Lena Serghides

Toronto General Research Institute, University Health Network

Affiliated withUniversity Health Network University Health Network

Research Area

Biography

Lena Serghides has not added Biography.
If you are Lena Serghides and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2015

Other Publications

Article	Year
CD36 deficiency induced by antiretroviral therapy. AIDS (London, England)\| PubMed ID: 11834946	2002
Mechanism of protection induced by vitamin A in falciparum malaria. Lancet (London, England)\| PubMed ID: 11978340	2002
CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. Infection and immunity\| PubMed ID: 12496189	2003
Innate immunity to malaria caused by Plasmodium falciparum. Clinical and investigative medicine. Médecine clinique et experimentale\| PubMed ID: 12516999	2002
CD36 and malaria: friends or foes? Trends in parasitology\| PubMed ID: 14519584	2003
Effect of HIV-1 antiretroviral drugs on cytoadherence and phagocytic clearance of Plasmodium falciparum-parasitised erythrocytes. Lancet (London, England)\| PubMed ID: 14522535	2003
CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. The Journal of infectious diseases\| PubMed ID: 14722884	2004
Peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists have minimal effects on the interaction of endothelial cells with Plasmodium falciparum-infected erythrocyte... Infection and immunity\| PubMed ID: 15664966	2005
Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum. Infection and immunity\| PubMed ID: 15784606	2005
Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16272289	2005
Placental chondroitin sulfate A-binding malarial isolates evade innate phagocytic clearance. The Journal of infectious diseases\| PubMed ID: 16741892	2006
Approaches to studying costimulation of human antiviral T cell responses: prospects for immunotherapeutic vaccines. Immunologic research\| PubMed ID: 17003516	2006
Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17056565	2006
Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17339496	2007
HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites. PLoS medicine\| PubMed ID: 17535103	2007
Pyruvate kinase deficiency and malaria. The New England journal of medicine\| PubMed ID: 18420493	2008
C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. The Journal of experimental medicine\| PubMed ID: 18426986	2008
C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. PloS one\| PubMed ID: 19308263	2009
Rosiglitazone modulates the innate immune response to Plasmodium falciparum infection and improves outcome in experimental cerebral malaria. The Journal of infectious diseases\| PubMed ID: 19392627	2009
Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 19673614	2009
Cerebral malaria: human versus mouse studies. Trends in parasitology\| PubMed ID: 20382077	2010
Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20876354	2010
Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale. Medical hypotheses\| PubMed ID: 21745716	2011
The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria. PPAR research\| PubMed ID: 21772838	2012
Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. PloS one\| PubMed ID: 22110737	2011
A phase I clinical study of inhaled nitric oxide in healthy adults. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society\| PubMed ID: 22520076	2012
HIV infection deregulates innate immunity to malaria despite combination antiretroviral therapy. AIDS (London, England)\| PubMed ID: 23291537	2013
HIV infection deregulates Tim-3 expression on innate cells: combination antiretroviral therapy results in partial restoration. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 23314411	2013
Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infection and immunity\| PubMed ID: 24191300	2014
The importance of motherhood in HIV-positive women of reproductive age in Ontario, Canada. AIDS care\| PubMed ID: 24206065	2014
Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 24256632	2014
PPARγ agonists improve survival and neurocognitive outcomes in experimental cerebral malaria and induce neuroprotective pathways in human malaria. PLoS pathogens\| PubMed ID: 24603727	2014
HIV protease inhibitor use during pregnancy is associated with decreased progesterone levels, suggesting a potential mechanism contributing to fetal growth restriction. The Journal of infectious diseases\| PubMed ID: 25030058	2015
Chronic HIV infection impairs nonopsonic phagocytosis of malaria parasites. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 25415293	2015