L. James Lee

NSF Nanoscale Science and Engineering Center for Affordable Nanoengineering of Polymeric Biomedical Devices, The Ohio State University

Affiliated withThe Ohio State University

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2015

Other Publications

Article	Year
A packaging technique for polymer microfluidic platforms. Analytical chemistry\| PubMed ID: 14961752	2004
Design of a novel hydrogel-based intelligent system for controlled drug release. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 15023451	2004
Design of a compact disk-like microfluidic platform for enzyme-linked immunosorbent assay. Analytical chemistry\| PubMed ID: 15053640	2004
Fabrication of well-defined PLGA scaffolds using novel microembossing and carbon dioxide bonding. Biomaterials\| PubMed ID: 15585261	2005
Generating highly ordered DNA nanostrand arrays. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16352724	2005
Self-folding of three-dimensional hydrogel microstructures. The journal of physical chemistry. B\| PubMed ID: 16375273	2005
Polymer nano-engineering for biomedical applications. Annals of biomedical engineering\| PubMed ID: 16541328	2006
Surface modification for enhancing antibody binding on polymer-based microfluidic device for enzyme-linked immunosorbent assay. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 17042569	2006
Assembly of three-dimensional polymeric constructs containing cells/biomolecules using carbon dioxide. Journal of the American Chemical Society\| PubMed ID: 17061882	2006
Microfluidic enzyme-linked immunosorbent assay technology. Advances in clinical chemistry\| PubMed ID: 17131629	2006
Dynamic assembly by electrokinetic microfluidics. Journal of the American Chemical Society\| PubMed ID: 17212387	2007
New valve and bonding designs for microfluidic biochips containing proteins. Analytical chemistry\| PubMed ID: 17263327	2007
Fabrication of particulate reservoir-containing, capsulelike, and self-folding polymer microstructures for drug delivery. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 17285662	2007
Hydrophilic surface modification of cyclic olefin copolymer microfluidic chips using sequential photografting. Journal of separation science\| PubMed ID: 17566345	2007
Gene transfection of mammalian cells using membrane sandwich electroporation. Analytical chemistry\| PubMed ID: 17600386	2007
A novel Raji-Burkitt's lymphoma model for preclinical and mechanistic evaluation of CD52-targeted immunotherapeutic agents. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18223233	2008
Packaging of microfluidic chips via interstitial bonding technique. Electrophoresis\| PubMed ID: 18318005	2008
Flow-guided assembly processes. Chemphyschem : a European journal of chemical physics and physical chemistry\| PubMed ID: 18351685	2008
Electrokinetics induced asymmetric transport in polymeric nanonozzles. Lab on a chip\| PubMed ID: 18369512	2008
Cationic lipid-coated magnetic nanoparticles associated with transferrin for gene delivery. International journal of pharmaceutics\| PubMed ID: 18384982	2008
A facile microfluidic method for production of liposomes. Anticancer research\| PubMed ID: 18507040	2008
Growth and alignment of polyaniline nanofibres with superhydrophobic, superhydrophilic and other properties. Nature nanotechnology\| PubMed ID: 18654306	2007
A biodegradable, immunoprotective, dual nanoporous capsule for cell-based therapies. Biomaterials\| PubMed ID: 18694595	2008
Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells. Blood\| PubMed ID: 18772452	2008
A novel liposomal formulation of flavopiridol. International journal of pharmaceutics\| PubMed ID: 18778761	2009
Protein A-based antibody immobilization onto polymeric microdevices for enhanced sensitivity of enzyme-linked immunosorbent assay. Biotechnology and bioengineering\| PubMed ID: 18942150	2009
Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against Bcl-2. Molecular pharmaceutics\| PubMed ID: 19183107	2009
Transferrin receptor targeted lipopolyplexes for delivery of antisense oligonucleotide g3139 in a murine k562 xenograft model. Pharmaceutical research\| PubMed ID: 19291371	2009
Targeted delivery systems for oligonucleotide therapeutics. The AAPS journal\| PubMed ID: 19296227	2009
Bioassembly of three-dimensional embryonic stem cell-scaffold complexes using compressed gases. Biotechnology progress\| PubMed ID: 19334083	2009
Semicontinuous flow electroporation chip for high-throughput transfection on mammalian cells. Analytical chemistry\| PubMed ID: 19419195	2009
Preparation, characterization and pharmacokinetics of folate receptor-targeted liposomes for docetaxel delivery. Journal of nanoscience and nanotechnology\| PubMed ID: 19435095	2009
Coaxial electrohydrodynamic spraying: a novel one-step technique to prepare oligodeoxynucleotide encapsulated lipoplex nanoparticles. Molecular pharmaceutics\| PubMed ID: 19499922	2009
Single-molecule DNA dynamics in tapered contraction-expansion microchannels under electrophoresis. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 19518260	2009
Delivery of polyethylenimine/DNA complexes assembled in a microfluidics device. Molecular pharmaceutics\| PubMed ID: 19552481	2009
Specific antibody immobilization with biotin-poly(L-lysine)-g-poly(ethylene glycol) and protein A on microfluidic chips. Journal of immunological methods\| PubMed ID: 19647744	2009
Design and testing of a microfluidic biochip for cytokine enzyme-linked immunosorbent assay. Biomicrofluidics\| PubMed ID: 19693336	2009
Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 19716852	2010
Efficient delivery of antisense oligodeoxyribonucleotide g3139 by human serum albumin-coated liposomes. Molecular pharmaceutics\| PubMed ID: 19725564	2009
Coaxial electrohydrodynamic spraying of plasmid DNA/polyethylenimine (PEI) polyplexes for enhanced nonviral gene delivery. Biotechnology and bioengineering\| PubMed ID: 19845020	2010
Targeted delivery of antisense oligodeoxynucleotide by transferrin conjugated pH-sensitive lipopolyplex nanoparticles: a novel oligonucleotide-based therapeutic strategy in acute myeloid leu... Molecular pharmaceutics\| PubMed ID: 19852511	2010
Microfluidic methods for production of liposomes. Methods in enzymology\| PubMed ID: 19913165	2009
Micronozzle array enhanced sandwich electroporation of embryonic stem cells. Analytical chemistry\| PubMed ID: 19961232	2010
Nanoimprinting using self-assembled ceramic nanoislands. Nanotechnology\| PubMed ID: 20009202	2010
Disulfide-linked liposomes: effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139. Anticancer research\| PubMed ID: 20150614	2010
Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells. International journal of pharmaceutics\| PubMed ID: 20156537	2010
Lipid-coated nano-calcium-phosphate (LNCP) for gene delivery. International journal of pharmaceutics\| PubMed ID: 20214964	2010
High throughput assembly of spatially controlled 3D cell clusters on a micro/nanoplatform. Lab on a chip\| PubMed ID: 20221567	2010
Ultrasound-enhanced microfluidic synthesis of liposomes. Anticancer research\| PubMed ID: 20332455	2010
Targeted nanoparticles enhanced flow electroporation of antisense oligonucleotides in leukemia cells. Biosensors & bioelectronics\| PubMed ID: 20630739	2010
Large laterally ordered nanochannel arrays from DNA combing and imprinting. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 20730809	2010
Patterning nanowire and micro-nanoparticle array on micropillar-structured surface: Experiment and modeling. Biomicrofluidics\| PubMed ID: 20805999	2010
Micropatterning and characterization of electrospun poly(ε-caprolactone)/gelatin nanofiber tissue scaffolds by femtosecond laser ablation for tissue engineering applications. Biotechnology and bioengineering\| PubMed ID: 20812254	2011
Formation and finite element analysis of tethered bilayer lipid structures. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20977245	2010
Receptor-targeted nanocarriers for therapeutic delivery to cancer. Molecular membrane biology\| PubMed ID: 21028937	2010
Use of a nanoporous biodegradable miniature device to regulate cytokine release for cancer treatment. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21362447	2011
A covalently stabilized lipid-polycation-DNA (sLPD) vector for antisense oligonucleotide delivery. Molecular pharmaceutics\| PubMed ID: 21366344	2011
Electroporation dependence on cell size: optical tweezers study. Analytical chemistry\| PubMed ID: 21473595	2011
Microfluidic assembly of lipid-based oligonucleotide nanoparticles. Anticancer research\| PubMed ID: 21498694	2011
Efficient down-regulation of CDK4 by novel lipid nanoparticle-mediated siRNA delivery. Anticancer research\| PubMed ID: 21617218	2011
MicroRNA delivery by cationic lipoplexes for lung cancer therapy. Molecular pharmaceutics\| PubMed ID: 21648427	2011
Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells. Pharmaceutical research\| PubMed ID: 21710341	2011
Uptake and intracellular fate of multifunctional nanoparticles: a comparison between lipoplexes and polyplexes via quantum dot mediated FÃ¶rster resonance energy transfer. Molecular pharmaceutics\| PubMed ID: 21740056	2011
Nanochannel electroporation delivers precise amounts of biomolecules into living cells. Nature nanotechnology\| PubMed ID: 22002097	2011
SPANosomes as Delivery Vehicles for Small Interfering RNA (siRNA). Molecular pharmaceutics\| PubMed ID: 22149175	2012
Efficient siRNA Delivery Using a Polyamidoamine Dendrimer with a Modified Pentaerythritol Core. Pharmaceutical research\| PubMed ID: 22274556	2012
Differential efficacy of DOTAP enantiomers for siRNA delivery in vitro. International journal of pharmaceutics\| PubMed ID: 22525086	2012
Micro/nanoscale technologies for the development of hormone-expressing islet-like cell clusters. Biomedical microdevices\| PubMed ID: 22573223	2012
The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-L-lysine. Biomaterials\| PubMed ID: 22575837	2012
Novel lipoidal amine-based nanocarrier formulations for siRNA delivery. Therapeutic delivery\| PubMed ID: 22838067	2012
Micropatterned thermoresponsive surfaces by polymerization of monomer crystals: modulating cellular morphology and cell-substrate interactions. Analytical chemistry\| PubMed ID: 23025496	2012
Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma. International journal of nanomedicine\| PubMed ID: 23093902	2012
High-performance nanopapers based on benzenesulfonic functionalized graphenes. ACS nano\| PubMed ID: 23098084	2012
Lenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia. Blood\| PubMed ID: 23100311	2013
Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 23117046	2013
Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia. Blood\| PubMed ID: 23165478	2012
A naonoporous cell-therapy device with controllable biodegradation for long-term drug release. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 23228849	2013
Micro-/nanofluidics based cell electroporation. Biomicrofluidics\| PubMed ID: 23405056	2013
Surface-mediated nucleic acid delivery by lipoplexes prepared in microwell arrays. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23471869	2013
Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer. Molecular therapy. Nucleic acids\| PubMed ID: 23591808	2013
Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells. Biomaterials\| PubMed ID: 23726226	2013
Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 23727126	2013
Atomic carbide bonding leading to superior graphene networks. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 23852915	2013
Graphene-coated Si mold for precision glass optics molding. Optics letters\| PubMed ID: 23939130	2013
A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 23969101	2014
Nonendocytic delivery of lipoplex nanoparticles into living cells using nanochannel electroporation. Advanced healthcare materials\| PubMed ID: 23996973	2014
Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons. Analytical chemistry\| PubMed ID: 24102152	2013
Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24121065	2013
Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology (Baltimore, Md.)\| PubMed ID: 24122827	2014
Design of a microchannel-nanochannel-microchannel array based nanoelectroporation system for precise gene transfection. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 24173879	2014
Microwell array guided assembly of lipoplex nanoparticles containing siRNA. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 24564319	2014
Insight into mechanisms of cellular uptake of lipid nanoparticles and intracellular release of small RNAs. Pharmaceutical research\| PubMed ID: 24740244	2014
Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 24927402	2014
A microfluidic method to synthesize transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia. Nanoscale\| PubMed ID: 25003978	2014
Microwell array-mediated delivery of lipoplexes containing nucleic acids for enhanced therapeutic efficacy. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25319649	2015
Targeted delivery of tumor suppressor microRNA-1 by transferrin-conjugated lipopolyplex nanoparticles to patient-derived glioblastoma stem cells. Current pharmaceutical biotechnology\| PubMed ID: 25374033	2014
Preparation and evaluation of a novel liposomal formulation of cisplatin. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences\| PubMed ID: 25446511	2014
Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog. Biochimica et biophysica acta\| PubMed ID: 25447674	2015
Magnetic Tweezers-Based 3D Microchannel Electroporation for High-Throughput Gene Transfection in Living Cells. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 25469659	2015
Effect of nonendocytic uptake of nanoparticles on human bronchial epithelial cells. Analytical chemistry\| PubMed ID: 25671340	2015
Selective targeting of alveolar type II respiratory epithelial cells by anti-surfactant protein-C antibody-conjugated lipoplexes. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 25687308	2015
CD33-Targeted Lipid Nanoparticles (aCD33LNs) for Therapeutic Delivery of GTI-2040 to Acute Myelogenous Leukemia. Molecular pharmaceutics\| PubMed ID: 25871632	2015
ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo. Experimental hematology\| PubMed ID: 25937048	2015