Dirk Elewaut

Department of Rheumatology, Ghent University Hospital

Affiliated withGhent University Hospital Ghent University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2015

Other Publications

Article	Year
Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice. Gastroenterology\| PubMed ID: 12055591	2002
Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage. Arthritis and rheumatism\| PubMed ID: 12746901	2003
NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. The Journal of experimental medicine\| PubMed ID: 12810685	2003
The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Valpha14i NKT cells. The Journal of experimental medicine\| PubMed ID: 14557411	2003
Mapping of the leptin binding sites and design of a leptin antagonist. The Journal of biological chemistry\| PubMed ID: 15213225	2004
Analysis of chondrocyte functional markers and pericellular matrix components by flow cytometry. Methods in molecular medicine\| PubMed ID: 15280596	2004
Lymphotoxin alpha 1 beta 2: a critical mediator in V alpha 14i NKT cell differentiation. Molecular immunology\| PubMed ID: 15607792	2005
Natural killer T cells and rheumatoid arthritis: friend or foe? Arthritis research & therapy\| PubMed ID: 15743495	2005
Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression. Blood\| PubMed ID: 15827137	2005
Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry. Proteomics\| PubMed ID: 15846842	2005
A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15905567	2005
Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis. Arthritis and rheumatism\| PubMed ID: 16736523	2006
A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16751279	2006
Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays. Arthritis research & therapy\| PubMed ID: 16859515	2006
The unconventional role of LT alpha beta in T cell differentiation. Trends in immunology\| PubMed ID: 17336158	2007
Osteochondral repair in synovial joints. Current opinion in rheumatology\| PubMed ID: 17414953	2007
The intimate relationship between gut and joint in spondyloarthropathies. Current opinion in rheumatology\| PubMed ID: 17551365	2007
A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17675491	2007
Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. The Journal of experimental medicine\| PubMed ID: 18250193	2008
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18250472	2008
Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18354184	2008
Synthesis and in vitro evaluation of alpha-GalCer epimers. ChemMedChem\| PubMed ID: 18418814	2008
Spondyloarthropathies: progress and challenges. Best practice & research. Clinical rheumatology\| PubMed ID: 18455688	2008
Adalimumab with or without methotrexate in juvenile rheumatoid arthritis. The New England journal of medicine\| PubMed ID: 18716298	2008
Synthesis and in vivo evaluation of 4-deoxy-4,4-difluoro-KRN7000. Organic letters\| PubMed ID: 18798635	2008
Clinical observations programme in SpA: disease parameters, treatment options and practical management issues. Rheumatology international\| PubMed ID: 18818924	2009
Differential expression of alphaB-crystallin and evidence of its role as a mediator of matrix gene expression in osteoarthritis. Arthritis and rheumatism\| PubMed ID: 19116904	2009
The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000. ChemMedChem\| PubMed ID: 19137519	2009
Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis. Annals of the rheumatic diseases\| PubMed ID: 19196728	2010
Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond. European journal of immunology\| PubMed ID: 19224640	2009
LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19380791	2009
6'-derivatised alpha-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice. Journal of the American Chemical Society\| PubMed ID: 19554718	2008
Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice. Rheumatology (Oxford, England)\| PubMed ID: 19561158	2009
Application of a new anti-zearalenone monoclonal antibody in different immunoassay formats. Analytical and bioanalytical chemistry\| PubMed ID: 19575188	2009
Progress in spondylarthritis. Immunopathogenesis of spondyloarthritis: which cells drive disease? Arthritis research & therapy\| PubMed ID: 19591637	2009
Cutting edge: the chemokine receptor CXCR3 retains invariant NK T cells in the thymus. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19620294	2009
Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability. Arthritis and rheumatism\| PubMed ID: 19714626	2009
Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice. The Journal of experimental medicine\| PubMed ID: 19808255	2009
Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts. Arthritis and rheumatism\| PubMed ID: 19877072	2009
Morbid anatomy of 'erosive osteoarthritis' of the interphalangeal finger joints: an optimised scoring system to monitor disease progression in affected joints. Annals of the rheumatic diseases\| PubMed ID: 19948521	2010
Invariant natural killer T cells in rheumatic disease: a joint dilemma. Nature reviews. Rheumatology\| PubMed ID: 20125176	2010
Invariant natural killer T cells are natural regulators of murine spondylarthritis. Arthritis and rheumatism\| PubMed ID: 20131252	2010
Interactions between gut inflammation and arthritis/spondylitis. Current opinion in rheumatology\| PubMed ID: 20485176	2010
Targeting inflammation using selective glucocorticoid receptor modulators. Current opinion in pharmacology\| PubMed ID: 20493772	2010
Synthesis and evaluation of amino-modified alpha-GalCer analogues. Organic letters\| PubMed ID: 20518554	2010
Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20592286	2010
Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins. Arthritis research & therapy\| PubMed ID: 20609218	2010
A multiparameter approach to monitor disease activity in collagen-induced arthritis. Arthritis research & therapy\| PubMed ID: 20731827	2010
Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20943999	2010
Novel autoantibody markers for early and seronegative rheumatoid arthritis. Journal of autoimmunity\| PubMed ID: 21071175	2011
Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis. PloS one\| PubMed ID: 21072187	2010
In pursuit of B-cell synovial autoantigens in rheumatoid arthritis: Confirmation of citrullinated fibrinogen, detection of vimentin, and introducing carbonic anhydrase as a possible new syno... Proteomics. Clinical applications\| PubMed ID: 21136610	2007
Proteomics in rheumatology: The beginning of a fairy tale? Proteomics. Clinical applications\| PubMed ID: 21136842	2008
Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease. BMC immunology\| PubMed ID: 21144017	2010
Linking Crohn's disease and ankylosing spondylitis: it's all about genes! PLoS genetics\| PubMed ID: 21152009	2010
Mechanisms regulating TNF-driven gut and joint inflammation. Advances in experimental medicine and biology\| PubMed ID: 21153345	2011
An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 21233489	2011
Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis. EMBO molecular medicine\| PubMed ID: 21328541	2011
Specific anti-nuclear antibodies in systemic sclerosis patients with and without skin involvement: an extended methodological approach. Rheumatology (Oxford, England)\| PubMed ID: 21330340	2011
Optimized alkylated cyclodextrin polysulphates with reduced risks on thromboembolic accidents improve osteoarthritic chondrocyte metabolism. Rheumatology (Oxford, England)\| PubMed ID: 21345936	2011
Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study. Arthritis research & therapy\| PubMed ID: 21356083	2011
Systematic candidate gene investigations in the SPA2 locus (9q32) show an association between TNFSF8 and susceptibility to spondylarthritis. Arthritis and rheumatism\| PubMed ID: 21480186	2011
Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis. The EMBO journal\| PubMed ID: 21552205	2011
Reliability and validity of the INFOOT three-dimensional foot digitizer for patients with rheumatoid arthritis. Journal of the American Podiatric Medical Association\| PubMed ID: 21622631	2011
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. Immunity\| PubMed ID: 21723156	2011
Mucosal inflammation in spondylarthritides: past, present, and future. Current rheumatology reports\| PubMed ID: 21744132	2011
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nature genetics\| PubMed ID: 21841782	2011
Selection of non-competitive leptin antagonists using a random nanobody-based approach. The Biochemical journal\| PubMed ID: 21851341	2012
Regulating the regulators: SOCS3 joins the dance. Annals of the rheumatic diseases\| PubMed ID: 21900286	2011
Midterm results of the treatment of cartilage defects in the knee using alginate beads containing human mature allogenic chondrocytes. The American journal of sports medicine\| PubMed ID: 21960559	2012
Safe and well tolerated. Rheumatology (Oxford, England)\| PubMed ID: 21994400	2011
A pilot study of the use of an osteochondral scaffold plug for cartilage repair in the knee and how to deal with early clinical failures. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association\| PubMed ID: 22014478	2012
A clinically applicable six-segmented foot model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 22021089	2012
Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease? PloS one\| PubMed ID: 22028783	2011
Divergent synthetic approach to 6''-modified α-GalCer analogues. Organic & biomolecular chemistry\| PubMed ID: 22042483	2011
Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification. Annals of the rheumatic diseases\| PubMed ID: 22128078	2012
Motion for debate: the development of ankylosis in ankylosing spondylitis is largely dependent on inflammation. Arthritis and rheumatism\| PubMed ID: 22354725	2012
Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice. Blood\| PubMed ID: 22383797	2012
The transition of acute to chronic bowel inflammation in spondyloarthritis. Nature reviews. Rheumatology\| PubMed ID: 22508429	2012
Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection. PloS one\| PubMed ID: 22649570	2012
Natural killer T cells: born in the thymus, raised in the gut. Gastroenterology\| PubMed ID: 22727664	2012
Quantitative assessment of foot structure in rheumatoid arthritis by a foot digitizer: detection of deformities even in the absence of erosions. Arthritis care & research\| PubMed ID: 22807070	2012
Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients. Rheumatology international\| PubMed ID: 22825303	2013
Natural killer T cells in adipose tissue prevent insulin resistance. The Journal of clinical investigation\| PubMed ID: 22863618	2012
Tumor necrosis factor α-induced proteins: natural brakes on inflammation. Arthritis and rheumatism\| PubMed ID: 22886549	2012
Investigating the genetic association between ERAP1 and spondyloarthritis. Annals of the rheumatic diseases\| PubMed ID: 22896742	2013
Quantification of citrullination by means of skewed isotope distribution pattern. Journal of proteome research\| PubMed ID: 22978259	2012
Pathophysiology and role of the gastrointestinal system in spondyloarthritides. Rheumatic diseases clinics of North America\| PubMed ID: 23083756	2012
Therapy for spondyloarthritis: the role of extra-articular manifestations (eye, skin). Rheumatic diseases clinics of North America\| PubMed ID: 23083757	2012
Two-year results of an open pilot study of a 2-treatment course with rituximab in patients with early systemic sclerosis with diffuse skin involvement. The Journal of rheumatology\| PubMed ID: 23118116	2013
Synthesis of 6"-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands. Bioorganic & medicinal chemistry\| PubMed ID: 23122935	2012
Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model. Annals of the rheumatic diseases\| PubMed ID: 23139267	2013
Spondyloarthritis: A conundrum: classifying patients with SpA in daily practice. Nature reviews. Rheumatology\| PubMed ID: 23165359	2012
Should we be morbid about comorbidities in the rheumatic diseases? Rheumatology (Oxford, England)\| PubMed ID: 23238977	2013
Entering the era of proteomics in rheumatology. Expert opinion on drug discovery\| PubMed ID: 23506065	2006
Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-α production by interaction with its soluble E-cadherin ligand in chronically inflamed joints. Annals of the rheumatic diseases\| PubMed ID: 23740233	2014
Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model. PloS one\| PubMed ID: 23741460	2013
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nature genetics\| PubMed ID: 23749187	2013
Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force. Annals of the rheumatic diseases\| PubMed ID: 23749611	2014
Microbes, the gut and ankylosing spondylitis. Arthritis research & therapy\| PubMed ID: 23750937	2013
How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy. Nature medicine\| PubMed ID: 23836224	2013
Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the ... Annals of the rheumatic diseases\| PubMed ID: 23868909	2014
Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23898038	2013
Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells. Annals of the rheumatic diseases\| PubMed ID: 23921997	2014
Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins? Rheumatology (Oxford, England)\| PubMed ID: 23955645	2014
Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23960235	2013
A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis. Journal of hepatology\| PubMed ID: 23973929	2014
Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort. Annals of the rheumatic diseases\| PubMed ID: 24276368	2014
Spondyloarthritis: Gut inflammation in SpA: flagellin joins the dance? Nature reviews. Rheumatology\| PubMed ID: 24323068	2014
An in silico approach for modelling T-helper polarizing iNKT cell agonists. PloS one\| PubMed ID: 24498010	2014
Growth differentiation factor 15, a marker of lung involvement in systemic sclerosis, is involved in fibrosis development but is not indispensable for fibrosis development. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 24504814	2014
Relevance of the gut/joint axis for the management of spondyloarthritis in daily clinical practice. Current opinion in rheumatology\| PubMed ID: 24841232	2014
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature\| PubMed ID: 25043000	2014
Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level. Cellular and molecular life sciences : CMLS\| PubMed ID: 25098352	2015
Etanercept versus monoclonal antibodies in axial spondyloarthritis: game over? The Journal of rheumatology\| PubMed ID: 25275090	2014
Distinct dysregulation of the small leucine-rich repeat protein family in osteoarthritic acetabular labrum compared to articular cartilage. Arthritis & rheumatology (Hoboken, N.J.)\| PubMed ID: 25371314	2015
The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25381434	2014
Referral patterns, diagnosis, and disease management of patients with axial spondyloarthritis: results of an international survey. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases\| PubMed ID: 25417676	2014
The role of the gut and microbes in the pathogenesis of spondyloarthritis. Best practice & research. Clinical rheumatology\| PubMed ID: 25488778	2014
Integrating the pathogenesis of spondyloarthritis: gut and joint united? Current opinion in rheumatology\| PubMed ID: 25588139	2015
Commensal microbiota influence systemic autoimmune responses. The EMBO journal\| PubMed ID: 25599993	2015
IL-23 responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear. Current rheumatology reports\| PubMed ID: 25874346	2015
ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients. Annals of the rheumatic diseases\| PubMed ID: 25917849	2015
Heterogeneity of synovial molecular patterns in patients with arthritis. PloS one\| PubMed ID: 25927832	2015
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1. Nature communications\| PubMed ID: 25994336	2015
Synthesis of C-5″ and C-6″-modified α-GalCer analogues as iNKT-cell agonists. Bioorganic & medicinal chemistry\| PubMed ID: 26003341	2015
Spreading spondyloarthritis: are ILCs cytokine shuttles from base camp gut? Annals of the rheumatic diseases\| PubMed ID: 26199396	2015