Harry Heimberg

Diabetes Research Center, Vrije Universiteit Brussel

Affiliated withVrije Universiteit Brussel Vrije Universiteit Brussel

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 19	2015

Other Publications

Article	Year
Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis. Endocrinology\| PubMed ID: 11751624	2002
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. The Journal of cell biology\| PubMed ID: 12403815	2002
Purification of rat pancreatic B-cells by fluorescence-activated cell sorting. Methods in molecular medicine\| PubMed ID: 12619712	2003
Nestin is expressed in vascular endothelial cells in the adult human pancreas. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 12754281	2003
Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling. Diabetes\| PubMed ID: 14514632	2003
Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc. Biochemical and biophysical research communications\| PubMed ID: 14651961	2003
Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas. Gene expression\| PubMed ID: 14686787	2003
Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochemical pharmacology\| PubMed ID: 15242807	2004
EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 15543206	2005
Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells. Life sciences\| PubMed ID: 15893773	2005
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. The EMBO journal\| PubMed ID: 16511571	2006
Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. The American journal of pathology\| PubMed ID: 17003479	2006
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. Free radical biology & medicine\| PubMed ID: 17157194	2007
Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development. Stem cells (Dayton, Ohio)\| PubMed ID: 17272496	2007
The genetic programme of pancreatic beta-cells: basic science for the development of beta-cell therapy. Workshop on programming pancreatic beta-cells. EMBO reports\| PubMed ID: 17363969	2007
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell\| PubMed ID: 18243096	2008
Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochemical pharmacology\| PubMed ID: 18377870	2008
Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters). The journal of gene medicine\| PubMed ID: 18470950	2008
Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction. Pancreas\| PubMed ID: 18665014	2009
Beta cells within single human islets originate from multiple progenitors. PloS one\| PubMed ID: 18958289	2008
Boosting beta-cell numbers. The New England journal of medicine\| PubMed ID: 19092158	2008
Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro. Gastroenterology\| PubMed ID: 19208356	2009
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell\| PubMed ID: 19665969	2009
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Developmental cell\| PubMed ID: 20059954	2009
Ectopic expression of E2F1 stimulates beta-cell proliferation and function. Diabetes\| PubMed ID: 20299467	2010
Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program. Genome research\| PubMed ID: 20395405	2010
Pancreatic beta-cells: from generation to regeneration. Seminars in cell & developmental biology\| PubMed ID: 20688184	2010
Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism. Cell transplantation\| PubMed ID: 21294959	2011
Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology\| PubMed ID: 21703267	2011
Clusters of conserved beta cell marker genes for assessment of beta cell phenotype. PloS one\| PubMed ID: 21912665	2011
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut\| PubMed ID: 22271799	2012
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming. PloS one\| PubMed ID: 22606327	2012
Gene delivery to pancreatic exocrine cells in vivo and in vitro. BMC biotechnology\| PubMed ID: 23088534	2012
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (Cambridge, England)\| PubMed ID: 23325761	2013
Suppression of Epithelial to Mesenchymal Transitioning (EMT) Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue towards Functional Insulin Producing Î²-Like Cells. Diabetes\| PubMed ID: 23610058	2013
Reversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cells. PloS one\| PubMed ID: 23671681	2013
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. Developmental cell\| PubMed ID: 23810513	2013
Conditional hypovascularization and hypoxia in islets do not overtly influence adult β-cell mass or function. Diabetes\| PubMed ID: 23974922	2013
Mouse beta cell proliferation is inhibited by thymidine analogue labelling. Diabetologia\| PubMed ID: 24026213	2013
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. The EMBO journal\| PubMed ID: 24045232	2013
Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes. Diabetologia\| PubMed ID: 24121626	2014
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS genetics\| PubMed ID: 24204325	2013
Reversal of hyperglycemia in diabetic mice by a marginal islet mass together with human blood outgrowth endothelial cells is independent of the delivery technique and blood clot-induced proc... Islets\| PubMed ID: 24213480	2013
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nature biotechnology\| PubMed ID: 24240391	2014
Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells. Stem cells translational medicine\| PubMed ID: 24493854	2014
Downregulation of Sox9 expression associates with hepatogenic differentiation of human liver mesenchymal stem/progenitor cells. Stem cells and development\| PubMed ID: 24548059	2014
IL-6-dependent proliferation of alpha cells in mice with partial pancreatic-duct ligation. Diabetologia\| PubMed ID: 24759958	2014
Partial duct ligation: β-cell proliferation and beyond. Diabetes\| PubMed ID: 25060885	2014
Clinical Immunosuppressants Inhibit Inflammatory, Proliferative And Reprogramming Potential, But Not Angiogenesis Of Human Pancreatic Duct Cells. Cell transplantation\| PubMed ID: 25198311	2014
In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression. Molecular and cellular endocrinology\| PubMed ID: 25224487	2015
Combining MK626, a novel DPP-4 inhibitor, and low-dose monoclonal CD3 antibody for stable remission of new-onset diabetes in mice. PloS one\| PubMed ID: 25268801	2014
Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas. European journal of immunology\| PubMed ID: 25645754	2015
Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration. Stem cells translational medicine\| PubMed ID: 25848123	2015
Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor. Stem cells and development\| PubMed ID: 25925840	2015
Estrogen Receptor α Regulates Beta Cell Formation During Pancreas Development and Following Injury. Diabetes\| PubMed ID: 26015547	2015
Islet Transplantation for Type 1 Diabetes: So Close and Yet So Far away. European journal of endocrinology / European Federation of Endocrine Societies\| PubMed ID: 26036437	2015