Helmut Butzkueven

Department of Neurology, Royal Melbourne Hospital

Affiliated withRoyal Melbourne Hospital The University of Melbourne

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2015

Other Publications

Article	Year
Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis. American journal of human genetics\| PubMed ID: 11923913	2002
LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival. Nature medicine\| PubMed ID: 12042813	2002
Prospects for stem cell transplantation in multiple sclerosis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 12217663	2002
Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor. Journal of neuropathology and experimental neurology\| PubMed ID: 12722832	2003
Extended haplotype analysis in the HLA complex reveals an increased frequency of the HFE-C282Y mutation in individuals with multiple sclerosis. Human genetics\| PubMed ID: 15014978	2004
Neuroglial responses to CNS injury: prospects for novel therapeutics. Expert review of neurotherapeutics\| PubMed ID: 15853513	2004
Multiple sclerosis: a haplotype association study. Novartis Foundation symposium\| PubMed ID: 15999799	2005
On the utility of data from the International HapMap Project for Australian association studies. Human genetics\| PubMed ID: 16404587	2006
Endogenous leukemia inhibitory factor production limits autoimmune demyelination and oligodendrocyte loss. Glia\| PubMed ID: 16498619	2006
Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16682639	2006
Dopamine agonist-induced pathological gambling in restless legs syndrome due to multiple sclerosis. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 17230484	2007
Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients. Immunogenetics\| PubMed ID: 17256150	2007
MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve. NeuroImage\| PubMed ID: 17689104	2007
Prolonged interval between sentinel pseudotumoral demyelination and development of primary CNS lymphoma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 17890092	2007
Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair. Glia\| PubMed ID: 18293407	2008
Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18480276	2008
Validation of a novel biomarker for acute axonal injury in experimental autoimmune encephalomyelitis. Journal of neuroscience research\| PubMed ID: 18709652	2008
Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis. NeuroImage\| PubMed ID: 19162205	2009
Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus. Journal of neuroimmunology\| PubMed ID: 19375175	2009
A role for galanin in human and experimental inflammatory demyelination. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19717462	2009
Neuroprotection in multiple sclerosis: a therapeutic challenge for the next decade. Pharmacology & therapeutics\| PubMed ID: 20122960	2010
Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients. PloS one\| PubMed ID: 20368992	2010
Common variation in the MOG gene influences transcript splicing in humans. Journal of neuroimmunology\| PubMed ID: 20800907	2010
A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis. PloS one\| PubMed ID: 21049023	2010
Galanin in glia: expression and potential roles in the CNS. EXS\| PubMed ID: 21299062	2010
Brain plasticity in relapsing-remitting multiple sclerosis: evidence from resting-state fMRI. Journal of the neurological sciences\| PubMed ID: 21349545	2011
Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice. PloS one\| PubMed ID: 21611124	2011
Clinical isolated syndrome: a 3-year follow-up study in China. Clinical neurology and neurosurgery\| PubMed ID: 21680087	2011
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature\| PubMed ID: 21833088	2011
Diffusion tensor imaging of the optic radiations after optic neuritis. Human brain mapping\| PubMed ID: 21915943	2012
Neurofilament proteins as body fluid biomarkers of neurodegeneration in multiple sclerosis. Multiple sclerosis international\| PubMed ID: 22096635	2011
A tract-based diffusion study of cerebral white matter in neuromyelitis optica reveals widespread pathological alterations. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 22183932	2011
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Annals of neurology\| PubMed ID: 22190364	2011
Neurodegeneration in MS and NMO: The Eye and the Blood. Multiple sclerosis international\| PubMed ID: 22203903	2011
The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 22205675	2012
Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis. Investigative ophthalmology & visual science\| PubMed ID: 22247457	2012
Increasing age at disability milestones among MS patients in the MSBase Registry. Journal of the neurological sciences\| PubMed ID: 22507751	2012
A double-blind, randomized, controlled study of botulinum toxin type A in MS-related tremor. Neurology\| PubMed ID: 22753445	2012
Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome. PloS one\| PubMed ID: 22768046	2012
Baseline brain activity changes in patients with clinically isolated syndrome revealed by resting-state functional MRI. Acta radiologica (Stockholm, Sweden : 1987)\| PubMed ID: 23002142	2012
Leukemia inhibitory factor protects axons in experimental autoimmune encephalomyelitis via an oligodendrocyte-independent mechanism. PloS one\| PubMed ID: 23077604	2012
Geographical variations in sex ratio trends over time in multiple sclerosis. PloS one\| PubMed ID: 23133550	2012
Altered topological organization of white matter structural networks in patients with neuromyelitis optica. PloS one\| PubMed ID: 23144994	2012
Commentary on "Possible induction of acute disseminated encephalomyelitis (ADEM)-like demyelinating illness by intrathecal mesenchymal stem cell injection". Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 23149272	2013
What do effective treatments for multiple sclerosis tell us about the molecular mechanisms involved in pathogenesis? International journal of molecular sciences\| PubMed ID: 23202920	2012
Microstructural abnormalities in the trigeminal nerves of patients with trigeminal neuralgia revealed by multiple diffusion metrics. European journal of radiology\| PubMed ID: 23265178	2013
Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes. PloS one\| PubMed ID: 23272235	2012
EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE). PloS one\| PubMed ID: 23390555	2013
The Australian Multiple Sclerosis (MS) immunotherapy study: a prospective, multicentre study of drug utilisation using the MSBase platform. PloS one\| PubMed ID: 23527252	2013
Persistence on therapy and propensity matched outcome comparison of two subcutaneous interferon Beta 1a dosages for multiple sclerosis. PloS one\| PubMed ID: 23704913	2013
Anti-aquaporin-4 antibody positivity in neuromyelitis optica is associated with lesion activity. European neurology\| PubMed ID: 23860467	2013
Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study. Health and quality of life outcomes\| PubMed ID: 23895207	2013
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature genetics\| PubMed ID: 24076602	2013
Predictors and dynamics of postpartum relapses in women with multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 24107309	2014
Sex as a determinant of relapse incidence and progressive course of multiple sclerosis. Brain : a journal of neurology\| PubMed ID: 24142147	2013
Endogenously regulated Dab2 worsens inflammatory injury in experimental autoimmune encephalomyelitis. Acta neuropathologica communications\| PubMed ID: 24252604	2013
Optic nerve diffusion tensor imaging after acute optic neuritis predicts axonal and visual outcomes. PloS one\| PubMed ID: 24386285	2013
Efficacy and safety of natalizumab in multiple sclerosis: interim observational programme results. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 24532785	2014
Fingolimod after natalizumab and the risk of short-term relapse. Neurology\| PubMed ID: 24610329	2014
Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution. Journal of neuroscience research\| PubMed ID: 24615902	2014
Risk of relapse phenotype recurrence in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 24777276	2014
Cortical thinning correlates with cognitive change in multiple sclerosis but not in neuromyelitis optica. European radiology\| PubMed ID: 24906701	2014
Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 2 new and emerging therapies and their efficacy. MS Neur... Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 24986155	2014
Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 1 historical and established therapies. MS Neurology Gro... Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 24993135	2014
Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 3 treatment practicalities and recommendations. MS Neuro... Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia\| PubMed ID: 24993136	2014
Seasonal variation of relapse rate in multiple sclerosis is latitude dependent. Annals of neurology\| PubMed ID: 25283272	2014
Axonally derived matrilin-2 induces proinflammatory responses that exacerbate autoimmune neuroinflammation. The Journal of clinical investigation\| PubMed ID: 25329699	2014
Continuing fingolimod after development of macular edema: A case report. Neurology® neuroimmunology & neuroinflammation\| PubMed ID: 25340066	2014
Comparative effectiveness of glatiramer acetate and interferon beta formulations in relapsing-remitting multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 25480857	2015
Switch to natalizumab versus fingolimod in active relapsing-remitting multiple sclerosis. Annals of neurology\| PubMed ID: 25546031	2015
Altered thalamic functional connectivity in multiple sclerosis. European journal of radiology\| PubMed ID: 25636387	2015
Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor. Glia\| PubMed ID: 25639936	2015
Comparison of switch to fingolimod or interferon beta/glatiramer acetate in active multiple sclerosis. JAMA neurology\| PubMed ID: 25665031	2015
Comparative efficacy of switching to natalizumab in active multiple sclerosis. Annals of clinical and translational neurology\| PubMed ID: 25909083	2015
Predictors of disability worsening in clinically isolated syndrome. Annals of clinical and translational neurology\| PubMed ID: 26000321	2015
Parallel changes in structural and functional measures of optic nerve myelination after optic neuritis. PloS one\| PubMed ID: 26020925	2015
Switching from natalizumab to fingolimod: A randomized, placebo-controlled study in RRMS. Neurology\| PubMed ID: 26024899	2015
Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS. PloS one\| PubMed ID: 26046348	2015
The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function. PloS one\| PubMed ID: 26068105	2015
A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis. Human molecular genetics\| PubMed ID: 26188005	2015
The effect of oral immunomodulatory therapy on treatment uptake and persistence in multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England)\| PubMed ID: 26199347	2015
A new era in the treatment of multiple sclerosis. The Medical journal of Australia\| PubMed ID: 26224184	2015
Defining reliable disability outcomes in multiple sclerosis. Brain : a journal of neurology\| PubMed ID: 26359291	2015