Chien-Kuo Lee

Graduate Institute of Immunology, National Taiwan University College of Medicine

Affiliated withNational Taiwan University College of Medicine

Research Area

Biography

Chien-Kuo Lee is a Professor in the Graduate Institute of Immunology, National Taiwan University College of Medicine. He received a Ph.D. degree in 1998 at New York University School of Medicine, USA.

Dr. Lee did his postdoctoral trainings at NYUSM and National Institute for Medical Research, UK (1998-2002). He has been interested in cytokine signal transduction and unveiling the roles of type I IFN and its downstream signal mediators, particularly STAT1 and STAT3, in immunomodulation, including dendritic cell development and functions, B cell differentiation and antiviral response.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 3	2015
Publication title	2022

Other Publications

Article	Year
What does Stat3 do? The Journal of clinical investigation\| PubMed ID: 11994402	2002
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity\| PubMed ID: 12150892	2002
Tissue-specific positive feedback requirements for production of type I interferon following virus infection. The Journal of biological chemistry\| PubMed ID: 15767254	2005
Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes. Molecular and cellular biology\| PubMed ID: 15964802	2005
STAT3 positively regulates an early step in B-cell development. Blood\| PubMed ID: 16825489	2006
Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression. The Journal of investigative dermatology\| PubMed ID: 18401423	2008
CLEC5A is critical for dengue-virus-induced lethal disease. Nature\| PubMed ID: 18496526	2008
STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response. Journal of biomedical science\| PubMed ID: 19272190	2009
Suppressor of cytokine signaling and accelerated atherosclerosis in kidney disease. Acta biochimica Polonica\| PubMed ID: 20725646	2010
STAT3 negatively regulates type I IFN-mediated antiviral response. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21810606	2011
Intrahepatic infiltrating NK and CD8 T cells cause liver cell death in different phases of dengue virus infection. PloS one\| PubMed ID: 23050007	2012
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors. The Journal of experimental medicine\| PubMed ID: 24145513	2013
Immunodeficient mouse models with different disease profiles by in vivo infection with the same clinical isolate of enterovirus 71. Journal of virology\| PubMed ID: 25142603	2014
The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection. Journal of biomedical science\| PubMed ID: 25407417	2014
STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1. The Biochemical journal\| PubMed ID: 25564224	2015
Effects of RING-SH2Grb², a chimeric protein containing the E3 ligase domain of Cbl, on the EGFR pathway. The Chinese journal of physiology\| PubMed ID: 25575524	2014
An alternatively spliced IL-15 isoform modulates abrasion-induced keratinocyte activation. The Journal of investigative dermatology\| PubMed ID: 25615554	2015
Efficient Generation of Plasmacytoid Dendritic Cell from Common Lymphoid Progenitors by Flt3 Ligand. PloS one\| PubMed ID: 26263178	2015
STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria. The Journal of experimental medicine\| PubMed ID: 27849553	2016
Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 28240747	2017
Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages. Scientific reports\| PubMed ID: 28383060	2017
Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28904127	2017
Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription. Frontiers in immunology\| PubMed ID: 31231385	2019
Fine-Tuning of Type I Interferon Response by STAT3. Frontiers in immunology\| PubMed ID: 31293595	2019
Editorial: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets. Frontiers in immunology\| PubMed ID: 31447843	2019