experimental-strategies-to-bridge-large-tissue-gaps-injured-spinal

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

After a spinal cord injury (SCI) a scar forms in the lesion core which hinders axonal regeneration. Bridging the site of injury after an insult to the ...

Hamburg University of Technology

BG Trauma Center Hamburg

Patients with diabetes mellitus (DM) have an unfavorable prognosis after myocardial infarction (MI), partially due to a higher risk of sudden cardiac death (SCD). QT dynamicity is an independent predictor of SCD in post-MI patients. However, the effects of diabetes on QT dynamicity in patients with MI have not been described.

Impact of diabetes on QT dynamicity in patients with and without myocardial infarction: The KORA Family Heart Study.

Good outcome after meniscal repair using an all-inside suturing system in combination with high-frequency biostimulation.

Pancreatic neuroendocrine tumors (PNETs) are a characteristic feature of the tumor syndromes multiple endocrine neoplasia type 1 (MEN-1) and von Hippel-Lindau disease (VHL). With VHL, about 10% of the patients exhibit PNETs by age 40 years. Metastatic potential is high if the tumors have grown to >3 cm in diameter. Optimal surgical treatment is still a challenge.

Laparoscopic organ-sparing resection of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors.

Generally, the high short-term mortality after percutaneous endoscopic gastrostomy (PEG) in geriatric patients is attributed to the severity of their underlying diseases. However, the procedure-related mortality in this group is unknown.

Complications and mortality after percutaneous endoscopic gastrostomy in geriatrics: a prospective multicenter observational trial.

Complete transection of the spinal cord leaves a gap of several mm which fills with fibrous scar tissue. Several approaches in rodent models have used tubes, foams, matrices or tissue implants to bridge this gap. Here, we describe a mechanical microconnector system (mMS) to re-adjust the retracted spinal cord stumps. The mMS is a multi-channel system of polymethylmethacrylate (PMMA), designed to fit into the spinal cord tissue gap after transection, with an outlet tubing system to apply negative pressure to the mMS thus sucking the spinal cord stumps into the honeycomb-structured holes. The stumps adhere to the microstructure of the mMS walls and remain in the mMS after removal of the vacuum. We show that the mMS preserves tissue integrity and allows axonal regrowth at 2, 5 and 19 weeks post lesion with no adverse tissue effects like in-bleeding or cyst formation. Preliminary assessment of locomotor function in the open field suggested beneficial effects of the mMS. Additional inner micro-channels enable local substance delivery into the lesion center via an attached osmotic minipump. We suggest that the mMS is a suitable device to adapt and stabilize the injured spinal cord after surgical resection of scar tissue (e.g., for chronic patients) or traumatic injuries with large tissue and bone damages.

Article	Year
Impact of diabetes on QT dynamicity in patients with and without myocardial infarction: The KORA Family Heart Study. Pacing and clinical electrophysiology : PACE\| PubMed ID: 17302701	2007
Good outcome after meniscal repair using an all-inside suturing system in combination with high-frequency biostimulation. Orthopedics\| PubMed ID: 20806749	2010
Laparoscopic organ-sparing resection of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors. World journal of surgery\| PubMed ID: 21181474	2011
Complications and mortality after percutaneous endoscopic gastrostomy in geriatrics: a prospective multicenter observational trial. Journal of the American Medical Directors Association\| PubMed ID: 21872536	2012
A mechanical microconnector system for restoration of tissue continuity and long-term drug application into the injured spinal cord. Biomaterials\| PubMed ID: 24090837	2013

Christian Voss

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