Ian Sigal

Department of Ophthalmology, University of Pittsburgh School of Medicine

Affiliated withUniversity of Pittsburgh School of Medicine University of Pittsburgh

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2015

Other Publications

Article	Year
Finite element modeling of optic nerve head biomechanics. Investigative ophthalmology & visual science\| PubMed ID: 15557446	2004
Reconstruction of human optic nerve heads for finite element modeling. Technology and health care : official journal of the European Society for Engineering and Medicine\| PubMed ID: 16055979	2005
Factors influencing optic nerve head biomechanics. Investigative ophthalmology & visual science\| PubMed ID: 16249498	2005
Predicted extension, compression and shearing of optic nerve head tissues. Experimental eye research\| PubMed ID: 17624325	2007
Modeling individual-specific human optic nerve head biomechanics. Part II: influence of material properties. Biomechanics and modeling in mechanobiology\| PubMed ID: 18301933	2009
Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry. Biomechanics and modeling in mechanobiology\| PubMed ID: 18309526	2009
Mesh-morphing algorithms for specimen-specific finite element modeling. Journal of biomechanics\| PubMed ID: 18397789	2008
Interactions between geometry and mechanical properties on the optic nerve head. Investigative ophthalmology & visual science\| PubMed ID: 19168906	2009
Biomechanics of the optic nerve head. Experimental eye research\| PubMed ID: 19217902	2009
Deformation of the normal monkey optic nerve head connective tissue after acute IOP elevation within 3-D histomorphometric reconstructions. Investigative ophthalmology & visual science\| PubMed ID: 19628739	2009
Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes. Investigative ophthalmology & visual science\| PubMed ID: 19696175	2010
3D morphometry of the human optic nerve head. Experimental eye research\| PubMed ID: 19772858	2010
Mesh morphing and response surface analysis: quantifying sensitivity of vertebral mechanical behavior. Annals of biomedical engineering\| PubMed ID: 19859809	2010
Morphing methods to parameterize specimen-specific finite element model geometries. Journal of biomechanics\| PubMed ID: 19878950	2010
Dimensions of the human sclera: Thickness measurement and regional changes with axial length. Experimental eye research\| PubMed ID: 19900442	2010
Changes in the biomechanical response of the optic nerve head in early experimental glaucoma. Investigative ophthalmology & visual science\| PubMed ID: 20538991	2010
A geometric morphometric assessment of the optic cup in glaucoma. Experimental eye research\| PubMed ID: 20599965	2010
Deformation of the early glaucomatous monkey optic nerve head connective tissue after acute IOP elevation in 3-D histomorphometric reconstructions. Investigative ophthalmology & visual science\| PubMed ID: 20702834	2011
Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism. Experimental eye research\| PubMed ID: 20708001	2011
IOP-induced lamina cribrosa displacement and scleral canal expansion: an analysis of factor interactions using parameterized eye-specific models. Investigative ophthalmology & visual science\| PubMed ID: 20881292	2011
Finite element modeling of the human sclera: influence on optic nerve head biomechanics and connections with glaucoma. Experimental eye research\| PubMed ID: 20883693	2011
Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma. Investigative ophthalmology & visual science\| PubMed ID: 21217108	2011
3D visualization of aqueous humor outflow structures in-situ in humans. Experimental eye research\| PubMed ID: 21514296	2011
An applet to estimate the IOP-induced stress and strain within the optic nerve head. Investigative ophthalmology & visual science\| PubMed ID: 21527378	2011
Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma. Investigative ophthalmology & visual science\| PubMed ID: 21715355	2011
IOP-induced lamina cribrosa deformation and scleral canal expansion: independent or related? Investigative ophthalmology & visual science\| PubMed ID: 21989723	2011
Effect of acute intraocular pressure elevation on the monkey optic nerve head as detected by spectral domain optical coherence tomography. Investigative ophthalmology & visual science\| PubMed ID: 22058335	2011
Lamina Cribrosa Thickening in Early Glaucoma Predicted by a Microstructure Motivated Growth and Remodeling Approach. Mechanics of materials : an international journal\| PubMed ID: 22389541	2012
The optic nerve head as a robust biomechanical system. Investigative ophthalmology & visual science\| PubMed ID: 22427598	2012
Morphometric analysis of aqueous humor outflow structures with spectral-domain optical coherence tomography. Investigative ophthalmology & visual science\| PubMed ID: 22499987	2012
A few good responses: which mechanical effects of IOP on the ONH to study? Investigative ophthalmology & visual science\| PubMed ID: 22570343	2012
Visualization of the conventional outflow pathway in the living human eye. Ophthalmology\| PubMed ID: 22683063	2012
Human lamina cribrosa insertion and age. Investigative ophthalmology & visual science\| PubMed ID: 22956611	2012
High dynamic range imaging concept-based signal enhancement method reduced the optical coherence tomography measurement variability. Investigative ophthalmology & visual science\| PubMed ID: 23299477	2013
Individual A-scan signal normalization between two spectral domain optical coherence tomography devices. Investigative ophthalmology & visual science\| PubMed ID: 23611992	2013
Signal normalization reduces systematic measurement differences between spectral-domain optical coherence tomography devices. Investigative ophthalmology & visual science\| PubMed ID: 24114534	2013
Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes. Biomedical optics express\| PubMed ID: 24298418	2013
In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as assessed by optical coherence tomography. Investigative ophthalmology & visual science\| PubMed ID: 24302585	2013
Eye-specific IOP-induced displacements and deformations of human lamina cribrosa. Investigative ophthalmology & visual science\| PubMed ID: 24334450	2014
IOP elevation reduces Schlemm's canal cross-sectional area. Investigative ophthalmology & visual science\| PubMed ID: 24526436	2014
Characterisation of Schlemm's canal cross-sectional area. The British journal of ophthalmology\| PubMed ID: 24590558	2014
Gold nanorods as a contrast agent for Doppler optical coherence tomography. PloS one\| PubMed ID: 24595044	2014
Reproducibility of in-vivo OCT measured three-dimensional human lamina cribrosa microarchitecture. PloS one\| PubMed ID: 24747957	2014
Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography. Biomedical optics express\| PubMed ID: 24761293	2014
Translating ocular biomechanics into clinical practice: current state and future prospects. Current eye research\| PubMed ID: 24832392	2015
Recent advances in OCT imaging of the lamina cribrosa. The British journal of ophthalmology\| PubMed ID: 24934221	2014
Magic angle-enhanced MRI of fibrous microstructures in sclera and cornea with and without intraocular pressure loading. Investigative ophthalmology & visual science\| PubMed ID: 25103267	2014
In vivo three-dimensional characterization of the healthy human lamina cribrosa with adaptive optics spectral-domain optical coherence tomography. Investigative ophthalmology & visual science\| PubMed ID: 25228539	2014
Parameters for lithium treatment are critical in its enhancement of fracture-healing in rodents. The Journal of bone and joint surgery. American volume\| PubMed ID: 25471914	2014
In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT. Investigative ophthalmology & visual science\| PubMed ID: 26066747	2015
Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images. Investigative ophthalmology & visual science\| PubMed ID: 26066749	2015