Thomas Tuschl

Howard Hughes Medical Institute, Rockefeller University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 264	2010

Other Publications

Article	Year
Expanding small RNA interference. Nature biotechnology\| PubMed ID: 11981553	2002
Identification of tissue-specific microRNAs from mouse. Current biology : CB\| PubMed ID: 12007417	2002
Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods (San Diego, Calif.)\| PubMed ID: 12054897	2002
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell\| PubMed ID: 12230974	2002
Functional genomics: RNA sets the standard. Nature\| PubMed ID: 12529623	2003
New microRNAs from mouse and human. RNA (New York, N.Y.)\| PubMed ID: 12554859	2003
A uniform system for microRNA annotation. RNA (New York, N.Y.)\| PubMed ID: 12592000	2003
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense & nucleic acid drug development\| PubMed ID: 12804036	2003
The small RNA profile during Drosophila melanogaster development. Developmental cell\| PubMed ID: 12919683	2003
Analysis of mammalian gene function using small interfering RNAs. Nucleic acids research. Supplement (2001)\| PubMed ID: 14510516	2003
MicroRNA targets in Drosophila. Genome biology\| PubMed ID: 14709173	2003
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA (New York, N.Y.)\| PubMed ID: 14970398	2004
Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy. Molecular interventions\| PubMed ID: 14993376	2002
siRNAs: applications in functional genomics and potential as therapeutics. Nature reviews. Drug discovery\| PubMed ID: 15060527	2004
RISC is a 5' phosphomonoester-producing RNA endonuclease. Genes & development\| PubMed ID: 15105377	2004
Identification of virus-encoded microRNAs. Science (New York, N.Y.)\| PubMed ID: 15118162	2004
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA (New York, N.Y.)\| PubMed ID: 15146077	2004
siRNA Selection Server: an automated siRNA oligonucleotide prediction server. Nucleic acids research\| PubMed ID: 15215365	2004
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Molecular cell\| PubMed ID: 15260970	2004
RNA interference by osmotic lysis of pinosomes: liposome-independent transfection of siRNAs into mammalian cells. BioTechniques\| PubMed ID: 15283206	2004
Mechanisms of gene silencing by double-stranded RNA. Nature\| PubMed ID: 15372041	2004
Human MicroRNA targets. PLoS biology\| PubMed ID: 15502875	2004
A pancreatic islet-specific microRNA regulates insulin secretion. Nature\| PubMed ID: 15538371	2004
The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Current biology : CB\| PubMed ID: 15589161	2004
Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science (New York, N.Y.)\| PubMed ID: 15591165	2005
Identification of microRNAs of the herpesvirus family. Nature methods\| PubMed ID: 15782219	2005
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature\| PubMed ID: 15800629	2005
Clustering and conservation patterns of human microRNAs. Nucleic acids research\| PubMed ID: 15891114	2005
The developmental miRNA profiles of zebrafish as determined by small RNA cloning. Genes & development\| PubMed ID: 15937218	2005
Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development. Cell\| PubMed ID: 15989958	2005
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Molecular cell\| PubMed ID: 16061186	2005
Identification and characterization of small RNAs involved in RNA silencing. FEBS letters\| PubMed ID: 16153643	2005
Silencing of microRNAs in vivo with 'antagomirs'. Nature\| PubMed ID: 16258535	2005
Identification of clustered microRNAs using an ab initio prediction method. BMC bioinformatics\| PubMed ID: 16274478	2005
Identification of novel argonaute-associated proteins. Current biology : CB\| PubMed ID: 16289642	2005
A novel class of small RNAs bind to MILI protein in mouse testes. Nature\| PubMed ID: 16751777	2006
On the art of identifying effective and specific siRNAs. Nature methods\| PubMed ID: 16929310	2006
A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA. Structure (London, England : 1993)\| PubMed ID: 17027504	2006
Specific RNAi mediated gene knockdown in zebrafish cell lines. RNA biology\| PubMed ID: 17114924	2005
Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs. RNA biology\| PubMed ID: 17114944	2006
Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. Genes & development\| PubMed ID: 17158744	2006
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. Blood\| PubMed ID: 17327404	2007
Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic acids research\| PubMed ID: 17439965	2007
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell\| PubMed ID: 17604727	2007
Cellular cofactors affecting hepatitis C virus infection and replication. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17616579	2007
Reactions of phosphate and phosphorothiolate diesters with nucleophiles: comparison of transition state structures. Organic & biomolecular chemistry\| PubMed ID: 17637971	2007
Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline. Nucleic acids research\| PubMed ID: 17702759	2007
Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA (New York, N.Y.)\| PubMed ID: 18094121	2008
Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing. Methods (San Diego, Calif.)\| PubMed ID: 18158127	2008
Cloning of small RNA molecules. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]\| PubMed ID: 18265364	2005
The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members. Development (Cambridge, England)\| PubMed ID: 18287206	2008
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity\| PubMed ID: 18450484	2008
MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas. The American journal of pathology\| PubMed ID: 18583325	2008
Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. The American journal of pathology\| PubMed ID: 18688024	2008
Structure of the guide-strand-containing argonaute silencing complex. Nature\| PubMed ID: 18754009	2008
Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs. RNA (New York, N.Y.)\| PubMed ID: 18978028	2008
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature\| PubMed ID: 19043405	2008
A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways. Molecular and cellular biology\| PubMed ID: 19047376	2009
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature\| PubMed ID: 19092929	2008
DGCR8-dependent microRNA biogenesis is essential for skin development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19114655	2009
miRNA in situ hybridization in formaldehyde and EDC-fixed tissues. Nature methods\| PubMed ID: 19137005	2009
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes & development\| PubMed ID: 19487573	2009
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity\| PubMed ID: 19576794	2009
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. The Journal of clinical investigation\| PubMed ID: 19620785	2009
Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron\| PubMed ID: 19778509	2009
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature\| PubMed ID: 19812667	2009
Absolute quantification of microRNAs by using a universal reference. RNA (New York, N.Y.)\| PubMed ID: 19861428	2009
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell\| PubMed ID: 20371350	2010
Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. The European journal of neuroscience\| PubMed ID: 20384810	2010
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nature structural & molecular biology\| PubMed ID: 20581823	2010
miRNAs in human cancer. The Journal of pathology\| PubMed ID: 21125669	2011
MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC. PloS one\| PubMed ID: 21283765	2011
Combined characterization of microRNA and mRNA profiles delineates early differentiation pathways of CD133+ and CD34+ hematopoietic stem and progenitor cells. Stem cells (Dayton, Ohio)\| PubMed ID: 21394831	2011
Deep sequencing of small RNAs specifically associated with Arabidopsis AGO1 and AGO4 uncovers new AGO functions. The Plant journal : for cell and molecular biology\| PubMed ID: 21457371	2011
Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex. Nature structural & molecular biology\| PubMed ID: 21552261	2011
MicroRNA sequence and expression analysis in breast tumors by deep sequencing. Cancer research\| PubMed ID: 21586611	2011
Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma. Cancer research\| PubMed ID: 21693658	2011
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. Molecular cell\| PubMed ID: 21723170	2011
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries. RNA (New York, N.Y.)\| PubMed ID: 21775473	2011
MicroRNA-24 regulates vascularity after myocardial infarction. Circulation\| PubMed ID: 21788589	2011
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nature cell biology\| PubMed ID: 21804543	2011
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. Genes & development\| PubMed ID: 22012620	2011
New insights in the mechanism of microRNA-mediated target repression. Nature structural & molecular biology\| PubMed ID: 22056803	2011
RNA targets of wild-type and mutant FET family proteins. Nature structural & molecular biology\| PubMed ID: 22081015	2011
Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines. Cell host & microbe\| PubMed ID: 22100165	2011
Identification of RNA-protein interaction networks using PAR-CLIP. Wiley interdisciplinary reviews. RNA\| PubMed ID: 22213601	2011
The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines. PLoS pathogens\| PubMed ID: 22291592	2012