Stephen M. Beverley

Department of Molecular Microbiology, Washington University School of Medicine

Affiliated withWashington University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 65	2010

Other Publications

Article	Year
Putting the Leishmania genome to work: functional genomics by transposon trapping and expression profiling. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 11839181	2002
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production. Protein expression and purification\| PubMed ID: 12135552	2002
Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major. The Journal of biological chemistry\| PubMed ID: 12151409	2002
Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability. The EMBO journal\| PubMed ID: 12198148	2002
Protozomics: trypanosomatid parasite genetics comes of age. Nature reviews. Genetics\| PubMed ID: 12509749	2003
Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival. Infection and immunity\| PubMed ID: 12540574	2003
Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactions. The Journal of biological chemistry\| PubMed ID: 12604613	2003
Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania. Molecular and biochemical parasitology\| PubMed ID: 12742588	2003
Identification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania major. The Journal of biological chemistry\| PubMed ID: 12750366	2003
The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12869694	2003
Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major. The Journal of biological chemistry\| PubMed ID: 12944391	2003
Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major. Molecular and biochemical parasitology\| PubMed ID: 12946844	2003
Persistence without pathology in phosphoglycan-deficient Leishmania major. Science (New York, N.Y.)\| PubMed ID: 12947201	2003
The H region HTBF gene mediates terbinafine resistance in Leishmania major. Molecular and biochemical parasitology\| PubMed ID: 12967714	2003
An in vitro system for developmental and genetic studies of Leishmania donovani phosphoglycans. Molecular and biochemical parasitology\| PubMed ID: 14550894	2003
Sphingolipids are essential for differentiation but not growth in Leishmania. The EMBO journal\| PubMed ID: 14609948	2003
Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15004184	2004
The LPG1 gene family of Leishmania major. Molecular and biochemical parasitology\| PubMed ID: 15138063	2004
Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania majo... Molecular and biochemical parasitology\| PubMed ID: 15138069	2004
In vitro shuttle mutagenesis using engineered mariner transposons. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15153636	2004
Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virule... Infection and immunity\| PubMed ID: 15155672	2004
The application of gene expression microarray technology to kinetoplastid research. Current molecular medicine\| PubMed ID: 15357212	2004
Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites. Nature medicine\| PubMed ID: 15448686	2004
Flypaper for parasites. Cell\| PubMed ID: 15507202	2004
Reconstitution of GDP-mannose transport activity with purified Leishmania LPG2 protein in liposomes. The Journal of biological chemistry\| PubMed ID: 15542612	2005
从诱导细菌或原生动物寄生虫利什曼原虫主要挑战的&#x6C9... Infection and immunity\| PubMed ID: 15557638	2004
Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis. Molecular microbiology\| PubMed ID: 15720561	2005
Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens. Eukaryotic cell\| PubMed ID: 15947206	2005
Identification of a DNA fragment that increases mitotic stability of episomal linear DNAs in Leishmania major. International journal for parasitology\| PubMed ID: 15996670	2005
The genome of the kinetoplastid parasite, Leishmania major. Science (New York, N.Y.)\| PubMed ID: 16020728	2005
Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. Journal of molecular biology\| PubMed ID: 16055151	2005
Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase. Glycobiology\| PubMed ID: 16272216	2006
Immunization with persistent attenuated Delta lpg2 Leishmania major parasites requires adjuvant to provide protective immunity in C57BL/6 mice. Infection and immunity\| PubMed ID: 16369039	2006
Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications... Molecular and biochemical parasitology\| PubMed ID: 16464509	2006
Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence. The Journal of biological chemistry\| PubMed ID: 17032644	2006
Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. The EMBO journal\| PubMed ID: 17290222	2007
A lipophosphoglycan-independent development of Leishmania in permissive sand flies. Microbes and infection / Institut Pasteur\| PubMed ID: 17307009	2007
Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major. The Journal of biological chemistry\| PubMed ID: 17347153	2007
Comparisons of mutants lacking the Golgi UDP-galactose or GDP-mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania maj... Infection and immunity\| PubMed ID: 17606605	2007
Characterization of inositol phosphorylceramides from Leishmania major by tandem mass spectrometry with electrospray ionization. Journal of the American Society for Mass Spectrometry\| PubMed ID: 17627842	2007
The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major. The Journal of biological chemistry\| PubMed ID: 17981801	2008
Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms. Plant physiology\| PubMed ID: 18245455	2008
Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice. Experimental parasitology\| PubMed ID: 18682252	2008
Developmentally regulated sphingolipid synthesis in African trypanosomes. Molecular microbiology\| PubMed ID: 18699867	2008
Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana. Molecular microbiology\| PubMed ID: 19017272	2009
Migratory dermal dendritic cells act as rapid sensors of protozoan parasites. PLoS pathogens\| PubMed ID: 19043558	2008
Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major. Molecular microbiology\| PubMed ID: 19183277	2009
Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts. Experimental parasitology\| PubMed ID: 19328787	2009
Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector. Science (New York, N.Y.)\| PubMed ID: 19359589	2009
A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major. PLoS pathogens\| PubMed ID: 19381261	2009
Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19383793	2009
Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice. Molecular and biochemical parasitology\| PubMed ID: 19393161	2009
PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major. Current genetics\| PubMed ID: 19396443	2009
The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major. Molecular and biochemical parasitology\| PubMed ID: 19450731	2009
Leishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functions. Infection and immunity\| PubMed ID: 19487470	2009
Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19666482	2009
A transposon toolkit for gene transfer and mutagenesis in protozoan parasites. Genetica\| PubMed ID: 19763844	2010
Identification of transport-critical residues in a folate transporter from the folate-biopterin transporter (FBT) family. The Journal of biological chemistry\| PubMed ID: 19923217	2010
Degradation of host sphingomyelin is essential for Leishmania virulence. PLoS pathogens\| PubMed ID: 20011126	2009
Phospholipid and sphingolipid metabolism in Leishmania. Molecular and biochemical parasitology\| PubMed ID: 20026359	2010
Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors. PLoS neglected tropical diseases\| PubMed ID: 20084096	2010
Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies. Cellular microbiology\| PubMed ID: 20088949	2010
Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major. Glycobiology\| PubMed ID: 20335578	2010
Monitoring the efficacy of antimicrobial photodynamic therapy in a murine model of cutaneous leishmaniasis using L. major expressing GFP. Journal of biophotonics\| PubMed ID: 20376860	2010
Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20404152	2010
A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20489182	2010
Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20551225	2010
Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes. Molecular and biochemical parasitology\| PubMed ID: 20869991	2011
Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major. Molecular and biochemical parasitology\| PubMed ID: 20887755	2011
Sphingolipids in parasitic protozoa. Advances in experimental medicine and biology\| PubMed ID: 20919659	2010
Retention and loss of RNA interference pathways in trypanosomatid protozoans. PLoS pathogens\| PubMed ID: 21060810	2010
Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern. PLoS pathogens\| PubMed ID: 21085609	2010
Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes. Infection and immunity\| PubMed ID: 21189319	2011
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. Science (New York, N.Y.)\| PubMed ID: 21311023	2011
The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing. PLoS neglected tropical diseases\| PubMed ID: 21886855	2011
Muco-cutaneous leishmaniasis in the New World: the ultimate subversion. Virulence\| PubMed ID: 21971185	2011
Folate metabolic pathways in Leishmania. Essays in biochemistry\| PubMed ID: 22023442	2011
[Mucocutaneous leishmaniasis and an undesired passenger]. MÃ©decine sciences : M/S\| PubMed ID: 22130014	2011
Killed but metabolically active Leishmania as a novel whole-cell vaccine for visceral leishmaniasis. Clinical and vaccine immunology : CVI\| PubMed ID: 22323556	2012