John Disterhoft

Department of Physiology, Northwestern University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2016

Other Publications

Article	Year
Age-related biophysical alterations of hippocampal pyramidal neurons: implications for learning and memory. Ageing research reviews\| PubMed ID: 12039438	2002
Temporal discrimination learning in abstinent chronic alcoholics. Alcoholism, clinical and experimental research\| PubMed ID: 12068248	2002
Age-related enhancement of the slow outward calcium-activated potassium current in hippocampal CA1 pyramidal neurons in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12177218	2002
Single neurons in CA1 hippocampus encode trace interval duration during trace heart rate (fear) conditioning in rabbit. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12598642	2003
Activity profiles of single neurons in caudal anterior cingulate cortex during trace eyeblink conditioning in the rabbit. Journal of neurophysiology\| PubMed ID: 12750412	2003
Watermaze learning enhances excitability of CA1 pyramidal neurons. Journal of neurophysiology\| PubMed ID: 12815013	2003
Lubeluzole and conditioned learning after cerebral ischemia. Experimental brain research\| PubMed ID: 12904938	2003
Modulation of cholinergic transmission enhances excitability of hippocampal pyramidal neurons and ameliorates learning impairments in aging animals. Neurobiology of learning and memory\| PubMed ID: 14521865	2003
Functional magnetic resonance imaging in the awake rabbit: a system for stimulus presentation and response detection during eyeblink conditioning. Journal of neuroscience methods\| PubMed ID: 14583403	2003
Conditional discrimination learning in patients with bilateral medial temporal lobe amnesia. Behavioral neuroscience\| PubMed ID: 14674839	2003
fMRI of the conscious rabbit during unilateral classical eyeblink conditioning reveals bilateral cerebellar activation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14684877	2003
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron\| PubMed ID: 14715132	2004
Galantamine facilitates acquisition of hippocampus-dependent trace eyeblink conditioning in aged rabbits. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 14747524	2004
Slow afterhyperpolarization governs the development of NMDA receptor-dependent afterdepolarization in CA1 pyramidal neurons during synaptic stimulation. Journal of neurophysiology\| PubMed ID: 15190096	2004
Biophysical alterations of hippocampal pyramidal neurons in learning, ageing and Alzheimer's disease. Ageing research reviews\| PubMed ID: 15541708	2004
A fiber optic-based system for behavioral eyeblink measurement in a MRI environment. Journal of neuroscience methods\| PubMed ID: 15585291	2005
Trace eyeblink conditioning in abstinent alcoholic individuals: effects of complex task demands and prior conditioning. Neuropsychology\| PubMed ID: 15769200	2005
Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 15805311	2005
Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 15897256	2005
GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator. Neuropharmacology\| PubMed ID: 16051282	2005
Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. The European journal of neuroscience\| PubMed ID: 16420434	2006
Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease. Journal of physiology, Paris\| PubMed ID: 16458491	2006
Simultaneous training on two hippocampus-dependent tasks facilitates acquisition of trace eyeblink conditioning. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 16585795	2006
Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability. The European journal of neuroscience\| PubMed ID: 16630070	2006
Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16738249	2006
Learning, aging and intrinsic neuronal plasticity. Trends in neurosciences\| PubMed ID: 16942805	2006
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17021169	2006
Stability and plasticity of intrinsic membrane properties in hippocampal CA1 pyramidal neurons: effects of internal anions. The Journal of physiology\| PubMed ID: 17138601	2007
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice. Neurobiology of disease\| PubMed ID: 17258906	2007
Cortical barrel lesions impair whisker-CS trace eyeblink conditioning. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 17272654	2007
Alterations in intrinsic neuronal excitability during normal aging. Aging cell\| PubMed ID: 17517042	2007
Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I M. Neurobiology of learning and memory\| PubMed ID: 17703960	2008
Where is the trace in trace conditioning? Trends in neurosciences\| PubMed ID: 18199490	2008
Delay discrimination and reversal eyeblink classical conditioning in abstinent chronic alcoholics. Neuropsychology\| PubMed ID: 18331162	2008
Procedural memory system supports single cue trace eyeblink conditioning in medial temporal lobe amnesia. Neuropsychology\| PubMed ID: 18331171	2008
Functional magnetic resonance imaging of delay and trace eyeblink conditioning in the primary visual cortex of the rabbit. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18463251	2008
Neural substrates underlying human delay and trace eyeblink conditioning. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18523017	2008
Evoking blinks with natural stimulation and detecting them with a noninvasive optical device: a simple, inexpensive method for use with freely moving animals. Journal of neuroscience methods\| PubMed ID: 18598716	2008
Synaptic strength and postsynaptically silent synapses through advanced aging in rat hippocampal CA1 pyramidal neurons. Neurobiology of aging\| PubMed ID: 18620783	2010
Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity. Journal of neurophysiology\| PubMed ID: 18715900	2008
The BK-mediated fAHP is modulated by learning a hippocampus-dependent task. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18799739	2008
A novel method for precisely timed stimulation of mouse whiskers in a freely moving preparation: application for delivery of the conditioned stimulus in trace eyeblink conditioning. Journal of neuroscience methods\| PubMed ID: 19041891	2009
Learning-related postburst afterhyperpolarization reduction in CA1 pyramidal neurons is mediated by protein kinase A. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19164584	2009
Blocking the BK channel impedes acquisition of trace eyeblink conditioning. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 19181615	2009
Autophosphorylation of alphaCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation. Neurobiology of learning and memory\| PubMed ID: 19245842	2009
The fast and slow afterhyperpolarizations are differentially modulated in hippocampal neurons by aging and learning. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19369544	2009
The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiology of aging\| PubMed ID: 19446371	2011
Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 19470651	2009
Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry. Nature neuroscience\| PubMed ID: 19620975	2009
Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19625617	2009
Intrinsic neuronal excitability is reversibly altered by a single experience in fear conditioning. Journal of neurophysiology\| PubMed ID: 19726729	2009
BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice. PloS one\| PubMed ID: 19841742	2009
Caudate nucleus is critically involved in trace eyeblink conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19923285	2009
Age-related deficits in a forebrain-dependent task, trace-eyeblink conditioning. Neurobiology of aging\| PubMed ID: 20018411	2011
Learning and aging related changes in intrinsic neuronal excitability. Frontiers in aging neuroscience\| PubMed ID: 20552042	2010
The effects of aging in delay and trace human eyeblink conditioning. Psychology and aging\| PubMed ID: 20677885	2010
Exploring prefrontal cortical memory mechanisms with eyeblink conditioning. Behavioral neuroscience\| PubMed ID: 21517143	2011
Physiological and anatomical studies of associative learning: Convergence with learning studies of W.T. Greenough. Developmental psychobiology\| PubMed ID: 21678397	2011
Reevaluating hippocampus-dependent learning in FVB/N mice. Behavioral neuroscience\| PubMed ID: 22122148	2011
A MRI-compatible system for whisker stimulation. Journal of neuroscience methods\| PubMed ID: 22322316	2012
Increasing SK2 channel activity impairs associative learning. Journal of neurophysiology\| PubMed ID: 22552186	2012
Infragranular barrel cortex activity is enhanced with learning. Journal of neurophysiology\| PubMed ID: 22696544	2012
Perirhinal and postrhinal, but not lateral entorhinal, cortices are essential for acquisition of trace eyeblink conditioning. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 23322556	2013
Caudate nucleus in retrieval of trace eyeblink conditioning after consolidation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23407942	2013
Cellular mechanisms for altered learning in aging. Future neurology\| PubMed ID: 23525658	2010
Learning increases intrinsic excitability of hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23536065	2013
Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23637181	2013
Functional MRI of cerebellar activity during eyeblink classical conditioning in children and adults. Human brain mapping\| PubMed ID: 23674498	2014
Surface L-type Ca2+ channel expression levels are increased in aged hippocampus. Aging cell\| PubMed ID: 24033980	2014
GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists... Expert opinion on investigational drugs\| PubMed ID: 24251380	2014
Functional reorganization of a prefrontal cortical network mediating consolidation of trace eyeblink conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24453332	2014
Increased Excitability of Both Principal Neurons and Interneurons during Associative Learning. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry\| PubMed ID: 24946769	2015
Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25246588	2014
Age-related impairments on one hippocampal-dependent task predict impairments on a subsequent hippocampal-dependent task. Behavioral neuroscience\| PubMed ID: 25420127	2014
Robust hippocampal responsivity during retrieval of consolidated associative memory. Hippocampus\| PubMed ID: 25515308	2015
Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefront... Behavioural brain research\| PubMed ID: 26210936	2015
The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions. Behavioral neuroscience\| PubMed ID: 26214216	2015
Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behavioral neuroscience\| PubMed ID: 26214217	2015
Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26400949	2015
Eyeblink Conditioning and Novel Object Recognition in the Rabbit: Behavioral Paradigms for Assaying Psychiatric Diseases. Frontiers in psychiatry\| PubMed ID: 26500564	2015
Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation. NeuroImage\| PubMed ID: 26589332	2016
Forebrain-Cerebellar Interactions During Learning. Cellscience\| PubMed ID: 26617664	2006
Intrinsic connectivity of neural networks in the awake rabbit. NeuroImage\| PubMed ID: 26774609	2016
Pretrial functional connectivity differentiates behavioral outcomes during trace eyeblink conditioning in the rabbit. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 26980784	2016
The Development of Rapastinel (Formerly GLYX-13); a rapid acting and long lasting antidepressant. Current neuropharmacology\| PubMed ID: 26997507	2016