Martial Ruat

CNRS, Université Paris Sud, UMR 9197, Neuroscience Paris-Saclay Institute, Molecules Circuits Department

Affiliated withCNRS, Université Paris Sud, UMR 9197, Neuroscience Paris-Saclay Institute, Molecules Circuits Department

Research Area

Biography

Martial Ruat has not added Biography.
If you are Martial Ruat and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 30	2015

Other Publications

Article	Year
N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing ... Bioorganic & medicinal chemistry letters\| PubMed ID: 15149704	2004
Sonic Hedgehog signalling in the developing and adult brain. Journal of physiology, Paris\| PubMed ID: 11755778	2002
Developmental expression of the cellular prion protein in elongating axons. The European journal of neuroscience\| PubMed ID: 11982627	2002
Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. The Journal of biological chemistry\| PubMed ID: 14506236	2003
[Pharmacology of the extracellular calcium ion receptor]. Thérapie\| PubMed ID: 14682186	2003
Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain. The Journal of biological chemistry\| PubMed ID: 14976203	2004
Functional analysis of novel sonic hedgehog gene mutations identified in basal cell carcinomas from xeroderma pigmentosum patients. Cancer research\| PubMed ID: 15150112	2004
Functional characterization of sonic hedgehog mutations associated with holoprosencephaly. The Journal of biological chemistry\| PubMed ID: 15292211	2004
N(1)-Arylsulfonyl-N(2)-(1-(1-naphthyl)ethyl)-1,2-diaminocyclohexanes: a new class of calcilytic agents acting at the calcium-sensing receptor. Chembiochem : a European journal of chemical biology\| PubMed ID: 15300839	2004
In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor. Biochemical and biophysical research communications\| PubMed ID: 15451421	2004
[New insights into the pharmacology of the extracellular calcium sensing receptor]. Médecine sciences : M/S\| PubMed ID: 15525493	2004
Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231. Circulation research\| PubMed ID: 16037572	2005
Sonic hedgehog signalling in neurons of adult ventrolateral nucleus tractus solitarius. The European journal of neuroscience\| PubMed ID: 16045492	2005
Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence o... The Journal of biological chemistry\| PubMed ID: 16135510	2005
Delineating a Ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor. The Journal of biological chemistry\| PubMed ID: 16147994	2005
Analysis of hedgehog interacting protein in the brain and its expression in nitric oxide synthase-positive cells. Neuroreport\| PubMed ID: 16272887	2005
Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens. Blood\| PubMed ID: 16778137	2006
Increase of proliferating oligodendroglial progenitors in the adult mouse brain upon Sonic hedgehog delivery in the lateral ventricle. Journal of neurochemistry\| PubMed ID: 16805844	2006
N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcily... Journal of medicinal chemistry\| PubMed ID: 16913701	2006
Identification and characterization of Hedgehog modulator properties after functional coupling of Smoothened to G15. Biochemical and biophysical research communications\| PubMed ID: 16945339	2006
Distribution of Smoothened at hippocampal mossy fiber synapses. Neuroreport\| PubMed ID: 17435610	2007
Oligodendrocyte ablation affects the coordinated interaction between granule and Purkinje neurons during cerebellum development. Experimental cell research\| PubMed ID: 17544395	2007
Evidence for the presence of GPRC6A receptors in rat mesenteric arteries. Cell calcium\| PubMed ID: 18221783	2008
Chemoattractive activity of sonic hedgehog in the adult subventricular zone modulates the number of neural precursors reaching the olfactory bulb. Stem cells (Dayton, Ohio)\| PubMed ID: 18617686	2008
Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast. Biochimica et biophysica acta\| PubMed ID: 19463780	2009
Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. Cell calcium\| PubMed ID: 19836834	2009
Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals. PloS one\| PubMed ID: 20052292	2010
Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate. Journal of cellular and molecular medicine\| PubMed ID: 20141614	2009
Sonic Hedgehog signaling in the mammalian brain. Journal of neurochemistry\| PubMed ID: 20218977	2010
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Molecular pharmacology\| PubMed ID: 20664000	2010
Design and synthesis of cyclic sulfonamides and sulfamates as new calcium sensing receptor agonists. Bioorganic & medicinal chemistry letters\| PubMed ID: 21041081	2010
Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Molecular pharmacology\| PubMed ID: 21177415	2011
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor. Bioorganic & medicinal chemistry letters\| PubMed ID: 21592788	2011
The hedgehog receptor patched is involved in cholesterol transport. PloS one\| PubMed ID: 21931618	2011
An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis. PloS one\| PubMed ID: 22028769	2011
[Shh signal and its functional roles in normal and diseased brain]. Médecine sciences : M/S\| PubMed ID: 22130025	2011
Hedgehog trafficking, cilia and brain functions. Differentiation; research in biological diversity\| PubMed ID: 22169886	2012
Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. Journal of medicinal chemistry\| PubMed ID: 22268551	2012
Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. Arthritis and rheumatism\| PubMed ID: 22354771	2012
Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Annals of the rheumatic diseases\| PubMed ID: 22402139	2012
PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor. The Journal of clinical investigation\| PubMed ID: 22886306	2012
Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. Circulation research\| PubMed ID: 23343527	2013
Sonic Hedgehog signaling is a positive oligodendrocyte regulator during demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23365216	2013
Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Molecular pharmacology\| PubMed ID: 23448715	2013
The choline transporter-like family SLC44: properties and roles in human diseases. Molecular aspects of medicine\| PubMed ID: 23506897	2013
Investigation of the proteolipid protein promoter activity during demyelination and repair. Differentiation; research in biological diversity\| PubMed ID: 23827460	2013
Roles of the calcium sensing receptor in the central nervous system. Best practice & research. Clinical endocrinology & metabolism\| PubMed ID: 23856270	2013
Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24135022	2013
[Structure of the Smoothened receptor]. Médecine sciences : M/S\| PubMed ID: 24148123	2013
Targeting of Smoothened for therapeutic gain. Trends in pharmacological sciences\| PubMed ID: 24703627	2014
[Symmetric or asymmetric division: sonic Hedgehog controls the fate of neural stem cells]. Médecine sciences : M/S\| PubMed ID: 25014467	2014
Genetic activation of Hedgehog signaling unbalances the rate of neural stem cell renewal by increasing symmetric divisions. Stem cell reports\| PubMed ID: 25254344	2014
MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25636740	2015