Daniela Verthelyi

Center for Drug Evaluation and Research, US Food and Drug Administration

Affiliated withUS Food and Drug Administration

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2015

Other Publications

Article	Year
Use of CpG oligodeoxynucleotides as immune adjuvants. Immunological reviews\| PubMed ID: 15233736	2004
CpG oligodeoxynucleotides as vaccine adjuvants in primates. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11823494	2002
Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide. Journal of leukocyte biology\| PubMed ID: 11994506	2002
CpG DNA: recognition by and activation of monocytes. Microbes and infection / Institut Pasteur\| PubMed ID: 12106782	2002
CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells. European journal of immunology\| PubMed ID: 12207346	2002
Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides. Arthritis and rheumatism\| PubMed ID: 12209528	2002
CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12707351	2003
Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis. Arthritis and rheumatism\| PubMed ID: 12794839	2003
Heterogeneity in the human response to immunostimulatory CpG oligodeoxynucleotides. Journal of immunotherapy (Hagerstown, Md. : 1997)\| PubMed ID: 12843793	2003
Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability. Infection and immunity\| PubMed ID: 12933855	2003
Differential signaling by CpG DNA in DCs and B cells: not just TLR9. Trends in immunology\| PubMed ID: 14552833	2003
Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates. Clinical immunology (Orlando, Fla.)\| PubMed ID: 14585277	2003
CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques. AIDS (London, England)\| PubMed ID: 15096802	2004
Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugs. Nucleic acids research\| PubMed ID: 15972797	2005
Prevention and treatment of cutaneous leishmaniasis in primates by using synthetic type D/A oligodeoxynucleotides expressing CpG motifs. Infection and immunity\| PubMed ID: 16041009	2005
Design and development of thermolytic DNA oligonucleotide prodrugs. Annals of the New York Academy of Sciences\| PubMed ID: 16394123	2005
Female's heightened immune status: estrogen, T cells, and inducible nitric oxide synthase in the balance. Endocrinology\| PubMed ID: 16418430	2006
CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic Tacaribe arenavirus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16585590	2006
Adjuvant properties of CpG oligonucleotides in primates. Methods in molecular medicine\| PubMed ID: 16988453	2006
Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates. Nucleic acids research\| PubMed ID: 17130156	2006
GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17182538	2007
Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion. European journal of immunology\| PubMed ID: 17557373	2007
The IP10 (CXCL10) specific cDNA probe of the mCK-5c multiprobe RNase protection assay kit carries two nucleotide insertions that complicate the interpretation of results. Cytokine\| PubMed ID: 18226543	2008
Immunotherapy with CpG oligonucleotides and antibodies to TNF-alpha rescues neonatal mice from lethal arenavirus-induced meningoencephalitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18523289	2008
Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment. Nature biotechnology\| PubMed ID: 18688246	2008
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality. Journal of pharmaceutical sciences\| PubMed ID: 18704929	2009
Inhibition of Taq polymerase as a method for screening heparin for oversulfated contaminants. Biomaterials\| PubMed ID: 18801571	2008
TLRs as therapeutic targets in CNS inflammation and infection. Frontiers in bioscience (Elite edition)\| PubMed ID: 19482661	2009
High-throughput real-time PCR for early detection and quantitation of arenavirus Tacaribe. Journal of virological methods\| PubMed ID: 19490980	2009
Expression and regulation in the brain of the chemokine CCL27 gene locus. Journal of neuroimmunology\| PubMed ID: 20605223	2010
Trace levels of innate immune response modulating impurities (IIRMIs) synergize to break tolerance to therapeutic proteins. PloS one\| PubMed ID: 21203556	2010
The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides. Biomaterials\| PubMed ID: 21421264	2011
TLR9 and TLR7 agonists mediate distinct type I IFN responses in humans and nonhuman primates in vitro and in vivo. Journal of leukocyte biology\| PubMed ID: 22058422	2012
Mucosal and peripheral Lin- HLA-DR+ CD11c/123- CD13+ CD14- mononuclear cells are preferentially infected during acute simian immunodeficiency virus infection. Journal of virology\| PubMed ID: 22090100	2012
Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent. Immunology and cell biology\| PubMed ID: 22249201	2012
Induction of ebolavirus cross-species immunity using retrovirus-like particles bearing the Ebola virus glycoprotein lacking the mucin-like domain. Virology journal\| PubMed ID: 22273269	2012
Regulatory T cells in γ irradiation-induced immune suppression. PloS one\| PubMed ID: 22723935	2012
Managing uncertainty: a perspective on risk pertaining to product quality attributes as they bear on immunogenicity of therapeutic proteins. Journal of pharmaceutical sciences\| PubMed ID: 22736548	2012
High-throughput quantitative real-time polymerase chain reaction array for absolute and relative quantification of rhesus macaque types I, II, and III interferon and their subtypes. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 22817480	2012
Scientific considerations in the review and approval of generic enoxaparin in the United States. Nature biotechnology\| PubMed ID: 23471071	2013
Assessment of the cellular internalization of thermolytic phosphorothioate DNA oligonucleotide prodrugs. Bioorganic & medicinal chemistry\| PubMed ID: 23755885	2013
Glycosylation, hypogammaglobulinemia, and resistance to viral infections. The New England journal of medicine\| PubMed ID: 24716661	2014
Immunology careers at the NIH, FDA and CDC: different paths that focus on advancing public health. Nature immunology\| PubMed ID: 25594454	2015