Timothy Billiar

Department of Surgery, University of Pittsburgh

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
$Pseudofracture: An Acute Peripheral Tissue Trauma Model$ Publication title Cited by 38	2011

Other Publications

Article	Year
The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock. Shock (Augusta, Ga.)\| PubMed ID: 11795663	2002
Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Biochemical and biophysical research communications\| PubMed ID: 11829475	2002
Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells. American journal of physiology. Cell physiology\| PubMed ID: 11832348	2002
TRISS unexpected survivors: an outdated standard? The Journal of trauma\| PubMed ID: 11834980	2002
A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock. Shock (Augusta, Ga.)\| PubMed ID: 11837796	2002
IFN-gamma inhibition of TRAIL-induced IAP-2 upregulation, a possible mechanism of IFN-gamma-enhanced TRAIL-induced apoptosis. Biochemical and biophysical research communications\| PubMed ID: 11846395	2002
Role of galectin-3 in breast cancer metastasis: involvement of nitric oxide. The American journal of pathology\| PubMed ID: 11891203	2002
Inducible nitric oxide synthase: from cloning to therapeutic applications. World journal of surgery\| PubMed ID: 11960209	2002
Requirements for NF-kappaB activation in hemorrhagic shock. Archives of orthopaedic and trauma surgery\| PubMed ID: 11995880	2002
Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis. Molecules and cells\| PubMed ID: 12018840	2002
Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infection and immunity\| PubMed ID: 12065483	2002
Mechanisms of hepatoprotection by nitric oxide. Annals of the New York Academy of Sciences\| PubMed ID: 12076992	2002
Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Hepatology (Baltimore, Md.)\| PubMed ID: 12085352	2002
Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli. The Journal of biological chemistry\| PubMed ID: 12167637	2002
A brief episode of hypotension increases mortality in critically ill trauma patients. The Journal of trauma\| PubMed ID: 12169927	2002
Nitric oxide and wound repair: role of cytokines? Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 12175813	2002
Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting induci... The Journal of biological chemistry\| PubMed ID: 12359727	2002
A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 12381414	2002
Maternity policy and practice during surgery residency: how we do it. Surgery\| PubMed ID: 12407353	2002
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nature medicine\| PubMed ID: 12539038	2003
Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock. Shock (Augusta, Ga.)\| PubMed ID: 12578118	2003
Ultraviolet irradiation increases FADD protein in apoptotic human keratinocytes. Biochemical and biophysical research communications\| PubMed ID: 12604344	2003
Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Annals of surgery\| PubMed ID: 12616113	2003
Regulation of tissue factor expression in smooth muscle cells with nitric oxide. Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter\| PubMed ID: 12618706	2003
Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 12620375	2003
Heme oxygenase-1: a cellular Hercules. Hepatology (Baltimore, Md.)\| PubMed ID: 12668964	2003
Autologous nitric oxide protects mouse and human keratinocytes from ultraviolet B radiation-induced apoptosis. American journal of physiology. Cell physiology\| PubMed ID: 12676653	2003
There's NO business like p53 business: nitric oxide regulates phosphorylation of p53 in chronic inflammatory disease. Cell cycle (Georgetown, Tex.)\| PubMed ID: 12695658	2003
Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12773486	2003
Nitric oxide and wound repair. The Surgical clinics of North America\| PubMed ID: 12822723	2003
Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 12830053	2003
RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression. Circulation\| PubMed ID: 12874183	2003
Nitric oxide-mediated inhibition of caspase-dependent T lymphocyte proliferation. Journal of leukocyte biology\| PubMed ID: 12949244	2003
A role for angiotensin II in the activation of extracellular signal-regulated kinases in the liver during hemorrhagic shock. Shock (Augusta, Ga.)\| PubMed ID: 14501944	2003
Role of nitric oxide in liver injury. Current molecular medicine\| PubMed ID: 14527083	2003
Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. The Journal of experimental medicine\| PubMed ID: 14657222	2003
Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility. Gastroenterology\| PubMed ID: 14699497	2004
Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14707100	2004
Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 14715517	2004
IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo. Oncogene\| PubMed ID: 14762441	2004
Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments. Biorheology\| PubMed ID: 14967890	2004
Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity. Cancer research\| PubMed ID: 14973054	2004
'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity. Biological chemistry\| PubMed ID: 14977041	2004
The Department of Surgery at the School of Medicine at the University Of Pittsburgh, Pittsburgh, Pa. Archives of surgery (Chicago, Ill. : 1960)\| PubMed ID: 15136344	2004
Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation. Cancer research\| PubMed ID: 15205314	2004
Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15304656	2004
The secretable form of trimeric TRAIL, a potent inducer of apoptosis. Biochemical and biophysical research communications\| PubMed ID: 15358116	2004
Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of IkappaB. Experimental & molecular medicine\| PubMed ID: 15365250	2004
Tissue hypoxia activates JNK in the liver during hemorrhagic shock. Shock (Augusta, Ga.)\| PubMed ID: 15377896	2004
IFN-gamma enhances TRAIL-induced apoptosis through IRF-1. European journal of biochemistry / FEBS\| PubMed ID: 15511228	2004
Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53. Cancer research\| PubMed ID: 15520210	2004
Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. Current molecular medicine\| PubMed ID: 15579022	2004
Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 15643987	2005
Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 15716856	2005
Application of genome-wide expression analysis to human health and disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15781863	2005
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. The Journal of experimental medicine\| PubMed ID: 15795240	2005
Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress. Surgery\| PubMed ID: 15800492	2005
Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions. Shock (Augusta, Ga.)\| PubMed ID: 15834312	2005
Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation. Shock (Augusta, Ga.)\| PubMed ID: 15897805	2005
The acute inflammatory response in diverse shock states. Shock (Augusta, Ga.)\| PubMed ID: 15988324	2005
The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock. Hepatology (Baltimore, Md.)\| PubMed ID: 16025510	2005
Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury. Circulation\| PubMed ID: 16027253	2005
Glutathione depletion renders rat hepatocytes sensitive to nitric oxide donor-mediated toxicity. Hepatology (Baltimore, Md.)\| PubMed ID: 16116630	2005
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 16272176	2006
Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. Journal of the American Chemical Society\| PubMed ID: 16277524	2005
Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16301676	2005
Nitric oxide: a clinical primer. Critical care medicine\| PubMed ID: 16340431	2005
Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16493066	2006
Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. Journal of the American College of Surgeons\| PubMed ID: 16500244	2006
Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway. Biochemical and biophysical research communications\| PubMed ID: 16647044	2006
Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 16675630	2006
The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 16751175	2006
Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16751357	2006
Leukocyte-derived inducible nitric oxide synthase mediates murine postoperative ileus. Annals of surgery\| PubMed ID: 16858184	2006
Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts. Surgery\| PubMed ID: 16904967	2006
Carbon monoxide reverses established pulmonary hypertension. The Journal of experimental medicine\| PubMed ID: 16908624	2006
In silico models of acute inflammation in animals. Shock (Augusta, Ga.)\| PubMed ID: 16912648	2006
Ischemic preconditioning of the murine liver protects through the Akt kinase pathway. Hepatology (Baltimore, Md.)\| PubMed ID: 16941697	2006
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 16953558	2006
In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 16953560	2006
Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage. Shock (Augusta, Ga.)\| PubMed ID: 17047512	2006
Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. Journal of leukocyte biology\| PubMed ID: 17062605	2007
The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis. Shock (Augusta, Ga.)\| PubMed ID: 17117135	2006
Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock. Shock (Augusta, Ga.)\| PubMed ID: 17224790	2007
Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17264172	2007
Targeting CD47: NO limit on therapeutic potential. Circulation research\| PubMed ID: 17363705	2007
Making progress in an enlightened era: opportunities and obstacles. Surgical infections\| PubMed ID: 17381393	2007
Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury. Journal of neurochemistry\| PubMed ID: 17394464	2007
A novel inhibitory peptide of Toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in mice. Shock (Augusta, Ga.)\| PubMed ID: 17414417	2007
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17475888	2007
Masquerader: high mobility group box-1 and cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17504981	2007
Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS. Shock (Augusta, Ga.)\| PubMed ID: 17515854	2007
Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes. Shock (Augusta, Ga.)\| PubMed ID: 17545941	2007
Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols. Biochemistry\| PubMed ID: 17580965	2007
Systemic inflammation and remote organ injury following trauma require HMGB1. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 17652366	2007
Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. Journal of leukocyte biology\| PubMed ID: 17925504	2008
Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidence. Journal of surgical education\| PubMed ID: 17961883	2007
The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity. Immunological reviews\| PubMed ID: 17979840	2007
HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. The Journal of experimental medicine\| PubMed ID: 17984303	2007
FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. Cardiovascular research\| PubMed ID: 18006431	2008
Early events in the recognition of danger signals after tissue injury. Journal of leukocyte biology\| PubMed ID: 18032691	2008
Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion. Transplantation\| PubMed ID: 18049113	2007
Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction. Biochemical and biophysical research communications\| PubMed ID: 18174021	2008
Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society\| PubMed ID: 18313411	2008
Protective effect of p53 in vascular smooth muscle cells against nitric oxide-induced apoptosis is mediated by up-regulation of heme oxygenase-2. BMB reports\| PubMed ID: 18315954	2008
Male gender is associated with excessive IL-6 expression following severe injury. The Journal of trauma\| PubMed ID: 18332795	2008
Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury. Journal of clinical biochemistry and nutrition\| PubMed ID: 18385824	2008
HMGB1: endogenous danger signaling. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 18431461	2008
Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury. Shock (Augusta, Ga.)\| PubMed ID: 18461022	2008
Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 18497334	2008
Computational insights on the competing effects of nitric oxide in regulating apoptosis. PloS one\| PubMed ID: 18509469	2008
Changes in FADD levels, distribution, and phosphorylation in TNFalpha-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent. Apoptosis : an international journal on programmed cell death\| PubMed ID: 18543108	2008
Detection and measurement for the modification and inactivation of caspase by nitrosative stress in vitro and in vivo. Methods in enzymology\| PubMed ID: 18554542	2008
Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture. Shock (Augusta, Ga.)\| PubMed ID: 18562923	2008
The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture. Journal of orthopaedic trauma\| PubMed ID: 18594302	2008
Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance. Journal of leukocyte biology\| PubMed ID: 18687905	2008
Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes. The Journal of biological chemistry\| PubMed ID: 18701460	2008
Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18802105	2008
Parenteral calcium for intensive care unit patients. Cochrane database of systematic reviews (Online)\| PubMed ID: 18843706	2008
An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. The Journal of trauma\| PubMed ID: 19001962	2008
Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19109190	2009
Studies toward the analysis of S-nitrosoproteins. Organic & biomolecular chemistry\| PubMed ID: 19109666	2009
Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19147804	2009
Therapeutic antioxidant medical gas. Journal of clinical biochemistry and nutrition\| PubMed ID: 19177183	2009
Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. PloS one\| PubMed ID: 19229339	2009
Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism. Hepatology (Baltimore, Md.)\| PubMed ID: 19296467	2009
Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart. Transplantation\| PubMed ID: 19461481	2009
Innate immune mechanisms in ischemia/reperfusion. Frontiers in bioscience (Elite edition)\| PubMed ID: 19482628	2009
Low-dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality. Journal of leukocyte biology\| PubMed ID: 19487305	2009
Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury. Hepatology (Baltimore, Md.)\| PubMed ID: 19492424	2009
Preactivation of NKT cells with alpha-GalCer protects against hepatic ischemia-reperfusion injury in mouse by a mechanism involving IL-13 and adenosine A2A receptor. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 19556359	2009
Activation of latent transforming growth factor-beta1 by nitric oxide in macrophages: role of soluble guanylate cyclase and MAP kinases. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society\| PubMed ID: 19614923	2009
Orally administered nitrite attenuates cardiac allograft rejection in rats. Surgery\| PubMed ID: 19628069	2009
Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. The Journal of trauma\| PubMed ID: 19667872	2009
Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis. The Journal of trauma\| PubMed ID: 19741387	2009
The nitric oxide donor S-nitrosoglutathione reduces apoptotic primary liver cell loss in a three-dimensional perfusion bioreactor culture model developed for liver support. Tissue engineering. Part A\| PubMed ID: 19814591	2010
Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells. FEBS letters\| PubMed ID: 19822150	2009
Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 19828841	2009
Oral hydrogen water prevents chronic allograft nephropathy in rats. Kidney international\| PubMed ID: 19907413	2010
Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells. Biochemical and biophysical research communications\| PubMed ID: 20005201	2010
An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage. PloS one\| PubMed ID: 20027315	2009
Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 20036162	2010
Linking oxidative stress to inflammation: Toll-like receptors. Free radical biology & medicine\| PubMed ID: 20083193	2010
Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlappin... Journal of leukocyte biology\| PubMed ID: 20413727	2010
Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase. American journal of respiratory cell and molecular biology\| PubMed ID: 20418360	2011
Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20479259	2010
Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 20508155	2010
Delay to therapeutic interventional radiology postinjury: time is of the essence. The Journal of trauma\| PubMed ID: 20539172	2010
Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrow-derived cells and parenchymal cells. Shock (Augusta, Ga.)\| PubMed ID: 20577143	2011
Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine production. Journal of hepatology\| PubMed ID: 20615568	2010
A critical role for IFN regulatory factor 1 in NKT cell-mediated liver injury induced by alpha-galactosylceramide. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20624945	2010
Superior myocardial preservation with HTK solution over Celsior in rat hearts with prolonged cold ischemia. Surgery\| PubMed ID: 20627336	2010
Toll-like receptors and myocardial ischemia/reperfusion, inflammation, and injury. Current cardiology reviews\| PubMed ID: 20676278	2009
Role of hemorrhage in the induction of systemic inflammation and remote organ damage: analysis of combined pseudo-fracture and hemorrhagic shock. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 20690183	2011
Complement factor 3 deficiency attenuates hemorrhagic shock-related hepatic injury and systemic inflammatory response syndrome. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 20702808	2010
Incidental radiographic findings after injury: dedicated attention results in improved capture, documentation, and management. Surgery\| PubMed ID: 20705305	2010
Toll-like receptors in hepatic ischemia/reperfusion and transplantation. Gastroenterology research and practice\| PubMed ID: 20811615	2010
Differential regulation by fucoidan of IFN-Î³-induced NO production in glial cells and macrophages. Journal of cellular biochemistry\| PubMed ID: 20830678	2010
Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight. Medical hypotheses\| PubMed ID: 20851533	2011
Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts. Cardiovascular research\| PubMed ID: 20851811	2011
Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury. Shock (Augusta, Ga.)\| PubMed ID: 20856174	2011
High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity. The Journal of biological chemistry\| PubMed ID: 20937823	2010
Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats. Transplantation\| PubMed ID: 21048533	2010
TNF/TNF receptor 1-mediated apoptosis in hepatocytes. Advances in experimental medicine and biology\| PubMed ID: 21153368	2011
Hydrogen inhalation ameliorates ventilator-induced lung injury. Critical care (London, England)\| PubMed ID: 21184683	2010
DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 21233273	2011
Models of lower extremity damage in mice: time course of organ damage and immune response. The Journal of surgical research\| PubMed ID: 21276982	2011
Over reliance on computed tomography imaging in patients with severe abdominal injury: is the delay worth the risk? The Journal of trauma\| PubMed ID: 21307722	2011
Body adipose content is independently associated with a higher risk of organ failure and nosocomial infection in the nonobese patient postinjury. The Journal of trauma\| PubMed ID: 21307724	2011
Histidine-tryptophan-ketoglutarate or celsior: which is more suitable for cold preservation for cardiac grafts from older donors? The Annals of thoracic surgery\| PubMed ID: 21352993	2011
Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochemical and biophysical research communications\| PubMed ID: 21473852	2011
Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1Î± in mouse hepatocytes. Shock (Augusta, Ga.)\| PubMed ID: 21558981	2011
A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks. PloS one\| PubMed ID: 21573002	2011
High-mobility group box 1 is essential for mitochondrial quality control. Cell metabolism\| PubMed ID: 21641551	2011
Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 21666957	2011
Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology (Baltimore, Md.)\| PubMed ID: 21721026	2011
Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-Î±-treated hepatocytes. The American journal of pathology\| PubMed ID: 21741934	2011
Toll-like receptor signaling in liver diseases. Gastroenterology research and practice\| PubMed ID: 21789039	2010
Sepsis: Something old, something new, and a systems view. Journal of critical care\| PubMed ID: 21798705	2011
The effect of donor treatment with hydrogen on lung allograft function in rats. Surgery\| PubMed ID: 21801961	2011
Early lower extremity fracture fixation and the risk of early pulmonary embolus: filter before fixation? The Journal of trauma\| PubMed ID: 21817975	2011
Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis. Physiological genomics\| PubMed ID: 21828244	2011
Mast cells play a critical role in the systemic inflammatory response and end-organ injury resulting from trauma. Journal of the American College of Surgeons\| PubMed ID: 21920785	2011
Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21940680	2011
Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation\| PubMed ID: 21956195	2011
Assessment of platelet transfusion for reversal of aspirin after traumatic brain injury. Surgery\| PubMed ID: 22000198	2011
Interferon Regulatory Factor-1 Regulates the Autophagic Response in LPS Stimulated Macrophages through Nitric Oxide. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 22105605	2011
A genomic storm in critically injured humans. The Journal of experimental medicine\| PubMed ID: 22110166	2011
Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PloS one\| PubMed ID: 22194859	2011
Splenocyte Apoptosis and Autophagy is Mediated by Interferon Regulatory Factor-1 During Murine Endotoxemia. Shock (Augusta, Ga.)\| PubMed ID: 22266972	2012
Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats. Cardiovascular research\| PubMed ID: 22287575	2012
Role of Macrophages in Mobilization of Hematopoietic Progenitor Cells From Bone Marrow After Hemorrhagic Shock. Shock (Augusta, Ga.)\| PubMed ID: 22293600	2012
Evolving role of endovascular techniques for traumatic vascular injury: A changing landscape? The Journal of trauma\| PubMed ID: 22310114	2012
Changes in massive transfusion over time: An early shift in the right direction? The Journal of trauma\| PubMed ID: 22310123	2012