Oliver Smithies

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill

Affiliated withUniversity of North Carolina at Chapel Hill

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2016

Other Publications

Article	Year
Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 11748047	2002
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science (New York, N.Y.)\| PubMed ID: 11799247	2002
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. The Journal of clinical investigation\| PubMed ID: 11854327	2002
Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene. Journal of the American Society of Nephrology : JASN\| PubMed ID: 11856763	2002
Impaired T cell function in RANTES-deficient mice. Clinical immunology (Orlando, Fla.)\| PubMed ID: 11890717	2002
Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11904385	2002
Multiple roles of adrenomedullin revealed by animal models. Microscopy research and technique\| PubMed ID: 11921356	2002
Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice. Hormones and behavior\| PubMed ID: 11971662	2002
A genetically clamped renin transgene for the induction of hypertension. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12034874	2002
Targeted disruption of hsp70.1 sensitizes to osmotic stress. EMBO reports\| PubMed ID: 12189176	2002
Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12655073	2003
Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system. Endocrinology\| PubMed ID: 12746272	2003
Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. American journal of physiology. Renal physiology\| PubMed ID: 12824076	2003
Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm. Surgery\| PubMed ID: 12947317	2003
Physiological impact of increased expression of the AT1 angiotensin receptor. Hypertension\| PubMed ID: 12963678	2003
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14978280	2004
Human genetics, animal models and computer simulations for studying hypertension. Trends in genetics : TIG\| PubMed ID: 15036807	2004
Altering the expression in mice of genes by modifying their 3' regions. Developmental cell\| PubMed ID: 15068798	2004
Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Developmental cell\| PubMed ID: 15130496	2004
E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15240726	2004
A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Physiological genomics\| PubMed ID: 15306694	2004
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15326315	2004
Three-dimensional diffusion tensor microscopy of fixed mouse hearts. Magnetic resonance in medicine\| PubMed ID: 15334561	2004
Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences. Genomics\| PubMed ID: 15498455	2004
Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. Journal of the American Society of Nephrology : JASN\| PubMed ID: 15563565	2005
Lifelong genetic minipumps. Physiological genomics\| PubMed ID: 15585607	2005
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15699326	2005
Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Endocrinology\| PubMed ID: 15731365	2005
Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene. Cardiovascular research\| PubMed ID: 15769452	2005
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. The Journal of clinical investigation\| PubMed ID: 15841186	2005
Many little things: one geneticist's view of complex diseases. Nature reviews. Genetics\| PubMed ID: 15861211	2005
An interview with... Oliver Smithies [interviewed by Magdalena Skipper]. Nature reviews. Genetics\| PubMed ID: 15880879	2005
Kidney function in mice lacking aldosterone. American journal of physiology. Renal physiology\| PubMed ID: 16118390	2006
An improved technique for tail-cuff blood pressure measurements with dark-tailed mice. Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science\| PubMed ID: 16138782	2005
Isolating gene-corrected stem cells without drug selection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16258059	2005
Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Molecular and cellular biology\| PubMed ID: 16537897	2006
Amino acids as modulators of endothelium-derived nitric oxide. American journal of physiology. Renal physiology\| PubMed ID: 16571593	2006
Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. The Journal of clinical investigation\| PubMed ID: 16604193	2006
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. The Journal of clinical investigation\| PubMed ID: 16741575	2006
A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16777957	2006
Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis. The Journal of biological chemistry\| PubMed ID: 16782708	2006
Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. The Journal of clinical investigation\| PubMed ID: 16981008	2006
Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17068123	2006
Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption. Hypertension\| PubMed ID: 17075030	2006
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17090678	2006
Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. Journal of molecular endocrinology\| PubMed ID: 17293444	2007
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360661	2007
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. The Journal of clinical investigation\| PubMed ID: 17431507	2007
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17452647	2007
Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age. The Journal of biological chemistry\| PubMed ID: 17470425	2007
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Molecular and cellular biology\| PubMed ID: 17526730	2007
Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension\| PubMed ID: 18039983	2008
Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice. Experimental physiology\| PubMed ID: 18192335	2008
Turning pages (Nobel lecture). Chembiochem : a European journal of chemical biology\| PubMed ID: 18543237	2008
Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18755891	2008
Tea with Dr Oliver Smithies, 2007 Nobel laureate in physiology and medicine. Interview by Dr. Anthony Viera. Journal of clinical hypertension (Greenwich, Conn.)\| PubMed ID: 18772647	2008
RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19164558	2009
The kallikrein-kinin system in health and in diseases of the kidney. Kidney international\| PubMed ID: 19190676	2009
Gender-dependent survival of allogeneic trophoblast stem cells in liver. Cell transplantation\| PubMed ID: 19523327	2009
Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. European journal of heart failure\| PubMed ID: 19553396	2009
Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin. PloS one\| PubMed ID: 19696925	2009
Mouse models of diabetic nephropathy. Journal of the American Society of Nephrology : JASN\| PubMed ID: 19729434	2009
Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochimica et biophysica acta\| PubMed ID: 19782130	2009
Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19884495	2009
Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20410496	2010
Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20479236	2010
Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice. Endocrinology\| PubMed ID: 20501666	2010
Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20667972	2010
Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20923879	2010
Science brick by brick. Nature\| PubMed ID: 20944621	2010
Therapeutic benefits in thalassemic mice transplanted with long-term-cultured bone marrow cells. Experimental hematology\| PubMed ID: 21184801	2011
A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21245338	2011
Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression. Gene expression\| PubMed ID: 21526716	2010
Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21555558	2011
β-MyHC and cardiac hypertrophy: size does matter. Circulation research\| PubMed ID: 21885833	2011
The kallikrein-kinin system and oxidative stress. Current opinion in nephrology and hypertension\| PubMed ID: 22048723	2012
Quantification of myocyte chemotaxis: a role for FAK in regulating directional motility. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22222526	2012
eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. Journal of the American Society of Nephrology : JASN\| PubMed ID: 22282588	2012
The kallikrein-kinin system in diabetic nephropathy. Kidney international\| PubMed ID: 22318421	2012
How it all began: a personal history of gel electrophoresis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22585472	2012
Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression. Gene expression\| PubMed ID: 22783727	2012
Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. American journal of physiology. Renal physiology\| PubMed ID: 23019230	2012
Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23503843	2013
The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Nature communications\| PubMed ID: 24335996	2013
Colour blindness: still too many red-green figures. Nature\| PubMed ID: 24943948	2014
Stable oligomeric clusters of gold nanoparticles: preparation, size distribution, derivatization, and physical and biological properties. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 25317930	2014
Transforming growth factor beta1 and aldosterone. Current opinion in nephrology and hypertension\| PubMed ID: 25587902	2015
A conversation with Oliver Smithies. Annual review of physiology\| PubMed ID: 25668016	2015
The role of transforming growth factor β1 in the regulation of blood pressure. Current hypertension reviews\| PubMed ID: 25801626	2014
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25848038	2015
Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25902541	2015
The whole of a scientific career: an interview with Oliver Smithies. PLoS genetics\| PubMed ID: 26020970	2015
A conversation with Oliver Smithies. The Journal of clinical investigation\| PubMed ID: 26524588	2015
Transforming growth factor β1 and diabetic nephropathy. American journal of physiology. Renal physiology\| PubMed ID: 26719364	2015