for cancer diagnosis and prognosis. Expert review of molecular diagnostics\| PubMed ID: 14510182	2003
Evidence for allelic evolution of C/EBPalpha mutations in acute myeloid leukaemia. British journal of haematology\| PubMed ID: 14616999	2003
An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14654525	2003
6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TA... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 14673036	2003
Multicolor karyotyping in acute myeloid leukemia. Leukemia & lymphoma\| PubMed ID: 14738135	2003
High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14977821	2004
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Molecular and cellular biology\| PubMed ID: 15024077	2004
Epigenetic regulation of tumor suppressors in t(8:21)-containing AML. Annals of hematology\| PubMed ID: 15052372	2004
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. The Journal of biological chemistry\| PubMed ID: 15159402	2004
Flt3 receptor tyrosine kinase as a drug target in leukemia. Current pharmaceutical design\| PubMed ID: 15180525	2004
Evolution of FLT3-ITD and D835 activating point mutations in relapsing acute myeloid leukemia and response to salvage therapy. Leukemia research\| PubMed ID: 15289019	2004
S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer. Cancer research\| PubMed ID: 15313892	2004
Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). Blood\| PubMed ID: 15345593	2005
Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanoma. The Journal of investigative dermatology\| PubMed ID: 15373779	2004
Influence of keratinocyte growth factor on clonal growth of epithelial tumor cells, lymphoma and leukemia cells and on sensitivity of tumor cells towards 5-fluorouracil in vitro. International journal of oncology\| PubMed ID: 15375550	2004
The cyclin A1-CDK2 complex regulates DNA double-strand break repair. Molecular and cellular biology\| PubMed ID: 15456866	2004
A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood\| PubMed ID: 15459012	2005
The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells. Oncogene\| PubMed ID: 15516979	2004
RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation. Blood\| PubMed ID: 15536149	2005
Genome-wide screening for prognosis-predicting genes in early-stage non-small-cell lung cancer. Lung cancer (Amsterdam, Netherlands)\| PubMed ID: 15552795	2004
In vivo analyses of UV-irradiation-induced p53 promoter binding using a novel quantitative real-time PCR assay. International journal of oncology\| PubMed ID: 15645135	2005
Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction. Blood\| PubMed ID: 15650056	2005
Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer. Cancer research\| PubMed ID: 15753374	2005
Alterations of lymphoid enhancer factor-1 isoform expression in solid tumors and acute leukemias. Acta biochimica et biophysica Sinica\| PubMed ID: 15756419	2005
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood\| PubMed ID: 15769897	2005
Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. International journal of cancer. Journal international du cancer\| PubMed ID: 15800920	2005
Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells. Oncogene\| PubMed ID: 15829981	2005
Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases. Molecular and cellular biology\| PubMed ID: 15831474	2005
Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant. Oncogene\| PubMed ID: 16091740	2005
Receptor for platelet-activating factor (PAF) is not detectable by flow cytometry on the surface of myeloid leukemic cells. Annals of hematology\| PubMed ID: 16094532	2005
Signal transduction of oncogenic Flt3. International journal of hematology\| PubMed ID: 16146838	2005
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain. Blood\| PubMed ID: 16150941	2006
The molecular pathogenesis of acute myeloid leukemia. Critical reviews in oncology/hematology\| PubMed ID: 16236521	2005
Acute myeloid leukemia presenting with a uterus tumor. Annals of hematology\| PubMed ID: 16237527	2006
Treatment of older patients with AML. Critical reviews in oncology/hematology\| PubMed ID: 16246568	2005
Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer research\| PubMed ID: 16266983	2005
First-line systemic treatment with gefitinib in stage IV non-small cell lung cancer. Oncology reports\| PubMed ID: 16273252	2005
Treatment of AML in biological subgroups. Hematology (Amsterdam, Netherlands)\| PubMed ID: 16276628	2005
Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined su... Blood\| PubMed ID: 16278310	2006
Emerging Flt3 kinase inhibitors in the treatment of leukaemia. Expert opinion on emerging drugs\| PubMed ID: 16503833	2006
Wnt signaling regulates transendothelial migration of monocytes. Journal of leukocyte biology\| PubMed ID: 16565323	2006
Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonge... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 16735702	2006
Growth inhibition and induction of apoptosis in acute myeloid leukemia cells by new indolinone derivatives targeting fibroblast growth factor, platelet-derived growth factor, and vascular en... Molecular cancer therapeutics\| PubMed ID: 17172413	2006
Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation. International journal of oncology\| PubMed ID: 17203216	2007
The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia. Blood\| PubMed ID: 17234736	2007
DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia. Cancer research\| PubMed ID: 17283175	2007
Oncogenic signaling in acute myeloid leukemia. Current drug targets\| PubMed ID: 17305501	2007
Activation mechanisms of STAT5 by oncogenic Flt3-ITD. Blood\| PubMed ID: 17356133	2007
Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood\| PubMed ID: 17446348	2007
DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells. International journal of cancer. Journal international du cancer\| PubMed ID: 17455244	2007
New molecular therapy targets in acute myeloid leukemia. Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer\| PubMed ID: 17607931	2007
CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha. Blood\| PubMed ID: 17671235	2007
Analysis of the genetic interactions between Cyclin A1, Atm and p53 during spermatogenesis. Asian journal of andrology\| PubMed ID: 17968459	2007
Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip. Blood\| PubMed ID: 18024792	2008
Identification of acute myeloid leukaemia associated microRNA expression patterns. British journal of haematology\| PubMed ID: 18173753	2008
Adjuvant therapy with small hairpin RNA interference prevents non-small cell lung cancer metastasis development in mice. Cancer research\| PubMed ID: 18339871	2008
Adaptor protein Lnk associates with Tyr(568) in c-Kit. The Biochemical journal\| PubMed ID: 18588518	2008
Activation of Wnt signaling in cKit-ITD mediated transformation and imatinib sensitivity in acute myeloid leukemia. International journal of hematology\| PubMed ID: 18668305	2008
Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4. International journal of oncology\| PubMed ID: 19020754	2008
S100A2 induces metastasis in non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19118029	2009
Dose-dense induction with sequential high-dose cytarabine and mitoxantone (S-HAM) and pegfilgrastim results in a high efficacy and a short duration of critical neutropenia in de novo acute m... Blood\| PubMed ID: 19131552	2009
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood\| PubMed ID: 19387008	2009
Increased human telomerase reverse transcriptase (hTERT) mRNA expression but not telomerase activity is related to survival in curatively resected non-small cell lung cancer. Anticancer research\| PubMed ID: 19414359	2009
Construction and application of an inducible system for homogenous expression levels in bulk cell lines. PloS one\| PubMed ID: 19649290	2009
An open-label, Phase I study of cediranib (RECENTIN) in patients with acute myeloid leukemia. Leukemia research\| PubMed ID: 19674789	2010
E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease. Blood\| PubMed ID: 19734451	2009
Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Molecular cell\| PubMed ID: 19854140	2009
BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells. Blood\| PubMed ID: 20053753	2010
Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model. Blood\| PubMed ID: 20215640	2010
The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20371680	2010
Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia. Blood\| PubMed ID: 20498303	2010
Low SMC1A protein expression predicts poor survival in acute myeloid leukemia. Oncology reports\| PubMed ID: 20514443	2010
Adaptor protein Lnk inhibits c-Fms-mediated macrophage function. Journal of leukocyte biology\| PubMed ID: 20571037	2010
Increased levels of 2-hydroxyglutarate in AML patients with IDH1-R132H and IDH2-R140Q mutations. European journal of haematology\| PubMed ID: 20659156	2010
The deacetylase inhibitor LAQ824 induces notch signalling in haematopoietic progenitor cells. Leukemia research\| PubMed ID: 20674020	2011
Liposomal cytarabine is effective and tolerable in the treatment of central nervous system relapse of acute lymphoblastic leukemia and very aggressive lymphoma. Haematologica\| PubMed ID: 20952517	2011
The European LeukemiaNet: achievements and perspectives. Haematologica\| PubMed ID: 21048032	2011
Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes. Lancet\| PubMed ID: 21131036	2010
Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival. Leukemia research\| PubMed ID: 21176959	2011
Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease. Blood\| PubMed ID: 21224473	2011
AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein. Blood\| PubMed ID: 21245488	2011
Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling. Experimental hematology\| PubMed ID: 21310211	2011
Enhanced immune response after a second dose of an AS03-adjuvanted H1N1 influenza A vaccine in patients after hematopoietic stem cell transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 21324375	2011
Allogeneic transplantation as post-remission therapy for cytogenetically high-risk acute myeloid leukemia: landmark analysis from a single prospective multicenter trial. Haematologica\| PubMed ID: 21459795	2011
Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. The Journal of biological chemistry\| PubMed ID: 21540187	2011
High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation. Blood\| PubMed ID: 21715318	2011
Antifungal management and resource use in patients with acute myeloid leukaemia after chemotherapy--retrospective analysis of changes over 3 yr in a German hospital. European journal of haematology\| PubMed ID: 21883484	2012
Adjuvant therapy for resectable high-risk soft tissue sarcoma: feasibility and efficacy of a sandwich chemoradiotherapy strategy. Cancer chemotherapy and pharmacology\| PubMed ID: 21947168	2012
Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood\| PubMed ID: 22012066	2011
Survey and analysis of the efficacy and prescription pattern of sorafenib in patients with acute myeloid leukemia. Leukemia & lymphoma\| PubMed ID: 22054287	2012
Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene. Blood\| PubMed ID: 22207736	2012
Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies. Blood\| PubMed ID: 22442346	2012
Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation. Blood\| PubMed ID: 22493293	2012
SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control. Blood\| PubMed ID: 22517899	2012
IT behind a platform for Translational Cancer Research - concept and objectives. Studies in health technology and informatics\| PubMed ID: 22874378	2012
A special query tool in the hospital information system to recognize patients and to increase patient numbers for clinical trials. Studies in health technology and informatics\| PubMed ID: 22874393	2012
Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22895185	2012
A novel hierarchical prognostic model of AML solely based on molecular mutations. Blood\| PubMed ID: 22915647	2012
Outcome of elderly patients with acute promyelocytic leukemia: results of the German Acute Myeloid Leukemia Cooperative Group. Annals of hematology\| PubMed ID: 23090499	2013
Evaluation of the proposed reporting system of the European LeukemiaNet and recommendations for prognosis of acute myeloid leukemia. Leukemia research\| PubMed ID: 23237559	2013
Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia--a randomised SAL pilot study. PloS one\| PubMed ID: 23300745	2012
β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis. Blood\| PubMed ID: 23509157	2013
High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia: results of the prospective randomized AML2003 trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 23630210	2013
Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 23897964	2013
Cutting edge: feed-forward activation of phospholipase Cγ2 via C2 domain-mediated binding to SLP65. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24166973	2013
Smac mimetic primes apoptosis-resistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis. Cancer letters\| PubMed ID: 24184825	2014
[Patient blood management--How does it work in practice?--the interdisciplinary cooperation]. Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS\| PubMed ID: 24792600	2014
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis. Blood\| PubMed ID: 24802772	2014
PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation. Nature communications\| PubMed ID: 24874575	2014
CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25189742	2015
Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial. Blood\| PubMed ID: 25359988	2014
Allogeneic Stem-Cell Transplantation in Patients With NPM1-Mutated Acute Myeloid Leukemia: Results From a Prospective Donor Versus No-Donor Analysis of Patients After Upfront HLA Typing With... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 25547501	2015
FLT3-ITD and TLR9 employ Bruton's tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation. Blood\| PubMed ID: 25605370	2015