Roland Tisch

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill

Affiliated withUniversity of North Carolina at Chapel Hill

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 14	2015

Other Publications

Article	Year
Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11751962	2002
L-selectin is not required for T cell-mediated autoimmune diabetes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11884430	2002
The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors. European journal of immunology\| PubMed ID: 12516557	2002
NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12574341	2003
More stringent conditions of plasmid DNA vaccination are required to protect grafted versus endogenous islets in nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12817032	2003
Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes. Diabetes\| PubMed ID: 12941766	2003
Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity. Blood\| PubMed ID: 15113757	2004
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. The Journal of experimental medicine\| PubMed ID: 15837817	2005
Immunoregulation of dendritic cells. Clinical medicine & research\| PubMed ID: 16160071	2005
Immunotherapy for the prevention and treatment of type 1 diabetes. International reviews of immunology\| PubMed ID: 16318984	2005
Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen. European journal of immunology\| PubMed ID: 16402405	2006
Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16424193	2006
Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice. European journal of immunology\| PubMed ID: 16821236	2006
EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16920914	2006
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells. Blood\| PubMed ID: 17008547	2007
Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17237386	2007
The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice. Diabetes\| PubMed ID: 17317763	2007
Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice. Vaccine\| PubMed ID: 17675184	2007
Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18093919	2007
MerTK is required for apoptotic cell-induced T cell tolerance. The Journal of experimental medicine\| PubMed ID: 18195070	2008
B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18292508	2008
On the pathogenicity of autoantigen-specific T-cell receptors. Diabetes\| PubMed ID: 18299317	2008
T-cell promiscuity in autoimmune diabetes. Diabetes\| PubMed ID: 18492786	2008
Parameters influencing antigen-specific immunotherapy for type 1 diabetes. Immunologic research\| PubMed ID: 18543112	2008
ANCA patients have T cells responsive to complementary PR-3 antigen. Kidney international\| PubMed ID: 18596726	2008
Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice. Clinical immunology (Orlando, Fla.)\| PubMed ID: 18675592	2008
Immunotherapy of type 1 diabetes. Archivum immunologiae et therapiae experimentalis\| PubMed ID: 18726144	2008
Parameters influencing antigen-specific immunotherapy for Type 1 diabetes. Immunologic research\| PubMed ID: 19052699	2008
Role of plasmacytoid dendritic cells in type 1 diabetes: friend or foe? Diabetes\| PubMed ID: 19114722	2009
MerTK regulates thymic selection of autoreactive T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19251650	2009
Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo. Journal of virology\| PubMed ID: 19369348	2009
Cellular immune response to cryptic epitopes during therapeutic gene transfer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19541644	2009
CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. European journal of immunology\| PubMed ID: 19658094	2009
A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells. Blood\| PubMed ID: 19667404	2009
Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19752238	2009
Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct. Autoimmunity\| PubMed ID: 19886740	2009
beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19917704	2009
Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20220085	2010
Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20348424	2010
Immunogenic versus tolerogenic dendritic cells: a matter of maturation. International reviews of immunology\| PubMed ID: 20367138	2010
Adiponectin lowers glucose production by increasing SOGA. The American journal of pathology\| PubMed ID: 20813965	2010
Dysregulation of thymic clonal deletion and the escape of autoreactive T cells. Archivum immunologiae et therapiae experimentalis\| PubMed ID: 20872284	2010
Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes. Human vaccines\| PubMed ID: 21157183	2011
Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21317396	2011
Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity. European journal of immunology\| PubMed ID: 21469091	2011
Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity. Frontiers in immunology\| PubMed ID: 22566837	2011
Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies. Diabetes\| PubMed ID: 22751694	2012
IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells. European journal of immunology\| PubMed ID: 22865049	2012
Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage. PloS one\| PubMed ID: 23251685	2012
Kinetics of adeno-associated virus serotype 2 (AAV2) and AAV8 capsid antigen presentation in vivo are identical. Human gene therapy\| PubMed ID: 23534873	2013
Manipulating T cell-mediated pathology: targets and functions of monoclonal antibody immunotherapy. Clinical immunology (Orlando, Fla.)\| PubMed ID: 23688653	2013
β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice. Diabetes\| PubMed ID: 23884888	2013
Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24198282	2013
Cutting edge: Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24890722	2014
IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25063876	2014
Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes. Archivum immunologiae et therapiae experimentalis\| PubMed ID: 25790749	2015