Jeffrey A. Bluestone

Diabetes Center, University of California, San Francisco - UCSF

Affiliated withUniversity of California, San Francisco - UCSF

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 119	2007
Publication title Cited by 98	2007

Other Publications

Article	Year
The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. European journal of immunology\| PubMed ID: 11920563	2002
The Src family kinase Fyn mediates signals induced by TCR antagonists. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11970992	2002
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. The New England journal of medicine\| PubMed ID: 12037148	2002
Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12097362	2002
The immune tolerance network: a new paradigm for developing tolerance-inducing therapies. The Journal of allergy and clinical immunology\| PubMed ID: 12110811	2002
Inability to induce tolerance through direct antigen presentation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 12118894	2002
Immunotherapy of insulin-dependent diabetes mellitus. Current opinion in immunology\| PubMed ID: 12183168	2002
Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial. The Journal of rheumatology\| PubMed ID: 12233885	2002
When ligand becomes receptor--tolerance via B7 signaling on DCs. Nature immunology\| PubMed ID: 12407416	2002
Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. The Journal of experimental medicine\| PubMed ID: 12515820	2003
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nature immunology\| PubMed ID: 12524538	2003
Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity\| PubMed ID: 12530974	2003
CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12538715	2003
Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala). The Journal of clinical investigation\| PubMed ID: 12569167	2003
Natural versus adaptive regulatory T cells. Nature reviews. Immunology\| PubMed ID: 12658273	2003
Directed evolution of a single-chain class II MHC product by yeast display. Protein engineering\| PubMed ID: 12676983	2003
Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis. The Journal of clinical investigation\| PubMed ID: 12813028	2003
Clinical trials of transplant tolerance: slow but steady progress. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 12814471	2003
TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nature medicine\| PubMed ID: 12937416	2003
Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14500627	2003
Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14607967	2003
The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells. Novartis Foundation symposium\| PubMed ID: 14609212	2003
CTLA-4 and tolerance: the biochemical point of view. Immunologic research\| PubMed ID: 14713717	2003
Importance of IL-10 for CTLA-4-mediated inhibition of tumor-eradicating immunity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14734721	2004
Beta-cell replacement for type I diabetes. Annual review of medicine\| PubMed ID: 14746513	2004
Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 14961992	2004
CTLA-4: acting at the synapse. Molecular interventions\| PubMed ID: 14993389	2002
Notch 1 signaling regulates peripheral T cell activation. Immunity\| PubMed ID: 15084270	2004
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. The Journal of experimental medicine\| PubMed ID: 15184499	2004
CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15187122	2004
NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity\| PubMed ID: 15189740	2004
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15322272	2004
Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes. Clinical immunology (Orlando, Fla.)\| PubMed ID: 15380527	2004
Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. The Journal of clinical investigation\| PubMed ID: 15467837	2004
Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. European journal of immunology\| PubMed ID: 15468055	2004
CTLA-4Ig is finally making it: a personal perspective. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 15707394	2005
The NOD mouse: a model of immune dysregulation. Annual review of immunology\| PubMed ID: 15771578	2005
Regulatory T-cell therapy: is it ready for the clinic? Nature reviews. Immunology\| PubMed ID: 15775994	2005
Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15814673	2005
Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15814694	2005
An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15843526	2005
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes... Diabetes\| PubMed ID: 15919798	2005
B7-independent inhibition of T cells by CTLA-4. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15972645	2005
A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity\| PubMed ID: 16111631	2005
Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16116193	2005
A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16148106	2005
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. The Journal of clinical investigation\| PubMed ID: 16167085	2005
How do CD4+CD25+ regulatory T cells control autoimmunity? Current opinion in immunology\| PubMed ID: 16209918	2005
Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16237054	2005
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. The Journal of experimental medicine\| PubMed ID: 16287710	2005
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nature immunology\| PubMed ID: 16311599	2006
Achieving antigen-specific tolerance in diabetes: regulating specifically. International reviews of immunology\| PubMed ID: 16318983	2005
Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential. Seminars in immunology\| PubMed ID: 16458533	2006
CTLA4Ig: bridging the basic immunology with clinical application. Immunity\| PubMed ID: 16546089	2006
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. The Journal of clinical investigation\| PubMed ID: 16628253	2006
Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship? Nature immunology\| PubMed ID: 16715063	2006
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. The Journal of experimental medicine\| PubMed ID: 16818678	2006
Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16849451	2006
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. The Journal of clinical investigation\| PubMed ID: 16886063	2006
Regulatory T-cell physiology and application to treat autoimmunity. Immunological reviews\| PubMed ID: 16903917	2006
Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes\| PubMed ID: 16936208	2006
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. The Journal of experimental medicine\| PubMed ID: 17116737	2006
Sensory neurons link the nervous system and autoimmune diabetes. Cell\| PubMed ID: 17174888	2006
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17389382	2007
Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease. European journal of immunology\| PubMed ID: 17429849	2007
Differential roles of costimulatory signaling pathways in type 1 diabetes mellitus. The review of diabetic studies : RDS\| PubMed ID: 17491700	2004
Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17617592	2007
Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clinical immunology (Orlando, Fla.)\| PubMed ID: 17627890	2007
CD3-specific antibodies: a portal to the treatment of autoimmunity. Nature reviews. Immunology\| PubMed ID: 17641665	2007
What does the future hold for cell-based tolerogenic therapy? Nature reviews. Immunology\| PubMed ID: 17653127	2007
Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology\| PubMed ID: 17673522	2007
对树突状细胞整合素 α (v) beta8 损失导致小鼠自身免疫和结&#x... Nature\| PubMed ID: 17694047	2007
B cell depletion: a novel therapy for autoimmune diabetes? The Journal of clinical investigation\| PubMed ID: 18060022	2007
Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes\| PubMed ID: 18083786	2008
Safer, longer-lasting regulatory T cells with beta-catenin. Nature medicine\| PubMed ID: 18256611	2008
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nature immunology\| PubMed ID: 18285775	2008
CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells. Nature medicine\| PubMed ID: 18438416	2008
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity\| PubMed ID: 18468463	2008
Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18523243	2008
Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunological reviews\| PubMed ID: 18613848	2008
T regulatory cells in autoimmune diabetes: past challenges, future prospects. Journal of clinical immunology\| PubMed ID: 18716861	2008
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. The Journal of experimental medicine\| PubMed ID: 18725525	2008
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunological reviews\| PubMed ID: 18759926	2008
Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature\| PubMed ID: 18806780	2008
Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19015530	2008
Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes\| PubMed ID: 19074986	2009
The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients. Clinical immunology (Orlando, Fla.)\| PubMed ID: 19150256	2009
A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. The Journal of experimental medicine\| PubMed ID: 19221395	2009
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Immunological reviews\| PubMed ID: 19426214	2009
Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. Clinical immunology (Orlando, Fla.)\| PubMed ID: 19443276	2009
Plasticity of CD4(+) FoxP3(+) T cells. Current opinion in immunology\| PubMed ID: 19500966	2009
T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19535634	2009
Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19561097	2009
Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology\| PubMed ID: 19574401	2009
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nature immunology\| PubMed ID: 19633673	2009
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nature immunology\| PubMed ID: 19783989	2009
Regulatory T cells as therapeutic targets in rheumatoid arthritis. Nature reviews. Rheumatology\| PubMed ID: 19798031	2009
The functional plasticity of T cell subsets. Nature reviews. Immunology\| PubMed ID: 19809471	2009
Is antigen specificity of autoreactive T cells the key to islet entry? Immunity\| PubMed ID: 19833083	2009
Autoimmunity. Current opinion in immunology\| PubMed ID: 19879742	2009
Regulatory T cells directed to the site of the action. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19955436	2009
Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes\| PubMed ID: 20299465	2010
Ten years of the Immune Tolerance Network: an integrated clinical research organization. Science translational medicine\| PubMed ID: 20371484	2010
Small RNA regulators of T cell-mediated autoimmunity. Journal of clinical immunology\| PubMed ID: 20393792	2010
Suppression of human anti-porcine natural killer cell xenogeneic responses by combinations of monoclonal antibodies specific to CD2 and NKG2D and extracellular signal-regulated kinase kinase... Immunology\| PubMed ID: 20406306	2010
Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature\| PubMed ID: 20432533	2010
Bringing transplantation tolerance into the clinic: lessons from the ITN and RISET for the Establishment of Tolerance consortia. Current opinion in organ transplantation\| PubMed ID: 20631613	2010
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer. PloS one\| PubMed ID: 20668510	2010
FK506 causes cellular and functional defects in human natural killer cells. Journal of leukocyte biology\| PubMed ID: 20671192	2010
Clusterin synergizes with IL-2 for the expansion and IFN-Î³ production of natural killer cells. Journal of leukocyte biology\| PubMed ID: 20729304	2010
The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nature reviews. Immunology\| PubMed ID: 20972473	2010
Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation\| PubMed ID: 20978464	2010
Expression of Î±vÎ²8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. The Journal of clinical investigation\| PubMed ID: 21099117	2010
Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PloS one\| PubMed ID: 21253593	2011
Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21357258	2011
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21368230	2011
Mechanisms of tolerance. Immunological reviews\| PubMed ID: 21488886	2011
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/â€ŠB7 family. Immunological reviews\| PubMed ID: 21488898	2011
How does type 1 diabetes develop?: the notion of homicide or Î²-cell suicide revisited. Diabetes\| PubMed ID: 21525508	2011
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts. The Journal of surgical research\| PubMed ID: 21571317	2011
Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21613616	2011
Regulatory T cells: stability revisited. Trends in immunology\| PubMed ID: 21620768	2011
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21742976	2011
Control of TH17 cells occurs in the small intestine. Nature\| PubMed ID: 21765430	2011
Type 1 diabetes immunotherapy: is the glass half empty or half full? Science translational medicine\| PubMed ID: 21832236	2011
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nature immunology\| PubMed ID: 21841785	2011
Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21934098	2011
A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21967896	2011
The yin and yang of interleukin-2-mediated immunotherapy. The New England journal of medicine\| PubMed ID: 22129258	2011
CD4+Foxp3+ regulatory T cell therapy in transplantation. Journal of molecular cell biology\| PubMed ID: 22170955	2012