Xiaoxin Chen

Cancer Research Program, North Carolina Central University

Affiliated withNorth Carolina Central University University of North Carolina at Chapel Hill University of Waterloo

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 8	2015
Publication title	2026

Other Publications

Article	Year
Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans. Carcinogenesis\| PubMed ID: 11756233	2002
Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis\| PubMed ID: 12151348	2002
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat su... Carcinogenesis\| PubMed ID: 12507933	2002
[Chemopreventive effect of tea and curcumin on DMBA-induced oral carcinogenesis in hamsters]. Wei sheng yan jiu = Journal of hygiene research\| PubMed ID: 12572355	2002
Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin. Journal of the National Cancer Institute\| PubMed ID: 12865451	2003
Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis\| PubMed ID: 15073046	2004
Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 15094711	2004
Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15475461	2004
Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15756036	2005
Selection of topically applied non-steroidal anti-inflammatory drugs for oral cancer chemoprevention. Oral oncology\| PubMed ID: 15975519	2005
Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenes... Carcinogenesis\| PubMed ID: 16632477	2006
Development of an immunocytokine, IL-2-183B2scFv, for targeted immunotherapy of ovarian cancer. Gynecologic oncology\| PubMed ID: 16806435	2006
Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. Carcinogenesis\| PubMed ID: 16990345	2007
Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids. Prostaglandins, leukotrienes, and essential fatty acids\| PubMed ID: 17011176	2006
Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention. Current cancer drug targets\| PubMed ID: 17100567	2006
Identification of arsenic-binding proteins in human breast cancer cells. Cancer letters\| PubMed ID: 17499915	2007
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of a dual inhibitor of epidermal growth factor receptor (EG... Oral oncology\| PubMed ID: 17936675	2008
Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers. BMC gastroenterology\| PubMed ID: 18190713	2008
Depletion of beta-arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18390755	2008
Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model. Carcinogenesis\| PubMed ID: 18687669	2008
Effect of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal adenocarcinoma formation in a rat surgical model. International journal of cancer. Journal international du cancer\| PubMed ID: 19058177	2009
Differential gene expression in normal esophagus and Barrett's esophagus. Journal of gastroenterology\| PubMed ID: 19468668	2009
Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice. BMC gastroenterology\| PubMed ID: 19627616	2009
Stimuli-responsive wettability of nonplanar substrates: pH-controlled floatation and supporting force. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 19639980	2010
Zebrafish K5 promoter driven GFP expression as a transgenic system for oral research. Oral oncology\| PubMed ID: 19932050	2010
Chemoprevention of oral cancer in animal models, and effect on leukoplakias in human patients with ZengShengPing, a mixture of medicinal herbs. Oral oncology\| PubMed ID: 20022553	2010
Detecting precancerous lesions in the hamster cheek pouch using spectroscopic white-light optical coherence tomography to assess nuclear morphology via spectral oscillations. Journal of biomedical optics\| PubMed ID: 20059268	2009
Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2 Delta N. Transgenic research\| PubMed ID: 20099029	2010
Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM\| PubMed ID: 20499322	2010
Tryptase staining of mast cells may differentiate eosinophilic esophagitis from gastroesophageal reflux disease. The American journal of gastroenterology\| PubMed ID: 20978486	2011
Chemopreventive effects of early-stage and late-stage supplementation of vitamin E and selenium on esophageal carcinogenesis in rats maintained on a low vitamin E/selenium diet. Carcinogenesis\| PubMed ID: 21186300	2011
Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 21881027	2011
Structural identification of mouse fecal metabolites of theaflavin 3,3'-digallate using liquid chromatography tandem mass spectrometry. Journal of chromatography. A\| PubMed ID: 21906744	2011
Molecular aspects of esophageal development. Annals of the New York Academy of Sciences\| PubMed ID: 21950820	2011
Molecular mechanisms of Barrett's esophagus and adenocarcinoma. Annals of the New York Academy of Sciences\| PubMed ID: 21950830	2011
Molecular mechanisms of Barrett's esophagus. Digestive diseases and sciences\| PubMed ID: 21984436	2011
Time-selective chemoprevention of vitamin E and selenium on esophageal carcinogenesis in rats: the possible role of nuclear factor kappaB signaling pathway. International journal of cancer. Journal international du cancer\| PubMed ID: 22223226	2012
Metabolism of [6]-shogaol in mice and in cancer cells. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 22246389	2012
The decreased expression of Beclin-1 correlates with progression to esophageal adenocarcinoma: the role of deoxycholic acid. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 22301112	2012
Review: Experimental models for Barrett's esophagus and esophageal adenocarcinoma. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 22421618	2012
Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus. International journal of biochemistry and molecular biology\| PubMed ID: 22509480	2012
Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus. PloS one\| PubMed ID: 22567161	2012
Focal endoscopic mucosal resection before radiofrequency ablation is equally effective and safe compared with radiofrequency ablation alone for the eradication of Barrett's esophagus with ad... Gastrointestinal endoscopy\| PubMed ID: 22732872	2012
Diagnostic utility of major basic protein, eotaxin-3, and leukotriene enzyme staining in eosinophilic esophagitis. The American journal of gastroenterology\| PubMed ID: 22777338	2012
6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cells. Journal of agricultural and food chemistry\| PubMed ID: 23066935	2012
Safety and efficacy of endoscopic mucosal therapy with radiofrequency ablation for patients with neoplastic Barrett's esophagus. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 23103824	2013
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol. Nutrition and cancer\| PubMed ID: 23137051	2012
Intestinal metaplasia recurs infrequently in patients successfully treated for Barrett's esophagus with radiofrequency ablation. The American journal of gastroenterology\| PubMed ID: 23247578	2013
Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol. Molecular nutrition & food research\| PubMed ID: 23322393	2013
Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. Cell stem cell\| PubMed ID: 23472872	2013
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23589623	2013
Two novel nanoscale preparations of micelle and thermosensitive hydrogel for docetaxel to treat malignant tumor. Journal of biomedical nanotechnology\| PubMed ID: 23620990	2013
Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice. Chemical research in toxicology\| PubMed ID: 23638641	2013
Gastroesophageal reflux activates the NF-κB pathway and impairs esophageal barrier function in mice. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 23639809	2013
Synthesis, characterization, and application of amino-terminated poly(ethylene glycol)-block-poly(epsilon-caprolactone) copolymer for paclitaxel. Journal of nanoscience and nanotechnology\| PubMed ID: 23646699	2013
Transgenic overexpression of cdx1b induces metaplastic changes of gene expression in zebrafish esophageal squamous epithelium. Zebrafish\| PubMed ID: 23672288	2013
Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Gut\| PubMed ID: 23676441	2014
Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus. Digestive diseases and sciences\| PubMed ID: 23918153	2014
Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma. Annals of the New York Academy of Sciences\| PubMed ID: 24117642	2013
Tissue resistance in the normal and diseased esophagus. Annals of the New York Academy of Sciences\| PubMed ID: 24117643	2013
Identification and pharmacokinetics of novel alkylresorcinol metabolites in human urine, new candidate biomarkers for whole-grain wheat and rye intake. The Journal of nutrition\| PubMed ID: 24259554	2014
Anti-tumor activity and safety evaluation of fisetin-loaded methoxy poly(ethylene glycol)-poly(epsilon-caprolactone) nanoparticles. Journal of biomedical nanotechnology\| PubMed ID: 24734510	2014
NFkB and Nrf2 in esophageal epithelial barrier function. Tissue barriers\| PubMed ID: 24790804	2013
Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia: a prospective study. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 24993367	2014
Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. Chemical research in toxicology\| PubMed ID: 25148906	2014
Pharmacological effects of the water fraction of key components in the traditional Chinese prescription Mai Tong Fang on 3T3-L1 adipocytes and ob/ob diabetic mice. Molecules (Basel, Switzerland)\| PubMed ID: 25230123	2014
Translational research on Barrett's esophagus. Annals of the New York Academy of Sciences\| PubMed ID: 25266024	2014
Surveying mercury levels in hair, blood and urine of under 7-year old children from a coastal city in China. International journal of environmental research and public health\| PubMed ID: 25419876	2014
Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma. Cancer letters\| PubMed ID: 25766659	2015
Mycoplasma pneumonia combined with pulmonary infarction in a child. International journal of clinical and experimental medicine\| PubMed ID: 25785159	2015
A case of late-onset riboflavin responsive multiple acyl-CoA dehydrogenase deficiency (MADD) with a novel mutation in ETFDH gene. Journal of the neurological sciences\| PubMed ID: 25913573	2015
Quantitative risk stratification of oral leukoplakia with exfoliative cytology. PloS one\| PubMed ID: 25978541	2015
The recyclable synthesis of hierarchical zeolite SAPO-34 with excellent MTO catalytic performance. Chemical communications (Cambridge, England)\| PubMed ID: 26121259	2015
Personalized targeted therapy for esophageal squamous cell carcinoma. World journal of gastroenterology : WJG\| PubMed ID: 26167067	2015
Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer Activity. Journal of medicinal chemistry\| PubMed ID: 26204233	2015