combined-invasive-subcortical-non-invasive-surface-neurophysiological

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

In spite of the success in applying non-invasive electroencephalography (EEG), magneto-encephalography (MEG) and functional magnetic resonance imaging ...

Medical Faculty, Heinrich-Heine-University

University Clinic Düsseldorf

Full recovery of adult onset opsoclonus myoclonus syndrome after early immunotherapy: a case report.

Gait disturbance in individuals with spinal cord lesion is attributed to the interruption of descending pathways to the spinal locomotor center, whereas neural circuits below and above the lesion maintain their functional capability. An artificial neural connection (ANC), which bridges supraspinal centers and locomotor networks in the lumbar spinal cord beyond the lesion site, may restore the functional impairment. To achieve an ANC that sends descending voluntary commands to the lumbar locomotor center and bypasses the thoracic spinal cord, upper limb muscle activity was converted to magnetic stimuli delivered noninvasively over the lumbar vertebra. Healthy participants were able to initiate and terminate walking-like behavior and to control the step cycle through an ANC controlled by volitional upper limb muscle activity. The walking-like behavior stopped just after the ANC was disconnected from the participants even when the participant continued to swing arms. Furthermore, additional simultaneous peripheral electrical stimulation to the foot via the ANC enhanced this walking-like behavior. Kinematics of the induced behaviors were identical to those observed in voluntary walking. These results demonstrate that the ANC induces volitionally controlled, walking-like behavior of the legs. This paradigm may be able to compensate for the dysfunction of descending pathways by sending commands to the preserved locomotor center at the lumbar spinal cord and may enable individuals with paraplegia to regain volitionally controlled walking.

Volitional walking via upper limb muscle-controlled stimulation of the lumbar locomotor center in man.

Movement disorders in Huntington's disease are often medically refractive. The aim of the trial was assessment of procedure safety of deep brain stimulation, equality of internal- and external-pallidal stimulation and efficacy followed-up for 6 months in a prospective pilot trial.

Article	Year
Full recovery of adult onset opsoclonus myoclonus syndrome after early immunotherapy: a case report. Movement disorders : official journal of the Movement Disorder Society\| PubMed ID: 21714012	2011
Volitional walking via upper limb muscle-controlled stimulation of the lumbar locomotor center in man. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25122909	2014
A Prospective Pilot Trial for Pallidal Deep Brain Stimulation in Huntington's Disease. Frontiers in neurology\| PubMed ID: 26347707	2015

Stefan J. Groiss

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