Alex B. Burgin

SPARC Committee, Broad Institute

Research Area

Biography

Alex B. Burgin has not added Biography.
If you are Alex B. Burgin and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2015

Other Publications

Article	Year
Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism. The Journal of biological chemistry\| PubMed ID: 12050172	2002
The mechanism of topoisomerase I poisoning by a camptothecin analog. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12426403	2002
Regulation of site-specific recombination by the C-terminus of lambda integrase. Nucleic acids research\| PubMed ID: 12466544	2002
A two-drug model for etoposide action against human topoisomerase IIalpha. The Journal of biological chemistry\| PubMed ID: 12473657	2003
Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex. The Journal of biological chemistry\| PubMed ID: 12533542	2003
Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage. Biochemistry\| PubMed ID: 12653542	2003
Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues. Journal of molecular biology\| PubMed ID: 15111055	2004
Mechanisms of camptothecin resistance by human topoisomerase I mutations. Journal of molecular biology\| PubMed ID: 15165849	2004
Design and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I. Nucleic acids research\| PubMed ID: 15333697	2004
Catalytic residues of the telomere resolvase ResT: a pattern similar to, but distinct from, tyrosine recombinases and type IB topoisomerases. The Journal of biological chemistry\| PubMed ID: 15471873	2004
Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I. The Journal of biological chemistry\| PubMed ID: 15489506	2004
DNA ligation catalyzed by human topoisomerase II alpha. Biochemistry\| PubMed ID: 15491148	2004
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. Journal of medicinal chemistry\| PubMed ID: 15801827	2005
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1). The Journal of biological chemistry\| PubMed ID: 15811850	2005
Uncoupling the chemical steps of telomere resolution by ResT. The Journal of biological chemistry\| PubMed ID: 15917226	2005
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Molecular cancer therapeutics\| PubMed ID: 16505102	2006
Tyrosyl-DNA phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA phosphodiesterase). Methods in enzymology\| PubMed ID: 16793421	2006
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry\| PubMed ID: 18318502	2008
Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage. Nucleic acids research\| PubMed ID: 18653531	2008
Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. Biochemistry\| PubMed ID: 19222228	2009
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. Journal of medicinal chemistry\| PubMed ID: 19618939	2009
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry\| PubMed ID: 19697956	2009
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nature biotechnology\| PubMed ID: 20037581	2010
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature\| PubMed ID: 20485342	2010
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Nucleic acids research\| PubMed ID: 21300644	2011
Small molecule allosteric modulators of phosphodiesterase 4. Handbook of experimental pharmacology\| PubMed ID: 21695640	2011
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell\| PubMed ID: 22304913	2012
Artificial neural networks trained to detect viral and phage structural proteins. PLoS computational biology\| PubMed ID: 22927809	2012
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23139410	2012
Structure and function of a cyanophage-encoded peptide deformylase. The ISME journal\| PubMed ID: 23407310	2013
Structural basis for the design of selective phosphodiesterase 4B inhibitors. Cellular signalling\| PubMed ID: 24361374	2014
Discovery of triazines as selective PDE4B versus PDE4D inhibitors. Bioorganic & medicinal chemistry letters\| PubMed ID: 24998378	2014
Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 25371167	2015
A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1. PloS one\| PubMed ID: 25909780	2015
Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor. Structure (London, England : 1993)\| PubMed ID: 26027732	2015